Synthesis and applications of mirror-image proteins

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Protein chemical synthesis by serine and threonine ligation

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D-peptide inhibitors of the p53–MDM2 interaction for targeted molecular therapy of malignant neoplasms

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A synthetic molecular system capable of mirror-image genetic replication and transcription

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The Origin of Biological Homochirality

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Racemic Protein Crystallography

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Bioorthogonal information storage in l-DNA with a high-fidelity mirror-image Pfu DNA polymerase

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Chemical Engineering of Artificial Transcription Factors by Orthogonal Palladium(II)‐Mediated S‐Arylation Reactions

Lin, X., Harel, O., & Jbara, M. (2023) · Angewandte Chemie International Edition · doi:10.1002/anie.202317511 · Cited by 24 · see citing works

The Potential of Peptide-Based Inhibitors in Disrupting Protein–Protein Interactions for Targeted Cancer Therapy

Afonso, A. L., Cavaleiro, C. T., Castanho, M. A. R. B., Neves, V., & Cavaco, M. C. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26073117 · Cited by 23 · see citing works

Mirror-image trypsin digestion and sequencing of D-proteins

Zhang, G., & Zhu, T. F. (2024) · Nature Chemistry · doi:10.1038/s41557-023-01411-x · Cited by 22 · see citing works

Enhanced native chemical ligation by peptide conjugation in trifluoroacetic acid

Huang, D., Guo, W.-C., Shi, W.-W., Gao, Y.-P., Zhou, Y., Wang, L.-J., Wang, C., Tang, S., Liu, L., & Zheng, J. (2024) · Science Advances · doi:10.1126/sciadv.ado9413 · Cited by 22 · see citing works

Mirror‐Image Random Nonstandard Peptides Integrated Discovery (MI‐RaPID) Technology Yields Highly Stable and Selective Macrocyclic Peptide Inhibitors for Matrix Metallopeptidase 7

Ghareeb, H., Li, C. Y., Shenoy, A., Rotenberg, N., Shifman, J. M., Katoh, T., Sagi, I., Suga, H., & Metanis, N. (2024) · Angewandte Chemie International Edition · doi:10.1002/anie.202414256 · Cited by 22 · see citing works

L‐Glycosidase‐Cleavable Natural Glycans Facilitate the Chemical Synthesis of Correctly Folded Disulfide‐Bonded D‐Proteins

Shi, W., Wang, T., Yang, Z., Ren, Y., Han, D., Zheng, Y., Deng, X., Tang, S., & Zheng, J. (2024) · Angewandte Chemie International Edition · doi:10.1002/anie.202313640 · Cited by 21 · see citing works

Generating a mirror-image monobody targeting MCP-1 via TRAP display and chemical protein synthesis

Hayashi, G., Naito, T., Miura, S., Iwamoto, N., Usui, Y., Bando-Shimizu, M., Suzuki, S., Higashi, K., Nonaka, M., Oishi, S., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-54902-x · Cited by 20 · see citing works

An Enzyme‐Cleavable Solubilizing‐Tag Facilitates the Chemical Synthesis of Mirror‐Image Proteins

Zheng, Y., Zhang, B., Shi, W., Deng, X., Wang, T., Han, D., Ren, Y., Yang, Z., Zhou, Y., Kuang, J., et al. (2024) · Angewandte Chemie International Edition · doi:10.1002/anie.202318897 · Cited by 18 · see citing works

Discovery of Selective Cyclic d -Sulfopeptide Ligands of the Chemokine CCL22 via Mirror-Image mRNA Display with Genetic Reprogramming

Zhang, B. B., Harrison, K., Zhong, Y., Maxwell, J. W. C., Ford, D. J., Calvey, L. P., So, S. S., Peterson, F. C., Volkman, B. F., Stone, M. J., et al. (2024) · Journal of the American Chemical Society · doi:10.1021/jacs.4c12057 · Cited by 18 · see citing works

Roles of inter- and intramolecular tryptophan interactions in membrane-active proteins revealed by racemic protein crystallography

Lander, A. J., Mercado, L. D., Li, X., Taily, I. M., Findlay, B., Jin, Y., & Luk, L. Y. P. (2023) · Communications Chemistry · doi:10.1038/s42004-023-00953-y · Cited by 16 · see citing works

