Cited by 292Cancer-related Molecular PathwaysCell death mechanisms and regulationPI3K/AKT/mTOR signaling in cancer

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Coordinated regulation of life and death by RB

Chau, B. Nelson, Wang, Jean Y.J.·2003·Nature Reviews Cancer

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Abstract

Recent studies have shown that RB can inhibit apoptosis, independently of its ability to block cell proliferation. This poses the question of how cells choose to grow or to die when RB becomes inactivated. RB is phosphorylated following mitogenic stimulation, but it is degraded in response to death stimuli. Most sporadic cancers also inactivate RB by phosphorylation, rather than losing RB entirely--possibly to exploit the survival advantage conferred by RB under stress. Drawing from the different mechanisms of RB inactivation, we propose two models for ways in which cells use RB to make the choice of life versus death.

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CDK inhibitors: positive and negative regulators of G1-phase progression
Sherr, C. J., & Roberts, J. M. (1999) · Genes & Development · doi:10.1101/gad.13.12.1501 · Cited by 6,115
Cancer Cell Cycles
Sherr, C. J. (1996) · Science · doi:10.1126/science.274.5293.1672 · Cited by 5,379
Cellular survival: a play in three Akts
Datta, S. R., Brunet, A., & Greenberg, M. E. (1999) · Genes & Development · doi:10.1101/gad.13.22.2905 · Cited by 4,216
Untitled work
(2001) · PubMed · Cited by 2,381
5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers
Merlo, A., Herman, J. G., Mao, L., Lee, D. J., Gabrielson, E. W., Burger, P. C., Baylin, S. B., & Sidransky, D. (1995) · Nature Medicine · doi:10.1038/nm0795-686 · Cited by 1,992
Alterations in DNA Methylation: A Fundamental Aspect of Neoplasia
Baylln, S. B., Herman, J. G., Graff, J. R., Vertino, P. M., & Issa, J. J. (1997) · Advances in cancer research · doi:10.1016/s0065-230x(08)60702-2 · Cited by 1,919
Effects of an Rb mutation in the mouse
Jacks, T., Fazeli, A., Schmitt, E. M., Bronson, R. T., Goodell, M. A., & Weinberg, R. A. (1992) · Nature · doi:10.1038/359295a0 · Cited by 1,755
Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers
Nobori, T., Miura, K., Wu, D. J., Lois, A., Takabayashi, K., & Carson, D. A. (1994) · Nature · doi:10.1038/368753a0 · Cited by 1,742
Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis
Lee, E. Y.-H. P., Chang, C.-Y., Hu, N., Wang, Y.-C. J., Lai, C., Herrup, K., Lee, W., & Bradley, A. (1992) · Nature · doi:10.1038/359288a0 · Cited by 1,264
Control of apoptosis by Rel/NF-κB transcription factors
Barkett, M., & Gilmore, T. D. (1999) · Oncogene · doi:10.1038/sj.onc.1203238 · Cited by 1,202

