Cholangiocarcinoma — evolving concepts and therapeutic strategies

Ilyas, Sumera I., Khan, Shahid A., Hallemeier, Christopher L., Kelley, Robin K., Gores, Gregory J.·2018·Nature Reviews Clinical Oncology

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Items 301–400 of 1,001

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  2. Transarterial chemoembolization versus percutaneous microwave coagulation therapy for recurrent unresectable intrahepatic cholangiocarcinoma: Development of a prognostic nomogram
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  3. Nanotechnology Based Approach for Hepatocellular Carcinoma Targeting
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  4. Association of prediabetes, diabetes, and diabetes duration with biliary tract cancer risk: A nationwide cohort study
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  5. A Novel Ferroptosis-Related 4-Gene Prognostic Signature for Cholangiocarcinoma and Photodynamic Therapy
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  6. Transcriptomic-Based Identification of the Immuno-Oncogenic Signature of Cholangiocarcinoma for HLC-018 Multi-Target Therapy Exploration
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  7. Micro-RNA in Cholangiocarcinoma: Implications for Diagnosis, Prognosis, and Therapy
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  8. CCL3 secreted by hepatocytes promotes the metastasis of intrahepatic cholangiocarcinoma by VIRMA-mediated N6-methyladenosine (m6A) modification
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  9. New drug approvals for 2022: Synthesis and clinical applications
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  10. Natural Flavonoids Quercetin and Kaempferol Targeting G2/M Cell Cycle-Related Genes and Synergize with Smac Mimetic LCL-161 to Induce Necroptosis in Cholangiocarcinoma Cells
    Thanpisit Lomphithak, Patthorn Jaikla, Apiwit Sae-Fung, Sasiprapa Sonkaew, Siriporn Jitkaew · 2023 · Nutrients
  11. Curcumin enhances chemotherapeutic effects and suppresses ANGPTL4 in anoikis-resistant cholangiocarcinoma cells
    Tin Tin San, Prasong Khaenam, Virapong Prachayasittikul, Banchob Sripa, Nawapol Kunkeaw, Waraporn Chan-on · 2020 · Heliyon
  12. The Landmark Series: Intrahepatic Cholangiocarcinoma
    Jordan M. Cloyd, Aslam M. Ejaz, Timothy Michael Pawlik · 2020 · Annals of Surgical Oncology
  13. Predictive value of the albumin-bilirubin grade on long-term outcomes of CT-guided percutaneous microwave ablation in intrahepatic cholangiocarcinoma
    Jia-Yan Ni, Chao An, Tian-Qi Zhang, Zhimei Huang, Xiongying Jiang, Jin-Hua Huang · 2019 · International Journal of Hyperthermia
  14. Emerging trends in modeling human liver disease in vitro
    Gregory H. Underhill, Salman R. Khetani · 2019 · APL Bioengineering
  15. Effect of postoperative early enteral nutrition on clinical outcomes and immune function of cholangiocarcinoma patients with malignant obstructive jaundice
    Bingqiang Ma, Shiyong Chen, Zebin Jiang, Biao Wu, Yu He, Xinxin Wang, Yuan Li, Peng Gao, Xiaojun Yang · 2020 · World Journal of Gastroenterology
  16. Diversity in cell differentiation, histology, phenotype and vasculature of mass‐forming intrahepatic cholangiocarcinomas
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  17. Anti-Glypican-1 Antibody–drug Conjugate as Potential Therapy Against Tumor Cells and Tumor Vasculature for Glypican-1–Positive Cholangiocarcinoma
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  18. Loss of Numb promotes hepatic progenitor expansion and intrahepatic cholangiocarcinoma by enhancing Notch signaling
    Yuke Shu, Qing Rong Xu, Yahong Xu, Qing Tao, Mingyang Shao, Xiaoyue Cao, Yuwei Chen, Zhenru Wu, Menglin Chen, Yongjie Zhou et al. · 2021 · Cell Death and Disease
  19. Generation of in situ CRISPR-mediated primary and metastatic cancer from monkey liver
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  20. Gallbladder microbiota composition is associated with pancreaticobiliary and gallbladder cancer prognosis
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  21. Liver Tumor Markers, HALP Score, and NLR: Simple, Cost-Effective, Easily Accessible Indexes for Predicting Prognosis in ICC Patients after Surgery
    Deyao Zhang, Huilan Zeng, Yangxun Pan, Yumo Zhao, Xin Wang, Jinbin Chen, Juncheng Wang, Yaojun Zhang, Zhongguo Zhou, Li Xu et al. · 2022 · Journal of Personalized Medicine
