Trends in clinical success rates
Cited by (277)
Items 101–200 of 277
- A comprehensive review of discovery and development of drugs discovered from 2020–2022Usman Shareef, Aisha Altaf, Madiha Ahmed, Nosheen Akhtar, Mohammed Saad Almuhayawi, Soad Khalil Al Jaouni, Samy Selim, Mohamed Abdelwahab Abdelgawad, Mohammed Kamal Nagshabandi · 2023 · Saudi Pharmaceutical Journal
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- International Strategy for Sustainable Growth in Multinational Pharmaceutical CompaniesFumio Teramae, Tomohiro Makino, Yeongjoo Lim, Shintaro Sengoku, Kota Kodama · 2020 · Sustainability
- Estimating Probabilities of Success of Vaccine and Other Anti-Infective Therapeutic Development ProgramsChi Heem Wong, Kien Wei Siah, Andrew W. Lo · 2020 · Harvard Data Science Review
- Using data analytics to accelerate biopharmaceutical process scale-upPierantonio Facco, Simeone Zomer, Ruth C. Rowland‐Jones, Douglas Marsh, Paloma Diaz‐Fernandez, Gary Finka, Fabrizio Bezzo, Massimiliano Barolo · 2020 · Biochemical Engineering Journal
- Heteroaryl ether analogues of an antileishmanial 7-substituted 2-nitroimidazooxazine lead afford attenuated hERG risk: In vitro and in vivo appraisalAndrew M. Thompson, Patrick D. O’Connor, Andrew J. Marshall et al. · 2020 · European Journal of Medicinal Chemistry
- TSSF-hERG: A machine-learning-based hERG potassium channel-specific scoring function for chemical cardiotoxicity predictionJinhui Meng, Li Zhang, Lian-Xin Wang, Shimeng Li, Di Xie, Yuxi Zhang, Hongsheng Liu · 2021 · Toxicology
- GelMA hydrogel: A game-changer in 3D tumor modelingWeijie Jiao, Jingxin Shan, Xue Gong, Yuanyuan Sun, Lin Sang, Xiaoying Ding, Huihui Zhou, Ming Yu · 2024 · Materials Today Chemistry
- Distribution of erlotinib in rash and normal skin in cancer patients receiving erlotinib visualized by matrix assisted laser desorption/ionization mass spectrometry imagingMeiko Nishimura, Mitsuhiro Hayashi, Yu Mizutani et al. · 2018 · Oncotarget
- Using Mendelian randomization to understand and develop treatments for neurodegenerative diseaseCatherine S. Storm, Demis A. Kia, Mona Mohammad Almramhi, Nicholas William Wood · 2020 · Brain Communications
- Improving Cardiovascular Drug and Device Development and Evidence Through Patient-Centered Research and Clinical TrialsJohn J. Warner, Hannah L. Crook, Karley Whelan, William K. Bleser, Rachel A. Roiland, Marianne Hamilton Lopez, Robert S. Saunders, Tracy Y. Wang, Adrian F. Hernandez, Mark McClellan et al. · 2020 · Circulation Cardiovascular Quality and Outcomes
- Pharmacodynamic Biomarkers for Emerging LRRK2 TherapeuticsKaela Kelly, Andrew B. West · 2020 · Frontiers in Neuroscience
- Ligandomics: a paradigm shift in biological drug discoveryWěi Li, Iok-Hou Pang, Mário Thiego Fernandes Pacheco, Hong Tian · 2018 · Drug Discovery Today
- Insights into mechanisms and severity of drug-induced liver injury via computational systems toxicology approachYayuan Peng, Zengrui Wu, Hongbin Yang, Yingchun Cai, Guixia Liu, Weihua Li, Yun Tang · 2019 · Toxicology Letters
- Strategies to Mitigate the Bioactivation of Aryl AminesChenghong Zhang, James J. Crawford, Matthew L. Landry, Huifen Chen, Jane R. Kenny, Siamak Cyrus Khojasteh, Wendy Lee, Shuguang Ma, Wendy B. Young · 2020 · Chemical Research in Toxicology
