Beyond classical benzodiazepines: novel therapeutic potential of GABAA receptor subtypes

Rudolph, Uwe, Knoflach, Frédéric·2011·Nature Reviews Drug Discovery

Cited by (745)

Items 301–400 of 745

  1. Gimmicks of gamma‐aminobutyric acid (GABA) in pancreatic β‐cell regeneration through transdifferentiation of pancreatic α‐ to β‐cells
    Yi Zhao, Muhammad Waseem Ghani, Hammad Ghani, Jiang Wu, Muhammad Waseem Birmani, Li Ye, Bin Liu, Lang Guan Cun, An Lilong, Mei Xiao · 2020 · Cell Biology International
  2. Functional expression of the GABAA receptor α2 and α3 subunits at synapses between intercalated medial paracapsular neurons of mouse amygdala
    Raffaella Geracitano, David Fischer, Yu Kasugai, Francesco Ferraguti, Marco Capogna · 2012 · Frontiers in Neural Circuits
  3. The selective neuropeptide Y Y5 agonist [cPP1–7,NPY19–23,Ala31,Aib32,Gln34]hPP differently modulates emotional processes and body weight in the rat
    Julio César Morales‐Medina, Sergio Domínguez-López, Gabriella Gobbi, Annette G. Beck‐Sickinger, Rémi Quirion · 2012 · Behavioural Brain Research
  4. Impact of Legacy Perfluorooctane Sulfonate (PFOS) and Perfluorooctanoate (PFOA) on GABA Receptor-Mediated Currents in Neuron-Like Neuroblastoma Cells: Insights into Neurotoxic Mechanisms and Health Implications
    Laura Lagostena, Davide Rotondo, Davide Gualandris, Antonio Calisi, Candida Lorusso, Valeria Magnelli, Francesco Dondero · 2024 · Journal of Xenobiotics
  5. Time- and Behavioral State-Dependent Changes in Posterior Hypothalamic GABAA Receptors Contribute to the Regulation of Sleep
    Denys V. Volgin, Jackie W. Lu, Georg Martin Stettner, Graziella L. Mann, Richard John M Ross, Adrian R. Morrison, Leszek K. Kubin · 2014 · PLoS ONE
  6. Identification of chemically diverse GABAA agonists as potential anti-epileptic agents using structure-guided virtual screening, ADMET, quantum mechanics and clinical validation through off-target analysis
    Pakhuri Mehta, Shubham Srivastava, Manish Sharma · 2018 · International Journal of Biological Macromolecules
  7. Characteristics of patients who were able to switch from benzodiazepine hypnotics to lemborexant
    Hidenobu Suzuki, Hiroyuki Hibino · 2021 · SAGE Open Medicine
  8. Therapeutic Implications of microRNAs in Depressive Disorders: A Review
    Mubashir Hassan, Aqsa Amir, Saba Shahzadi, Andrzej Kloczkowski · 2022 · International Journal of Molecular Sciences
  9. Reperfusion and cytoprotective agents are a mutually beneficial pair in ischaemic stroke therapy: an overview of pathophysiology, pharmacological targets and candidate drugs focusing on excitotoxicity and free radical
    Xiumei Xu, Mingyu Chen, Dong‐Ya Zhu · 2023 · Stroke and Vascular Neurology
  10. Tangeretin enhances sedative activity of diazepam in Swiss mice through GABAA receptor interaction: In vivo and in silico approaches
    Md. Sakib Al Hasan, Md. Shimul Bhuia, Raihan Chowdhury, Zakir Husain, Md. Saifuzzaman, Emon Mia, Md. Showkoth Akbor, Noshin Tasnim Yana, Md. Amirul Islam, Siddique Akber Ansari et al. · 2025 · Neuroscience