Synthesis and structural optimization of oncolytic peptide LTX-315

Song, M., Liu, Q., Yao, J.-F., Wang, Y., Ma, Y., Xu, H., Yu, Q.-Y., Li, Z., Du, S., & Qi, Y. (2024) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2024.117760 · Cited by 15 · see citing works

Site-Specific Acetylation of the Transcription Factor Protein Max Modulates Its DNA Binding Activity

Nithun, R. V., Yao, Y. M., Harel, O., Habiballah, S., Afek, A., & Jbara, M. (2024) · ACS Central Science · doi:10.1021/acscentsci.4c00686 · Cited by 14 · see citing works

Automated Flow Synthesis of Artificial Heme Enzymes for Enantiodivergent Biocatalysis

Fittolani, G., Kutateladze, D. A., Loas, A., Buchwald, S. L., & Pentelute, B. L. (2025) · Journal of the American Chemical Society · doi:10.1021/jacs.4c13832 · Cited by 13 · see citing works

Altering Spin Distribution of Tb2Pc3 via Molecular Chirality Manipulation

Liao, X., Minamitani, E., Xie, T., Yang, L., Zhang, W., Klyatskaya, S. V., Ruben, M., & Fu, Y. (2024) · Journal of the American Chemical Society · doi:10.1021/jacs.3c11882 · Cited by 13 · see citing works

Backbone Protecting Groups for Enhanced Peptide and Protein Synthesis

Paravizzini, S. J., Haugaard‐Kedström, L. M., Hutton, C. A., & Karas, J. A. (2025) · Angewandte Chemie International Edition · doi:10.1002/anie.202509939 · Cited by 12 · see citing works

d-type peptides based fluorescent probes for “turn on” sensing of heparin

Xu, H., Fu, X., Bao, Y., Zhu, S.-Y., Xu, Z., Song, M., Qi, Y., Li, Z., & Du, S. (2024) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2024.107356 · Cited by 12 · see citing works

Efficient Chemical Synthesis and Folding of Mirror‐Image Tropomyosin Receptor Kinase A Using the Strategy of Removable Glycosylation Modification†

Wang, T., Shi, W., Chu, G., & Li, Y. (2024) · Chinese Journal of Chemistry · doi:10.1002/cjoc.202400381 · Cited by 12 · see citing works

The clinical potential of l -oligonucleotides: challenges and opportunities

Shearer, V., Yu, C., Han, X., & Sczepanski, J. T. (2024) · Chemical Science · doi:10.1039/d4sc05157b · Cited by 14 · see citing works

Chemically Synthetic d -Sortase Enables Enzymatic Ligation of d -Peptides

Ding, R., Shi, W., & Zheng, J. (2023) · Organic Letters · doi:10.1021/acs.orglett.3c01657 · Cited by 12 · see citing works

Engineering a Low-Immunogenic Mirror-Image VHH against Vascular Endothelial Growth Factor

Aoki, K., Higashi, K., Oda, S., Manabe, A., Maeda, K., Morise, J., Oka, S., Inuki, S., Ohno, H., Oishi, S., et al. (2024) · ACS Chemical Biology · doi:10.1021/acschembio.4c00197 · Cited by 12 · see citing works

Mirror-Image Single-Domain Antibody for a Novel Nonimmunogenic Drug Scaffold

Aoki, K., Manabe, A., Kimura, H., Katoh, Y., Inuki, S., Ohno, H., Nonaka, M., & Oishi, S. (2023) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.3c00372 · Cited by 11 · see citing works

Mechanism Unraveling of Scalable Antifreeze Oligopeptides for Enhanced Cryopreservation

Zhou, H., Song, M., Zhang, X., Ke, T., Shi, G., Wu, Y., & Geng, H. (2025) · Langmuir · doi:10.1021/acs.langmuir.5c00569 · Cited by 11 · see citing works

Discovery of d -Miniprotein Inhibitors of PD-1/PD-L1 Interaction via Mirror-Image Phage Display against Synthetic d -PD-1