- Current Drug DiscoveryJeffrey J. Hale · 2022 · Wiley eBooks
- Dynamic clinical trial success rates for drugs in the 21st centuryYing Zhou, Yintao Zhang, Hangwei Xu, Zhen Chen, Shijie Huang, Yinghong Li, Jianbo Fu, Hongning Zhang, Donghai Zhao, Xichen Lian et al. · 2025 · Nature Communications
- Impact of Research and Development Strategy on Sustainable Growth in Multinational Pharmaceutical CompaniesFumio Teramae, Tomohiro Makino, Yeongjoo Lim, Shintaro Sengoku, Kota Kodama · 2020 · Sustainability
- Estimating Clinical Trial Success Rates and Related Parameters in OncologyChi Heem Wong, Kien Wei Siah, Andrew W. Lo · 2019 · SSRN Electronic Journal
- Data-driven toxicity prediction in drug discovery: Current status and future directionsNingning Wang, Xinliang David Li, Jing Xiao, Shao Liu, Dongsheng Cao · 2024 · Drug Discovery Today
- Pharmaceutical innovation and its crisis: drug markets, screening, and the dialectics of valueJean‐Paul Gaudillière · 2021 · BioSocieties
- Embedding Dynamics in Intrinsic Physicochemical Profiles of Market-Stage Antibody-Based BiotherapeuticsGiuseppe Licari, Kyle Martin, Maureen Crames, Joseph Mozdzierz, Michael S. Marlow, Anne R. Karow‐Zwick, Sandeep Kumar, Joschka Bauer · 2022 · Molecular Pharmaceutics
- The Impact of Foundation Medicine Testing on Cancer Patients: A Single Academic Centre ExperienceDalia Karol, Mathieu McKinnon, Lenah E. Mukhtar · 2021 · Frontiers in Oncology
- Pharmacological vs. classical approaches in the design of first in man clinical drug trialsCornelis A. van den Bogert, Adam F. Cohen, Hubert G. M. Leufkens, Joop van Gerven · 2017 · British Journal of Clinical Pharmacology
- Developing an Improved Risk-Adjusted Net Present Value Technology Valuation Model for the Biopharmaceutical IndustryJonghak Woo, Eungdo Kim, Tae-Eung Sung · 2019 · Journal of Open Innovation Technology Market and Complexity
- Novel Linker Variants of Antileishmanial/Antitubercular 7-Substituted 2-Nitroimidazooxazines Offer Enhanced SolubilityAndrew M. Thompson, Patrick D. O’Connor, Vanessa Yardley et al. · 2021 · ACS Medicinal Chemistry Letters
- In-depth understanding of the structure-based reactive metabolite formation of organic functional groupsChunyong He, Yuchang Mao, Hong Wan · 2025 · Drug Metabolism Reviews
- Polygenic autoimmune disease risk alleles impacting B cell tolerance act in concert across shared molecular networks in mouse and in humansIsaac T. W. Harley, Kristen Allison, Robert Hal Scofield · 2022 · Frontiers in Immunology
- Reconstructed Human Epidermis Predicts Barrier-Improving Effects of Lactococcus lactis Emulsion in HumansChristian Hausmann, Dominique Hertz-Kleptow, Christian Zoschke, Barbara Wanjiku, Alexandra Wentzien-Odenthal, Martina J. Kerscher, Monika Schäfer‐Korting · 2019 · Skin Pharmacology and Physiology
- Integrating sequence and graph information for enhanced drug-target affinity predictionHaohuai He, Guanxing Chen, Calvin Yu‐Chian Chen · 2024 · Science China Information Sciences
- Machine learning & deep learning tools in pharmaceutical sciences: A comprehensive reviewSaleem Javid, Abdul Rahmanulla, Mohammed Gulzar Ahmed, Rokeya Sultana, B. R. Prashantha Kumar · 2025 · Intelligent Pharmacy
- The emergence of AntibodyPlus: the future trend of antibody-based therapeuticsYong Zhu, Shawn Shouye Wang, Zhaohui Sunny Zhou, Mitchell Ho · 2022 · Antibody Therapeutics
