Glimmers in illuminating the druggable genome

Rodgers, Griffin, Austin, Christopher, Anderson, James, Pawlyk, Aaron, Colvis, Christine, Margolis, Ronald, Baker, Jenna·2018·Nature Reviews Drug Discovery

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  7. Prevalent mouse phenotypes in the unexplored druggable genome
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  9. Strategy for Lead Identification for Understudied Kinases
    David Harold Drewry, Joel K. Annor‐Gyamfi, Carrow I. Wells, Julie E. Pickett, Alison Donnelly Axtman · 2021 · ChemRxiv
  10. Drug discovery: Standing on the shoulders of giants
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  11. High-performance computing leadership to enable advances in artificial intelligence and a thriving compute ecosystem
    Georgia D. Tourassi, Mallikarjun Arjun Shankar, Feiyi Wang · 2023 · OECD eBooks
  12. Eroom’s Law and the decline in the productivity of biopharmaceutical R&D
    Jack W. Scannell · 2023 · OECD eBooks
  13. The end of Moore’s Law? Innovation in computer systems continues at a high pace
    H. Kressel · 2023 · OECD eBooks
  14. Quantifying the “cognitive extent” of science and how it has changed over time and across countries
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  15. Interpretability: Should – and can – we understand the reasoning of machine-learning systems?
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  16. Preface
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  19. Meta-Research: understudied genes are lost in a leaky pipeline between genome-wide assays and reporting of results
    Reese A. K. Richardson, Heliodoro Tejedor Navarro, Luı́s A. Nunes Amaral, Thomas Stoeger · 2023 · eLife
  20. Constitutive G protein coupling profiles of understudied orphan GPCRs
    Sumin Lu, Wonjo Jang, Asuka Inoue, Nevin A. Lambert · 2024
  21. Meta-Research: understudied genes are lost in a leaky pipeline between genome-wide assays and reporting of results
    Richardson, Reese AK, Navarro, Heliodoro Tejedor, Nunes Amaral, Luis A, Stoeger, Thomas · 2024
  22. Disruption of NUAK2-Mediated RNA Splicing by Trilaciclib Reveals a Therapeutic Vulnerability in AR-Indifferent Prostate Cancer
    Umar Mehraj, Uran Maimekov, Shaista Manzoor, Emily Cordova, Manasiben Patel, Ikeer Y. Mancera-Ortiz, Stefanie Howell, Zachary W. Davis‐Gilbert, Mu‐En Wang, Ming Chen et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  23. Characterizing the landscape of gene process dependencies in cancer
    Julia B. Curd, Navin Kumar Balagopal, Adam L. Green, Gregory P. Way · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  24. Categorization of Protein Kinases by Combining Data from Cell Biology and Medicinal Chemistry Enables Further Evaluation and Differentiation of the Understudied Kinome
    Elena Kullmann, Selina Koch, Jürgen Bajorath · 2026 · Journal of Medicinal Chemistry
  25. Evolutionary and functional constraints structure human gene research visibility
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  26. BindRNAgen: Protein-binding RNA Sequence Generation Using Latent Diffusion Models
    Yi Zhou, Xiaojian Liu, Shengfan Wang, Lin Zhu, Biao Zhang, Y Huang, Hong‐Bin Shen, Xiaoyong Pan · 2026 · Journal of Molecular Biology
  27. BindingDB Entry 50015305: Identification of Pyrimidine-Based Lead Compounds for Understudied Kinases Implicated in Driving Neurodegeneration.
    BindingDB · 2023 · UC San Diego