The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Activity-based protein profiling for biochemical pathway discovery in cancer
Open accessAbstract
Large-scale profiling methods have uncovered numerous gene and protein expression changes that correlate with tumorigenesis. However, determining the relevance of these expression changes and which biochemical pathways they affect has been hindered by our incomplete understanding of the proteome and its myriad functions and modes of regulation. Activity-based profiling platforms enable both the discovery of cancer-relevant enzymes and selective pharmacological probes to perturb and characterize these proteins in tumour cells. When integrated with other large-scale profiling methods, activity-based proteomics can provide insight into the metabolic and signalling pathways that support cancer pathogenesis and illuminate new strategies for disease diagnosis and treatment.
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Cites
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Self-citationNHS-Esters As Versatile Reactivity-Based Probes for Mapping Proteome-Wide Ligandable Hotspots
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Self-citationLigandability of E3 Ligases for Targeted Protein Degradation Applications
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Metadata
- Authors
- Nomura, D. K., Dix, M. M., & Cravatt, B. F.
- Venue
- Nature Reviews Cancer
- Published
- 2010-08-12
- Volume
- 10
- Issue
- 9
- Pages
- 630-638
- ISSN
- 1474-175X (ISSN-L)
- 1474-1768
- OpenAlex
- W2021790986
- Cited by
- 341
- References
- 10
- FWCI
- 1.24
- Type
- journal article
- Language
- en
- Open access
- green
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