mRNA-based therapeutics--developing a new class of drugs

Sahin, Ugur, Karikó, Katalin, Türeci, Özlem·2014·Nature Reviews Drug Discovery
DOI 10.1038/nrd4278

Cites (256)

Items 201–256 of 256

  1. Immunize and disappear—Safety-optimized mRNA vaccination with a panel of 29 allergens
    Roesler, Elisabeth, Weiss, Richard, Weinberger, Esther E., Fruehwirth, Angelika, Stoecklinger, Angelika, Mostböck, Sven, Ferreira, Fatima, Thalhamer, Josef, Scheiblhofer, Sandra · 2009 · Journal of Allergy and Clinical Immunology
  2. Induction of Anti-Tumor Immunity with Epidermal Cells Pulsed with Tumor-Derived RNA or Intradermal Administration of RNA
    Richard D. Granstein, Wanhong Ding, Hiroaki Ozawa · 2000 · Journal of Investigative Dermatology
  3. Autocrine–Paracrine Effects of Overexpression of Hepatocyte Growth Factor Gene on Growth of Endothelial Cells
    Shin-ichiro Hayashi, Ryuichi Morishita, Jitsuo Higaki, Motokuni Aoki, Atushi Moriguchi, Iwao Kida, Sawa Yoshiki, Kunio Matsumoto, Toshikazu Nakamura, Yasufumi Kaneda et al. · 1996 · Biochemical and Biophysical Research Communications
  4. Transfection of cells using flow-through electroporation based on constant voltage
    Tao Geng, Yihong Zhan, Jun Wang, Chang Lu · 2011 · Nature Protocols
  5. Dendritic cells transfected with interleukin-12 and tumor-associated antigen messenger RNA induce high avidity cytotoxic T cells
    Hetty J. Bontkes, Debbie Kramer, Janneke J. Ruizendaal, Esther W. Taanman-Kueter, Viggo F. Van Tendeloo, Chris J.L.M. Meijer, Erik Hooijberg · 2006 · Gene Therapy
  6. FLT3 Ligand Enhances the Cancer Therapeutic Potency of Naked RNA Vaccines
    Sebastian Kreiter, Mustafa Diken, Abderraouf Selmi, Jan Diekmann, Sebastian Attig, Yves Hüsemann, Michael Koslowski, Christoph Huber, Özlem Türeci, Uğur Şahin · 2011 · Cancer Research
  7. Kunjin Virus Replicon Vaccine Vectors Induce Protective CD8+T-Cell Immunity
    Itaru Anraku, Tracey J. Harvey, Richard Linedale, Joy Gardner, David Harrich, Andreas Suhrbier, Alexander A. Khromykh · 2002 · Journal of Virology
  8. Induction of cytotoxic T-cell responses against the oncofetal antigen-immature laminin receptor for the treatment of hematologic malignancies
    Sandra Siegel, Andreas Wagner, Dieter Kabelitz, Matthias Marget, Joseph H. Coggin, Adel L. Barsoum, James W. Rohrer, Norbert Schmitz, Matthias Zeis · 2003 · Blood
  9. Synthetic Messenger RNA as a Tool for Gene Therapy
    Pter M. Rabinovich, M. Komarovskaya, Zhi-Jia Ye, C. Imai, D. Campana, E. Bahceci, S. Weissman · 2006 · Human Gene Therapy
  10. mRNA as a Versatile Tool for Exogenous Protein Expression
    Andreas N. Kuhn, Tim Beißert, Petra Simon, Britta Vallazza, Janina Buck, Brian P. Davies, Özlem Türeci, Uğur Şahin · 2012 · Current Gene Therapy
  11. Transiently redirected T cells for adoptive transfer
    Hilde Almåsbak, Edith Rian, Hanna Julie Hoel, Martin A. Pulè, Sébastien Wälchli, Gunnar Kvalheim, Gustav Gaudernack, Anne‐Marie Rasmussen · 2010 · Cytotherapy
  12. Gene electro-transfer of an improved erythropoietin plasmid in mice and non-human primates
    Elena Fattori, Manuela Cappelletti, Immacolata Zampaglione, Carmela Mennuni, Francesco Calvaruso, Mirko Arcuri, Gabriella Rizzuto, Patrizia Costa, Gemma Perretta, Gennaro Ciliberto et al. · 2005 · The Journal of Gene Medicine
