The DOI matches its Crossref record; 166 of the 166 references it cites were found in a registry or an index.
Aquaporins: important but elusive drug targets
Open accessAbstract
The aquaporins (AQPs) are a family of small, integral membrane proteins that facilitate water transport across the plasma membranes of cells in response to osmotic gradients. Data from knockout mice support the involvement of AQPs in epithelial fluid secretion, cell migration, brain oedema and adipocyte metabolism, which suggests that modulation of AQP function or expression could have therapeutic potential in oedema, cancer, obesity, brain injury, glaucoma and several other conditions. Moreover, loss-of-function mutations in human AQPs cause congenital cataracts (AQP0) and nephrogenic diabetes insipidus (AQP2), and autoantibodies against AQP4 cause the autoimmune demyelinating disease neuromyelitis optica. Although some potential AQP modulators have been identified, challenges associated with the development of better modulators include the druggability of the target and the suitability of the assay methods used to identify modulators.
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ZINC − A Free Database of Commercially Available Compounds for Virtual Screening
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A serum autoantibody marker of neuromyelitis optica: distinction from multiple sclerosis
Lennon, V. A., Wingerchuk, D. M., Kryzer, T. J., Pittock, S. J., Lucchinetti, C. F., Fujihara, K., Nakashima, I., & Weinshenker, B. G. (2004) · The Lancet · doi:10.1016/s0140-6736(04)17551-x · Cited by 3,239
IgG marker of optic-spinal multiple sclerosis binds to the aquaporin-4 water channel
Lennon, V. A., Kryzer, T. J., Pittock, S. J., Verkman, A. S., & Hinson, S. R. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20050304 · Cited by 2,288
Self-citationThe spectrum of neuromyelitis optica
Wingerchuk, D. M., Lennon, V. A., Lucchinetti, C. F., Pittock, S. J., & Weinshenker, B. G. (2007) · The Lancet Neurology · doi:10.1016/s1474-4422(07)70216-8 · Cited by 2,179
Appearance of Water Channels in Xenopus Oocytes Expressing Red Cell CHIP28 Protein
Preston, G. M., Carroll, T. P., Guggino, W. B., & Agre, P. (1992) · Science · doi:10.1126/science.256.5055.385 · Cited by 2,059
Structural determinants of water permeation through aquaporin-1
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Aquaporin-4 deletion in mice reduces brain edema after acute water intoxication and ischemic stroke
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Specific Aquaporins Facilitate the Diffusion of Hydrogen Peroxide across Membranes
Bienert, G. P., Møller, A. L. B., Kristiansen, K. A., Schulz, A., Møller, I. M., Schjoerring, J. K., & Jahn, T. P. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m603761200 · Cited by 1,306
Cited by
Targeting Aquaporin-4 Subcellular Localization to Treat Central Nervous System Edema
Kitchen, P., Salman, M. M., Halsey, A. M., Clarke-Bland, C., MacDonald, J. A., Ishida, H., Vogel, H. J., Almutiri, S., Logan, A., Kreida, S., et al. (2020) · Cell · doi:10.1016/j.cell.2020.03.037 · Cited by 452
Wang, Y., Song, W., Wang, J., Wang, T., Xiong, X., Qi, Z., Fu, W., Yang, X., & Chen, Y.-G. (2020) · Journal of Experimental Medicine · doi:10.1084/jem.20191130 · Cited by 399
Cerebrospinal fluid dynamics and intracranial pressure elevation in neurological diseases
Bothwell, S. W., Janigro, D., & Patabendige, A. (2019) · Fluids and Barriers of the CNS · doi:10.1186/s12987-019-0129-6 · Cited by 319
Emerging roles for dynamic aquaporin-4 subcellular relocalization in CNS water homeostasis
Salman, M. M., Kitchen, P., Halsey, A., Wang, M. X., Törnroth-Horsefield, S., Conner, A. C., Badaut, J., Iliff, J. J., & Bill, R. M. (2022) · Brain · doi:10.1093/brain/awab311 · Cited by 303
Combining different ion-selective channelrhodopsins to control water flux by light
Lin, F., Tang, R., Zhang, C., Scholz, N., Nagel, G., & Gao, S. (2023) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-023-02853-5 · Cited by 9
Metadata
- Authors
- Verkman, A. S., Anderson, M. O., & Papadopoulos, M. C.
- Venue
- Nature Reviews Drug Discovery
- Published
- 2014-03-14
- Volume
- 13
- Issue
- 4
- Pages
- 259-277
- ISSN
- 1474-1776 (ISSN-L)
- 1474-1784
- OpenAlex
- W2091722185
- Cited by
- 586
- References
- 166
- FWCI
- 3.59
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
