The metabolic phenotype in obesity: Fat mass, body fat distribution, and adipose tissue function

Obesity as a medical problem

Kopelman, P. G. (2000) · Nature · doi:10.1038/35007508 · Cited by 4,795 · see citing works

Obesity and the risk of myocardial infarction in 27,000 participants from 52 countries: a case–control study

Yusuf, S., Hawken, S., Ôunpuu, S., Bautista, L., Franzosi, M. G., Commerford, P., Lang, C. C., Rumboldt, Z., Onen, C. L., Lisheng, L., et al. (2005) · The Lancet · doi:10.1016/s0140-6736(05)67663-5 · Cited by 2,903 · see citing works

Body-mass index and all-cause mortality: individual-participant-data meta-analysis of 239 prospective studies in four continents

Di Angelantonio, E., Bhupathiraju, S. N., Wormser, D., Gao, P., Kaptoge, S., de Gonzalez, A. B., Cairns, B. J., Huxley, R., Jackson, C. L., Joshy, G., et al. (2016) · The Lancet · doi:10.1016/s0140-6736(16)30175-1 · Cited by 2,821 · see citing works

What we talk about when we talk about fat

Rosen, E. D., & Spiegelman, B. M. (2014) · Cell · doi:10.1016/j.cell.2013.12.012 · Cited by 2,373 · see citing works

The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of type 2 diabetes

Kahn, S. E. (2003) · Diabetologia · doi:10.1007/s00125-002-1009-0 · Cited by 2,166 · see citing works

Variations in the Prevalence of Obesity Among European Countries, and a Consideration of Possible Causes

Blundell, J. E., Baker, J. L., Boyland, E. J., Blaak, E. E., Charzewska, J., Henauw, S. D., Frühbeck, G., González‐Gross, M., Hebebrand, J., Holm, L., et al. (2017) · Obesity Facts · doi:10.1159/000455952 · Cited by 1,980 · see citing works

Sarcopenic obesity: definition, cause and consequences

Stenholm, S., Harris, T. B., Rantanen, T., Visser, M., Kritchevsky, S. B., & Ferrucci, L. (2008) · Current Opinion in Clinical Nutrition and Metabolic Care · doi:10.1097/mco.0b013e328312c37d · Cited by 1,070 · see citing works

Adipose tissue expandability, lipotoxicity and the Metabolic Syndrome — An allostatic perspective

Virtue, S., & Vidal-Puig, A. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2009.12.006 · Cited by 1,013 · see citing works

Are Metabolically Healthy Overweight and Obesity Benign Conditions?

Kramer, C. K., Zinman, B., & Retnakaran, R. R. (2013) · Annals of Internal Medicine · doi:10.7326/0003-4819-159-11-201312030-00008 · Cited by 958 · see citing works

Sexual dimorphism of body composition

Wells, J. C. K. (2007) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2007.04.007 · Cited by 928 · see citing works

Absence of an Effect of Liposuction on Insulin Action and Risk Factors for Coronary Heart Disease

Klein, S., Fontana, L., Young, V. L., Coggan, A. R., Kilo, C., Patterson, B. W., & Mohammed, B. S. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa033179 · Cited by 909 · see citing works

Hypoxia and Adipose Tissue Function and Dysfunction in Obesity

Trayhurn, P. (2013) · Physiological Reviews · doi:10.1152/physrev.00017.2012 · Cited by 884 · see citing works

Metabolically healthy obesity: Epidemiology, mechanisms, and clinical implications

Stefan, N., Häring, H.-U., Hu, F. B., & Schulze, M. B. (2013) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(13)70062-7 · Cited by 857 · see citing works

Insulin-sensitive obesity

Klöting, N., Fasshauer, M., Dietrich, A., Kovacs, P., Schön, M. R., Kern, M., Stumvoll, M., & Blüher, M. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00586.2009 · Cited by 856 · see citing works

Hypoxia is a potential risk factor for chronic inflammation and adiponectin reduction in adipose tissue of <i>ob</i> / <i>ob</i> and dietary obese mice

Ye, J., Gao, Z., Yin, J., & He, Q. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00435.2007 · Cited by 840 · see citing works

Reduced Adipose Tissue Oxygenation in Human Obesity

Pasarica, M., Sereda, O. R., Redman, L. M., Albarado, D. C., Hymel, D. T., Roan, L. E., Rood, J. C., Burk, D. H., & Smith, S. R. (2009) · Diabetes · doi:10.2337/db08-1098 · Cited by 786 · see citing works

Mechanisms and Metabolic Implications of Regional Differences among Fat Depots

Tchkonia, T., Thomou, T., Zhu, Y. Z., Karagiannides, I., Pothoulakis, C., Jensen, M. D., & Kirkland, J. L. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.03.008 · Cited by 728 · see citing works

Surgical implantation of adipose tissue reverses diabetes in lipoatrophic mice

Gavrilova, O., Marcus-Samuels, B., Graham, D., Kim, J. K., Shulman, G. I., Castle, A. L., Vinson, C., Eckhaus, M., & Reitman, M. L. (2000) · Journal of Clinical Investigation · doi:10.1172/jci7901 · Cited by 676 · see citing works

Adipocyte inflammation is essential for healthy adipose tissue expansion and remodeling

Wernstedt Asterholm, I., Tao, C., Morley, T. S., Wang, Q. A., Delgado-Lopez, F., Wang, Z. V., & Scherer, P. E. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.05.005 · Cited by 668 · see citing works

Characterizing the profile of obese patients who are metabolically healthy

Primeau, V., Coderre, L., Karelis, A. D., Brochu, M., Lavoie, M.-È., Messier, V., SLADEK, R. M., & RABASA-LHORET, R. P. R. (2010) · International Journal of Obesity · doi:10.1038/ijo.2010.216 · Cited by 630 · see citing works

The prevalence of metabolic syndrome and metabolically healthy obesity in Europe: A collaborative analysis of ten large cohort studies

van Vliet‐Ostaptchouk, J. V., Nuotio, M.-L., Slagter, S. N., Doiron, D., Fischer, K., Foco, L., Gaye, A., Gögele, M., Heier, M., Hiekkalinna, T., et al. (2014) · NORA - Norwegian Open Research Archives · Cited by 620 · see citing works

The role of adipose tissue dysfunction in the pathogenesis of obesity-related insulin resistance

Goossens, G. H. (2008) · Physiology &amp; Behavior · doi:10.1016/j.physbeh.2007.10.010 · Cited by 591 · see citing works

Obesity in C57BL/6J mice is characterized by adipose tissue hypoxia and cytotoxic T-cell infiltration

Rausch, M. E., Weisberg, S., Vardhana, P., & Tortoriello, D. V. (2008) · International Journal of Obesity · doi:10.1038/sj.ijo.0803744 · Cited by 585 · see citing works

What causes the insulin resistance underlying obesity?