  13. RNA-Based Tools for Nuclear Reprogramming and Lineage-Conversion: Towards Clinical Applications
    J. A. Bernal · 2013 · Journal of Cardiovascular Translational Research
  14. Intravenous and intradermal TriMix-dendritic cell therapy results in a broad T-cell response and durable tumor response in a chemorefractory stage IV-M1c melanoma patient
    An M. T. Van Nuffel, Daphné Benteyn, Sofie Wilgenhof, Jurgen Corthals, Carlo Heirman, Bart Neyns, Kris Thielemans, Aude Bonehill · 2011 · Cancer Immunology Immunotherapy
  15. Generation of targeted mouse mutants by embryo microinjection of TALEN mRNA
    Benedikt Wefers, Sudeepta Kumar Panda, Oskar Ortiz, Christina Brandl, Svenja-Viola Hensler, Jens Hansen, Wolfgang Wurst, Ralf Kühn · 2013 · Nature Protocols
  16. Immunostimulatory RNA oligonucleotides trigger an antigen-specific cytotoxic T-cell and IgG2a response
    Carole Bourquin, Laura Schmidt, Veit Hornung, Cornelia Wurzenberger, David Anz, Nadja Sandholzer, Susanne C. Schreiber, Andreas Voelkl, Gunther Hartmann, Stefan Endres · 2006 · Blood
  17. Ways and means of eukaryotic mRNA decay
    Vidya Balagopal, Lydia Fluch, Tracy A Nissan · 2012 · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms
  18. Site Specific Mutation of the Zic2 Locus by Microinjection of TALEN mRNA in Mouse CD1, C3H and C57BL/6J Oocytes
    Benjamin Davies, Graham Davies, Christopher Preece, Rathi Puliyadi, Dorota Szumska, Shoumo Bhattacharya · 2013 · PLoS ONE
  19. Efficient stimulation of HIV-1-specific T cells using dendritic cells electroporated with mRNA encoding autologous HIV-1 Gag and Env proteins
    E. R. A. Van Gulck · 2005 · Blood
  20. Induction of Human Dendritic Cell Maturation Using Transfection with RNA Encoding a Dominant Positive Toll-Like Receptor 4
    Robin M. Cisco, Zeinab Abdel-Wahab, Jens Dannull, Smita K. Nair, Douglas S. Tyler, Eli Gilboa, Johannes Vieweg, Yehia Daaka, Scott Knowles Pruitt · 2004 · The Journal of Immunology
  21. Targeting the tumor mutanome for personalized vaccination therapy
    Sebastian Kreiter, John C. Castle, Özlem Türeci, Uğur Şahin · 2012 · OncoImmunology
  22. Chimeric Receptor mRNA Transfection as a Tool to Generate Antineoplastic Lymphocytes
    P. Rabinovich, M. Komarovskaya, Stephen H. Wrzesinski, Jonathan L. Alderman, T. Budak-Alpdogan, A. Karpikov, Hongfeng Guo, R. Flavell, Nai-Kong V. Cheung, S. Weissman et al. · 2008 · Human Gene Therapy
  23. The regulatory landscape for actively personalized cancer immunotherapies
    Cedrik Michael Britten, Harpreet Singh‐Jasuja, Bruno Flamion, Axel Hoos, Christoph Huber, Karl‐Josef Kallen, Samir N. Khleif, Sebastian Kreiter, Michaela Nielsen, Hans‐Georg Rammensee et al. · 2013 · Nature Biotechnology
  24. Antibodies against Erythropoietin and Other Protein‐Based Therapeutics: An Overview
    Arno Kromminga, Huub Schellekens · 2005 · Annals of the New York Academy of Sciences
  25. mRNA
    Sandra Van Lint, Carlo Heirman, Kris Thielemans, Karine Breckpot · 2013 · Human Vaccines & Immunotherapeutics
  26. The latex allergen Hev b 5 transcript is widely distributed after subcutaneous injection in BALB/c mice of its DNA vaccine