  11. Pharmacological interventions for the treatment of insomnia: quantitative comparison of drug efficacy
    Xijun Zheng, Yingchun He, Fang Yin, Hongxia Liu, Yunfei Li, Qingshan Zheng, Lujin Li · 2020 · Sleep Medicine
  12. Novel and Nonroutine Benzodiazepines and Suvorexant by LC–MS-MS
    Luke Garcia, Nicholas B Tiscione, Dustin Tate Yeatman · 2020 · Journal of Analytical Toxicology
  13. Ginsenoside Rg3 regulates GABAA receptor channel activity: Involvement of interaction with the γ2 subunit
    Byung-Hwan Lee, Hyeon‐Joong Kim, Leeyup Chung · 2013 · European Journal of Pharmacology
  14. Novel analogues of chlormethiazole are neuroprotective in four cellular models of neurodegeneration by a mechanism with variable dependence on GABAA receptor potentiation
    Lawren A. VandeVrede, Ehsan Tavassoli, Jia Luo, Zhihui Qin, Yue Lan, David R. Pepperberg, Gregory R. J. Thatcher · 2013 · British Journal of Pharmacology
  15. Humanin ameliorates diazepam-induced memory deficit in mice
    Minetaka Murakami, Masatoshi Nagahama, Takuma Maruyama · 2016 · Neuropeptides
  16. Chemoproteomics Reveals the Antiproliferative Potential of Parkinson’s Disease Kinase Inhibitor LRRK2-IN-1 by Targeting PCNA Protein
    Weichao Li, Yiqing Zhou, Guanghui Tang, Nai-Kei Wong, Mengquan Yang, Dan Tan, Youli Xiao · 2018 · Molecular Pharmaceutics
  17. Remimazolam vs. propofol for induction and maintenance of general anesthesia: A systematic review and meta-analysis of emergence agitation risk in surgical populations
    Jian-li Song, Yong Ye, Ping Hou, Qiang Li, Bin Lu, Guanyu Chen · 2025 · Journal of Clinical Anesthesia
  18. The effect of lemborexant for insomnia disorder
    Hidenobu Suzuki, Hiroyuki Hibino · 2021 · SAGE Open Medicine
  19. Coriandrum sativum and Its Utility in Psychiatric Disorders
    Anislada Santibáñez, Enrique Jiménez‐Ferrer, Paola Isabel Angulo‐Bejarano, Ashutosh Kumar Sharma, Maribel Lucila Herrera-Ruiz · 2023 · Molecules
  20. Modulatory Sedative Activity of Abrine on Diazepam in Thiopental Sodium Mediated Sleeping Mice: An In Vivo Approach with Receptor Binding Affinity of GABAergic Transmission
    Jannatul Ferdous, Md. Shimul Bhuia, Raihan Chowdhury · 2024 · ChemistrySelect
  21. Potassiumtert-Butoxide-Catalyzed Synthesis of Benzofuroazepines via Cyclization of (2-Alkynylbenzyl)oxy Nitriles
    Rafaela M. Gai, Davi F. Back, Gilson Rogério Zeni · 2015 · The Journal of Organic Chemistry
  22. Modulation of extrasynaptic GABAergic receptor activity influences glutamate release and neuronal survival following excitotoxic damage to mouse spinal cord neurons
    Graciela L. Mazzone, Andrea Nistri · 2019 · Neurochemistry International
  23. Odorants: a tool to provide nonpharmacological intervention to reduce anxiety during normal and pathological aging
    Bénédicte Ballanger, Kevin G. Bath, Nathalie Mandairon · 2019 · Neurobiology of Aging
  24. Reliability of behavioral test with fish: How neurotransmitters may exert neuromodulatory effects and alter the biological responses to neuroactive agents
