The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Molecular imaging of cardiovascular disease with contrast-enhanced ultrasonography
Abstract
Techniques for noninvasive imaging of specific disease-related molecular changes are being developed to enhance diagnosis and therapeutic decision making in the clinical setting, and to facilitate research efforts. Molecular imaging with contrast-enhanced ultrasonography relies on the detection of the acoustic signal produced by microbubble or nanoparticle agents that are targeted to sites of disease. This Review describes the basis for ultrasound molecular imaging, the unique features of contrast agent behavior or detector performance in relation to clinical or research needs, and the progress that has been made to date in imaging key events in cardiovascular medicine, such as atherosclerosis, postischemic inflammation, angiogenesis, transplant rejection and thrombus formation.
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“The echogenicity for effective ultrasound-mediated imaging favours the use of probes that are larger than nanoparticles, including microbubbles and larger liposomes that are 500–800 nm in size155.”
From Perspectives and opportunities for nanomedicine in the management of atherosclerosis (2011) · cites this paper as [155]
Citations
Cites
On the Stability of Gas Bubbles in Liquid-Gas Solutions
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Intraplaque Hemorrhage and Progression of Coronary Atheroma
Kolodgie, F. D., Gold, H. K., BURKE, A. P., Fowler, D. R., Kruth, H. S., Weber, D. K., Farb, A. A., Guerrero, L. J., Hayase, M., Kutys, R., et al. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa035655 · Cited by 1,491
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Neovascularization in Human Atherosclerosis
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Imaging Tumor Angiogenesis With Contrast Ultrasound and Microbubbles Targeted to α v β 3
Ellegala, D. B., Leong-Poi, H. M., Carpenter, J. E., Klibanov, A. L., Kaul, S., Shaffrey, M. E., Sklenar, J., & Lindner, J. R. (2003) · Circulation · doi:10.1161/01.cir.0000080326.15367.0c · Cited by 454
Self-citationMolina, C. A., Ribó, M., Rubiera, M., Montaner, J., Santamarina, E., Delgado‐Mederos, R., Arenillas, J. F., Huertas, R., Purroy, F. F., Delgado, P., et al. (2005) · Stroke · doi:10.1161/01.str.0000199064.94588.39 · Cited by 451
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Self-citationA Novel Site-Targeted Ultrasonic Contrast Agent With Broad Biomedical Application
Lanza, G. M., Wallace, K. D., Scott, M. J., Cacheris, W. P., Abendschein, D. R., Christy, D. H., Sharkey, A. M., Miller, J. G., Gaffney, P. J., & Wickline, S. A. (1996) · Circulation · doi:10.1161/01.cir.94.12.3334 · Cited by 406
Research works printed but not linked: 1
- Kaufmann, B. A. et al. Molecular imaging of endothelial cell activation predicts future atherosclerotic plaque development [abstract 904-253]. J. Am. Coll. Cardiol. 51 (Suppl. A), A125 (2008).
Cited by
Sorted by citations
Ultrafast imaging in biomedical ultrasound
Tanter, M., & Fink, M. (2014) · IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control · doi:10.1109/tuffc.2014.2882 · Cited by 1,157
Qian, X., Zheng, Y., & Chen, Y. (2016) · Advanced Materials · doi:10.1002/adma.201602012 · Cited by 888
Molecular imaging: current status and emerging strategies
Pysz, M. A., Gambhir, S. S., & Willmann, J. K. (2010) · Clinical Radiology · doi:10.1016/j.crad.2010.03.011 · Cited by 570
MicroRNA-181b regulates NF-κB–mediated vascular inflammation
Sun, X., Icli, B., Wara, A. K., Belkin, N., He, S., Kobzik, L., Hunninghake, G. M., Pinilla-Vera, M., Blackwell, T. S., Baron, R. M., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci61495 · Cited by 456
Porter, T. R., Mulvagh, S. L., Abdelmoneim, S. S., Becher, H. H., Belcik, J. T., Bierig, M., Choy, J. B., Gaibazzi, N., Gillam, L. D., Janardhanan, R., et al. (2018) · Journal of the American Society of Echocardiography · doi:10.1016/j.echo.2017.11.013 · Cited by 432
Self-citation
Metadata
- Authors
- Lindner, J. R.
- Affiliations
- Oregon Health & Science University (US)
- Corresponding author
- Lindner, Jonathan R.
- ORCID
- Lindner, Jonathan R.
- Venue
- Nature Reviews Cardiology
- Published
- 2009-06-09
- Volume
- 6
- Issue
- 7
- Pages
- 475-481
- ISSN
- 1759-5002 (ISSN-L)
- 1759-5010
- OpenAlex
- W2092160452
- Cited by
- 111
- References
- 40
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 2 · 2023: 1 · 2022: 3 · 2021: 2 · 2020: 8 · 2019: 5 · 2018: 8 · 2017: 8 · 2016: 5 · 2015: 9 · 2014: 8 · 2013: 9 · 2012: 9
- FWCI
- 1.10
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Ultrasound and Hyperthermia Applications
- Physical Sciences › Engineering › Biomedical Engineering › Photoacoustic and Ultrasonic Imaging
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
- Keywords
- molecular imaging, contrast-enhanced ultrasound, targeted ultrasound contrast agents, microbubbles, nanoparticle contrast agents, atherosclerosis, post-ischemic inflammation, angiogenesis, graft rejection, thrombus formation, non-invasive imaging
- MeSH terms
- Animals, Cardiovascular Diseases, Contrast Media, Humans, Inflammation, Neovascularization, Pathologic, Predictive Value of Tests, Thrombosis, Ultrasonography, Interventional, Neovascularization, Physiologic, Microbubbles, Nanoparticles
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