    Jay E. Slater, Elizabeth J. Paupore, Ying T. Zhang, Anamaris M. Colberg‐Poley · 1998 · Journal of Allergy and Clinical Immunology
  27. A Short Pulse of IL-4 Delivered by DCs Electroporated With Modified mRNA Can Both Prevent and Treat Autoimmune Diabetes in NOD Mice
    Rémi J. Creusot, Pearl P. Chang, Don G. Healey, Irina Y. Tcherepanova, Charles A. Nicolette, C. Garrison Fathman · 2010 · Molecular Therapy
  28. Simultaneous ex vivo quantification of antigen-specific CD4+ and CD8+ T cell responses using in vitro transcribed RNA
    Sebastian Kreiter, Thorsten Konrad, Martina Sester, Christoph Huber, Özlem Türeci, Uğur Şahin · 2007 · Cancer Immunology Immunotherapy
  29. Comparison of replication complexes synthesizing poliovirus RNA
    Diane Etchinson, Ellie Ehrenfeld · 1981 · Virology
  30. +1 Frameshifting as a Novel Mechanism to Generate a Cryptic Cytotoxic T Lymphocyte Epitope Derived from Human Interleukin 10
    Xavier Saulquin, Emmanuel Scotet, Lydie Trautmann, Marie‐Alix Peyrat, Franck Albert Halary, Marc Bonneville, Elisabeth Houssaint · 2002 · The Journal of Experimental Medicine
  31. Lsm proteins bind and stabilize RNAs containing 5′ poly(A) tracts
    Naomi Bergman, Karen C. M. Moraes, John R Anderson, Božidarka L. Zarić, Christian Kambach, Robert J. Schneider, Carol J. Wilusz, Jeffrey Wilusz · 2007 · Nature Structural & Molecular Biology
  32. Alphaviruses in Gene Therapy
    Kenneth H. Lundstrom · 2009 · Viruses
  33. Endoribonucleases – enzymes gaining spotlight in mRNA metabolism
    Wai Ming Li, Tavish Barnes, Chow H. Lee · 2009 · FEBS Journal
  34. Cytokine Maturation Followed by CD40L mRNA Electroporation Results in a Clinically Relevant Dendritic Cell Product Capable of Inducing a Potent Proinflammatory CTL Response
    David M. Calderhead, Mark A. Debenedette, Helen Ketteringham, Alicia H. Gamble, Joe M. Horvatinovich, Irina Y. Tcherepanova, Charles A. Nicolette, Don G. Healey · 2008 · Journal of Immunotherapy
  35. mTOR Inhibition Improves Antitumor Effects of Vaccination with Antigen-Encoding RNA
    Mustafa Diken, Sebastian Kreiter, Fulvia Vascotto, Abderraouf Selmi, Sebastian Attig, Jan Diekmann, Christoph Huber, Özlem Türeci, Uğur Şahin · 2013 · Cancer Immunology Research
  36. Intra-pinna anti-tumor vaccination with self-replicating infectious RNA or with DNA encoding a model tumor antigen and a cytokine
    Volker Schirrmacher, P Förg, Wilfried Dalemans, Katerina Chlichlia, Y Zeng, P Fournier, Paul von Hoegen · 2000 · Gene Therapy
  37. Selective Modification of Antigen-Specific T Cells by RNA Electroporation
    Duane A. Mitchell, Isaac O. Karikari, Xiuyu Cui, Weihua Xie, Robert J. Schmittling, John Howard Sampson · 2008 · Human Gene Therapy
  38. Is silence still golden? Mapping the RNAi patent landscape
    Per Lundin · 2011 · Nature Biotechnology
  39. Exogenous mRNA delivery and bioavailability in gene transfer mediated by piggyBac transposition
    Solenne Bire, David Gosset, Gwenhaël Jégot, Patrick Midoux, Chantal Pichon, Florence Rouleux‐Bonnin · 2013 · BMC Biotechnology
  40. Defective mitochondrial DNA replication and NRTIs: pathophysiological implications in AIDS cardiomyopathy
    William Lewis · 2003 · American Journal of Physiology-Heart and Circulatory Physiology