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Phosphorylation site mutated RB exerts contrasting effects on apoptotic response to different stimuli
Masselli, A., & Wang, J. Y. J. (2005) · Oncogene · doi:10.1038/sj.onc.1209161 · Cited by 15
Self-citation
Retinoblastoma protein is required for efficient colorectal carcinoma cell apoptosis by histone deacetylase inhibitors in the absence of p21Waf
Wagner, S., & Roemer, K. (2005) · Biochemical Pharmacology · doi:10.1016/j.bcp.2004.12.017 · Cited by 15
Reduction of apoptosis in Rb-deficient embryos via Abl knockout
Borges, H. L., Hunton, I. C., & Wang, J. Y. J. (2007) · Oncogene · doi:10.1038/sj.onc.1210157 · Cited by 14
Self-citation
PKC inhibitor Go6976 induces mitosis and enhances doxorubicin-paclitaxel cytotoxicity in urinary bladder carcinoma cells
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Simultaneous expression of MMB-FOXM1 complex components enables efficient bypass of senescence
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Involvement of Bcl-XL deamidation in E1A-mediated cisplatin sensitization of ovarian cancer cells
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Inhibition of PC-PLC Blocked the Survival of Mouse Neural Cells by Up-Regulating the Expression of Integrin beta4 and Rb
Lv, X., Wang, N., Su, L., Zhang, S., & Miao, J. (2006) · Developmental Neuroscience · doi:10.1159/000095112 · Cited by 13
Integrated Stability and Activity Control of the Drosophila Rbf1 Retinoblastoma Protein
Zhang, L., Wei, Y., Pushel, I., Heinze, K., Elenbaas, J. S., Henry, R. W., & Arnosti, D. N. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.586818 · Cited by 12
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Wang, G., Ren, Z., Wang, P., Su, C., Zhang, W., LIU, Z.-G., Zhang, L., Zhao, X., & Chen, G. (2014) · Oncology Reports · doi:10.3892/or.2014.3233 · Cited by 11
The Apoptotic Paradox in Retinoblastoma
Sitorus, R. S., Gumay, S., & van der Valk, P. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.04719.x · Cited by 11
Epithelial-Specific Deletion of 11β-HSD2 Hinders Apcmin/+ Mouse Tumorigenesis
Jiang, L., Yang, S., Yin, H., Fan, X., Wang, S., Yao, B., Pozzi, A., Chen, X., Harris, R. C., & Zhang, M. (2013) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-13-0084-t · Cited by 11
Generation of a Retinoblastoma (Rb)1-inducible dominant-negative (DN) mouse model
Tarang, S., Doi, S. M. D. S. R., Gurumurthy, C. B., Harms, D. W., Quadros, R. M., & Rocha-Sanchez, S. M. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00052 · Cited by 12
Functional and physical communication between oncoproteins and tumor suppressors
Prochownik, E. V. (2005) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-005-5199-8 · Cited by 10
Inhibition of pRB Pathway Differentially Modulates Apoptosis in Esophageal Cancer Cells
Soletti, R. C., Biasoli, D., Rodrigues, N. A. L. V., Delou, J. M. D. A., Maciel, R. D. M., Chagas, V. L. A., Martins, R. A. P., Rehen, S. K., & Borges, H. L. (2017) · Translational Oncology · doi:10.1016/j.tranon.2017.06.008 · Cited by 9
Synergistic effects of co-expression plasmid-based ADAM10-specific siRNA and GRIM-19 on hepatocellular carcinoma in vitro and in vivo
Liu, S., Zhang, W., Liu, K., WANG, Y., Ji, B., & Liu, Y. (2014) · Oncology Reports · doi:10.3892/or.2014.3503 · Cited by 9
Retracted
TAT-Mediated Protein Transduction into Human Corneal Epithelial Cells: p15 INK4b Inhibits Cell Proliferation and Stimulates Cell Migration
Guo, X., Hutcheon, A. E. K., & Zieske, J. D. (2004) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.03-1164 · Cited by 9
Timing will tell
Berns, A. J. M. (2003) · Nature · doi:10.1038/424140a · Cited by 9
Screening and Treating Prostate Cancer in the Older Patient: Decision Making Across the Clinical Spectrum
Morgans, A. K., Dale, W., & Briganti, A. (2017) · American Society of Clinical Oncology Educational Book · doi:10.1200/edbk_175491 · Cited by 9
Acute lymphoblastic leukemia
Pui, C. (2006) · Cambridge University Press eBooks · doi:10.1017/cbo9780511471001.017 · Cited by 9
Adenovirus E1A requires c‐Ras for full neoplastic transformation or suppression of differentiation of murine preadipocytes
Cao, J., Arulanandam, R., Vultur, A., Anagnostopoulou, A., & Raptis, L. H. (2007) · Molecular Carcinogenesis · doi:10.1002/mc.20278 · Cited by 9

Authors: Chau, B. N., & Wang, J. Y. J.
Affiliations: University of California San Diego (US)
Corresponding author: Wang, Jean Y.J.
ORCID: Wang, Jean Y.J.
Venue: Nature Reviews Cancer
Publisher: Springer Science and Business Media LLC
Published: 2003-02
Volume: 3
Issue: 2
Pages: 130-138
ISSN: 1474-175X (ISSN-L)
1474-1768
DOI: 10.1038/nrc993
OpenAlex: W1979104079
Cited by: 292
References: 64
Citations by year: 2025: 2 · 2024: 5 · 2023: 9 · 2022: 6 · 2021: 8 · 2020: 6 · 2019: 3 · 2018: 8 · 2017: 6 · 2016: 5 · 2015: 10 · 2014: 10 · 2013: 11 · 2012: 12
FWCI: 3.40
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Cancer (publishedVersion)
PubMed (publishedVersion)
Funders: Damon Runyon Cancer Research Foundation
National Cancer Institute (R01CA058320)
Topics: Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
Keywords: retinoblastoma protein, apoptosis, cell proliferation, retinoblastoma protein phosphorylation, mitogen stimulation, cancer survival, cell fate determination, Rb inactivation
MeSH terms: Animals, Cell Cycle, Cell Survival, Humans, Neoplasms, Retinoblastoma Protein, Apoptosis, Mice, Knockout, Mice

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