    Beatriz Sousa, Bruno Nunes · 2020 · The Science of The Total Environment
  25. Metabolome analysis using cerebrospinal fluid from narcolepsy type 1 patients
    Mihoko Shimada, Taku Miyagawa, Tohru Kodama, Hiromi Toyoda, Katsushi Tokunaga, Makoto Honda · 2020 · SLEEP
  26. Synthesis and radioligand‐binding assay of 2,5‐disubstituted thiadiazoles and evaluation of their anticonvulsant activities
    Mahsa Toolabi, Mona Khoramjouy, Ayoub Aghcheli, Adileh Ayati, Setareh Moghimi, Loghman Firoozpour, Soraya Shahhosseini, Rouhallah Shojaei, Ali Asadipour, Kouros Divsalar et al. · 2020 · Archiv der Pharmazie
  27. Methyleugenol Potentiates Central Amygdala GABAergic Inhibition and Reduces Anxiety
    Yanmei Liu, Hui-Ran Fan, Shining Deng, Tailin Zhu, Yuhua Yan, Weihong Ge, Wei‐Guang Li, Fei Ran Li · 2018 · Journal of Pharmacology and Experimental Therapeutics
  28. Inhibitory Synapse Formation in a Co-culture Model Incorporating GABAergic Medium Spiny Neurons and HEK293 Cells Stably Expressing GABAA Receptors
    Laura E. Brown, Céline Fuchs, Martin W. Nicholson, F. Anne Stephenson, Alex M. Thomson, Jasmina N. Jovanovic · 2014 · Journal of Visualized Experiments
  29. The Anxiolytic-like Properties of a Tryptic Hydrolysate of Bovine αs1 Casein Containing α-Casozepine Rely on GABAA Receptor Benzodiazepine Binding Sites but Not the Vagus Nerve
    Simon Benoit, Catherine Chaumontet, Nicolas Violle, Audrey Boulier, Zeeshan Hafeez, Céline Cakir‐Kiefer, Daniel Tomé, Jessica Schwarz, Laurent Miclo · 2022 · Nutrients
  30. Identification of a Novel Benzoxazolone Derivative as a Selective, Orally Active 18 kDa Translocator Protein (TSPO) Ligand
    Takayuki Fukaya, Takeo Ishiyama, Satoko Baba, Shuji Masumoto · 2013 · Journal of Medicinal Chemistry
  31. The immunohistochemical distribution of the GABA A receptor α 1 , α 2 , α 3 , β 2/3 and γ 2 subunits in the human thalamus
    Henry John Waldvogel, M.C Münkle, Willeke van Roon‐Mom, Hanns Möhler, Richard L. M. Faull · 2017 · Journal of Chemical Neuroanatomy
  32. GABAA receptors in the ventral tegmental area control the outcome of a social competition in rats
    Michael A. van der Kooij, Ioannis Zalachoras, Carmen Sandi · 2018 · Neuropharmacology
  33. Contribution of GABAA receptor subunits to attention and social behavior
    Tracie A. Paine, Sara Chang, Rachel Poyle · 2019 · Behavioural Brain Research
  34. Functional characterization of the antiepileptic drug candidate, padsevonil, on GABA A receptors
    Isabelle Niespodziany, Philippe Ghisdal, Brice Mullier, Martyn D. Wood, Laurent Provins, Rafal Marian Kaminski, Christian Wolff · 2020 · Epilepsia
  35. Sh-I-048A, an in vitro non-selective super-agonist at the benzodiazepine site of GABAA receptors: The approximated activation of receptor subtypes may explain behavioral effects
    Aleksandar Lj. Obradović, Srdjan M. Joksimovic, Michael M. Poe, Joachim Ramerstorfer, Zdravko Varagić, Ojas A. Namjoshi, Bojan Batinić, Tamara Radulović, Bojan D. Marković, Brian L. Roth et al. · 2014 · Brain Research
