Cited by 564Viral Infectious Diseases and Gene Expression in InsectsBiomedical Ethics and RegulationAnimal testing and alternatives

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HeLa cells 50 years on: the good, the bad and the ugly

Masters, John R.·2002·Nature Reviews Cancer

DOI 10.1038/nrc775

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(1952) · Cancer Research · Cited by 987
STUDIES ON THE PROPAGATION IN VITRO OF POLIOMYELITIS VIRUSES
Scherer, W. F., Syverton, J. T., & Gey, G. O. (1953) · Journal of Experimental Medicine · doi:10.1084/jem.97.5.695 · Cited by 856
Production of Malignancy in Vitro. IV. The Mouse Fibroblast Cultures and Changes Seen in the Living Cells
(1943) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/4.2.165 · Cited by 833
Observations on the living developing nerve fiber
Harrison, R. G. (1906) · Experimental Biology and Medicine · doi:10.3181/00379727-4-98 · Cited by 609
ON THE PERMANENT LIFE OF TISSUES OUTSIDE OF THE ORGANISM
Carrel, A. (1912) · The Journal of Experimental Medicine · doi:10.1084/jem.15.5.516 · Cited by 492
Propagation in a Fluid Medium of a Human Epidermoid Carcinoma, Strain KB
Eagle, H. (1955) · Experimental Biology and Medicine · doi:10.3181/00379727-89-21811 · Cited by 483
Short tandem repeat profiling provides an international reference standard for human cell lines
Masters, J. R., Thomson, J. A., Daly-Burns, B., Reid, Y. A., Dirks, W. G., Packer, P., Toji, L. H., Ohno, T., Tanabe, H., Arlett, C. F., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.121616198 · Cited by 478
Self-citation
The N‐terminal 34 kDa fragment of Helicobacter pylori vacuolating cytotoxin targets mitochondria and induces cytochrome c release
Galmiche, A., Rassow, J., Doye, A., Cagnol, S., Chambard, J., Contamin, S., de Thillot, V., Just, I., Ricci, V., Solcia, E., et al. (2000) · The EMBO Journal · doi:10.1093/emboj/19.23.6361 · Cited by 362
Human cancer cell lines: fact and fantasy
Masters, J. R. W. (2000) · Nature Reviews Molecular Cell Biology · doi:10.1038/35043102 · Cited by 352
Self-citation
Cross-contamination of cells in culture
Nelson-Rees, W. A., Daniels, D. W., & Flandermeyer, R. R. (1981) · Science · doi:10.1126/science.6451928 · Cited by 329

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Research works printed but not linked: 5

Lewis, W. H. Malignant cells. The Harvey Lectures 31, 214–234 (1936).
Gold, M. A Conspiracy of Cells. One Woman's Immortal Legacy and the Scandal it Caused (State Univ. New York Press, New York, 1986).
Jones, H. W., McKusick, V. A., Harper, P. S. & Wuu K. D. The HeLa cell and a reappraisal of its origin. Obstet. Gynecol. 38, 945–949 (1971).
Rothfels, K. H., Axelrad, A. A., Siminovitch, L., McCulloch, E. A. & Parker, R. C. in Proc. 3rd Canadian Cancer Research Conference 1958 (ed. Begg, R. W.) 189–214 (Academic, New York, 1958).
Davis, E. V. & Bolin, V. S. Continuous cultivation of isogenous cell lines from the human embryo. Fed. Proc. 19, 386 (1960).

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Authors: Masters, J. R.
Affiliations: University College London (GB)
Corresponding author: Masters, John R.
Venue: Nature Reviews Cancer
Publisher: Springer Science and Business Media LLC
Published: 2002-04
Volume: 2
Issue: 4
Pages: 315-319
ISSN: 1474-175X (ISSN-L)
1474-1768
DOI: 10.1038/nrc775
OpenAlex: W2070468167
Cited by: 560
References: 49
Citations by year: 2026: 28 · 2025: 33 · 2024: 23 · 2023: 41 · 2022: 26 · 2021: 32 · 2020: 30 · 2019: 29 · 2018: 15 · 2017: 32 · 2016: 31 · 2015: 23 · 2014: 31 · 2013: 29 · 2012: 18
FWCI: 0.46
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Cancer (publishedVersion)
PubMed (publishedVersion)
UCL Discovery (University College London) (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Viral Infectious Diseases and Gene Expression in Insects
Health Sciences › Nursing › Issues, ethics and legal aspects › Biomedical Ethics and Regulation
Health Sciences › Veterinary › Small Animals › Animal testing and alternatives
Keywords: HeLa cells, human cancer cell lines, cervical cancer, immortalized cell lines, scientific fraud, cell line authentication, history of cancer research
MeSH terms: Cytogenetics, Female, HeLa Cells, Humans, Research Design, Time Factors, Tumor Cells, Cultured

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