The DOI matches its Crossref record; 194 of the 194 references it cites were found in a registry or an index.
New Mechanistic and Functional Insights into DNA Topoisomerases
Abstract
DNA topoisomerases are nature's tools for resolving the unique problems of DNA entanglement that occur owing to unwinding and rewinding of the DNA helix during replication, transcription, recombination, repair, and chromatin remodeling. These enzymes perform topological transformations by providing a transient DNA break, formed by a covalent adduct with the enzyme, through which strand passage can occur. The active site tyrosine is responsible for initiating two transesterifications to cleave and then religate the DNA backbone. The cleavage reaction intermediate is exploited by cytotoxic agents, which have important applications as antibiotics and anticancer drugs. The reactions mediated by these enzymes can also be regulated by their binding partners; one example is a DNA helicase capable of modulating the directionality of strand passage, enabling important functions like reannealing denatured DNA and resolving recombination intermediates. In this review, we cover recent advances in mechanistic insights into topoisomerases and their various cellular functions.
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Cites
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Cited by
Topoisomerases as anticancer targets
Delgado, J. L., Hsieh, C.-M., Chan, N.-L., & Hiasa, H. (2018) · Biochemical Journal · doi:10.1042/bcj20160583 · Cited by 481
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Bhagat, A., & Kleinerman, E. S. (2020) · Advances in Experimental Medicine and Biology · doi:10.1007/978-3-030-43032-0_15 · Cited by 208
Naphthoquinones: A continuing source for discovery of therapeutic antineoplastic agents
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Metadata
- Authors
- Chen, S. H., Chan, N.-L., & Hsieh, T.-S.
- Venue
- Annual Review of Biochemistry
- Publisher
- Annual Reviews
- Published
- 2013-06-02
- Volume
- 82
- Issue
- 1
- Pages
- 139-170
- ISSN
- 0066-4154 (ISSN-L)
- 1545-4509
- OpenAlex
- W2162764839
- Cited by
- 369
- References
- 194
- FWCI
- 2.23
- Type
- journal article
- Language
- en
- Open access
- closed
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- Chen, S. H., Chan, N.-L., & Hsieh, T.-S. (2013). New Mechanistic and Functional Insights into DNA Topoisomerases. Annual Review of Biochemistry. https://doi.org/10.1146/annurev-biochem-061809-100002
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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