Cited by 465Inflammasome and immune disordersImmune Response and InflammationNatural Compounds in Disease Treatment

Erratum: Targeting the NLRP3 inflammasome in inflammatory diseases

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Mangan, Matthew S. J., Olhava, Edward J., Roush, William R., Seidel, H. Martin, Glick, Gary D., Latz, Eicke·2018·Nature Reviews Drug Discovery

Abstract

This corrects the article DOI: 10.1038/nrd.2018.97.

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Crossref · 10.1038/nrd.2018.149

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  • This response includes the recruitment of neutrophils and monocytes, which play crucial roles in tissue repair and healing processes.

    “This response includes the recruitment of neutrophils and monocytes, which play crucial roles in tissue repair and healing processes.”
  • DAMPs from senescent, damaged, and dying cells trigger various cell death modalities, including necrosis, pyroptosis, necroptosis, PANoptosis, NETosis, and ferroptosis.

    “In summary, DAMPs from senescent, damaged, and dying cells trigger various cell death modalities, including necrosis, pyroptosis, necroptosis, PANoptosis, NETosis, and ferroptosis (Fig. 4).”
  • DAMPs bind to specific receptors, initiating inflammation and orchestrating a coordinated response involving immune cells.

    “DAMPs bind to specific receptors, initiating inflammation and orchestrating a coordinated response involving immune cells.”
  • When leukocytes fail to clear immunostimulatory molecules, inflammation persists, which further causes cancer and aging.

    “When leukocytes fail to clear immunostimulatory molecules, inflammation persists, which further causes cancer and aging.”
  • Endogenous DAMPs can activate PRRs and non-PRR transmembrane proteins, resulting in massive inflammation, cellular senescence, diseases of the organs, and aging.

    “Endogenous DAMPs can activate PRRs and non-PRR transmembrane proteins, resulting in massive inflammation, cellular senescence, diseases of the organs, and aging.277–279”

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Authors
Mangan, M. S. J., Olhava, E. J., Roush, W. R., Seidel, H. M., Glick, G. D., & Latz, E.
Venue
Nature Reviews Drug Discovery
Published
2018-08-17
Volume
17
Issue
9
Pages
688-688
ISSN
  • 1474-1776 (ISSN-L)
  • 1474-1784
OpenAlex
W2947089396
Cited by
465
References
1
Citations by year
2026: 49 · 2025: 64 · 2024: 83 · 2023: 77 · 2022: 74 · 2021: 40 · 2020: 56 · 2019: 19 · 2018: 3
Type
journal article
Language
en
Open access
Locations
Nature Reviews Drug Discovery (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
  • Health Sciences › Medicine › Complementary and alternative medicine › Natural Compounds in Disease Treatment
Keywords
NLRP3 inflammasome, inflammatory diseases, inflammasome inhibitors, drug discovery

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