Hardy, O. T., Czech, M. P., & Corvera, S. (2012) · Current Opinion in Endocrinology, Diabetes &amp; Obesity · doi:10.1097/med.0b013e3283514e13 · Cited by 563 · see citing works

Biology of upper-body and lower-body adipose tissue—link to whole-body phenotypes.

Karpe, F., & Pinnick, K. E. (2015) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2014.185 · Cited by 543 · see citing works

Accurate Assessment of β-Cell Function

Bergman, R. N., Ader, M., Hücking, K., & Citters, G. V. (2002) · Diabetes · doi:10.2337/diabetes.51.2007.s212 · Cited by 517 · see citing works

Diabetes and Cardiovascular Disease Outcomes in the Metabolically Healthy Obese Phenotype

Appleton, S., Seaborn, C. J., Visvanathan, R., Hill, C. L., Gill, T. K., Taylor, A. W., Adams, R., & on behalf of the North West Adelaide Health Study Team (2013) · Diabetes Care · doi:10.2337/dc12-1971 · Cited by 477 · see citing works

Metabolically healthy obesity and risk of incident type 2 diabetes: a meta‐analysis of prospective cohort studies

Bell, J. A., Mika Kivimaki, B., & Hamer, M. (2014) · Obesity Reviews · doi:10.1111/obr.12157 · Cited by 455 · see citing works

Mechanism of Insulin Resistance in A-ZIP/F-1 Fatless Mice

Kim, J. K., Gavrilova, O., Chen, Y., Reitman, M. L., & Shulman, G. I. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.12.8456 · Cited by 443 · see citing works

Adipose tissue dysfunction contributes to obesity related metabolic diseases

Blüher, M. (2013) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2013.02.005 · Cited by 407 · see citing works

Metabolically healthy obesity and cardiovascular events: a systematic review and meta-analysis.

Eckel, N., Meidtner, K., Kalle-Uhlmann, T., Stefan, N., & Schulze, M. B. (2016) · European Journal of Preventive Cardiology · doi:10.1177/2047487315623884 · Cited by 405 · see citing works

Independent and opposite associations of waist and hip circumferences with diabetes, hypertension and dyslipidemia: the AusDiab Study

Snijder, M. B., Zimmet, P., Visser, M., Dekker, J. M., Seidell, J. C., & Shaw, J. E. (2004) · International Journal of Obesity · doi:10.1038/sj.ijo.0802567 · Cited by 341 · see citing works

Increased Adipose Tissue Oxygen Tension in Obese Compared With Lean Men Is Accompanied by Insulin Resistance, Impaired Adipose Tissue Capillarization, and Inflammation

Goossens, G. H., Bizzarri, A., Venteclef, N., Essers, Y., Cleutjens, J. P., Konings, E., Jocken, J. W. E., Čajlaković, M., Ribitsch, V., Clément, K., et al. (2011) · Circulation · doi:10.1161/circulationaha.111.027813 · Cited by 324 · see citing works

Role of hypoxia in obesity-induced disorders of glucose and lipid metabolism in adipose tissue.

Yin, J., Gao, Z., He, Q., Zhou, D., Guo, Z., & Ye, J. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90760.2008 · Cited by 319 · see citing works

Effect of thiazolidinediones on body weight in patients with diabetes mellitus

Fonseca, V. (2003) · The American Journal of Medicine · doi:10.1016/j.amjmed.2003.09.005 · Cited by 283 · see citing works

Sex dimorphism and depot differences in adipose tissue function

White, U. A., & Tchoukalova, Y. D. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.05.006 · Cited by 281 · see citing works

Healthy obese versus unhealthy lean: the obesity paradox

Lavie, C. J., De Schutter, A., & Milani, R. V. (2015) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2014.165 · Cited by 266 · see citing works

Adipose tissue and the insulin resistance syndrome

Frayn, K. N. (2001) · Proceedings of The Nutrition Society · doi:10.1079/pns200195 · Cited by 215 · see citing works

Phenotypes of prediabetes and stratification of cardiometabolic risk

Stefan, N., Fritsche, A., Schick, F., & Häring, H.-U. (2016) · The Lancet Diabetes &amp; Endocrinology · doi:10.1016/s2213-8587(16)00082-6 · Cited by 208 · see citing works

Beyond BMI - Phenotyping the Obesities

Blundell, J. E., Dulloo, A. G., Salvador, J., Frühbeck, G., & G. on behalf of the EASO SAB Working Group on BMI (2014) · Obesity Facts · doi:10.1159/000368783 · Cited by 198 · see citing works

Hypoxia and Adipocyte Physiology: Implications for Adipose Tissue Dysfunction in Obesity

Trayhurn, P. (2014) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071812-161156 · Cited by 194 · see citing works

BMI, fat and muscle differences in urban women of five ethnicities from two countries

Rush, E. C., Goedecke, J. H., Jennings, C., Micklesfield, L. K., Dugas, L. R., Lambert, E. V., & Plank, L. D. (2007) · International Journal of Obesity · doi:10.1038/sj.ijo.0803576 · Cited by 192 · see citing works

Distinct Developmental Profile of Lower-Body Adipose Tissue Defines Resistance Against Obesity-Associated Metabolic Complications

Pinnick, K. E., Nicholson, G., Manolopoulos, K. N., McQuaid, S., Valet, P., Frayn, K. N., Denton, N., Min, J. L., Zondervan, K. T., Fleckner, J., et al. (2014) · Diabetes · doi:10.2337/db14-0385 · Cited by 187 · see citing works

Targeting fatty acid metabolism to improve glucose metabolism

Stinkens, R., Goossens, G. H., Jocken, J. W. E., & Blaak, E. E. (2015) · Obesity Reviews · doi:10.1111/obr.12298 · Cited by 183 · see citing works

MECHANISMS IN ENDOCRINOLOGY: Are metabolically healthy obese individuals really healthy?