Zhou, H., Wu, H., Zhong, Z., Blasco, P., Zeng, J., Wang, J., Liu, H., & Li, X. (2025) · JACS Au · doi:10.1021/jacsau.5c01181 · Cited by 10 · see citing works

Atom-level machine learning of protein-glycan interactions and cross-chiral recognition in glycobiology

Carpenter, E. J., Peng, C., Haregu, S., Twells, N., Woudstra, L., Sood, A., Cartmell, J., Woods, R. J., Mahal, L. K., Wang, S.-K., et al. (2025) · Science Advances · doi:10.1126/sciadv.adx6373 · Cited by 10 · see citing works

Temporary Structural Supports for Chemical Protein Synthesis

Liu, Y., Han, D., & Liu, L. (2025) · Angewandte Chemie International Edition · doi:10.1002/anie.202504405 · Cited by 9 · see citing works

Mirror Life: Bridging Chirality, Ethics, and the Foundations of Life Creation

Li, Y., Moradialvand, M., Asbridge, L., FRAZIER, K. B., Tay, F. R., & Makvandi, P. (2025) · Advanced Materials · doi:10.1002/adma.202510791 · Cited by 11 · see citing works

Traceless 6- O -Lysyl Modification of N -Acetylglucosamine Enables Synthesis and Derivatization of Aggregation-Prone GlcNAcylated Peptides

Chen, J., Zhang, Q., Mo, R., Deng, Q. W., Hu, B., & Dong, S. (2025) · Journal of the American Chemical Society · doi:10.1021/jacs.5c11038 · Cited by 8 · see citing works

A horizon scan of biological conservation issues for 2026

Sutherland, W. J., Butchart, S. H. M., Clarke, S. J., Doar, N., Doran, H., Douglas, I. C., Field, D. J., Fleishman, E., Gaston, K. J., Herbert‐Read, J. E., et al. (2025) · Trends in Ecology & Evolution · doi:10.1016/j.tree.2025.10.016 · Cited by 8 · see citing works

An improved installation of 2-hydroxy-4-methoxybenzyl (iHmb) method for chemical protein synthesis

Li, Y., Wang, L.-J., Zhou, Y., Liang, J., Xiao, B., & Zheng, J. (2023) · Chinese Chemical Letters · doi:10.1016/j.cclet.2023.109033 · Cited by 8 · see citing works

The path to biotechnological singularity: Current breakthroughs and outlook

Wen, Z., Yang, D., Yang, Y., Hu, J., Parviainen, A., Chen, X., Li, Q., VanDeusen, E. A., Ma, J., & Tay, F. R. (2025) · Biotechnology Advances · doi:10.1016/j.biotechadv.2025.108667 · Cited by 7 · see citing works

Rapid Production of Native and Mirror-Image Tumor Necrosis Factor-α Enabled by Automated Flow Peptide Synthesis Technology

Yeşilçimen, A., Callahan, A. J., Travaline, T. L., Gandhesiri, S., Tokareva, O. S., Loas, A., McGee, J. H., & Pentelute, B. L. (2024) · The Journal of Organic Chemistry · doi:10.1021/acs.joc.4c01866 · Cited by 6 · see citing works

Thioproline-Based Oxidation Strategy for Direct Preparation of N-Terminal Thiazolidine-Containing Peptide Thioesters from Peptide Hydrazides

Wan, X.-C., Zhu, W., Chen, Y., Cui, Z., Zhang, H., Zheng, F.-H., Zhang, Y., & Fang, G. (2024) · Organic Letters · doi:10.1021/acs.orglett.4c01687 · Cited by 6 · see citing works

Mirror of the unknown: should research on mirror-image molecular biology be stopped?