- The Scientific Problems with Using Non-Human Animals to Predict Human Response to Drugs and DiseaseRay Greek, Lisa A. Kramer · 2019 · BRILL eBooks
- Medicines discovery for auditory disorders: Challenges for industryRick P. C. Cousins · 2019 · The Journal of the Acoustical Society of America
- Improving the Prediction of Clinical Success Using Machine LearningBernard H. Munos, Jan Niederreiter, Massimo Riccaboni · 2021 · medRxiv
- Role of Diverse Smooth Muscle Cell Phenotypic Transitions in Atherosclerosis Development and Late-Stage PathogenesisVlad Serbulea, James Martin, Gary K. Owens · 2025 · Annual Review of Physiology
- Perspectives on the clinical use of anti‐amyloid therapy for the treatment of Alzheimer's disease: Insights from the fields of cancer, rheumatology, and neurologyGregory A. Jicha, Erin L. Abner, Elif Pinar Coskun, Mark J. Huffmyer, Thomas C. Tucker, Peter T. Nelson · 2024 · Alzheimer s & Dementia Translational Research & Clinical Interventions
- Neural circuits of eating behaviour: Opportunities for therapeutic developmentPeter G. Clifton · 2017 · Journal of Psychopharmacology
- 3D Models as a Tool to Assess the Anti-Tumor Efficacy of Therapeutic Antibodies: Advantages and LimitationsVirginia Guzzeloni, Lorenzo Veschini, Federica Pedica, Elisabetta Ferrero, Marina Ferrarini · 2022 · Antibodies
- Prediction of the pharmacokinetics of the GLP-1 receptor agonist semaglutide in humans via a population pharmacokinetic model integrating interspecies scalingJoonhee Kim, Keon Kim, Tae Suk Lee, Hyunmin Cho, Seung-Dong Yoo, Tae‐Hwan Kim, Beom Soo Shin, Soyoung Shin · 2024 · Journal of Pharmaceutical Investigation
- Brain Organoids: Tools for Understanding the Uniqueness and Individual Variability of the Human BrainIrene Faravelli, Noelia Antón-Bolaños, Juliana R. Brown, Paola Arlotta · 2025 · Annual Review of Genomics and Human Genetics
- Complex injectablesAbhijeet P. Pandey, Debjani Singh, Namdev L. Dhas, Akhilesh Kumar Tewari, Kamla Pathak, Vivekanand Kisan Chatap, Kamal Singh Rathore, Srinivas Mutalik · 2020 · Elsevier eBooks
- Stress-dependent Flexibility of a Full-length Human Monoclonal Antibody: Insights from Molecular Dynamics to Support Biopharmaceutical DevelopmentDheeraj S. Tomar, Giuseppe Licari, Joschka Bauer, Satish Kumar Singh, Li Li, Sandeep Kumar · 2021 · Journal of Pharmaceutical Sciences
- Estimating Probabilities of Success of Vaccine and Other Anti-Infective Therapeutic Development ProgramsAndrew W. Lo, Kien Wei Siah, Chi Heem Wong · 2020 · National Bureau of Economic Research
- Diffusion Models at the Drug Discovery Frontier: A Review on Generating Small Molecules Versus Therapeutic PeptidesYiquan Wang, Yahui Ma, Yu-Han Chang, Jiayao Yan, Jialin Zhang, Ming-Yi Cai, Kai Wei · 2025 · Biology
- Continuous Flow Conditions for High Temperature Formation of a Benzodioxan Pharmaceutical Intermediate: Rapid Scaleup for Early Phase Material DeliveryPengbin Li, Shaohui Yang, Ruiheng Zhu · 2020 · Organic Process Research & Development
- A scalable 3D tissue culture pipeline to enable functional therapeutic screening for pulmonary fibrosisKatherine A. Cummins, Peter B. Bitterman, Daniel J. Tschumperlin, David K. Wood · 2021 · APL Bioengineering