Blüher, M. (2014) · European Journal of Endocrinology · doi:10.1530/eje-14-0540 · Cited by 177 · see citing works

Structural and Functional Properties of Deep Abdominal Subcutaneous Adipose Tissue Explain Its Association With Insulin Resistance and Cardiovascular Risk in Men

Marinou, K., Hodson, L., Vasan, S. K., Fielding, B. A., Banerjee, R., Brismar, K., Koutsilieris, M., Clark, A., Neville, M. J., & Karpe, F. (2013) · Diabetes Care · doi:10.2337/dc13-1353 · Cited by 176 · see citing works

Effects of different acute hypoxic regimens on tissue oxygen profiles and metabolic outcomes

Reinke, C., Bevans‐Fonti, S., Drager, L. F., Shin, M., & Polotsky, V. Y. (2011) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00492.2011 · Cited by 174 · see citing works

Diabetes in South Asians: Is the Phenotype Different?

Unnikrishnan, R., Anjana, R., & Mohan, V. (2013) · Diabetes · doi:10.2337/db13-1592 · Cited by 166 · see citing works

Total and Regional Fat Distribution is Strongly Influenced by Genetic Factors in Young and Elderly Twins

Malis, C., Rasmussen, E. L., Poulsen, P., Petersen, I., Christensen, K., Beck‐Nielsen, H., Astrup, A. V., & Vaag, A. A. (2005) · Obesity Research · doi:10.1038/oby.2005.265 · Cited by 164 · see citing works

Adipose Tissue Dysfunction and Impaired Metabolic Health in Human Obesity: A Matter of Oxygen?

Goossens, G. H., & Blaak, E. E. (2015) · Frontiers in Endocrinology · doi:10.3389/fendo.2015.00055 · Cited by 147 · see citing works

Effect of 8 Weeks of Overfeeding on Ectopic Fat Deposition and Insulin Sensitivity: Testing the “Adipose Tissue Expandability” Hypothesis

Johannsen, D. L., Tchoukalova, Y. D., Tam, C. S., Covington, J. D., Xie, W., Schwarz, J., Bajpeyi, S., & Ravussin, É. (2014) · Diabetes Care · doi:10.2337/dc14-0761 · Cited by 145 · see citing works

Association of metabolically healthy obesity with depressive symptoms: pooled analysis of eight studies

Jokela, M., Hamer, M., Singh-Manoux, A., Batty, G. D., & Kivimäki, M. (2014) · Molecular Psychiatry · doi:10.1038/mp.2013.162 · Cited by 132 · see citing works

Molecular and morphologic characterization of superficial‐ and deep‐subcutaneous adipose tissue subdivisions in human obesity

Cancello, R., Zulian, A., Gentilini, D., Maestrini, S., Barba, A. D., Invitti, C., Corà, D., Caselle, M., Liuzzi, A., & Blasio, A. M. D. (2013) · Obesity · doi:10.1002/oby.20417 · Cited by 84 · see citing works

Altered body fat distribution in patients with glucocorticoid treatment and in patients on long-term dialysis

Horber, F., Zürcher, R., Herren, H., et al. (1986) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/43.5.758 · Cited by 70 · see citing works

Adipose tissue oxygen tension

Goossens, G. H., & Blaak, E. E. (2012) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e328358fa87 · Cited by 62 · see citing works

A high-risk phenotype associates with reduced improvement in glycaemia during a lifestyle intervention in prediabetes

Stefan, N., Staiger, H., Wagner, R. J., Machann, J., Schick, F., Häring, H., & Fritsche, A. (2015) · Diabetologia · doi:10.1007/s00125-015-3760-z · Cited by 61 · see citing works

Role of developmental transcription factors in white, brown and beige adipose tissues

Hilton, C., Karpe, F., & Pinnick, K. E. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2015.02.003 · Cited by 58 · see citing works

Ten Nights of Moderate Hypoxia Improves Insulin Sensitivity in Obese Humans

Lecoultre, V., Peterson, C. M., Covington, J. D., Ebenezer, P. J., Frost, E. A. M., Schwarz, J., & Ravussin, É. (2013) · Diabetes Care · doi:10.2337/dc13-1350 · Cited by 53 · see citing works

Lipoatrophy, Lipodystrophy, and Insulin Resistance

Ganda, O. P. (2000) · Annals of Internal Medicine · doi:10.7326/0003-4819-133-4-200008150-00017 · Cited by 37 · see citing works

Human adipocytes from the subcutaneous superficial layer have greater adipogenic potential and lower PPAR-γ DNA methylation levels than deep layer adipocytes

Kosaka, K., Kubota, Y., Adachi, N., et al. (2016) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00301.2015 · Cited by 26 · see citing works

Expression of Inflammation-Related Genes in Gluteal and Abdominal Subcutaneous Adipose Tissue During Weight-Reducing Dietary Intervention in Obese Women

Mališová, L., Rossmeislová, L., Kováčová, Z., Kračmerová, J., Tencerová, M., Langin, D., Šiklová, M., & Štich, V. (2014) · Physiological Research · doi:10.33549/physiolres.932537 · Cited by 18 · see citing works

Response to Comment on Lecoultre et al. Ten Nights of Moderate Hypoxia Improves Insulin Sensitivity in Obese Humans. Diabetes Care 2013;36:e197–e198

Peterson, C. M., Lecoultre, V., Schwarz, J., et al. (2014) · Diabetes Care · doi:10.2337/dc14-0620 · Cited by 9 · see citing works

Heart Disease and Stroke Statistics—2017 Update: A Report From the American Heart Association

Benjamin, E. J., Blaha, M. J., Chiuve, S. E., Cushman, M., Das, S. R., Deo, R., de Ferranti, S. D., Floyd, J., Fornage, M., Gillespie, C., et al. (2017) · Circulation · doi:10.1161/cir.0000000000000485 · Cited by 12,591 · see citing works

Health effects of overweight and obesity in 195 countries over 25 years

Collaborators, T. G. 2. O. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1614362 · Cited by 7,918 · see citing works