  36. Z-drug for schizophrenia: A systematic review and meta-analysis
    Taro Kishi, Ken Inada, Yuki Matsui, Nakao Iwata · 2017 · Psychiatry Research
  37. Design, Synthesis, and Pharmacological Evaluation of Novel β2/3 Subunit-Selective γ-Aminobutyric Acid Type A (GABA A ) Receptor Modulators
    Marco Stadler, Serena Monticelli, Thomas Seidel, Denise Luger, Isabella Salzer, Stefan Boehm, Wolfgang Hölzer, Christoph Schwarzer, Ernst Urban, Sophia Khom et al. · 2018 · Journal of Medicinal Chemistry
  38. Effects of Diazepam on Low-Frequency and High-Frequency Electrocortical γ-Power Mediated by α1- and α2-GABAA Receptors
    Julian I. Hofmann, Cornelius Schwarz, Uwe Rudolph, Bernd Antkowiak · 2019 · International Journal of Molecular Sciences
  39. α1 Subunit Histidine 55 at the Interface between Extracellular and Transmembrane Domains Affects Preactivation and Desensitization of the GABAA Receptor
    Przemysław T. Kaczor, Aleksandra Wolska, Jerzy Wladyslaw Mozrzymas · 2021 · ACS Chemical Neuroscience
  40. The Autism-Related Protein PX-RICS Mediates GABAergic Synaptic Plasticity in Hippocampal Neurons and Emotional Learning in Mice
    Tsutomu Nakamura, Fumika Sakaue, Yukiko Nasu‐Nishimura, Yasuko Takeda, Ken Matsuura, Tetsu Akiyama · 2018 · EBioMedicine
  41. The role of spinal cord extrasynaptic α 5 GABA A receptors in chronic pain
    Rodolfo Delgado‐Lezama, Mariana Bravo‐Hernández, Úrzula Franco‐Enzástiga, Yarim Elideth De la Luz-Cuellar, Nara S. Alvarado‐Cervantes, Guadalupe Raya‐Tafolla, Luis A. Martínez‐Zaldivar, Alberto Vargas‐Parada, Erick Josué Rodríguez-Palma, Guadalupe C. Vidal‐Cantú et al. · 2021 · Physiological Reports
  42. Discovery of 7-alkyloxy- [1,2,4] triazolo[1,5-a] pyrimidine derivatives as selective positive modulators of GABAA1 and GABAA4 receptors with potent antiepileptic activity
    Jun Wu, Zhipeng Hou, Yan Wang, Liping Chen, Chengxi Lian, Qingfei Meng, Chaoying Zhang, Xiufen Li, Longjiang Huang, Haibo Yu · 2021 · Bioorganic Chemistry
  43. Atypical antipsychotics antagonize GABAA receptors in the ventral tegmental area GABA neurons to relieve psychotic behaviors
    Chen Lu, Xiaona Zhu, Yifan Feng, Weizhen Ao, Jie Li, Zilong Gao, Huoqing Luo, Ming Chen, Fang Cai, Shulu Zhan et al. · 2023 · Molecular Psychiatry
  44. Targeting Anti-Inflammatory Pathways to Treat Diabetes-Induced Neuropathy by 6-Hydroxyflavanone
    Shehla Akbar, Fazal Subhan, Aroosha Akbar · 2023 · Nutrients
  45. Enhanced Na+‐K+‐2Cl‐ cotransporter 1 underlies motor dysfunction in huntington's disease
    Yi‐Ting Hsu, Ya‐Gin Chang, Yu‐Chao Liu, Kai‐Yi Wang, Hui‐Mei Chen, Ding‐Jin Lee, Sung‐Sen Yang, Chon‐Haw Tsai, Cheng‐Chang Lien, Yijuang Chern · 2019 · Movement Disorders
  46. Targeting GABAC Receptors Improves Post-Stroke Motor Recovery
    Petra S. Van Nieuwenhuijzen, Kim Parker, Vivian W. Y. Liao, Josh Houlton, Hye-Lim Kim, Graham A.R. Johnston, Jane R. Hanrahan, Mary Chebib, Andrew N. Clarkson · 2021 · Brain Sciences