  41. Modulating gene expression using DNA vaccines with different 3′-UTRs influences antibody titer, seroconversion and cytokine profiles
    John W. Zinckgraf, Lawrence K. Silbart · 2003 · Vaccine
  42. Prophylactic mRNA vaccination against allergy
    Richard Weiss, Sandra Scheiblhofer, Elisabeth Roesler, Fátima Ferreira, Josef Thalhamer · 2010 · Current Opinion in Allergy and Clinical Immunology
  43. Successful Use of mRNA‐Nucleofection for Overexpression of Interleukin‐10 in Murine Monocytes/Macrophages for Anti‐inflammatory Therapy in a Murine Model of Autoimmune Myocarditis
    Oliver Zimmermann, Jörg M. Homann, Anna Bangert, Anna‐Maria Müller, Georgi Hristov, Stefan Göser, Juliane M. Wiehe, Stefan Zittrich, Wolfgang Rottbauer, Jan Torzewski et al. · 2012 · Journal of the American Heart Association
  44. Bax mRNA therapy using cationic liposomes for human malignant melanoma
    Okumura, Kenya, Nakase, Minoru, Inui, Madoka, Nakamura, Shinnosuke, Watanabe, Yoshihiro, Tagawa, Toshiro · 2008 · The Journal of Gene Medicine
  45. The use of basic proteins to increase the infectivity of enterovirus ribonucleic acid
    Christine E. Smull, M. F. Mallette, ERNEST H. LUDWIG · 1961 · Biochemical and Biophysical Research Communications
  46. Insertional Mutagenesis by a Hybrid PiggyBac and Sleeping Beauty Transposon in the Rat
    Kenryo Furushima, Chuan‐Wei Jang, Diane Wenhua Chen, Ningna Xiao, Paul A. Overbeek, Richard R. Behringer · 2012 · Genetics
  47. A chimeric alphavirus RNA replicon gene-based vaccine for human parainfluenza virus type 3 induces protective immunity against intranasal virus challenge
    Catherine E. Greer, Fengmin Zhou, Harold S. Legg, Zequn Tang, Silvia Perri, Barbara A. Sloan, Jan zur Megede, Yasushi Uematsu, Michael Vajdy, John M. Polo · 2006 · Vaccine
  48. RNA viruses: emerging vectors for vaccination and gene therapy
    Roger Hewson · 2000 · Molecular Medicine Today
  49. DNA vaccines for the prevention and treatment of allergy
    Kaw Yan Chua, I-Chun Kuo, Chiung‐Hui Huang · 2008 · Current Opinion in Allergy and Clinical Immunology
  50. Eukaryotic translation initiation is controlled by cooperativity effects within ternary complexes of 4E‐BP1, eIF4E, and the mRNA 5′ cap
    Anna Modrak‐Wójcik, Michał Górka, Katarzyna Niedźwiecka, Konrad Zdanowski, Joanna Zuberek, Anna Niedźwiecka-Kornaś, Ryszard Stolarski · 2013 · FEBS Letters
  51. Antitumor Vaccination with Synthetic mRNA: Strategies for In Vitro and In Vivo Preclinical Studies
    Mustafa Diken, Sebastian Kreiter, Abderraouf Selmi, Özlem Türeci, Uğur Şahin · 2012 · Methods in molecular biology
  52. Autoimmune epitopes in messenger RNA
    Barbara D. Lipes, Jack D. Keene · 2002 · RNA
  53. Engineering Factor Viii for Hemophilia Gene Therapy
    Sean A. Roberts, Biao Dong, Jenni Firrman · 2012 · Journal of Genetic Syndromes & Gene Therapy
  54. RNA stability: is it the endo' the world as we know it?
    Jeffrey Wilusz · 2009 · Nature Structural & Molecular Biology
  55. Nanoparticle-Derived Non-Viral Genetic Transfection at the Blood-Brain Barrier to Enable Neuronal Growth Factor Delivery by Secretion from Brain Endothelium
    Louiza Bohn Thomsen, A. B. Larsen, Jacek Lichota, Torben Moos · 2011 · Current Medicinal Chemistry
  56. Untitled work
    I Hoerr · 2000 · 10.1002/1521-4141(200001)30:1