- A novel perspective on pharmaceutical R&D costs: opportunities for reductionsSimon van der Schans, Frans De Loos, Cornelis Boersma · 2021 · Expert Review of Pharmacoeconomics & Outcomes Research
- Patient-derived tumoroids and proteomic signatures: tools for early drug discoveryHélène Lê, Jules Deforges, Pasquale Cutolo, Anissa Lamarque, Guoqiang Hua, Véronique Lindner, Shreyansh Jain, Jean‐Marc Balloul, Nadia Benkirane-Jessel, Éric Quéméneur · 2024 · Frontiers in Immunology
- Consideration of the Root Causes in Candidate Attrition During Oncology Drug DevelopmentYin‐Ming Kuo, Jeffrey S. Barrett · 2024 · Clinical Pharmacology in Drug Development
- Pharmacological Potential of Pyrmidine Derivatives: A Review With Emphasis on Antiviral Effects and Virtual Screening Against Sars‐Cov‐2 Molecular TargetsErick Costa, Zenaide Severina do Monte, Emerson P. S. Falcão, Mayara dos Santos Maia, Renata Priscila Barros de Menezes, Luciana Scotti, Marcus Tullius Scotti, Sebastiao Jose de Melo · 2023 · ChemistrySelect
- Late-stage Product Development and Approvals by Biotechnology Companies After Initial Public Offering, 1997–2016Laura M. McNamee, Ekaterina Galkina Cleary, Sunyi Zhang, Usama Salim, Fred David Ledley · 2020 · Clinical Therapeutics
- CONSORT-DEFINE explanation and elaboration: recommendations for enhancing reporting quality and impact of early phase dose-finding clinical trialsJan Rekowski, Christina W. Guo, Olga Solovyeva, Munyaradzi Dimairo, Mahtab Rouhifard, Dhrusti Patel, Emily Alger, Deborah Ashby, Jordan D. Berlin, Oliver Boix et al. · 2025 · EClinicalMedicine
- Biomaterial-driven regenerative drug delivery: a vicennial bibliometric landscapeXin Shen, Haobin Deng, Jing Lin, Jianhua Wang, Yilun Liu, Shikun Mo · 2025 · Frontiers in Medicine
- The evolving global landscape of first-in-class oncology drug innovationXiangyun Mao, Zhaoqing Wang, Shu Kong, Yue Yang, Nancy A Dreyer, Yi Ba, Michael T. Lotze, Qimin Zhan, Guanqiao Li · 2026 · Signal Transduction and Targeted Therapy
- GCLmf: A Novel Molecular Graph Contrastive Learning Framework Based on Hard Negatives and Application in Toxicity Prediction**Xinxin Yu, Yuanting Chen, Long Chen, Weihua Li, Yuhao Wang, Yun Tang, Guixia Liu · 2024 · Molecular Informatics
- Repurposing of PSMA-targeted diagnostic and therapeutic agents for the detection and treatment of giant cell tumors of boneBrenna C. McAllister, Nooshin Mesbahi, Esther E. Dodson, Sakinah Abdulsalam, Clifford E. Berkman, Leslie Ann Caromile · 2024 · Frontiers in Oncology
- Exploratory Analysis of the Factors Associated With Success Rates of Confirmatory Randomized Controlled Trials in Cancer Drug DevelopmentCan Wu, Shunsuke Ono · 2020 · Clinical and Translational Science
- A Brainer on NeurotoxicityEllen Fritsche, Helena T. Högberg · 2020 · Frontiers in Toxicology
- Human Forest vs. Random Forest in Time-Sensitive COVID-19 Clinical Trial PredictionPavel Dimitrov Atanasov, Regina Joseph, Felipe Feijoo, Max Marshall, Amanda Conway, Sauleh Siddiqui · 2021 · SSRN Electronic Journal
- Accelerating biopharmaceutical cell line selection with label-free multimodal nonlinear optical microscopy and machine learningJindou Shi, Alexander Ho, Corey E. Snyder, Eric James Chaney, Janet Elise Sorrells, Aneesh Alex, Remben V. Talaban, Darold R. Spillman, Marina Marjanović, Minh Doan et al. · 2025 · Communications Biology
