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Cited by 644Analytical Chemistry and ChromatographyChemistry and Stereochemistry StudiesAsymmetric Synthesis and Catalysis

The DOI matches its Crossref record; 77 of the 100 references it cites were found in a registry or an index.

Putting chirality to work: the strategy of chiral switches

Agranat, Israel, Caner, Hava, Caldwell, John·2002·Nature Reviews Drug Discovery
DOI 10.1038/nrd915
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Abstract

Most of the new drugs reaching the market today are single enantiomers, rather than the racemic mixtures that dominated up to ten years ago. Many of the new single-enantiomer drugs were developed as such, but there are also important examples of new single-enantiomer drugs derived from 'chiral switches' of established racemates. Indeed, a well-timed chiral switch can offer enhanced therapy and further profitability as a 'line extension' of a major racemic drug with patents that are expiring.

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Metadata

Authors
Agranat, I., Caner, H., & Caldwell, J.
Affiliations
  • Hebrew University of Jerusalem (IL)
  • Imperial College London (GB)
Corresponding author
Agranat, Israel
ORCID
Venue
Nature Reviews Drug Discovery
Publisher
Springer Science and Business Media LLC
Published
2002-10
Volume
1
Issue
10
Pages
753-768
ISSN
  • 1474-1776 (ISSN-L)
  • 1474-1784
DOI
10.1038/nrd915
OpenAlex
W1991998089
Cited by
637
References
100
Citations by year
2026: 32 · 2025: 31 · 2024: 43 · 2023: 29 · 2022: 31 · 2021: 36 · 2020: 33 · 2019: 32 · 2018: 32 · 2017: 31 · 2016: 15 · 2015: 31 · 2014: 25 · 2013: 22 · 2012: 32
FWCI
1.67
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Nature Reviews Drug Discovery (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Physical Sciences › Chemistry › Analytical Chemistry › Analytical Chemistry and Chromatography
  • Physical Sciences › Chemistry › Organic Chemistry › Chemistry and Stereochemistry Studies
  • Physical Sciences › Chemistry › Organic Chemistry › Asymmetric Synthesis and Catalysis
Keywords
chiral switch, racemic drugs, enantiomers, drug development strategy, line extension, patent expiry, pharmaceutical patents
MeSH terms
Animals, Chemistry, Pharmaceutical, Humans, Stereoisomerism, Technology, Pharmaceutical

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