The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Voltage-gated potassium channels as therapeutic targets
Open accessAbstract
The human genome encodes 40 voltage-gated K+ channels (KV), which are involved in diverse physiological processes ranging from repolarization of neuronal and cardiac action potentials, to regulating Ca2+ signalling and cell volume, to driving cellular proliferation and migration. KV channels offer tremendous opportunities for the development of new drugs to treat cancer, autoimmune diseases and metabolic, neurological and cardiovascular disorders. This Review discusses pharmacological strategies for targeting KV channels with venom peptides, antibodies and small molecules, and highlights recent progress in the preclinical and clinical development of drugs targeting the KV1 subfamily, the KV7 subfamily (also known as KCNQ), KV10.1 (also known as EAG1 and KCNH1) and KV11.1 (also known as HERG and KCNH2) channels.
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The roles of K+ channels in cancer
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Self-citationKCNQ channel openers reverse depressive symptoms via an active resilience mechanism
Friedman, A. K., Juarez, B., Ku, S. M., Zhang, H., Calizo, R. C., Walsh, J. J., Chaudhury, D., Zhang, S., Hawkins, A., Dietz, D. M., et al. (2016) · Nature Communications · doi:10.1038/ncomms11671 · Cited by 172
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Self-citationSynthesis and applications of mirror-image proteins
Harrison, K., Mackay, A. S., Kambanis, L., Maxwell, J. W. C., & Payne, R. J. (2023) · Nature Reviews Chemistry · doi:10.1038/s41570-023-00493-y · Cited by 104
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Metadata
- Authors
- Wulff, H., Castle, N. A., & Pardo, L. A.
- Venue
- Nature Reviews Drug Discovery
- Published
- 2009-12
- Volume
- 8
- Issue
- 12
- Pages
- 982-1001
- ISSN
- 1474-1776 (ISSN-L)
- 1474-1784
- OpenAlex
- W2021704663
- Cited by
- 799
- References
- 9
- FWCI
- 2.21
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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