2016 European Guidelines on cardiovascular disease prevention in clinical practice

Piepoli, M. F., Hoes, A. W., Agewall, S., Albus, C., Brotons, C., Catapano, A. L., Cooney, M.-T., Corrà, U., Cosyns, B., Deaton, C., et al. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehw106 · Cited by 6,457 · see citing works

Adipokines in inflammation and metabolic disease

Ouchi, N., Parker, J. L., Lugus, J. J., & Walsh, K. (2011) · Nature Reviews Immunology · doi:10.1038/nri2921 · Cited by 4,625 · see citing works

National, regional, and global trends in body-mass index since 1980: systematic analysis of health examination surveys and epidemiological studies with 960 country-years and 9·1 million participants

Finucane, M. M., Stevens, G. A., Cowan, M. J., Danaei, G., Lin, J. K., Paciorek, C. J., Singh, G. M., Gutierrez, H. R., Lu, Y., Bahalim, A. N., et al. (2011) · The Lancet · doi:10.1016/s0140-6736(10)62037-5 · Cited by 4,050 · see citing works

Obesity and cardiovascular disease: a scientific statement from the American Heart Association

Powell-Wiley, T. M., Poirier, P., Burke, L. E., Després, J.-P., Gordon-Larsen, P., Lavie, C. J., Lear, S. A., Ndumele, C. E., Neeland, I. J., Sanders, P., et al. (2021) · Circulation · doi:10.1161/cir.0000000000000973 · Cited by 3,691 · see citing works

Management of Hyperglycemia in Type 2 Diabetes: A Patient-Centered Approach

Inzucchi, S. E., Bergenstal, R. M., Buse, J. B., Diamant, M., Ferrannini, E., Nauck, M., Peters, A. L., Tsapas, A., Wender, R., & Matthews, D. R. (2012) · Diabetes Care · doi:10.2337/dc12-0413 · Cited by 3,207 · see citing works

Mechanisms of Insulin Action and Insulin Resistance

Petersen, M. C., & Shulman, G. I. (2018) · Physiological Reviews · doi:10.1152/physrev.00063.2017 · Cited by 3,028 · see citing works

Prediabetes: a high-risk state for diabetes development

Tabák, A. G., Herder, C., Rathmann, W., Brunner, E. J., & Kivimäki, M. (2012) · The Lancet · doi:10.1016/s0140-6736(12)60283-9 · Cited by 2,958 · see citing works

Body-mass index and all-cause mortality: individual-participant-data meta-analysis of 239 prospective studies in four continents

Di Angelantonio, E., Bhupathiraju, S. N., Wormser, D., Gao, P., Kaptoge, S., de Gonzalez, A. B., Cairns, B. J., Huxley, R., Jackson, C. L., Joshy, G., et al. (2016) · The Lancet · doi:10.1016/s0140-6736(16)30175-1 · Cited by 2,821 · see citing works

Cellular mechanisms of insulin resistance

Shulman, G. I. (2000) · Journal of Clinical Investigation · doi:10.1172/jci10583 · Cited by 2,714 · see citing works

Inflammation, metaflammation and immunometabolic disorders

Hotamisligil, G. S. (2017) · Nature · doi:10.1038/nature21363 · Cited by 2,570 · see citing works

Senolytics improve physical function and increase lifespan in old age

Xu, M., Pirtskhalava, T., Farr, J. N., Weigand, B. M., Palmer, A. K., Weivoda, M. M., Inman, C. L., Ogrodnik, M. B., Hachfeld, C. M., Fraser, D. G., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0092-9 · Cited by 2,287 · see citing works

Short-chain fatty acids in control of body weight and insulin sensitivity

Canfora, E. E., Jocken, J. W., & Blaak, E. E. (2015) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2015.128 · Cited by 2,298 · see citing works

Inflammatory mechanisms linking obesity and metabolic disease

Saltiel, A. R., & Olefsky, J. M. (2017) · Journal of Clinical Investigation · doi:10.1172/jci92035 · Cited by 2,212 · see citing works

Triglyceride accumulation protects against fatty acid-induced lipotoxicity

Listenberger, L. L., Han, X., Lewis, S. E., Cases, S., Farese, R. V., Ory, D. S., & Schaffer, J. E. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0630588100 · Cited by 2,075 · see citing works

Sex and Gender Differences in Risk, Pathophysiology and Complications of Type 2 Diabetes Mellitus

Kautzky-Willer, A., Harreiter, J., & Pacini, G. (2016) · Endocrine Reviews · doi:10.1210/er.2015-1137 · Cited by 2,043 · see citing works

The Metabolic Syndrome

Cornier, M.-A., Dabelea, D., Hernandez, T. L., Lindstrom, R. C., Steig, A. J., Stob, N. R., Van Pelt, R. E., Wang, H., & Eckel, R. H. (2008) · Endocrine Reviews · doi:10.1210/er.2008-0024 · Cited by 2,162 · see citing works

Probiotics and prebiotics in intestinal health and disease: from biology to the clinic

Sanders, M. E., Merenstein, D. J., Reid, G., Gibson, G. R., & Rastall, R. A. (2019) · Nature Reviews Gastroenterology &amp; Hepatology · doi:10.1038/s41575-019-0173-3 · Cited by 2,059 · see citing works

The promising future of microalgae: Current status, challenges, and optimization of a sustainable and renewable industry for biofuels, feed, and other products

Khan, M. I., Shin, J. H., & Kim, J. D. (2018) · Microbial Cell Factories · doi:10.1186/s12934-018-0879-x · Cited by 2,082 · see citing works

Inflammation in obesity, diabetes, and related disorders

Rohm, T. V., Meier, D. T., Olefsky, J. M., & Donath, M. Y. (2022) · Immunity · doi:10.1016/j.immuni.2021.12.013 · Cited by 2,066 · see citing works

Adipose tissue inflammation and metabolic dysfunction in obesity

Kawai, T., Autieri, M. V., & Scalia, R. (2021) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00379.2020 · Cited by 1,947 · see citing works

Understanding the Mysterious M2 Macrophage through Activation Markers and Effector Mechanisms

