Glimmers in illuminating the druggable genome
Rodgers, Griffin, Austin, Christopher, Anderson, James, Pawlyk, Aaron, Colvis, Christine, Margolis, Ronald, Baker, Jenna·2018·Nature Reviews Drug Discovery
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- Target identification for potential drug discoverySaurabh Sharma, J Kumaravel, Gurjeet Kaur, Ajay Prakash, Bikash Medhi · 2023 · Elsevier eBooks
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- Machine Learning Techniques for Development of Drugs Against Coronavirus Disease 2019 (COVID-19): A Case Study ProtocolSaurabh Sharma, Ajay Prakash, Phulen Sarma, Bikash Medhi · 2021 · Methods in pharmacology and toxicology
- Multiplexed profiling of kinase interactomes quantifies cellular network plasticityMartin G. Golkowski, Andrea Lius, Tanmay Sapre, Ho-Tak Lau, Taylor Moreno, Dustin J. Maly, Shao‐En Ong · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
- Prevalent mouse phenotypes in the unexplored druggable genomeOlga Gulyaeva, Zicheng Hu, Tudor Ionel Oprea, K. C. Kent Lloyd, Shawn M. Gomez, Bryan L. Roth, Michael T. McManus · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
- Pharmacy, the continuously expanding field of sciencePál Perjési · 2022 · Journal of Pharmaceutical and Biopharmaceutical Research
- Strategy for Lead Identification for Understudied KinasesDavid Harold Drewry, Joel K. Annor‐Gyamfi, Carrow I. Wells, Julie E. Pickett, Alison Donnelly Axtman · 2021 · ChemRxiv
- Drug discovery: Standing on the shoulders of giantsSusan M. Miller, Walter H. Moos, Barbara H. Munk, Stephen A. Munk, Charles P. Hart, David C. Spellmeyer · 2023 · Elsevier eBooks
- High-performance computing leadership to enable advances in artificial intelligence and a thriving compute ecosystemGeorgia D. Tourassi, Mallikarjun Arjun Shankar, Feiyi Wang · 2023 · OECD eBooks
- Eroom’s Law and the decline in the productivity of biopharmaceutical R&DJack W. Scannell · 2023 · OECD eBooks
- The end of Moore’s Law? Innovation in computer systems continues at a high paceH. Kressel · 2023 · OECD eBooks
- Quantifying the “cognitive extent” of science and how it has changed over time and across countriesStaša Milojević · 2023 · OECD eBooks
- Interpretability: Should – and can – we understand the reasoning of machine-learning systems?Hugh Cartwright · 2023 · OECD eBooks
- PrefaceOECD · 2023 · OECD eBooks
- Public health institutions and systemsArun George Paul · 2023 · Elsevier eBooks
- Das funktionelle UnbekanntomManfred Spitzer · 2023 · Nervenheilkunde
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- Constitutive G protein coupling profiles of understudied orphan GPCRsSumin Lu, Wonjo Jang, Asuka Inoue, Nevin A. Lambert · 2024
- Meta-Research: understudied genes are lost in a leaky pipeline between genome-wide assays and reporting of resultsRichardson, Reese AK, Navarro, Heliodoro Tejedor, Nunes Amaral, Luis A, Stoeger, Thomas · 2024
- Disruption of NUAK2-Mediated RNA Splicing by Trilaciclib Reveals a Therapeutic Vulnerability in AR-Indifferent Prostate CancerUmar Mehraj, Uran Maimekov, Shaista Manzoor, Emily Cordova, Manasiben Patel, Ikeer Y. Mancera-Ortiz, Stefanie Howell, Zachary W. Davis‐Gilbert, Mu‐En Wang, Ming Chen et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
- Characterizing the landscape of gene process dependencies in cancerJulia B. Curd, Navin Kumar Balagopal, Adam L. Green, Gregory P. Way · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
- Categorization of Protein Kinases by Combining Data from Cell Biology and Medicinal Chemistry Enables Further Evaluation and Differentiation of the Understudied KinomeElena Kullmann, Selina Koch, Jürgen Bajorath · 2026 · Journal of Medicinal Chemistry
- Evolutionary and functional constraints structure human gene research visibilityEswarrijah Eswaran, Marvin Zimmermann, Gamchini Krishnagopalan, Jelja M. Ottersbach, Toni Ingolf Gossmann · 2026 · BMC Genomics
- BindRNAgen: Protein-binding RNA Sequence Generation Using Latent Diffusion ModelsYi Zhou, Xiaojian Liu, Shengfan Wang, Lin Zhu, Biao Zhang, Y Huang, Hong‐Bin Shen, Xiaoyong Pan · 2026 · Journal of Molecular Biology
- BindingDB Entry 50015305: Identification of Pyrimidine-Based Lead Compounds for Understudied Kinases Implicated in Driving Neurodegeneration.BindingDB · 2023 · UC San Diego