The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
From carbohydrate leads to glycomimetic drugs
Open accessAbstract
Carbohydrates are the most abundant natural products. Besides their role in metabolism and as structural building blocks, they are fundamental constituents of every cell surface, where they are involved in vital cellular recognition processes. Carbohydrates are a relatively untapped source of new drugs and therefore offer exciting new therapeutic opportunities. Advances in the functional understanding of carbohydrate–protein interactions have enabled the development of a new class of small-molecule drugs, known as glycomimetics. These compounds mimic the bioactive function of carbohydrates and address the drawbacks of carbohydrate leads, namely their low activity and insufficient drug-like properties. Here, we examine examples of approved carbohydrate-derived drugs, discuss the potential of carbohydrate-binding proteins as new drug targets (focusing on the lectin families) and consider ways to overcome the challenges of developing this unique class of novel therapeutics.
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Rational design of potent sialidase-based inhibitors of influenza virus replication
von Itzstein, M., Wu, W.-Y., Kok, G. B., Pegg, M. S., Dyason, J. C., Jin, B., Van Phan, T., Smythe, M. L., White, H. F., Oliver, S. W., et al. (1993) · Nature · doi:10.1038/363418a0 · Cited by 1,862
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Drug-target residence time and its implications for lead optimization
Copeland, R. A., Pompliano, D. L., & Meek, T. D. (2006) · Nature Reviews Drug Discovery · doi:10.1038/nrd2082 · Cited by 1,464
van Die, I. (2003) · Glycobiology · doi:10.1093/glycob/cwg052 · Cited by 316
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Cited by
Glycomimetics versus Multivalent Glycoconjugates for the Design of High Affinity Lectin Ligands
Cecioni, S., Imberty, A., & Vidal, S. (2015) · Chemical Reviews · doi:10.1021/cr500303t · Cited by 544
Bokor, É., Kun, S., Goyard, D., Tóth, M., Praly, J.-P., Vidal, S., & Somsák, L. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.6b00475 · Cited by 304
Marine Polysaccharides: A Source of Bioactive Molecules for Cell Therapy and Tissue Engineering
Senni, K., Pereira, J., Gueniche, F., Delbarre-Ladrat, C., Sinquin, C., Ratiskol, J., Godeau, G., Fischer, A.-M., Helley, D., & Colliec-Jouault, S. (2011) · Marine Drugs · doi:10.3390/md9091664 · Cited by 282
Carbohydrate-based drugs launched during 2000−2021
Cao, X., Du, X., Jiao, H., An, Q., Chen, R., Fang, P., Wang, J., & Yu, B. (2022) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2022.05.020 · Cited by 267
Unmasking Fucosylation: from Cell Adhesion to Immune System Regulation and Diseases
Li, J., Hsu, H.-C., Mountz, J. D., & Allen, J. G. (2018) · Cell Chemical Biology · doi:10.1016/j.chembiol.2018.02.005 · Cited by 256
Metadata
- Authors
- Ernst, B., & Magnani, J. L.
- Venue
- Nature Reviews Drug Discovery
- Published
- 2009-07-24
- Volume
- 8
- Issue
- 8
- Pages
- 661-677
- ISSN
- 1474-1776 (ISSN-L)
- 1474-1784
- OpenAlex
- W2149170824
- Cited by
- 820
- References
- 7
- FWCI
- 1.40
- Type
- journal article
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