Rőszer, T. (2015) · Mediators of Inflammation · doi:10.1155/2015/816460 · Cited by 1,762 · see citing works

New genetic loci link adipose and insulin biology to body fat distribution

The ADIPOGen Consortium, Shungin, D., The CARDIOGRAMplusC4D Consortium, The CKDGen Consortium, The GEFOS Consortium, The GENIE Consortium, The, G. L. G. C., The, I. C. B. P., The International Endogene Consortium, Study, T. L. C., et al. (2015) · Nature · doi:10.1038/nature14132 · Cited by 1,580 · see citing works

The pathogenesis of polycystic ovary syndrome (PCOS): the hypothesis of PCOS as functional ovarian hyperandrogenism revisited

Rosenfield, R. L., & Ehrmann, D. A. (2016) · Endocrine Reviews · doi:10.1210/er.2015-1104 · Cited by 1,603 · see citing works

The pathogenesis of insulin resistance: integrating signaling pathways and substrate flux

Samuel, V. T., & Shulman, G. I. (2016) · Journal of Clinical Investigation · doi:10.1172/jci77812 · Cited by 1,484 · see citing works

Adipogenesis and metabolic health

Ghaben, A. L., & Scherer, P. E. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0093-z · Cited by 1,395 · see citing works

Sarcopenic obesity in older adults: aetiology, epidemiology and treatment strategies

Batsis, J. A., & Villareal, D. T. (2018) · Nature Reviews Endocrinology · doi:10.1038/s41574-018-0062-9 · Cited by 1,382 · see citing works

Lipid-associated macrophages control metabolic homeostasis in a Trem2-dependent manner

Jaitin, D. A., Adlung, L., Thaiss, C. A., Weiner, A., Li, B., Descamps, H., Lundgren, P., Bleriot, C., Liu, Z., Deczkowska, A., et al. (2019) · Cell · doi:10.1016/j.cell.2019.05.054 · Cited by 1,377 · see citing works

The metabolic consequences of sleep deprivation

Knutson, K. L., Spiegel, K., Penev, P., & Van Cauter, E. (2007) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2007.01.002 · Cited by 1,365 · see citing works

Association of BMI with overall and cause-specific mortality: a population-based cohort study of 3· 6 million adults in the UK

Bhaskaran, K., dos-Santos-Silva, I., Leon, D. A., Douglas, I. J., & Smeeth, L. (2018) · The Lancet Diabetes &amp; Endocrinology · doi:10.1016/s2213-8587(18)30288-2 · Cited by 1,228 · see citing works

Separate and combined associations of body-mass index and abdominal adiposity with cardiovascular disease: collaborative analysis of 58 prospective studies

The Emerging Risk Factors Collaboration (2011) · The Lancet · doi:10.1016/s0140-6736(11)60105-0 · Cited by 1,216 · see citing works

Adapting to obesity with adipose tissue inflammation

Reilly, S. M., & Saltiel, A. R. (2017) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2017.90 · Cited by 1,204 · see citing works

Reversal of type 2 diabetes: normalisation of beta cell function in association with decreased pancreas and liver triacylglycerol

Lim, E. L., Hollingsworth, K. G., Aribisala, B. S., Chen, M. J., Mathers, J. C., & Taylor, R. (2011) · Diabetologia · doi:10.1007/s00125-011-2204-7 · Cited by 1,164 · see citing works

Metabolism disrupting chemicals and metabolic disorders

Heindel, J. J., Blumberg, B., Cave, M., Machtinger, R., Mantovani, A., Mendez, M. A., Nadal, A., Palanza, P., Panzica, G., Sargis, R., et al. (2017) · Reproductive Toxicology · doi:10.1016/j.reprotox.2016.10.001 · Cited by 1,101 · see citing works

Depression and obesity: evidence of shared biological mechanisms

Milaneschi, Y., Simmons, W. K., van Rossum, E. F. C., & Penninx, B. W. (2019) · Molecular Psychiatry · doi:10.1038/s41380-018-0017-5 · Cited by 1,073 · see citing works

Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity

Wahl, S., Drong, A., Lehne, B., Loh, M., Scott, W. R., Kunze, S., Tsai, P.-C., Ried, J. S., Zhang, W., Yang, Y., et al. (2017) · Nature · doi:10.1038/nature20784 · Cited by 945 · see citing works

Scientific Statement on the Diagnostic Criteria, Epidemiology, Pathophysiology, and Molecular Genetics of Polycystic Ovary Syndrome

Dumesic, D. A., Oberfield, S. E., Stener-Victorin, E., Marshall, J. C., Laven, J. S., & Legro, R. S. (2015) · Endocrine Reviews · doi:10.1210/er.2015-1018 · Cited by 1,020 · see citing works

Anti-obesity drug discovery: advances and challenges

Müller, T. D., Blüher, M., Tschöp, M. H., & DiMarchi, R. D. (2022) · Nature Reviews Drug Discovery · doi:10.1038/s41573-021-00337-8 · Cited by 1,021 · see citing works

Metabolic Flexibility in Health and Disease

Goodpaster, B. H., & Sparks, L. M. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.04.015 · Cited by 995 · see citing works

Gut Hormone Profiles Following Bariatric Surgery Favor an Anorectic State, Facilitate Weight Loss, and Improve Metabolic Parameters

Roux, C. W. L., Aylwin, S. J. B., Batterham, R. L., Borg, C. M., Coyle, F., Prasad, V., Shurey, S., Ghatei, M. A., Patel, A. G., & Bloom, S. R. (2006) · Annals of Surgery · doi:10.1097/01.sla.0000183349.16877.84 · Cited by 985 · see citing works

Why does obesity cause diabetes?

