Cited by 1,862Influenza Virus Research StudiesCarbohydrate Chemistry and SynthesisComputational Drug Discovery Methods

Rational design of potent sialidase-based inhibitors of influenza virus replication

von Itzstein, Mark, Wu, Wen-Yang, Kok, Gaik B., Pegg, Michael S., Dyason, Jeffrey C., Jin, Betty, Van Phan, Tho, Smythe, Mark L. +10 more·1993·Nature

Abstract

Two potent inhibitors based on the crystal structure of influenza virus sialidase have been designed. These compounds are effective inhibitors not only of the enzyme, but also of the virus in cell culture and in animal models. The results provide an example of the power of rational, computer-assisted drug design, as well as indicating significant progress in the development of a new therapeutic or prophylactic treatment for influenza infection.

Integrity signals

Registry

Crossref · 10.1038/363418a0

Cites

38 of 38 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
von Itzstein, M., Wu, W.-Y., Kok, G. B., Pegg, M. S., Dyason, J. C., Jin, B., Van Phan, T., Smythe, M. L., White, H. F., Oliver, S. W., Colman, P. M., Varghese, J. N., Ryan, D. M., Woods, J. M., Bethell, R. C., Hotham, V. J., Cameron, J. M., & Penn, C. R.
Affiliations
  • Monash University (AU)
  • Commonwealth Scientific and Industrial Research Organisation (AU)
Venue
Nature
Published
1993-06
Volume
363
Issue
6428
Pages
418-423
ISSN
  • 0028-0836 (ISSN-L)
  • 1476-4687
OpenAlex
W2086358466
Cited by
1,862
References
38
Citations by year
2026: 27 · 2025: 25 · 2024: 34 · 2023: 30 · 2022: 46 · 2021: 50 · 2020: 60 · 2019: 50 · 2018: 58 · 2017: 45 · 2016: 68 · 2015: 48 · 2014: 71 · 2013: 83 · 2012: 84
FWCI
58.57
Type
journal article
Language
en
Open access
closed
Locations
  • Nature (publishedVersion)
  • PubMed (publishedVersion)
  • Griffith Research Online (submittedVersion)
Topics
  • Health Sciences › Medicine › Epidemiology › Influenza Virus Research Studies
  • Physical Sciences › Chemistry › Organic Chemistry › Carbohydrate Chemistry and Synthesis
  • Physical Sciences › Computer Science › Computational Theory and Mathematics › Computational Drug Discovery Methods
Keywords
influenza virus, sialidase inhibitors, neuraminidase, rational drug design, computer-aided drug design, antiviral agents, influenza treatment, prophylaxis, enzyme inhibition
MeSH terms
Animals, Antiviral Agents, Cell Line, Disease Models, Animal, Female, Ferrets, Guanidines, Humans, Influenza, Human, Models, Molecular, Neuraminidase, Influenza A virus, Viral Plaque Assay, Pyrans, Sheep, Sialic Acids, Virus Replication, Drug Design, Computer-Aided Design, Mice, Zanamivir

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review