The RUNX family: developmental regulators in cancer
Abstract
RUNX proteins belong to a family of metazoan transcription factors that serve as master regulators of development. They are frequently deregulated in human cancers, indicating a prominent and, at times, paradoxical role in cancer pathogenesis. The contextual cues that direct RUNX function represent a fast-growing field in cancer research and could provide insights that are applicable to early cancer detection and treatment. This Review describes how RUNX proteins communicate with key signalling pathways during the multistep progression to malignancy; in particular, we highlight the emerging partnership of RUNX with p53 in cancer suppression.
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Runx3 has roles in cancers including melanoma but has not previously been ascribed roles in normal pigment cells.
“Runx3 has roles in cancers including melanoma but has not previously been ascribed roles in normal pigment cells (63–66).”
From Agouti and BMP signaling drive a naturally occurring fate conversion of melanophores to leucophores in zebrafish (2025) · cites this paper as [64]
Cites
Canonical WNT Signaling Promotes Osteogenesis by Directly Stimulating Runx2 Gene Expression
Gaur, T., Lengner, C. J., Hovhannisyan, H., Bhat, R. A., Bodine, P. V. N., Komm, B. S., Javed, A., van Wijnen, A. J., Stein, J. L., Stein, G. S., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m500608200 · Cited by 1,170 · see citing works
Hilton, M. J., Tu, X., Wu, X., Bai, S., Zhao, H., Kobayashi, T., Kronenberg, H. M., Teitelbaum, S. L., Ross, F. P., Kopan, R., et al. (2008) · Nature Medicine · doi:10.1038/nm1716 · Cited by 604 · see citing works
Ichikawa, M., Asai, T., Saito, T., Yamamoto, G., Seo, S., Yamazaki, I., Yamagata, T., Mitani, K., Chiba, S., Hirai, H., et al. (2004) · Nature Medicine · doi:10.1038/nm997 · Cited by 596 · see citing works
Levanon, D., Negreanu, V., Bernstein, Y., Bar-Am, I., Avivi, L., & Groner, Y. (1994) · Genomics · doi:10.1006/geno.1994.1519 · Cited by 391 · see citing works
Thomas, D. M., Carty, S. A., Piscopo, D. M., Lee, J.-S., Wang, W.-F., Forrester, W. C., & Hinds, P. W. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00327-6 · Cited by 361 · see citing works
T helper 17 cells play a critical pathogenic role in lung cancer
Chang, S. H., Mirabolfathinejad, S. G., Katta, H., Cumpian, A. M., Gong, L., Caetano, M. S., Moghaddam, S. J., & Dong, C. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1319051111 · Cited by 326 · see citing works
Kim, W., Sieweke, M., Ogawa, E., Wee, H., Englmeier, U., Graf, T., & Ito, Y. (1999) · The EMBO Journal · doi:10.1093/emboj/18.6.1609 · Cited by 230 · see citing works
Structural basis for hijacking CBF-β and CUL5 E3 ligase complex by HIV-1 Vif
Guo, Y., Dong, L., Qiu, X., Wang, Y., Zhang, B., Liu, H., Yu, Y., Zang, Y., Yang, M., & Huang, Z. (2014) · Nature · doi:10.1038/nature12884 · Cited by 202 · see citing works
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Ferrarotto, R., Eckhardt, G., Patnaik, A., LoRusso, P., Faoro, L., Heymach, J. V., Kapoun, A. M., Xu, L., & Munster, P. (2018) · Annals of Oncology · doi:10.1093/annonc/mdy171 · Cited by 138 · see citing works
Regulation of Src Family Kinases during Colorectal Cancer Development and Its Clinical Implications
Jin, W. (2020) · Cancers · doi:10.3390/cancers12051339 · Cited by 86 · see citing works
Covalent Modifications of RUNX Proteins: Structure Affects Function
Blumenthal, E., Greenblatt, S., Huang, G., Ando, K., Xu, Y., & Nimer, S. D. (2017) · Advances in Experimental Medicine and Biology · doi:10.1007/978-981-10-3233-2_3 · Cited by 16 · see citing works
Huang, D., Kapadia, E. H., Liang, Y., Shriver, L. P., Dai, S., Patti, G. J., Humbel, B. M., Laudet, V., & Parichy, D. M. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2424180122 · Cited by 15 · see citing works
- Authors
- Ito, Y., Bae, S.-C., & Chuang, L. S. H.
- Affiliations
- National University of Singapore (SG)
- Chungbuk National University (KR)
- Corresponding author
- Ito, Yoshiaki
- Venue
- Nature Reviews Cancer
- Published
- 2015-01-16
- Volume
- 15
- Issue
- 2
- Pages
- 81-95
- ISSN
- 1474-175X (ISSN-L)
- 1474-1768
- OpenAlex
- W2131110612
- Cited by
- 399
- References
- 8
- Citations by year
- 2026: 21 · 2025: 20 · 2024: 32 · 2023: 49 · 2022: 34 · 2021: 37 · 2020: 46 · 2019: 25 · 2018: 35 · 2017: 50 · 2016: 30 · 2015: 20
- FWCI
- 4.79
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Cancer (publishedVersion)
- PubMed (publishedVersion)
- National University of Singapore (submittedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- Runx transcription factors, cancer, tumour suppressor, oncogenic transcription factor, developmental regulation, signaling pathways, p53, tumor progression, early cancer detection, cancer therapy
- MeSH terms
- Cell Differentiation, DNA Damage, DNA Repair, Humans, Inflammation, Neoplasms, Phosphorylation, Transcription, Genetic, Signal Transduction, Tumor Suppressor Protein p53, Cyclin-Dependent Kinases, DNA Methylation, ADP-Ribosylation Factors, Cell Proliferation, Core Binding Factor alpha Subunits
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