Klein, S., Gastaldelli, A., Yki-Järvinen, H., & Scherer, P. E. (2022) · Cell Metabolism · doi:10.1016/j.cmet.2021.12.012 · Cited by 939 · see citing works

JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age

Xu, M., Tchkonia, T., Ding, H., Ogrodnik, M., Lubbers, E. R., Pirtskhalava, T., White, T. A., Johnson, K. O., Stout, M. B., Mezera, V., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1515386112 · Cited by 915 · see citing works

The sexual dimorphism of obesity

Palmer, B. F., & Clegg, D. J. (2015) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2014.11.029 · Cited by 919 · see citing works

Oxidative stress in obesity: A critical component in human diseases

Marseglia, L., Manti, S., D’Angelo, G., Nicotera, A., Parisi, E., Di Rosa, G., Gitto, E., & Arrigo, T. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms16010378 · Cited by 933 · see citing works

Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution

MAGIC, Heid, I. M., Jackson, A. U., Randall, J. C., Winkler, T. W., Qi, L., Steinthorsdottir, V., Thorleifsson, G., Zillikens, M. C., Speliotes, E. K., et al. (2010) · Nature Genetics · doi:10.1038/ng.685 · Cited by 931 · see citing works

Trends in insulin resistance: insights into mechanisms and therapeutic strategy

Li, M., Chi, X., Wang, Y., Setrerrahmane, S., Xie, W., & Xu, H. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01073-0 · Cited by 939 · see citing works

Slow-wave sleep and the risk of type 2 diabetes in humans

Tasali, E., Leproult, R., Ehrmann, D. A., & Van Cauter, E. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706446105 · Cited by 921 · see citing works

Reversal of Nonalcoholic Hepatic Steatosis, Hepatic Insulin Resistance, and Hyperglycemia by Moderate Weight Reduction in Patients With Type 2 Diabetes

Petersen, K. F., Dufour, S., Befroy, D., Lehrke, M., Hendler, R. E., & Shulman, G. I. (2005) · Diabetes · doi:10.2337/diabetes.54.3.603 · Cited by 911 · see citing works

FGF/FGFR signaling in health and disease

Xie, Y., Su, N., Yang, J., Tan, Q., Huang, S., Jin, M., Ni, Z., Zhang, B., Zhang, D., Luo, F., et al. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00222-7 · Cited by 904 · see citing works

Cardiovascular and Metabolic Heterogeneity of Obesity: Clinical Challenges and Implications for Management

Neeland, I. J., Poirier, P., & Després, J.-P. (2018) · Circulation · doi:10.1161/circulationaha.117.029617 · Cited by 881 · see citing works

Effects of Moderate and Subsequent Progressive Weight Loss on Metabolic Function and Adipose Tissue Biology in Humans with Obesity

Magkos, F., Fraterrigo, G., Yoshino, J., Luecking, C., Kirbach, K., Kelly, S. C., de las Fuentes, L., He, S., Okunade, A. L., Patterson, B. W., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.02.005 · Cited by 886 · see citing works

Role of the ACE2/angiotensin 1-7 axis of the renin-angiotensin system in heart failure

Patel, V. B., Zhong, J.-C., Grant, M. B., & Oudit, G. Y. (2016) · Circulation Research · doi:10.1161/circresaha.116.307708 · Cited by 833 · see citing works

The 2024 report of the Lancet Countdown on health and climate change: facing record-breaking threats from delayed action

Romanello, M., Walawender, M., Hsu, S.-C., Moskeland, A., Palmeiro-Silva, Y., Scamman, D., Ali, Z., Ameli, N., Angelova, D., Ayeb-Karlsson, S., et al. (2024) · The Lancet · doi:10.1016/s0140-6736(24)01822-1 · Cited by 897 · see citing works

Global, regional, and national under-5 mortality, adult mortality, age-specific mortality, and life expectancy, 1970–2016: a systematic analysis for the Global Burden of Disease Study 2016

Wang, H., Abajobir, A. A., Abate, K. H., Abbafati, C., Abbas, K. M., Abd-Allah, F., Abera, S. F., Abraha, H. N., Abu-Raddad, L. J., Abu-Rmeileh, N. M. E., et al. (2017) · The Lancet · doi:10.1016/s0140-6736(17)31833-0 · Cited by 801 · see citing works

Etiology of Insulin Resistance

Petersen, K. F., & Shulman, G. I. (2006) · The American Journal of Medicine · doi:10.1016/j.amjmed.2006.01.009 · Cited by 825 · see citing works

The prevalence of loneliness across 113 countries: systematic review and meta-analysis

Surkalim, D. L., Luo, M., Eres, R., Gebel, K., van Buskirk, J., Bauman, A., & Ding, D. (2022) · BMJ · doi:10.1136/bmj-2021-067068 · Cited by 821 · see citing works

Obesity and type 2 diabetes mellitus: connections in epidemiology, pathogenesis, and treatments

Ruze, R., Liu, T., Zou, X., Song, J., Chen, Y., Xu, R., Yin, X., & Xu, Q. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1161521 · Cited by 799 · see citing works

Tissue-specific overexpression of lipoprotein lipase causes tissue-specific insulin resistance

Kim, J. K., Fillmore, J. J., Chen, Y., Yu, C., Moore, I. K., Pypaert, M., Lutz, E. P., Kako, Y., Velez-Carrasco, W., Goldberg, I. J., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.121164498 · Cited by 753 · see citing works

Insulin resistance drives hepatic de novo lipogenesis in nonalcoholic fatty liver disease

Smith, G. I., Shankaran, M., Yoshino, M., Schweitzer, G. G., Chondronikola, M., Beals, J. W., Okunade, A. L., Patterson, B. W., Nyangau, E., Field, T., et al. (2020) · Journal of Clinical Investigation · doi:10.1172/jci134165 · Cited by 771 · see citing works

Nonalcoholic fatty liver disease as a nexus of metabolic and hepatic diseases

Samuel, V. T., & Shulman, G. I. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2017.08.002 · Cited by 745 · see citing works

New agents that target senescent cells: the flavone, fisetin, and the BCL-XL inhibitors, A1331852 and A1155463

Zhu, Y., Doornebal, E. J., Pirtskhalava, T., Giorgadze, N., Wentworth, M., Fuhrmann-Stroissnigg, H., Niedernhofer, L. J., Robbins, P. D., Tchkonia, T., & Kirkland, J. L. (2017) · Aging · doi:10.18632/aging.101202 · Cited by 757 · see citing works

The role of skeletal muscle insulin resistance in the pathogenesis of the metabolic syndrome

Petersen, K. F., Dufour, S., Savage, D. B., Bilz, S., Solomon, G., Yonemitsu, S., Cline, G. W., Befroy, D., Zemany, L., Kahn, B. B., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705408104 · Cited by 759 · see citing works

