Bax mRNA therapy using cationic liposomes for human malignant melanoma

Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade

Li, P., Nijhawan, D., Budihardjo, I., Srinivasula, S. M., Ahmad, M., Alnemri, E. S., & Wang, X. (1997) · Cell · doi:10.1016/s0092-8674(00)80434-1 · Cited by 7,289 · see citing works

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death

Oltval, Z. N., Milliman, C. L., & Korsmeyer, S. J. (1993) · Cell · doi:10.1016/0092-8674(93)90509-o · Cited by 6,003 · see citing works

Apaf-1, a Human Protein Homologous to C. elegans CED-4, Participates in Cytochrome c–Dependent Activation of Caspase-3

Zou, H., Henzel, W. J., Liu, X., Lutschg, A., & Wang, X. (1997) · Cell · doi:10.1016/s0092-8674(00)80501-2 · Cited by 3,145 · see citing works

Cancer regression in patients after transfer of genetically engineered lymphocytes

Morgan, R. A., Dudley, M. E., Wunderlich, J. R., Hughes, M. S., Yang, J. C., Sherry, R. M., Royal, R. E., Topalian, S. L., Kammula, U. S., Restifo, N. P., et al. (2006) · Science · doi:10.1126/science.1129003 · Cited by 2,603 · see citing works

Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC

Shimizu, S., Narita, M., Tsujimoto, Y., & Tsujimoto, Y. (1999) · Nature · doi:10.1038/20959 · Cited by 2,178 · see citing works

Bax and Adenine Nucleotide Translocator Cooperate in the Mitochondrial Control of Apoptosis

Marzo, I., Brenner, C., Zamzami, N., Jürgensmeier, J. M., Susin, S. A., Vieira, H. L. A., Prévost, M.-C., Xie, Z., Matsuyama, S., Reed, J. C., et al. (1998) · Science · doi:10.1126/science.281.5385.2027 · Cited by 1,168 · see citing works

Gene Therapy Death Prompts Review of Adenovirus Vector

Marshall, E. (1999) · Science · doi:10.1126/science.286.5448.2244 · Cited by 918 · see citing works

Cationic liposome-mediated RNA transfection.

Malone, R. W., Felgner, P. L., & Verma, I. M. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.16.6077 · Cited by 911 · see citing works

Untitled work

(2001) · PubMed Central · Cited by 342 · see citing works

A tragic setback

Check, E. (2002) · Nature · doi:10.1038/420116a · Cited by 291 · see citing works

Peptide-mediated RNA delivery: a novel approach for enhanced transfection of primary and post-mitotic cells

Bettinger, T. (2001) · Nucleic Acids Research · doi:10.1093/nar/29.18.3882 · Cited by 224 · see citing works

mRNA transfection of dendritic cells: Synergistic effect of ARCA mRNA capping with Poly(A) chains in cis and in trans for a high protein expression level

Mockey, M., Gonçalves, C., Dupuy, F. P., Lemoine, F. M., Pichon, C., & Midoux, P. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.12.105 · Cited by 165 · see citing works

mRNA-based cancer vaccine: prevention of B16 melanoma progression and metastasis by systemic injection of MART1 mRNA histidylated lipopolyplexes

Mockey, M., Bourseau, E., Voshavar, C., Chaudhuri, A., Lafosse, S., Cam, É. L., Quesniaux, V. F. J., Ryffel, B., Pichon, C., & Midoux, P. (2007) · Cancer Gene Therapy · doi:10.1038/sj.cgt.7701072 · Cited by 161 · see citing works

Dual Interactions of the Translational Repressor Paip2 with Poly(A) Binding Protein

Khaleghpour, K., Kahvejian, A., Crescenzo, G. D., Roy, G., Svitkin, Y. V., Imataka, H., O'Connor‐McCourt, M. D., & Sonenberg, N. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.15.5200-5213.2001 · Cited by 159 · see citing works

Vaccination with mRNAs encoding tumor-associated antigens and granulocyte-macrophage colony-stimulating factor efficiently primes CTL responses, but is insufficient to overcome tolerance to a model tumor/self antigen

Hess, P. R., Boczkowski, D., Nair, S. K., Snyder, D. J., & Gilboa, E. (2005) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-005-0064-z · Cited by 113 · see citing works

Adenovirus-mediated Bax overexpression for the induction of therapeutic apoptosis in prostate cancer.

Kellis, M., Marani, M., Yu, J., et al. (2001) · PubMed · Cited by 90 · see citing works

Optimization of methods to achieve mRNA-mediated transfection of tumor cells in vitro and in vivo employing cationic liposome vectors.