Zhu, T. F. (2025) · Nature · doi:10.1038/d41586-025-02912-0 · Cited by 5 · see citing works

Development and applications of enzymatic peptide and protein ligation

Cui, Y., Han, D., Bai, X., & Shi, W.-W. (2024) · Journal of Peptide Science · doi:10.1002/psc.3657 · Cited by 5 · see citing works

Automated fast-flow synthesis of the immune checkpoint receptors PD-1 and PD-L1

Fittolani, G., Callahan, A. J., Loas, A., & Pentelute, B. L. (2025) · Chemical Communications · doi:10.1039/d4cc05982d · Cited by 5 · see citing works

L-glucose-modified mirror-image zinc phthalocyanine photosensitizers for enhanced tumor-targeted photodynamic therapy

Xu, K., Kong, L., Song, Z., Mu, X., Wang, D., Zhou, L., Wang, W., & Wei, S. (2025) · Journal of Molecular Structure · doi:10.1016/j.molstruc.2025.143095 · Cited by 4 · see citing works

Chemical Synthesis, Refolding, and Characterization of Mirror-Image Cyclophilin A

Yeşilçimen, A., Gandhesiri, S., Travaline, T. L., Callahan, A. J., Tokareva, O. S., Loas, A., McGee, J. H., & Pentelute, B. L. (2025) · The Journal of Organic Chemistry · doi:10.1021/acs.joc.4c03049 · Cited by 4 · see citing works

A Dual-Specificity d -Peptide Antagonist of MDM2 and MDMX for Antitumor Immunotherapy

Liao, C., Yan, J., Tolbert, W. D., Chen, X., Pazgier, M., Lu, W., Zhan, C., & Lu, W. (2025) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.4c02057 · Cited by 4 · see citing works

Chemical synthesis of a 28 kDa full-length PET degrading enzyme ICCG by the removable backbone modification strategy

Gao, Y.-P., Sun, P.-F., Guo, W.-C., Zhou, Y., Zheng, J., & Tang, S. (2023) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2023.107047 · Cited by 4 · see citing works

Thiazolidine Deprotection Using an Organic Solvent Extractable Aldehyde Scavenger for One-Pot Four-Segment Ligation

Zheng, F.-H., Cui, Z., Wang, Y., Zhu, W., Wei, H.-M., Xue, J.-H., Wan, X.-C., & Fang, G. (2024) · Organic Letters · doi:10.1021/acs.orglett.4c02816 · Cited by 3 · see citing works

Design and Evaluation of Stable Cysteine-Modified Monobody Scaffolds for Mirror-Image Synthesis

Iwamoto, N., Ohno, S., Nakamura, K., Naito, T., Miura, S., Inuki, S., Ohno, H., Hayashi, G., Murakami, H., & Oishi, S. (2025) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.5c00181 · Cited by 3 · see citing works

Thermally Responsive White Circularly Polarized Light from Elastic Chiral Crystals via Dual Fluorescence‐Phosphorescence

Pan, X., Lan, L., Qu, Y., Wang, Y., & Zhang, H. (2025) · Advanced Optical Materials · doi:10.1002/adom.202502121 · Cited by 3 · see citing works

De Novo Design of Mirror-Image Dimeric Antimicrobial Peptides with Low Drug Resistance and In Vivo Efficacy

Zhang, J., Chu, A., Yang, P., Ouyang, X., Li, B., Mao, W., Wu, X., Zhong, C., Gou, S., Zhang, Y., et al. (2025) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.5c01375 · Cited by 3 · see citing works

Assembly of dynamic helical β-peptides with switchable handedness into multiple types of metal-peptide frameworks

Han, I., Lee, H.-J., Guzei, I. A., & Choi, S. H. (2025) · Nature Communications · doi:10.1038/s41467-025-64544-2 · Cited by 3 · see citing works

A General Strategy to Access All Stereosequences in a Synthetic Polymer

Barman, R., & Lutz, J. (2025) · Journal of the American Chemical Society · doi:10.1021/jacs.5c15603 · Cited by 3 · see citing works

Advancing protein engineering via organic chemistry

Nithun, R. V., Singh, M., Baransi, A., & Jbara, M. (2026) · Communications Chemistry · doi:10.1038/s42004-026-02033-3 · Cited by 3 · see citing works

Chemical Synthesis of Interleukin-6 for Mirror-Image Screening

Aoki, K., Maeda, K., Inuki, S., Ohno, H., Nonaka, M., & Oishi, S. (2024) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.4c00204 · Cited by 3 · see citing works

Iterative Synthesis of Intrinsically Disordered Protein Mimics

Wan, J., Tang, Z., Zhong, Q., Wang, T., Tan, R., Cao, S., Zhang, Z., Zhou, D., & Su, H. (2025) · Journal of the American Chemical Society · doi:10.1021/jacs.5c09156 · Cited by 3 · see citing works

