Cited by 218Cardiovascular Function and Risk FactorsCardiovascular Disease and AdiposityDiabetes, Cardiovascular Risks, and Lipoproteins

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Management of cardiovascular diseases in patients with obesity

Lavie, Carl J., Arena, Ross, Alpert, Martin A., Milani, Richard V., Ventura, Hector O.·2018·Nature Reviews Cardiology

DOI 10.1038/nrcardio.2017.108

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Abstract

The management of cardiovascular diseases (CVD) in patients with obesity presents numerous challenges. Obesity has a negative effect on almost all of the major CVD risk factors, and adversely influences cardiovascular structure and function. Patients who are overweight or obese have a higher incidence of almost all CVDs compared with patients who are of normal weight. However, those who are overweight or obese seem to have a better short-term and medium-term prognosis after major CVD events and interventional procedures or cardiac surgeries than leaner patients, a phenomenon termed the 'obesity paradox'. In considering the mechanisms underlying this paradox, we review evidence of the deleterious consequences of obesity in patients with coronary heart disease, and the limited data on the benefits of weight loss in patients with CVD. Additional studies are needed on the efficacy of purposeful weight loss on cardiovascular outcomes to determine the ideal body composition for patients with CVD.

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Authors: Lavie, C. J., Arena, R., Alpert, M. A., Milani, R. V., & Ventura, H. O.
Affiliations: Ochsner Health System (US)
University of Illinois Chicago (US)
University of Missouri (US)
Corresponding author: Lavie, Carl J.
ORCID: Lavie, Carl J.
Arena, Ross
Alpert, Martin A.
Milani, Richard V.
Venue: Nature Reviews Cardiology
Publisher: Springer Science and Business Media LLC
Published: 2017-07-27
Volume: 15
Issue: 1
Pages: 45-56
ISSN: 1759-5002 (ISSN-L)
1759-5010
DOI: 10.1038/nrcardio.2017.108
OpenAlex: W2741252257
Cited by: 218
References: 135
Citations by year: 2026: 9 · 2025: 18 · 2024: 23 · 2023: 34 · 2022: 34 · 2021: 27 · 2020: 26 · 2019: 16 · 2018: 30 · 2017: 1
FWCI: 2.81
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Reviews Cardiology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords: obesity, cardiovascular disease, obesity paradox, weight loss, coronary artery disease, cardiovascular risk factors, body composition, cardiovascular outcomes
MeSH terms: Cardiovascular Diseases, Humans, Obesity, Morbid, Weight Loss

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