  22. Dual FGFR and VEGFR inhibition synergistically restrain hexokinase 2-dependent lymphangiogenesis and immune escape in intrahepatic cholangiocarcinoma
    Min Peng, Hui Li, Huấn Cao, Yamei Huang, Weiping Yu, Chuanlai Shen, Jinyang Gu · 2023 · Journal of Gastroenterology
  23. Peribiliary Glands as the Cellular Origin of Biliary Tract Cancer
    Hayato Nakagawa, Yuki Hayata, Tomoharu Yamada, Satoshi Kawamura, Nobumi Suzuki, Kazuhiko Koike · 2018 · International Journal of Molecular Sciences
  24. Potential survival benefit of radiofrequency ablation for small solitary intrahepatic cholangiocarcinoma in nonsurgically managed patients: A population‐based analysis
    Lu Yi Wu, Diamantis I. Tsilimigras, Ayesha Farooq, J. Madison Hyer, Katiuscha Merath, Anghela Z. Paredes, Rittal Mehta, Kota Sahara, Feng Shen, Timothy Michael Pawlik · 2019 · Journal of Surgical Oncology
  25. Neoadjuvant chemoradiotherapy before resection of perihilar cholangiocarcinoma: A systematic review
    Minas Baltatzis, Santhalingam Jegatheeswaran, Ajith Kumar Siriwardena · 2020 · Hepatobiliary & pancreatic diseases international
  26. Burden of mortality from hepatocellular carcinoma and biliary tract cancers by race and ethnicity and sex in US, 2018–2023
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  27. Organoids and spheroids: advanced in vitro models for liver cancer research
    Mirella Pastore, Alessia Giachi, Elena Spínola-Lasso, Fabio Marra, Chiara Raggi · 2025 · Frontiers in Cell and Developmental Biology
  28. Simvastatin overcomes the pPCK1‐pLDHA‐SPRINGlac axis‐mediated ferroptosis and chemo‐immunotherapy resistance in AKT‐hyperactivated intrahepatic cholangiocarcinoma
    Jinghan Zhu, Yixiao Xiong, Yuxin Zhang, Huifang Liang, Kun Cheng, Yuanxiang Lu, Guangzhen Cai, Yang Feng Wu, Yunhui Fan, Xiaoping Chen et al. · 2025 · 癌症:英文版
  29. Liver and Pancreas: Do Similar Embryonic Development and Tissue Organization Lead to Similar Mechanisms of Tumorigenesis?
    Elsa Ghurburrun, Ivan Borbath, Frédéric P. Lemaigre, Patrick Jacquemin · 2018 · Gene Expression
  30. Animal models of cholangiocarcinoma: What they teach us about the human disease
    Massimiliano Cadamuro, Simone Brivio, Tommaso Stecca, Eleanna Kaffe, Valeria Mariotti, Chiara Milani, Romina Fiorotto, Carlo Spirlı̀, Mario Strazzabosco, Luca Fabris · 2018 · Clinics and Research in Hepatology and Gastroenterology
  31. Assessment of Liver Function for Evaluation of Long-Term Outcomes of Intrahepatic Cholangiocarcinoma: A Multi-Institutional Analysis of 620 Patients
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  32. Circular RNA Circ0021205 Promotes Cholangiocarcinoma Progression Through MiR-204-5p/RAB22A Axis
    Jianfei Tu, Weiqian Chen, Liyun Zheng, Shiji Fang, Dengke Zhang, Chunli Kong, Yang Yang, Rongfang Qiu, Zhongwei Zhao, Chenying Lu et al. · 2021 · Frontiers in Cell and Developmental Biology
  33. Tanshinone IIA affects the malignant growth of Cholangiocarcinoma cells by inhibiting the PI3K-Akt-mTOR pathway
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  34. Laparoscopic versus open surgery for hilar cholangiocarcinoma: a retrospective cohort study on short-term and long-term outcomes
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  35. Safety and initial efficacy of ablative radioembolization for the treatment of unresectable intrahepatic cholangiocarcinoma
    Ricardo Paz‐Fumagalli, Jacob M. Core, Carlos A. Padula, Seyed Ali Montazeri, J. Mark McKinney, Gregory T. Frey, Zlatko Devcic, Andrew R. Lewis, Charles A. Ritchie, Kabir Mody et al. · 2021 · Oncotarget
  36. TNF receptor–related factor 3 inactivation promotes the development of intrahepatic cholangiocarcinoma through NF‐κB‐inducing kinase–mediated hepatocyte transdifferentiation
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  37. The Acquired Vulnerability Caused by CDK4/6 Inhibition Promotes Drug Synergism Between Oxaliplatin and Palbociclib in Cholangiocarcinoma
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  38. Lenvatinib Combined With a PD-1 Inhibitor as Effective Therapy for Advanced Intrahepatic Cholangiocarcinoma
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  39. Advances in CAR T-cell therapy in bile duct, pancreatic, and gastric cancers
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  40. Function of mast cell and bile-cholangiocarcinoma interplay in cholangiocarcinoma microenvironment