Lu, D., Benjamin, R., Kim, M., Conry, R. M., & Curiel, D. (1994) · PubMed · Cited by 89 · see citing works

p53 gene therapy of human osteosarcoma using a transferrin-modified cationic liposome

Nakase, M., Inui, M., Okumura, K., Kamei, T., Nakamura, S., & Tagawa, T. (2005) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-04-0196 · Cited by 72 · see citing works

Trial halted after gene shows up in semen

Boyce, N. (2001) · Nature · doi:10.1038/414677a · Cited by 62 · see citing works

An Adenovirus Encoding Proapoptotic Bax Induces Apoptosis and Enhances the Radiation Effect in Human Ovarian Cancer

Arafat, W. O., Gómez-Navarro, J., Xiang, J., Barnes, M. N., Mahasreshti, P. J., Alvarez, R. D., Siegal, G. P., Badib, A. O., Buchsbaum, D. J., Curiel, D. T., et al. (2000) · Molecular Therapy · doi:10.1006/mthe.2000.0071 · Cited by 55 · see citing works

Bax Induction Activates Apoptotic Cascade via Mitochondrial Cytochrome c Release and Bax Overexpression Enhances Apoptosis Induced by Chemotherapeutic Agents in DLD‐1 Colon Cancer Cells

Kobayashi, T., Sawa, H., Morikawa, J., Zhang, W., & Shiku, H. (2000) · Japanese journal of cancer research : Gann · doi:10.1111/j.1349-7006.2000.tb00913.x · Cited by 52 · see citing works

Antitumor Activity of bax and p53 Naked Gene Transfer in Lung Cancer: In Vitro and In Vivo Analysis

Coll, J., NEGOESCU, A., Louis, N., et al. (1998) · Human Gene Therapy · doi:10.1089/hum.1998.9.14-2063 · Cited by 52 · see citing works

Bax-Induction Gene Therapy of Pancreatic Cancer

Pirocanac, E. C., Nassirpour, R., Yang, M., Wang, J., Nardin, S. R., Gu, J. H., Fang, B., Moossa, A. R., Hoffman, R. M., & Bouvet, M. (2002) · Journal of Surgical Research · doi:10.1006/jsre.2002.6473 · Cited by 40 · see citing works

Molecular therapy for peritoneal dissemination of xenotransplanted human MKN-45 gastric cancer cells with adenovirus mediated Bax gene transfer

Tsunemitsu, Y., Kagawa, S., Tokunaga, N., et al. (2004) · Gut · doi:10.1136/gut.2003.021683 · Cited by 36 · see citing works

An adenovirus encoding proapoptotic Bax synergistically radiosensitizes malignant glioma

Arafat, W. O., Buchsbaum, D. J., mez-Navarro, J. G., Tawil, S. A., Olsen, C. C., Xiang, J., El-Akad, H., Salama, A. M., Badib, A. O., Stackhouse, M. A., et al. (2003) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/s0360-3016(02)04488-7 · Cited by 36 · see citing works

Effects of epidermal growth factor, transferrin, and insulin on lipofection efficiency in human lung carcinoma cells

Yanagihara, K., Cheng, H., & Cheng, P. (2000) · Cancer Gene Therapy · doi:10.1038/sj.cgt.7700092 · Cited by 36 · see citing works

[43] Cationic liposome-mediated RNA transfection

Dwarki, V., Malone, R. W., & Verma, I. M. (1993) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(93)17093-k · Cited by 34 · see citing works

Lectin enhancement of the lipofection efficiency in human lung carcinoma cells

Yanagihara, K., & Cheng, P. (1999) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/s0304-4165(99)00100-2 · Cited by 30 · see citing works

Bax-Induced Apoptosis as a Novel Gene Therapy Approach for Carcinoma of the Cervix

Huh, W. K., Gómez-Navarro, J., Arafat, W. O., et al. (2001) · Gynecologic Oncology · doi:10.1006/gyno.2001.6403 · Cited by 28 · see citing works

Growth inhibition of subcutaneous mouse melanoma and induction of natural killer cells by liposome-mediated interferon-β gene therapy

Ryuke, Y., Mizuno, M., Natsume, A., et al. (2003) · Melanoma Research · doi:10.1097/00008390-200308000-00003 · Cited by 19 · see citing works

Bax is an important determinant for radiation sensitivity in esophageal carcinoma cells.

Kim, R., Inoue, H., & Toge, T. (2004) · International Journal of Molecular Medicine · doi:10.3892/ijmm.14.4.697 · Cited by 16 · see citing works

Dimerization of mitochondrial Bax is associated with increased drug response in Bax-transfected A253 cells.

Guo, B., Yin, M. B., Tóth, K., et al. (1999) · PubMed · Cited by 16 · see citing works

Upregulation of drug sensitivity of multidrug-resistant SGC7901/VCR human gastric cancer cells by bax gene transduction.

Zhao, Y., Xiao, B., Chen, B., et al. (2000) · PubMed · Cited by 14 · see citing works

Primary malignant melanoma of the oral cavity. Case report and establishment of melanoma cell line.

