Erratum: Targeting the NLRP3 inflammasome in inflammatory diseases
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This corrects the article DOI: 10.1038/nrd.2018.97.
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This response includes the recruitment of neutrophils and monocytes, which play crucial roles in tissue repair and healing processes.
“This response includes the recruitment of neutrophils and monocytes, which play crucial roles in tissue repair and healing processes.”
From Inflammation and aging: signaling pathways and intervention therapies (2023) · cites this paper as [278]
DAMPs from senescent, damaged, and dying cells trigger various cell death modalities, including necrosis, pyroptosis, necroptosis, PANoptosis, NETosis, and ferroptosis.
“In summary, DAMPs from senescent, damaged, and dying cells trigger various cell death modalities, including necrosis, pyroptosis, necroptosis, PANoptosis, NETosis, and ferroptosis (Fig. 4).”
From Inflammation and aging: signaling pathways and intervention therapies (2023) · cites this paper as [278]
DAMPs bind to specific receptors, initiating inflammation and orchestrating a coordinated response involving immune cells.
“DAMPs bind to specific receptors, initiating inflammation and orchestrating a coordinated response involving immune cells.”
From Inflammation and aging: signaling pathways and intervention therapies (2023) · cites this paper as [278]
When leukocytes fail to clear immunostimulatory molecules, inflammation persists, which further causes cancer and aging.
“When leukocytes fail to clear immunostimulatory molecules, inflammation persists, which further causes cancer and aging.”
From Inflammation and aging: signaling pathways and intervention therapies (2023) · cites this paper as [278]
Endogenous DAMPs can activate PRRs and non-PRR transmembrane proteins, resulting in massive inflammation, cellular senescence, diseases of the organs, and aging.
“Endogenous DAMPs can activate PRRs and non-PRR transmembrane proteins, resulting in massive inflammation, cellular senescence, diseases of the organs, and aging.277–279”
From Inflammation and aging: signaling pathways and intervention therapies (2023) · cites this paper as [278]
Cites
Targeting the NLRP3 inflammasome in inflammatory diseases
Mangan, M. S. J., Olhava, E. J., Roush, W. R., Seidel, H. M., Glick, G. D., & Latz, E. (2018) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2018.97 · Cited by 1,885 · see citing works
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Inflammation and aging: signaling pathways and intervention therapies
Li, X., Li, C., Zhang, W., Wang, Y., Qian, P., & Huang, H. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01502-8 · Cited by 1,443 · see citing works
Xian, H., Watari, K., Sanchez-Lopez, E., Offenberger, J., Onyuru, J., Sampath, H., Ying, W., Hoffman, H. M., Shadel, G. S., & Karin, M. (2022) · Immunity · doi:10.1016/j.immuni.2022.06.007 · Cited by 850 · see citing works
The central role of inflammatory signaling in the pathogenesis of myelodysplastic syndromes
Sallman, D. A., & List, A. (2019) · Blood · doi:10.1182/blood-2018-10-844654 · Cited by 273 · see citing works
Therapeutic potential of MCC950, a specific inhibitor of NLRP3 inflammasome
Li, H., Guan, Y., Liang, B., Ding, P., Hou, X., Wei, W., & Ma, Y. (2022) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2022.175091 · Cited by 258 · see citing works
Pellegrini, C., Antonioli, L., Calderone, V., Colucci, R., Fornai, M., & Blandizzi, C. (2020) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2020.101806 · Cited by 174 · see citing works
Novel antiatherosclerotic therapies
Libby, P., & Everett, B. M. (2019) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.118.310958 · Cited by 145 · see citing works
Zhu, C., Li, H., Kong, X., Wang, Y., Sun, T., & Wang, F. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.819470 · Cited by 26 · see citing works
- Authors
- Mangan, M. S. J., Olhava, E. J., Roush, W. R., Seidel, H. M., Glick, G. D., & Latz, E.
- Venue
- Nature Reviews Drug Discovery
- Published
- 2018-08-17
- Volume
- 17
- Issue
- 9
- Pages
- 688-688
- ISSN
- 1474-1776 (ISSN-L)
- 1474-1784
- OpenAlex
- W2947089396
- Cited by
- 465
- References
- 1
- Citations by year
- 2026: 49 · 2025: 64 · 2024: 83 · 2023: 77 · 2022: 74 · 2021: 40 · 2020: 56 · 2019: 19 · 2018: 3
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Drug Discovery (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Health Sciences › Medicine › Complementary and alternative medicine › Natural Compounds in Disease Treatment
- Keywords
- NLRP3 inflammasome, inflammatory diseases, inflammasome inhibitors, drug discovery
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