Rising rural body-mass index is the main driver of the global obesity epidemic in adults

NCD Risk Factor Collaboration (NCD-RisC), Bixby, H., Bentham, J., Zhou, B., Di Cesare, M., Paciorek, C. J., Bennett, J. E., Taddei, C., Stevens, G. A., Rodriguez-Martinez, A., et al. (2019) · Nature · doi:10.1038/s41586-019-1171-x · Cited by 735 · see citing works

Angiogenesis modulates adipogenesis and obesity

Cao, Y. (2007) · Journal of Clinical Investigation · doi:10.1172/jci32239 · Cited by 736 · see citing works

Weight loss and lipolysis promote a dynamic immune response in murine adipose tissue

Kosteli, A., Sugaru, E., Haemmerle, G., Martin, J. F., Lei, J., Zechner, R., & Ferrante, A. W. (2010) · Journal of Clinical Investigation · doi:10.1172/jci42845 · Cited by 726 · see citing works

Role of Inactivity in Chronic Diseases: Evolutionary Insight and Pathophysiological Mechanisms

Booth, F. W., Roberts, C. K., Thyfault, J. P., Ruegsegger, G. N., & Toedebusch, R. G. (2017) · Physiological Reviews · doi:10.1152/physrev.00019.2016 · Cited by 696 · see citing works

The Impact of High-Intensity Interval Training Versus Moderate-Intensity Continuous Training on Vascular Function: a Systematic Review and Meta-Analysis

Ramos, J. S., Dalleck, L. C., Tjonna, A. E., Beetham, K. S., & Coombes, J. S. (2015) · Sports Medicine · doi:10.1007/s40279-015-0321-z · Cited by 715 · see citing works

The ominous triad of adipose tissue dysfunction: inflammation, fibrosis, and impaired angiogenesis.

Crewe, C., An, Y. A., & Scherer, P. E. (2017) · Journal of Clinical Investigation · doi:10.1172/jci88883 · Cited by 732 · see citing works

Prevention of fat-induced insulin resistance by salicylate

Kim, J. K., Kim, Y.-J., Fillmore, J. J., Chen, Y., Moore, I., Lee, J., Yuan, M., Li, Z. W., Karin, M., Perret, P., et al. (2001) · Journal of Clinical Investigation · doi:10.1172/jci11559 · Cited by 737 · see citing works

Risk factors for type 2 diabetes mellitus: An exposure-wide umbrella review of meta-analyses

Bellou, V., Belbasis, L., Tzoulaki, I., & Evangelou, E. (2018) · PLOS ONE · doi:10.1371/journal.pone.0194127 · Cited by 713 · see citing works

Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophy

Petersen (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215001 · Cited by 622 · see citing works

Mechanisms of nutritional and hormonal regulation of lipogenesis

Kersten, S. (2001) · The EMBO Reports · doi:10.1093/embo-reports/kve071 · Cited by 700 · see citing works

Targeting adipose tissue in the treatment of obesity-associated diabetes

Kusminski, C. M., Bickel, P. E., & Scherer, P. E. (2016) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2016.75 · Cited by 678 · see citing works

Targeting senescent cells alleviates obesity-induced metabolic dysfunction

Palmer, A. K., Xu, M., Zhu, Y., Pirtskhalava, T., Weivoda, M. M., Hachfeld, C. M., Prata, L. G., van Dijk, T. H., Verkade, E., Casaclang‐Verzosa, G., et al. (2019) · Aging Cell · doi:10.1111/acel.12950 · Cited by 658 · see citing works

Regulation of metabolism by the innate immune system

Lackey, D. E., & Olefsky, J. M. (2016) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2015.189 · Cited by 667 · see citing works

Mortality in biopsy-confirmed nonalcoholic fatty liver disease: results from a nationwide cohort

Simon, T. G., Roelstraete, B., Khalili, H., Hagström, H., & Ludvigsson, J. F. (2021) · Gut · doi:10.1136/gutjnl-2020-322786 · Cited by 673 · see citing works

The endocrine function of adipose tissues in health and cardiometabolic disease

Scheja, L., & Heeren, J. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-019-0230-6 · Cited by 663 · see citing works

Diabetes associated cell stress and dysfunction: role of mitochondrial and non-mitochondrial ROS production and activity.

Newsholme, P., Haber, E. P., Hirabara, S. M., Rebelato, E. L. O., Procopio, J., Morgan, D., Oliveira‐Emilio, H. C., Carpinelli, A. R., & Curi, R. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2007.135871 · Cited by 684 · see citing works

Adiposity and cancer risk: new mechanistic insights from epidemiology

Renehan, A. G., Zwahlen, M., & Egger, M. (2015) · Nature Reviews Cancer · doi:10.1038/nrc3967 · Cited by 654 · see citing works

NAFLD as a Continuum: From Obesity to Metabolic Syndrome and Diabetes

Godoy-Matos, A. F., Silva Júnior, W. S., & Valerio, C. M. (2020) · Diabetology &amp; Metabolic Syndrome · doi:10.1186/s13098-020-00570-y · Cited by 643 · see citing works

The reactive oxygen species in macrophage polarization: reflecting its dual role in progression and treatment of human diseases

Tan, H.-Y., Wang, N., Li, S., Hong, M., Wang, X., & Feng, Y. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/2795090 · Cited by 657 · see citing works

The Effects of Rosiglitazone on Insulin Sensitivity, Lipolysis, and Hepatic and Skeletal Muscle Triglyceride Content in Patients With Type 2 Diabetes

Mayerson, A. B., Hundal, R. S., Dufour, S., Lebon, V., Befroy, D., Cline, G. W., Enocksson, S., Inzucchi, S. E., Shulman, G. I., & Petersen, K. F. (2002) · Diabetes · doi:10.2337/diabetes.51.3.797 · Cited by 647 · see citing works

Pathogenesis of sarcopenia and the relationship with fat mass: descriptive review

Li, C., Yu, K., Shyh‐Chang, N., Jiang, Z., Liu, T., Ma, S., Luo, L., Guang, L., Liang, K., Ma, W., et al. (2022) · Journal of Cachexia, Sarcopenia and Muscle · doi:10.1002/jcsm.12901 · Cited by 626 · see citing works