Synthetic studies on the extracellular domain of the T cell immunoreceptor with immunoglobulin and immunoreceptor tyrosine-based inhibitory motif domain (TIGIT) using Trt-K10 solubilizing tags

Iwamoto, N., Sasaki, J., Ohno, S., Aoki, K., Usui, Y., Inuki, S., Ohno, H., & Oishi, S. (2023) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2023.117585 · Cited by 3 · see citing works

Deciphering the Synthetic and Refolding Strategy of a Cysteine-Rich Domain in the Tumor Necrosis Factor Receptor (TNF-R) for Racemic Crystallography Analysis and d -Peptide Ligand Discovery

Lander, A. J., Kong, Y.-F., Jin, Y., Wu, C., & Luk, L. Y. P. (2023) · ACS Bio & Med Chem Au · doi:10.1021/acsbiomedchemau.3c00060 · Cited by 2 · see citing works

Chemokine-Binding All-D-CLIPS Peptides Identified Using Mirror-Image Phage Display

Denisov, S. S., Bialek, E. L., Beretta, F., Smagurauskaite, G., Ippel, H., Fijlstra, E., Kale, S. S., Timmerman, P., Hackeng, T. M., Proost, P., et al. (2025) · ACS Chemical Biology · doi:10.1021/acschembio.5c00726 · Cited by 2 · see citing works

Leveraging mirror-image glycans in carbohydrate materials

Weh, D., & Delbianco, M. (2026) · Organic & Biomolecular Chemistry · doi:10.1039/d5ob01778e · Cited by 2 · see citing works

Lipase-Catalyzed Enantioselective Resolution of Chiral Pesticides and Herbicides: Advances in Biocatalysis and Enzyme Engineering

Hu, L., Ge, F., Li, A., Liu, X., Tang, M., Tang, J., Ren, S., Tian, B., Zhou, J., Shi, H., et al. (2026) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.6c01422 · Cited by 2 · see citing works

Chemical Synthesis of Mirror-Image Proteins Reveals Chirality-Dependent Cellular Uptake Mediated by a Cell-Penetrating Peptide

Nassar, E., Donthoju, A., Hasan, M., & Brik, A. (2026) · Journal of the American Chemical Society · doi:10.1021/jacs.6c03792 · Cited by 2 · see citing works

Efficient chemical synthesis of mirror-image DNA polymerase Dpo4 assisted by one-pot multi-segment condensation

Wang, M., Cui, T., Huang, S., Han, D., Deng, X., Liu, Y., & Shi, C. (2025) · Organic & Biomolecular Chemistry · doi:10.1039/d5ob00243e · Cited by 2 · see citing works

Temporary Structural Supports for Chemical Protein Synthesis

Liu, Y., Han, D., & Liu, L. (2025) · Angewandte Chemie · doi:10.1002/ange.202504405 · Cited by 2 · see citing works

Automated Flow Synthesis of Artificial Heme Enzymes for Enantioselective BiocatalysisPreprint

Fittolani, G., Kutateladze, D. A., Loas, A., Buchwald, S. L., & Pentelute, B. L. (2024) · ChemRxiv · doi:10.26434/chemrxiv-2024-k0wkb · Cited by 2 · see citing works

Evaluating Generative Adversarial Networks Performance in Image Synthesis with Graphical Analysis of Loss Functions and Quality Metrics

Biju, J., Jeevitha, R., Richard, T., Chowdhury, R., Kumar, P., & Radhika, K. (2024) · International Conference on Integrated Intelligence and Communication Systems (ICIICS) · doi:10.1109/iciics63763.2024.10859959 · Cited by 1 · see citing works

Backbone Protecting Groups for Enhanced Peptide and Protein Synthesis

Paravizzini, S. J., Haugaard‐Kedström, L. M., Hutton, C. A., & Karas, J. A. (2025) · Angewandte Chemie · doi:10.1002/ange.202509939 · Cited by 1 · see citing works

Chemical Synthesis of the Mirror‐Image Fast‐PETase by the Enzyme‐Cleavable Solubilizing‐Tag Strategy