  47. Age‐related differences of γ‐aminobutyric acid (GABA)ergic transmission in human colonic smooth muscle
    Maria Grazia Zizzo, Adele Cicio, Stefania Raimondo, Riccardo Alessandro, Rosa Serio · 2021 · Neurogastroenterology & Motility
  48. Efficacy and tolerability of Z-drug adjunction to antidepressant treatment for major depressive disorder: a systematic review and meta-analysis of randomized controlled trials
    Taro Kishi, Shinji Matsunaga, Nakao Iwata · 2016 · European Archives of Psychiatry and Clinical Neuroscience
  49. Developmental and age-dependent plasticity of GABAA receptors in the mouse colon: Implications in colonic motility and inflammation
    Mohsen Seifi, Jerome D. Swinny · 2019 · Autonomic Neuroscience
  50. A bibliometric analysis of the recent advances in diazepam from 2012 to 2021
    Ming Zhang, Lin Kou, Yaya Qin, Junwen Chen, Dazhang Bai, Li Zhao, Hongyu Lin, Guohui Jiang · 2022 · Frontiers in Pharmacology
  51. Efficacy and safety of intravenous ketamine treatment in Japanese patients with treatment‐resistant depression: A double‐blind, randomized, placebo‐controlled trial
    Yohei Ohtani, Hideaki Tani, Kie Nomoto‐Takahashi, Taisuke Yatomi, Kengo Yonezawa, Sota Tomiyama, Nobuhiro Nagai, Keisuke Kusudo, Shiori Honda, Sotaro Moriyama et al. · 2024 · Psychiatry and Clinical Neurosciences
  52. Developmental changes in expression of inhibitory neuronal proteins in the Fragile X Syndrome mouse basolateral amygdala
    Sebila Kratovac, Joshua G. Corbin · 2013 · Brain Research
  53. Localisation and stress-induced plasticity of GABAA receptor subunits within the cellular networks of the mouse dorsal raphe nucleus
    Nicole L. Corteen, Jessica A. Carter, Uwe Rudolph, Delia Belelli, Jeremy J. Lambert, Jerome D. Swinny · 2014 · Brain Structure and Function
  54. Diversity of Neuronal Inhibition
    Rebecca S. Benham, Elif Engin, Uwe Rudolph · 2013 · JAMA Psychiatry
  55. Self-administration of benzodiazepine and cocaine combinations by male and female rhesus monkeys in a choice procedure: role of α1 subunit–containing GABAA receptors
    Sally L. Huskinson, Kevin B. Freeman, James K. Rowlett · 2019 · Psychopharmacology
  56. Usefulness of echocardiography in detection of subclinical carditis in acute rheumatic polyarthritis and rheumatic chorea.
    Puneet Agarwal, Mukul Misra, N. B. S. Sarkari, A. K. Gupta, Puneet Agarwal · 1998 · PubMed
  57. Midazolam at Low Nanomolar Concentrations Affects Long-term Potentiation and Synaptic Transmission Predominantly via the α1–γ-Aminobutyric Acid Type A Receptor Subunit in Mice
    Xénia Puig-Bosch, Stefan Bieletzki, Hanns Ulrich Zeilhofer · 2022 · Anesthesiology
  58. Increased Excitability of Layer 2 Cortical Pyramidal Neurons in the Supplementary Motor Cortex Underlies High Cocaine-Seeking Behaviors
    Donald Huang, Yao‐Ying Ma · 2023 · Biological Psychiatry
  59. Medication and Road Test Performance Among Cognitively Healthy Older Adults