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  41. Characterization of hepatitis B virus DNA integration patterns in intrahepatic cholangiocarcinoma
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  42. HOTTIP Enhances Gemcitabine and Cisplatin Resistance Through Sponging miR-637 in Cholangiocarcinoma
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  43. Identification of a novel mutation gene signature HAMP for cholangiocarcinoma through comprehensive TCGA and GEO data mining
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  44. Deep Learning Radiomics to Predict Regional Lymph Node Staging for Hilar Cholangiocarcinoma
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  45. Newest Therapies for Cholangiocarcinoma: An Updated Overview of Approved Treatments with Transplant Oncology Vision
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  46. Sulforaphane Potentiates Gemcitabine-Mediated Anti-Cancer Effects against Intrahepatic Cholangiocarcinoma by Inhibiting HDAC Activity
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  47. The molecular interaction pattern of lenvatinib enables inhibition of wild-type or kinase-mutated FGFR2-driven cholangiocarcinoma
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  48. Novel staging system using carbohydrate antigen (CA) 19-9 in extra-hepatic cholangiocarcinoma and its implications on overall survival
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  49. Circulating levels of soluble urokinase plasminogen activator receptor predict outcome after resection of biliary tract cancer
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  50. Mobilization and activation of tumor-infiltrating dendritic cells inhibits lymph node metastasis in intrahepatic cholangiocarcinoma
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  51. ACSL3 is an unfavorable prognostic marker in cholangiocarcinoma patients and confers ferroptosis resistance in cholangiocarcinoma cells
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  52. Atorvastatin Augments Gemcitabine-Mediated Anti-Cancer Effects by Inhibiting Yes-Associated Protein in Human Cholangiocarcinoma Cells
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  53. Cordycepin Sensitizes Cholangiocarcinoma Cells to Be Killed by Natural Killer-92 (NK-92) Cells
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  54. Exosomes in the tumor microenvironment of cholangiocarcinoma: current status and future perspectives
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  55. Local palliative therapies for unresectable malignant biliary obstruction: radiofrequency ablation combined with stent or biliary stent alone? An updated meta-analysis of nineteen trials
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  57. Contrast-Enhanced Imaging in the Management of Intrahepatic Cholangiocarcinoma: State of Art and Future Perspectives
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  58. Expert Consensus on Pathological Diagnosis of Intrahepatic Cholangiocarcinoma (2022 version)
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  59. Advances in the Early Detection of Hepatobiliary Cancers
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  60. Radiomic Analysis of Intrahepatic Cholangiocarcinoma: Non-Invasive Prediction of Pathology Data: A Multicenter Study to Develop a Clinical–Radiomic Model
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  61. HSDL2 knockdown promotes the progression of cholangiocarcinoma by inhibiting ferroptosis through the P53/SLC7A11 axis
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  62. Review of incidence and outcomes of treatment of cholangiocarcinoma in patients with primary sclerosing cholangitis
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  63. Differential of cholangiocarcinoma disease using Raman spectroscopy combined with multivariate analysis
    Joanna Depciuch, Magdalena Parlińska‐Wojtan, Kursat Rahmi Serin, Huri Bulut, Engı̇n Ulukaya, Nevzat Tarhan, Zozan Güleken · 2022 · Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy
  64. EZH2 Promotes Cholangiocarcinoma Development and Progression through Histone Methylation and microRNA-Mediated Down-Regulation of Tumor Suppressor Genes
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  65. In vivo detection of bile duct pre-cancer with endoscopic light scattering spectroscopy
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  66. An overview of extrahepatic cholangiocarcinoma: from here to where?