Zou, S., Yu, G., Zhou, Y., & Zheng, J. (2025) · Chemistry - A European Journal · doi:10.1002/chem.202501410 · Cited by 1 · see citing works

An Integrated Solubilizing-Tag-Free Strategy for Chemical Synthesis of Mirror-Image Interleukin-6

Ren, Y., Liu, Y., Han, D., & Liang, L.-J. (2025) · Organic Letters · doi:10.1021/acs.orglett.5c03364 · Cited by 1 · see citing works

Optical chirality in Raman scattering

Wu, Y., Zhuang, J., Wang, Z.-Q., Li, Y., & Gong, L. (2025) · Physical Review Research · doi:10.1103/b7bv-fpz9 · Cited by 1 · see citing works

Oa AEP1-Mediated Ligation of Mirror-Image Peptides via Acyl Donor Substrate Engineering

Shu, Q., Wang, Y., Shi, C., Sun, Y., Zhao, R., & Shi, J. (2026) · Journal of the American Chemical Society · doi:10.1021/jacs.6c00057 · Cited by 1 · see citing works

Synthetic Mirror Bacteria as a Frontier for Chiral Synthetic Biology and Biocontainment

Bhuiyan, M. N. I. (2026) · MicrobiologyOpen · doi:10.1002/mbo3.70356 · Cited by 1 · see citing works

Ferricyanide-mediated direct ligation of peptide hydrazides in neutral water

Han, D., Zhu, X., Deng, G., He, W., Zhang, T., Ai, H., Chu, G., & Liu, L. (2026) · Nature Synthesis · doi:10.1038/s44160-026-01121-5 · Cited by 1 · see citing works

Protein Modifications for Cellular Protein Delivery

Arafiles, J. V. V., Franke, J., Dubatouka, P., Franz, L., & Hackenberger, C. P. R. (2026) · Chemical Reviews · doi:10.1021/acs.chemrev.6c00267 · Cited by 1 · see citing works

Chemical Engineering of Artificial Transcription Factors by Orthogonal Palladium(II)‐Mediated S‐Arylation Reactions

Lin, X., Harel, O., & Jbara, M. (2023) · Angewandte Chemie · doi:10.1002/ange.202317511 · Cited by 1 · see citing works

L‐Glycosidase‐Cleavable Natural Glycans Facilitate the Chemical Synthesis of Correctly Folded Disulfide‐Bonded D‐Proteins

Shi, W., Wang, T., Yang, Z., Ren, Y., Han, D., Zheng, Y., Deng, X., Tang, S., & Zheng, J. (2024) · Angewandte Chemie · doi:10.1002/ange.202313640 · Cited by 1 · see citing works

Shaping the future of constrained peptides and compact proteins in drug discovery

Ullrich, S. (2025) · Australian Journal of Chemistry · doi:10.1071/ch25122 · Cited by 1 · see citing works

Rapid Production of Native and Mirror-Image Tumor Necrosis Factor-α through the Synergy of Automated Flow Peptide Synthesis and Native Chemical LigationPreprint

Yeşilçimen, A., Callahan, A. J., Travaline, T. L., Gandhesiri, S., Tokareva, O. S., Loas, A., McGee, J. H., & Pentelute, B. L. (2024) · ChemRxiv · doi:10.26434/chemrxiv-2024-trwx9 · Cited by 1 · see citing works

Peptide oxo-esters for ligation of peptide hydrazide at Gln and Asn sites

Yin, Q.-H., Zheng, F.-H., Wan, X.-C., Zhang, Y., & Fang, G. (2023) · Tetrahedron Letters · doi:10.1016/j.tetlet.2023.154892

An Enzyme‐Cleavable Solubilizing‐Tag Facilitates the Chemical Synthesis of Mirror‐Image Proteins

Zheng, Y., Zhang, B., Shi, W., Deng, X., Wang, T., Han, D., Ren, Y., Yang, Z., Zhou, Y., Kuang, J., et al. (2024) · Angewandte Chemie · doi:10.1002/ange.202318897

Cost-Effective Synthesis, Stability-Guided Structural Optimization and Anticancer Evaluation of First-in-Class Oncolytic Peptide Ltx-315Preprint

