The DOI matches its Crossref record; 64 of the 64 references it cites were found in a registry or an index.
Coordinated regulation of life and death by RB
Abstract
Recent studies have shown that RB can inhibit apoptosis, independently of its ability to block cell proliferation. This poses the question of how cells choose to grow or to die when RB becomes inactivated. RB is phosphorylated following mitogenic stimulation, but it is degraded in response to death stimuli. Most sporadic cancers also inactivate RB by phosphorylation, rather than losing RB entirely--possibly to exploit the survival advantage conferred by RB under stress. Drawing from the different mechanisms of RB inactivation, we propose two models for ways in which cells use RB to make the choice of life versus death.
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“Both these pathways are complex as they involve many upstream regulators and downstream effectors along with varying side branches (Chau and Wang, 2003; Levine and Oren, 2009).”
From Mechanisms of Cellular Senescence: Cell Cycle Arrest and Senescence Associated Secretory Phenotype (2021) · cites this paper as Chau and Wang, 2003
In the citing paper
“abnormal proliferation that is induced by loss of RB is often accompanied by increased cell death, through p53-dependent and independent mechanisms49,57,87–91.”
From Cellular mechanisms of tumour suppression by the retinoblastoma gene (2008) · cites this paper as [88]
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Cites
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Aging, Cellular Senescence, and Cancer
Campisi, J. (2013) · Annual Review of Physiology · doi:10.1146/annurev-physiol-030212-183653 · Cited by 2,954
Mechanisms of Cellular Senescence: Cell Cycle Arrest and Senescence Associated Secretory Phenotype
Kumari, R., & Jat, P. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.645593 · Cited by 1,622
The emerging roles of forkhead box (Fox) proteins in cancer
Myatt, S. S., & Lam, E. W. ‐. (2007) · Nature reviews. Cancer · doi:10.1038/nrc2223 · Cited by 1,077
Cellular mechanisms of tumour suppression by the retinoblastoma gene
Burkhart, D. L., & Sage, J. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2399 · Cited by 974
Autophagy as a target for anticancer therapy
Jankú, F., McConkey, D. J., Hong, D. S., & Kurzrock, R. (2011) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2011.71 · Cited by 814
Metadata
- Authors
- Chau, B. N., & Wang, J. Y. J.
- Affiliations
- University of California San Diego (US)
- Corresponding author
- Wang, Jean Y.J.
- ORCID
- Wang, Jean Y.J.
- Venue
- Nature Reviews Cancer
- Published
- 2003-02
- Volume
- 3
- Issue
- 2
- Pages
- 130-138
- ISSN
- 1474-175X (ISSN-L)
- 1474-1768
- OpenAlex
- W1979104079
- Cited by
- 292
- References
- 64
- Citations by year
- 2025: 2 · 2024: 5 · 2023: 9 · 2022: 6 · 2021: 8 · 2020: 6 · 2019: 3 · 2018: 8 · 2017: 6 · 2016: 5 · 2015: 10 · 2014: 10 · 2013: 11 · 2012: 12
- FWCI
- 3.40
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Cancer (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Damon Runyon Cancer Research Foundation
- National Cancer Institute (R01CA058320)
- Topics
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
- Keywords
- retinoblastoma protein, apoptosis, cell proliferation, retinoblastoma protein phosphorylation, mitogen stimulation, cancer survival, cell fate determination, Rb inactivation
- MeSH terms
- Animals, Cell Cycle, Cell Survival, Humans, Neoplasms, Retinoblastoma Protein, Apoptosis, Mice, Knockout, Mice
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