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  67. Surufatinib combined with photodynamic therapy induces ferroptosis to inhibit cholangiocarcinoma in vitro and in tumor models
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  68. The cyclin‑dependent kinase pathway involving CDK1 is a potential therapeutic target for cholangiocarcinoma
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  69. Upregulated microRNA‐194 impairs stemness of cholangiocarcinoma cells through the Rho pathway via inhibition of ECT2
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  70. Mass spectrometry-based analysis of formalin-fixed, paraffin-embedded distal cholangiocarcinoma identifies stromal thrombospondin-2 as a potential prognostic marker
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  71. A radiomic-based model of different contrast-enhanced CT phase for differentiate intrahepatic cholangiocarcinoma from inflammatory mass with hepatolithiasis
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  72. Comprehensive Immunogenomic Profiling of IDH1- / 2 -Altered Cholangiocarcinoma
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  73. FOLFIRI as second-line treatment of metastatic biliary tract cancer patients
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  74. Targeting the FGFR signaling pathway in cholangiocarcinoma: promise or delusion?
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  75. The long noncoding RNA DLGAP1‐AS2 facilitates cholangiocarcinoma progression via miR‐505 and GALNT10
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  76. Sulfatase 2 (SULF2) Monoclonal Antibody 5D5 Suppresses Human Cholangiocarcinoma Xenograft Growth Through Regulation of a SULF2–Platelet‐Derived Growth Factor Receptor Beta–Yes‐Associated Protein Signaling Axis
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  77. Analysis of metastasis and survival between extrahepatic and intrahepatic cholangiocarcinoma
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  78. Liver Resection for Intrahepatic Cholangiocarcinoma—Single-Center Experience with 286 Patients Undergoing Surgical Exploration over a Thirteen Year Period
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  79. Hydroxychloroquine Induces Apoptosis in Cholangiocarcinoma via Reactive Oxygen Species Accumulation Induced by Autophagy Inhibition
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  80. Cullin3 deficiency shapes tumor microenvironment and promotes cholangiocarcinoma in liver-specific Smad4/Pten mutant mice
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  81. Comparing palliative treatment options for cholangiocarcinoma: photodynamic therapy vs. radiofrequency ablation
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  82. The prognostic impact of preoperative body composition in perihilar and intrahepatic cholangiocarcinoma
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  83. mRNA Vaccine - A New Cancer Treatment Strategy
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  84. Increased ETV4 expression correlates with estrogen-enhanced proliferation and invasiveness of cholangiocarcinoma cells
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  85. Differences in Prognostic Factors and Recurrence Patterns After Curative-Intent Resection of Perihilar and Distal Cholangiocarcinomas
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  86. Current status of laparoscopic radical hilar cholangiocarcinoma in Mainland China
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  87. Systemic treatment options for advanced biliary tract carcinoma
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  88. Long Non-coding RNA FOXD2-AS1 Promotes Proliferation, Migration, and Invasion in Cholangiocarcinoma Through Regulating miR-760/E2F3 Axis
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  89. MiR-206 suppresses the deterioration of intrahepatic cholangiocarcinoma and promotes sensitivity to chemotherapy by inhibiting interactions with stromal CAFs
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  93. Immunotherapy in cholangiocarcinoma: From concept to clinical trials
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  94. Endoscopic radiofrequency ablation for malignant biliary obstruction
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  95. TP53 /KRAS Co-Mutations Create Divergent Prognosis Signatures in Intrahepatic Cholangiocarcinoma
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  96. Light-to-Moderate Alcohol Consumption Increases the Risk of Biliary Tract Cancer in Prediabetes and Diabetes, but Not in Normoglycemic Status: A Nationwide Cohort Study
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  97. PD-L1 expression on immune cells, but not on tumor cells, is a favorable prognostic factor for patients with intrahepatic cholangiocarcinoma
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