Song, M., Liu, Q., Yao, J.-F., Wang, Y., Ma, Y., Xu, H., Yu, Q.-Y., Li, Z., Du, S., & Qi, Y. (2024) · SSRN Electronic Journal · doi:10.2139/ssrn.4801734

Mirror-Image Human Serum Albumin Domain III as a Tool for Analyzing Site II-Dependent Molecular Recognition

Iwamoto, N., Kai, T., Inuki, S., Ohno, H., Maeda, H., Watanabe, H., Maruyama, T., & Oishi, S. (2024) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.4c00150

Mirror‐Image Random Nonstandard Peptides Integrated Discovery (MI‐RaPID) Technology Yields Highly Stable and Selective Macrocyclic Peptide Inhibitors for Matrix Metallopeptidase 7

Ghareeb, H., Li, C. Y., Shenoy, A., Rotenberg, N., Shifman, J. M., Katoh, T., Sagi, I., Suga, H., & Metanis, N. (2024) · Angewandte Chemie · doi:10.1002/ange.202414256

Introduction

Aoki, K. (2025) · Springer theses · doi:10.1007/978-981-96-1301-4_1

Synthetic Study of Full-Length Hepatitis B Virus Core Protein and Its Capsid Assembly

Aoki, K. (2025) · Springer theses · doi:10.1007/978-981-96-1301-4_4

Chemical Protein Engineering: Backbone Cyclization Rescues Folding of a 183‐Residue Truncated Domain of Malaria Parasite Protein PfAMA1

Mannuthodikayil, J., Malik, V., Kar, A., Singh, S., & Mandal, K. (2025) · Chemistry - A European Journal · doi:10.1002/chem.202500894

Metabolic diversity of microorganisms toward atypical sugar enantiomersPreprint

Nishijima, H., Igarashi, K., Kitagawa, W., Tabata, H., Nakanishi, S., & Kato, S. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.01.17.700050

Erbgut schreiben

Wünschiers, R. (2026) · Springer eBooks · doi:10.1007/978-3-662-71410-2_6

Introduction

Iwamoto, N. (2026) · Springer theses · doi:10.1007/978-981-95-5366-2_1

Molecular nanoarchitectonics with peptide chirality directs osteoimmune regulation for bone repair

Li, L., Wang, M., Zhang, Y., Kong, N., Zhang, S., Zhang, M., Cui, D., Wang, X., Yan, F., & Yan, F. (2026) · Chinese Chemical Letters · doi:10.1016/j.cclet.2026.112704 · Cited by 1 · see citing works

Synthesis of Chiral Thioethers

Zeng, Q., & Khuzaifa, M. (2026) · Springer eBooks · doi:10.1007/978-981-95-7273-1_2

Chirality Effect on Physical and Biological Properties of Peptide-Based Hydrogels

Rosa, L. D., D’Andrea, L. D., & Romanelli, A. (2026) · Gels · doi:10.3390/gels12050399

Chemical Synthesis of Mirror-image Proteins and Their Application to Drug Discovery

Iwamoto, N., & Oishi, S. (2026) · Journal of Synthetic Organic Chemistry Japan · doi:10.5059/yukigoseikyokaishi.84.466

Ecological constraints to mirror lifePreprint

Pla, J., Maull, V., Tabi, A., Shpilkina, Y., de Lorenzo, V., & Solé, R. V. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.05.07.723461

De novo design of binder proteins targeting Helicobacter pylori adhesin BabAPreprint

Zhu, Y., Isah, M. B., & Zhang, X. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.05.24.727452

Recent advances in chemoselective protein desulfurization: from VA-044 to emerging boron, photochemical, iron-catalyzed, and ultrasound methods

Ding, X., Li, C., Wang, X., & Liang, L.-J. (2026) · Organic & Biomolecular Chemistry · doi:10.1039/d6ob00780e

Examining Part–Part Interactions Toward Improving Mechanistic Explanations in Cell Biology

Ehsani, S. (2026) · Journal for General Philosophy of Science · doi:10.1007/s10838-026-09767-7

Acid-free activation of acyl hydrazides

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