    David B. Carr, Kebede Abera Beyene, Jason M. Doherty, Samantha A. Murphy, Ann M. Johnson, Hailee Domash, Noah Riley, Alexis I.B. Walker, Ashwin Sabapathy, John C. Morris et al. · 2023 · JAMA Network Open
  60. An ultra-short-acting benzodiazepine in thalamic nucleus reuniens undermines fear extinction via intermediation of hippocamposeptal circuits
    Hoiyin Cheung, Tong-Zhou Yu, Xin Yi, Yan‐Jiao Wu, Qi Wang, Xuefeng Gu, Miao Xu, Meihua Cai, Wen Wen, Xin-Ni Li et al. · 2024 · Communications Biology
  61. Trans-Ferulic acid reduces the sedative activity of diazepam in thiopental sodium-induced sleeping mice: A potential GABAergic transmission
    Md. Shimul Bhuia, Md. Sakib Al Hasan, Raihan Chowdhury, Siddique Akber Ansari, Irfan Aamer Ansari, Muhammad Torequl Islam · 2024 · Neurotoxicology and Teratology
  62. Genetic analysis of GABRB3 at 15q12 as a candidate gene of schizophrenia
    Chia-Chun Huang, Min-Chih Cheng, Ho-Min Tsai, Chih-Hao Lai, Chia‐Hsiang Chen · 2014 · Psychiatric Genetics
  63. TP003 is a non-selective benzodiazepine site agonist that induces anxiolysis via α2GABAA receptors
    Elena Neumann, William T. Ralvenius, Mario A. Acuña, Uwe Rudolph, Hanns Ulrich Zeilhofer · 2018 · Neuropharmacology
  64. The effects of the nonselective benzodiazepine lorazepam and the α2/α3 subunit‐selective GABAA receptor modulators AZD7325 and AZD6280 on plasma prolactin levels
    Erik T. te Beek, Xia Chen, Gabriël E. Jacobs, Kimberly J. Nahon, Marieke L. de Kam, Jaakko Lappalainen, Alan J. Cross, Joop van Gerven, Justin L. Hay · 2014 · Clinical Pharmacology in Drug Development
  65. Monocyte Chemoattractant Protein-1 upregulates GABA-induced current: Evidence of modified GABAA subunit composition in cortical neurons from the G93A mouse model of Amyotrophic Lateral Sclerosis
    Silvia Caioli, Massimo Pieri, Alessia Antonini, Angelo Guglielmotti, Cinzia Severini, Cristina Zona · 2013 · Neuropharmacology
  66. Analysis of β-Subunit-dependent GABAA Receptor Modulation and Behavioral Effects of Valerenic Acid Derivatives
    Sophia Khom, Juliane Hintersteiner, Denise Luger, M. Haider, Gerit Pototschnig, Marko D. Mihovilovič, Christoph Schwarzer, Steffen Hering · 2016 · Journal of Pharmacology and Experimental Therapeutics
  67. Comparative efficacy and acceptability of pharmacological treatments for insomnia in adults: a systematic review and network meta-analysis
    Franco De Crescenzo, Francesca Foti, Marco Ciabattini, Cinzia Del Giovane, Norio Watanabe, Monica Sañé Schepisi, Digby J. Quested, Andrea Cipriani, Corrado Barbui, Laura Amato · 2016 · Cochrane Database of Systematic Reviews
  68. GABAA receptor subtype selectivity of the proconvulsant rodenticide TETS
    Brandon Pressly, Hai Minh Nguyen, Heike Wulff · 2017 · Archives of Toxicology
  69. Real-world evidence of the safety and efficacy profile of suvorexant in elderly patients with insomnia: a sub-analysis of the post-marketing drug-use results survey in Japan
    Yûkô Takeuchi, Hideki Sano, Yuko Asai, Makoto Miyazaki, Mika Iwakura, Yoshikazu Maeda · 2019 · Current Medical Research and Opinion