Targeting senescent cells enhances adipogenesis and metabolic function in old age

Xu, M., Palmer, A. K., Ding, H., Weivoda, M. M., Pirtskhalava, T., White, T. A., Sepe, A., Johnson, K. O., Stout, M. B., Giorgadze, N., et al. (2015) · eLife · doi:10.7554/elife.12997 · Cited by 604 · see citing works

Increased Adipocyte O2 Consumption Triggers HIF-1α, Causing Inflammation and Insulin Resistance in Obesity

Lee, Y. S., Kim, J.-W., Osborne, O., Oh, D. Y., Sasik, R., Schenk, S., Chen, A., Chung, H., Murphy, A., Watkins, S. M., et al. (2014) · Cell · doi:10.1016/j.cell.2014.05.012 · Cited by 598 · see citing works

Pathogenesis and Management of Sarcopenia

Dhillon, R. J. S., & Hasni, S. (2017) · Clinics in Geriatric Medicine · doi:10.1016/j.cger.2016.08.002 · Cited by 574 · see citing works

Oral disposition index predicts the development of future diabetes above and beyond fasting and 2-h glucose levels

Utzschneider, K. M., Prigeon, R. L., Faulenbach, M. V., Tong, J., Carr, D. B., Boyko, E. J., Leonetti, D. L., McNeely, M. J., Fujimoto, W. Y., & Kahn, S. E. (2009) · Diabetes Care · doi:10.2337/dc08-1478 · Cited by 572 · see citing works

The macrophage switch in obesity development

Castoldi, A., Naffah de Souza, C., Câmara, N. O. S., & Moraes-Vieira, P. M. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00637 · Cited by 575 · see citing works

Tissue Tregs

Panduro, M., Benoist, C., & Mathis, D. (2016) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032712-095948 · Cited by 536 · see citing works

Contribution of adipogenesis to healthy adipose tissue expansion in obesity

Vishvanath, L., & Gupta, R. K. (2019) · Journal of Clinical Investigation · doi:10.1172/jci129191 · Cited by 558 · see citing works

Measuring adiposity in patients: the utility of body mass index (BMI), percent body fat, and leptin

Shah, N. R., & Braverman, E. R. (2012) · PLoS ONE · doi:10.1371/journal.pone.0033308 · Cited by 554 · see citing works

The obese adipose tissue microenvironment in cancer development and progression

Quail, D. F., & Dannenberg, A. J. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-018-0126-x · Cited by 542 · see citing works

Calorie restriction in humans: An update

Most, J., Tosti, V., Redman, L. M., & Fontana, L. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2016.08.005 · Cited by 530 · see citing works

The cell biology of fat expansion

Rutkowski, J. M., Stern, J. H., & Scherer, P. E. (2015) · Journal of Cell Biology · doi:10.1083/jcb.201409063 · Cited by 541 · see citing works

The healthiness and sustainability of national and global food based dietary guidelines: modelling study

Springmann, M., Spajic, L., Clark, M. A., Poore, J., Herforth, A., Webb, P., Rayner, M., & Scarborough, P. (2020) · BMJ · doi:10.1136/bmj.m2322 · Cited by 520 · see citing works

A clinical perspective of obesity, metabolic syndrome and cardiovascular disease

Han, T. S., & Lean, M. E. (2016) · JRSM Cardiovascular Disease · doi:10.1177/2048004016633371 · Cited by 500 · see citing works

Diabetes, pancreatogenic diabetes, and pancreatic cancer

Andersen, D. K., Korc, M., Petersen, G. M., Eibl, G., Li, D., Rickels, M. R., Chari, S. T., & Abbruzzese, J. L. (2017) · Diabetes · doi:10.2337/db16-1477 · Cited by 516 · see citing works

Phenotypic effects of leptin replacement on morbid obesity, diabetes mellitus, hypogonadism, and behavior in leptin-deficient adults

Licinio, J., Caglayan, S., Ozata, M., Yildiz, B. O., de Miranda, P. B., O'Kirwan, F., Whitby, R., Liang, L., Cohen, P., Bhasin, S., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308767101 · Cited by 505 · see citing works

Insulin resistance causes inflammation in adipose tissue

Shimobayashi, M., Albert, V., Woelnerhanssen, B., Frei, I. C., Weissenberger, D., Meyer-Gerspach, A. C., Clement, N., Moes, S., Colombi, M., Meier, J. A., et al. (2018) · Journal of Clinical Investigation · doi:10.1172/jci96139 · Cited by 480 · see citing works

Comparison of Pre-Adipocyte Yield, Growth and Differentiation Characteristics from Excised versus Aspirated Adipose Tissue

Torio‐Padron, N., Huotari, A. M., Eisenhardt, S. U., et al. (2010) · Cells Tissues Organs · doi:10.1159/000276594 · Cited by 25 · see citing works

Expression of the adrenomedullin gene in adipose tissue

Nambu, T., Arai, H., Komatsu, Y., Yasoda, A., Moriyama, K., Kanamoto, N., Itoh, H., & Nakao, K. (2005) · Regulatory Peptides · doi:10.1016/j.regpep.2005.07.006 · Cited by 45 · see citing works

Influence of adipocyte size and adipose depot on the in vitro lipolytic activity and insulin sensitivity of adipose tissue in dairy cows at the end of the dry period

Koster, J. D., Broeck, W. V. D., Hulpio, L., Claeys, E., Eetvelde, M. V., Hermans, K., Hostens, M., Fievez, V., & OPSOMER, G. (2015) · Journal of Dairy Science · doi:10.3168/jds.2015-10440 · Cited by 42 · see citing works

OR12-4 Adipocyte Subpopulations Mediate Obesity-Associated Inflammation in Adipose Tissues

Luong, Q. V., Lee, K., Sharma, R., & Huang, J. R. (2019) · Journal of the Endocrine Society · doi:10.1210/js.2019-or12-4

Effect of adipocyte-derived IGF-I on adipose tissue mass and glucose metabolism in the Berlin Fat Mouse

Hesse, D., Trost, J., Schäfer, N., Schwerbel, K., Hoeflich, A., Schürmann, A., & Brockmann, G. A. (2018) · Growth Factors · doi:10.1080/08977194.2018.1497621 · Cited by 10 · see citing works