TAGAWA, T., Yatani, R., Nishioka, H., et al. (1981) · PubMed · Cited by 11 · see citing works

Bax-induction alone is sufficient to activate apoptosis cascade in wild-type Bax-bearing K562 cells, and the initiation of apoptosis requires simultaneous caspase activation

Kobayashi, T., Sawa, H., Morikawa, J., et al. (2002) · International Journal of Oncology · doi:10.3892/ijo.20.4.723 · Cited by 10 · see citing works

Bax gene therapy for human osteosarcoma using cationic liposomes in vivo

Okumura, K., Nakase, M., Nakamura, S., et al. (2007) · Oncology Reports · doi:10.3892/or.17.4.769 · Cited by 9 · see citing works

Antitumor activity of cationic liposome-mediated Bax gene transfer in osteosarcoma cells: Induction of apoptosis and caspase-independent cell death

Okumura, K., Nakase, M., Nakamura, S., et al. (2005) · International Journal of Oncology · doi:10.3892/ijo.27.2.433 · Cited by 5 · see citing works

Upregulation of drug sensitivity of multidrug resistant SGC7901/VCR human gastric cancer cells by bax gene transduction

赵燕秋, 肖冰, 陈宝军, et al. (2000) · 中华医学杂志：英文版 · Cited by 4 · see citing works

Expression of a 32 kDa protein in rat mammary tumors induced by anti‐benzo[c]phenanthrene‐3,4‐diol‐1,2‐epoxide

Ronai, Z. A., Polotskaya, A., Gradia, S., Amin, S. G., & Hecht, S. S. (1996) · International Journal of Cancer · doi:10.1002/(sici)1097-0215(19960703)67:1 · Cited by 2 · see citing works

Lipid nanoparticles for mRNA delivery

Hou, X., Zaks, T., Langer, R., & Dong, Y. (2021) · Nature Reviews Materials · doi:10.1038/s41578-021-00358-0 · Cited by 4,076 · see citing works

mRNA-based therapeutics--developing a new class of drugs

Sahin, U., Karikó, K., & Türeci, Ö. (2014) · Nature Reviews Drug Discovery · doi:10.1038/nrd4278 · Cited by 2,474 · see citing works

Anti-HER2 scFv-Directed Extracellular Vesicle-Mediated mRNA-Based Gene Delivery Inhibits Growth of HER2-Positive Human Breast Tumor Xenografts by Prodrug Activation

Wang, J.-H., Forterre, A. V., Zhao, J., Frimannsson, D. O., Delcayre, A., Antes, T. J., Efron, B., Jeffrey, S. S., Pegram, M. D., & Matin, A. C. (2018) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-17-0827 · Cited by 181 · see citing works

Biomedical applications of mRNA nanomedicine

Xiong, Q., Lee, G. Y., Ding, J., Li, W., & Shi, J. (2018) · Nano Research · doi:10.1007/s12274-018-2146-1 · Cited by 125 · see citing works

Evading innate immunity in nonviral mRNA delivery: don't shoot the messenger.

Devoldere, J., Dewitte, H., De Smedt, S. C., & Remaut, K. (2016) · Drug Discovery Today · doi:10.1016/j.drudis.2015.07.009 · Cited by 112 · see citing works

Extracellular Vesicle–Mediated <i>In Vitro</i> Transcribed mRNA Delivery for Treatment of HER2+ Breast Cancer Xenografts in Mice by Prodrug CB1954 without General Toxicity

Forterre, A. V., Wang, J.-H., Delcayre, A., Kim, K., Green, C., Pegram, M. D., Jeffrey, S. S., & Matin, A. C. (2020) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-19-0928 · Cited by 62 · see citing works

Terminal Deoxynucleotidyl Transferase (TdT)-Mediated dUTP Nick-End Labeling (TUNEL) for Detection of Apoptotic Cells in DrosophilaPreprint

Denton, D., & Kumar, S. (2015) · Cold Spring Harbor Protocols · doi:10.1101/pdb.prot086199 · Cited by 23 · see citing works

Apoptosis occurs more frequently in metastatic foci than in primary lesions of human colorectal carcinomas: analysis by terminal-deoxynucleotidyl-transferase-mediated dUTP-biotin nick end labeling(ヒト大腸癌の原発巣と転移巣におけるアポトーシスTUNEL法による解析)

建部茂 (1997) · Medical Entomology and Zoology · doi:10.11501/3125232

Detection of Apoptosis by TUNEL Assay

Kyrylkova, K., Kyryachenko, S., Leid, M., & Kioussi, C. (2012) · Methods in Molecular Biology · doi:10.1007/978-1-61779-860-3_5 · Cited by 510 · see citing works

ROS mediated program cell death in rice endosperm development: in situ evidence through TUNEL [Terminal deoxynucleotidyl transferase dUTP Nick End Labeling]

Oane, R. H., Enriquez, B. A., Min, A., et al. (2013)

In situ label-free and sensitive detection assay for cell apoptosis via polyadenosine-coralyne fluorescence enhancement strategy

Wu, C., Wang, J., Chen, Y., et al. (2021) · Analytical Biochemistry · doi:10.1016/j.ab.2021.114329 · Cited by 5 · see citing works