  70. Spinal GABAA receptors for pain control: back to the future?
    Hanns Ulrich Zeilhofer, Elena Neumann, Gordon Munro · 2019 · British Journal of Anaesthesia
  71. Schisandrin B, a dual positive allosteric modulator of GABAA and glycine receptors, alleviates seizures in multiple mouse models
    Jun Wu, Miao Zhao, Yuchen Jin, Min Li, Ke-xin Yu, Haibo Yu · 2023 · Acta Pharmacologica Sinica
  72. Sedative and hypnotic effects of the saponins from a traditional edible plant Liriope spicata Lour. in PCPA-induced insomnia mice
    Yi-Meng Li, Chunyan Shen, Jian‐Guo Jiang · 2024 · Journal of Ethnopharmacology
  73. Biomarkers of cognitive and memory decline in psychotropic drug users
    Monica M. Grigore, Mihai Andrei Ruscu, Dirk Matthias Hermann, Ivan-Cezar Colita, Thorsten Roland Doeppner, Daniela Glăvan, Aurel Popa‐Wagner · 2024 · Journal of Neural Transmission
  74. Optimizing Pediatric Sedation: Evaluating Remimazolam and Dexmedetomidine for Safety and Efficacy in Clinical Practice
    Vera Scheckenbach, Frank Fideler · 2024 · Pediatric Drugs
  75. Comparative effects of pentobarbital on spontaneous and evoked transmitter release from inhibitory and excitatory nerve terminals in rat CA3 neurons
    Min-Chul Shin, Masahito Wakita, Satomi Iwata · 2012 · Brain Research Bulletin
  76. Limited central side effects of a β-subunit subtype-selective GABA A receptor allosteric modulator
    Ryan F. Yoshimura, Minhtam B. Tran, Derk J. Hogenkamp, Timothy B. C. Johnstone, Jennifer Yanhua Xie, Frank Porreca, Kelvin W. Gee · 2013 · Journal of Psychopharmacology
  77. Flumazenil-Insensitive Benzodiazepine Effects in Recombinant αβ and Neuronal GABAA Receptors
    Jing-Jing Lian, Yanqing Cao, Yu-Lei Li, Gang Yu, Ruibin Su · 2020 · Brain Sciences
  78. Oral Administration of Armillaria mellea Mycelia Promotes Non-Rapid Eye Movement and Rapid Eye Movement Sleep in Rats
    I-Chen Li, Ting‐Wei Lin, Tung-Yen Lee, Yun Lo, Yih-Min Jiang, Yu-Hsuan Kuo, Chin‐Chu Chen, Fang‐Chia Chang · 2021 · Journal of Fungi
  79. Drug Treatment of Epilepsy: From Serendipitous Discovery to Evolutionary Mechanisms
    Shengying Lou, Sunliang Cui · 2021 · Current Medicinal Chemistry
  80. High-Dose Benzodiazepines Positively Modulate GABAA Receptors via a Flumazenil-Insensitive Mechanism
    Na Wang, Jingjing Lian, Yanqing Cao, Alai Muheyati, Shanshan Yuan, Yujie Ma, Shuzhuo Zhang, Gang Yu, Ruibin Su · 2021 · International Journal of Molecular Sciences
  81. Teaching an Old GABA Receptor New Tricks
    James R. Trudell, Edward J. Bertaccini, M Bruce MacIver · 2012 · Anesthesia & Analgesia
  82. Probing the Mode of Neurotransmitter Binding to GABA Receptors Using Selectively Fluorinated GABA Analogues
    Nathan L. Absalom, Izumi Yamamoto, David O’Hagan · 2014 · Australian Journal of Chemistry
  83. A new class of pyrazolo[5,1-c][1,2,4]triazines as γ-aminobutyric type A (GABAA) receptor subtype ligand: synthesis and pharmacological evaluation
    Gabriella Guerrini, Giovanna Ciciani, Simona Daniele · 2018 · Bioorganic & Medicinal Chemistry
  84. Negative allosteric modulation of GABAA receptors inhibits facilitation of brain stimulation reward by drugs of abuse in C57BL6/J mice
    Matthew E. Tracy, Matthew L. Banks, Keith Larry Shelton · 2015 · Psychopharmacology
  85. Protein complexes as psychiatric and neurological drug targets
    Akihiko Kato, Jeffrey M. Witkin · 2018 · Biochemical Pharmacology
  86. Trigeminal neuropathic pain reduces 50-kHz ultrasonic vocalizations in rats, which are restored by analgesic drugs
    Erika Ivanna Araya, Darciane Favero Baggio, Laura de Oliveira Koren, Rainer K.W. Schwarting, Juliana Geremias Chichorro · 2022 · European Journal of Pharmacology