- Integrating Genomics into Drug Discovery and Development: Challenges and AspirationsRajiv G. Raja, Young Shin Lee, Katie L. Streicher, James Conway, Song Wu, Sriram Sridhar, Mike Kuziora, Hao Liu, Brandon W. Higgs, Philip Z. Brohawn et al. · 2017 · Pharmaceutical Medicine
- Development of a 3-D Organoid System Using Human Induced Pluripotent Stem Cells to Model Idiopathic AutismJason W. Lunden, Madel Durens, Jonathan E. Nestor, Robert F. Niescier, Kevin Herold, Cheryl Brandenburg, Yu‐Chih Lin, Gene J. Blatt, Michael W. Nestor · 2020 · Advances in neurobiology
- Convergence of artificial intelligence and nanotechnology in the development of novel formulations for cancer treatmentAbid Naeem, Muhammad Suhail, Abdul Basit, Liu Yali, Zhang Ming Xia, Zheng Qin, Yang Ming · 2023 · Elsevier eBooks
- Fully Liquid Phase Oligonucleotide SynthesisPiers R. J. Gaffney, Charles Jarrett-Wilkins, Jet Yeo et al. · 2025 · Organic Process Research & Development
- Natural Products in Precision Neurological Disease (Cryptococcal Meningitis): Structure‐Based Phytochemical Screening of Glycyrrhiza glabra Plant Against Cryptococcus neoformans Farnesyltransferase (FTase)Noimul Hasan Siddiquee, Md. Shiful Islam Sujan, Tasnuva Islam Dremit et al. · 2024 · Chemistry & Biodiversity
- MALDI Imaging and Spatial SILAC Proteomics of Three-Dimensional Multicellular Spheroids Dynamically Dosed with Doxorubicin-Encapsulating LiposomesArbil Lopez, Joseph H. Holbrook, Amanda B. Hummon · 2025 · Analytical Chemistry
- Non-commercial pharmaceutical R&D: what do neglected diseases suggest about costs and efficiency?Marcela Vieira, Ryan Kimmitt, Suerie Moon · 2021 · F1000Research
- Early, precise, and safe clinical evaluation of the pharmacodynamic effects of novel agents in the intact human tumor microenvironmentKenneth R. Gundle, Karthik Rajasekaran, Jeffrey J. Houlton et al. · 2024 · Frontiers in Pharmacology
- Public sector replacement of privately funded pharmaceutical R&D: cost and efficiency considerationsDavid G. Proudman, Urvi S. Desai, Dumingu Aparna Gomes, Maks Khomenko, Silas Martin, Dave Nellesen, Ulrich Neumann, Henry G. Grabowski · 2024 · Journal of Medical Economics
- Combining Single-Cell RNA Sequencing and Mendelian Randomization to Explore Novel Drug Targets for Parkinson’s DiseaseXiaolong Wu, Kailiang Wang, Qinghua Li, Yuqing Zhang, Penghu Wei, Yongzhi Shan, Guoguang Zhao · 2025 · Molecular Neurobiology
- Does Firm’s Alliances Increase New Drug Development Time? A Multiple Regression Analysis of Clinical Development TimeHo-Kyoung Kim, Hyesung Lee, Sangwon Lee · 2023 · Journal of Pharmaceutical Innovation
- From academia to industry: a road more travelledWilliam J. Pao · 2017 · Annals of Oncology
- The reproducibility issue and preclinical academic drug discovery: educational and institutional initiatives fostering translation successDavid R. Janero · 2016 · Expert Opinion on Drug Discovery
- What's Past Is Prologue: Clinical Pharmacology at the Intersection of Science, Policy, and PatientsIssam Zineh, Dan Hartman · 2019 · Clinical Pharmacology & Therapeutics
- Editorial: Use of quantitative systems pharmacology pipelines to bridge in vitro and in vivo results in drug discoveryFederico Reali, Attila Csikász‐Nagy, Gianluca Selvaggio · 2023 · Frontiers in Systems Biology
