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Cited by 110Thyroid Disorders and TreatmentsGenetic Associations and EpidemiologyThyroid Cancer Diagnosis and Treatment

Novel insights into thyroid hormones from the study of common genetic variation

Dayan, Colin M., Panicker, Vijay·2009·Nature Reviews Endocrinology
DOI 10.1038/nrendo.2009.19
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Abstract

Effects of thyroid hormones in individual tissues are determined by many factors beyond their serum levels, including local deiodination and expression and activity of thyroid hormone transporters. These effects are difficult to examine by traditional techniques, but a novel approach that exploits the existence of common genetic variants has yielded new and surprising insights. Convincing evidence indicates a role of type 1 iodothyronine deiodinase (D1) in determining the serum T(4):T(3) ratio and a role of phosphodiesterase 8B in determining TSH levels. In addition, studies of type 2 iodothyronine deiodinase (D2) variants have shown that thyroid hormones contribute to osteoarthritis and these variants influence Intelligence quotient alterations associated with iodine deficiency. Preliminary evidence suggests associations between TSH-receptor variants and fasting glucose level, D1 variants and insulin-like growth factor I production, and D2 variants and hypertension, psychological well-being and response to T(3) or T(4) treatment. Intriguingly, most of these associations are independent of serum thyroid hormone levels, which highlights the importance of local regulation of thyroid hormones in tissues. Future research might reveal novel roles for thyroid hormones in obesity, cardiovascular disease, osteoporosis and depression and could have implications for interpretation of thyroid function tests and individualization of thyroid hormone replacement therapy.

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Crossref · 10.1038/nrendo.2009.19

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  • Effects of thyroid hormones in target tissues are determined by many factors beyond their serum levels, including local expression and activity of thyroid hormone transporters and deiodinases.

    “The effects of thyroid hormones in target tissues are determined by many factors beyond their serum levels, including local expression and activity of thyroid hormone transporters and deiodinases [51] .”

    From 2012 ETA Guidelines: The Use of L-T4 + L-T3 in the Treatment of Hypothyroidism (2012) · cites this paper as [51]

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Authors
Dayan, C. M., & Panicker, V.
Affiliations
  • University of Bristol (GB)
  • The University of Western Australia (AU)
Corresponding author
Dayan, Colin M.
ORCID
Venue
Nature Reviews Endocrinology
Publisher
Springer Science and Business Media LLC
Published
2009-04
Volume
5
Issue
4
Pages
211-218
ISSN
  • 1759-5029 (ISSN-L)
  • 1759-5037
DOI
10.1038/nrendo.2009.19
OpenAlex
W1976734397
Cited by
110
References
14
Citations by year
2025: 1 · 2024: 3 · 2023: 6 · 2022: 2 · 2021: 4 · 2020: 2 · 2019: 6 · 2018: 4 · 2017: 11 · 2016: 9 · 2015: 10 · 2014: 8 · 2013: 7 · 2012: 9
FWCI
1.61
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Nature Reviews Endocrinology (publishedVersion)
  • PubMed (publishedVersion)
  • UWA Profiles and Research Repository (UWA) (submittedVersion)
  • University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Cancer Diagnosis and Treatment
Keywords
thyroid hormones, common genetic variants, genetic polymorphism, thyroid-stimulating hormone, T4/T3 ratio, thyroid hormone transporters, osteoarthritis, iodine deficiency, intelligence quotient, TSH receptor, insulin-like growth factor I, hypertension, thyroid hormone replacement, thyroid function tests
MeSH terms
Animals, Humans, Iodide Peroxidase, Thyroid Hormones, Thyrotropin, Thyroxine, Triiodothyronine, Genetic Variation, 3',5'-Cyclic-AMP Phosphodiesterases

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