  87. IUPHAR review: Moving beyond dopamine-based therapeutic strategies for schizophrenia
    Paula M. Moran, Kiri T. Granger · 2025 · Pharmacological Research
  88. The Medical use of Lemon Balm (Melissa officinalis) and Valerian (Valeriana officinalis) as Natural Sedatives: Insight into their Interactions with GABA Transmission
    S. Pineau, C. Legros, César Mattei · 2016 · International Journal of Clinical Pharmacology & Pharmacotherapy
  89. Sesquiterpenes and sesquiterpenoids harbor modulatory allosteric potential and affect inhibitory GABAA receptor function in vitro
    Dieter Janzen, Benedikt Slavik, Markus Zehe, Christoph Sotriffer, Helene M. Loos, Andrea Buettner, Carmen Villmann · 2021 · Journal of Neurochemistry
  90. The efficacy of γ-aminobutyric acid type A receptor (GABA AR) subtype-selective positive allosteric modulators in blocking tetramethylenedisulfotetramine (TETS)-induced seizure-like behavior in larval zebrafish with minimal sedation
    Paige C. Mundy, Brandon Pressly, Dennis R. Carty · 2021 · Toxicology and Applied Pharmacology
  91. GABAA Receptor Autoantibodies Decrease GABAergic Synaptic Transmission in the Hippocampal CA3 Network
    Amélie F. Menke, Fatme Seval Ismail, Klaus Dornmair · 2022 · International Journal of Molecular Sciences
  92. Molecular Mingling: Multimodal Predictions of Ligand Promiscuity in Pentameric Ligand-Gated Ion Channels
    Filip Koniuszewski, Florian Daniel Vogel, Konstantina Bampali, Jure Fabjan, Thomas Seidel, Petra Scholze, Philip B. Schmiedhofer, Thierry Langer, Margot Christiana Ernst · 2022 · Frontiers in Molecular Biosciences
  93. Benzodiazepine receptor ligands: a patent review (2006 – 2012)
    Gabriella Guerrini, Giovanna Ciciani · 2013 · Expert Opinion on Therapeutic Patents
  94. Novel Indications for Benzodiazepine Antagonist Flumazenil in GABA Mediated Pathological Conditions of the Central Nervous System
    Gary Kenneth Hulse, Erin A. Kelty, Sean D. Hood, Amanda F. Norman, Maria Basso, Albert Stuart Reece · 2015 · Current Pharmaceutical Design
  95. GABA, Selank, and Olanzapine Affect the Expression of Genes Involved in GABAergic Neurotransmission in IMR-32 Cells
    Elena V. Filatova, Anastasiya Kasian, Timur A. Kolomin, Ekaterina Rybalkina, Anelya Kh. Alieva, Л. А. Андреева, Svetlana Limborska, Nikolai F. Myasoedov, Galina Valerievna Pavlova, Petr A. Slominsky et al. · 2017 · Frontiers in Pharmacology
  96. Novel Molecule Exhibiting Selective Affinity for GABAA Receptor Subtypes
    Cecilia M. Borghese, Melissa A. Herman, Lawrence D. Snell, Keri J. Lawrence, Hyun Young Lee, Donald S. Backos, Lauren A. Vanderlinden, Robert Adron Harris, Marisa Roberto, Paula L. Hoffman et al. · 2017 · Scientific Reports
  97. Oxidized Carbon Black as Catalyst for the Enamine Formation in Solvent‐Free Conditions: A Green Strategy to Build the Benzodiazepine Scaffold
    Rosaria Villano, Maria Rosaria Acocella, Gaetano Guerra · 2017 · ChemistrySelect
  98. Diazepam blocks 50 kHz ultrasonic vocalizations and stereotypies but not the increase in locomotor activity induced in rats by amphetamine
    Gisele de Oliveira Guaita, Débora Dalla Vecchia, Roberto Andreatini, Donita L. Robinson, Rainer K.W. Schwarting, Cláudio Da Cunha · 2018 · Psychopharmacology
  99. Positive allosteric modulators of nonbenzodiazepine γ-aminobutyric acidA receptor subtypes for the treatment of chronic pain
    Timothy B. C. Johnstone, Jennifer Yanhua Xie, Chaoling Qu, David J. Wasiak, Derk J. Hogenkamp, Frank Porreca, Kelvin W. Gee · 2018 · Pain
  100. Photopotentiation of the GABA A receptor with caged diazepam
    Lorenzo Sansalone, Joshua X. Bratsch-Prince, Sicheng Tang, Burjor Captain, David D. Mott, Françisco M. Raymo · 2019 · Proceedings of the National Academy of Sciences