- Exploring druggable targets and inflammation-mediated pathways in cancer: a Mendelian randomization analysis integrating transcriptomic and proteomic dataHao Pan, Changqing Jing · 2025 · Inflammation Research
- Development of Highly Chemoselective Oxidative Transformations by Designing OrganoradicalsKounosuke Oisaki · 2018 · Chemical and Pharmaceutical Bulletin
- Human-relevant preclinical in vitro models for studying hepatobiliary development and liver diseases using induced pluripotent stem cellsPooja Chaudhari, Lipeng Tian, Zhaohui Ye, Yoon-Young Jang · 2019 · Experimental Biology and Medicine
- 11PS04 is a new chemical entity identified by microRNA-based biosensing with promising therapeutic potential against cancer stem cellsTania Aguado, Jose A. Romero‐Revilla, Rosario Granados, Susana Campuzano, Rebeca Magnolia Torrente-Rodríguez, Ángel M. Cuesta, Virginia Albiñana, Luisa M. Botella, Silvia Santamaría Santamaría, José A. García‐Sanz et al. · 2019 · Scientific Reports
- Mechanistic Image-Based Modelling: Concepts and ApplicationsDenis Menshykau, Simon Tanaka · 2019 · Handbook of experimental pharmacology
- Warning About Shortcuts in Drug DevelopmentRobert M. Califf · 2017 · Journal of the American Heart Association
- New Trends in Drug DiscoveryGerd Schnorrenberg · 2018 · Wiley eBooks
- Finding drug targeting mechanisms with genetic evidence for Parkinson’s diseaseCatherine S. Storm, Demis A. Kia, Mona Mohammad Almramhi, Sara Bandrés‐Ciga, Chris Finan, Aroon Dinesh Hingorani, Nicholas William Wood · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
- Predicting the efficacy of exenatide in Parkinson’s disease using genetics – a Mendelian randomization studyCatherine S. Storm, Demis A. Kia, Mona Mohammad Almramhi, Dilan S. Athauda, Stephen Burgess, Thomas Foltynie, Nicholas William Wood · 2020 · medRxiv
- Predicting Success of Phase III Trials in OncologyStephan J Hegge, Markus Thunecke, Matthias Krings, Leonard Ruedin, Jan Saputra Mueller, Paul von Bünau · 2020 · medRxiv
- An approach to produce thousands of single-chain antibody variants on a SPR biosensor chip for measuring target binding kinetics and for deep characterization of antibody paratopesRebecca L. Cook, William Martelly, Chidozie Victor Agu, Lydia R. Gushgari, Salvador Moreno, Sailaja Kesiraju, Mukilan Mohan, Bharath R. Takulapalli · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
- Combining AI design and molecular dynamics to disrupt amyloid aggregation in Alzheimer’s diseaseAyla Esmaeilzadeh, Maryam Azimzadeh Irani, Ali Javanmard, Mahdiyeh Gharaei Khezri · 2026 · Discover Applied Sciences
- Antibacterial Drug Discovery: Deep Learning Successes and Challenges through the Structural Biology LensJameel M. A. Abduljalil, Sandro F. Ataide, Ann H. Kwan · 2026 · Computational and Structural Biotechnology Journal
- Analysis of Nutrition Clinical Studies Involving Children in the Middle East and GloballyFatih Özdener, Feza Kırbıyık, Ali Evrim Doğan · 2018 · Future Science OA
- A Comparative Study on the SWOG Two-Stage Design Extension to Stop Early for Efficacy in Single Arm Phase II TrialsMonica Chaudhari, John Crowley, Antje Hoering · 2020 · Statistics in Biopharmaceutical Research
- Preexisting evidence and outcome of phase III trials in gastrointestinal oncology: a systematic reviewGiacomo Bregni, Elena Trevisi, Rita Saúde Conde · 2023 · JNCI Journal of the National Cancer Institute