The DOI matches its Crossref record; 76 of the 76 references it cites were found in a registry or an index.
The current state of pancreas transplantation
Abstract
For many patients with type 1 diabetes mellitus and selected patients with type 2 diabetes mellitus, a successful pancreas transplant is the only definitive long-term treatment that both restores euglycaemia without the risk of severe hypoglycaemia and prevents, halts or reverses secondary complications. These benefits come at the cost of major surgery and lifelong immunosuppression. Nevertheless, pancreas transplants are safe and effective, with patient survival rates currently >95% at 1 year and >88% at 5 years; graft survival rates are almost 85% at 1 year and >60% at 5 years. The estimated half-life of a pancreas graft is now 7-14 years. The improvements in graft survival are attributable to considerable reductions in technical failures and in immunologic graft losses. Pancreas recipients have reduced mortality compared with waiting candidates or patients with diabetes mellitus who undergo a kidney transplant alone. Pancreas transplants should be more frequently offered to nonuraemic patients with brittle diabetes mellitus to prevent the development of secondary diabetic complications and to avoid the need for a kidney transplant. Although the results of islet transplantation have also improved, islet recipients rarely maintain long-term insulin independence despite the use of multiple organ donor pancreases. Pancreas transplants and islet transplants should be considered complementary, not mutually exclusive, procedures that are chosen on the basis of the individual patient's surgical risk.
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In the citing paper
“Simultaneous kidney and pancreas transplantation in experienced centres can offer an up to 80% chance of insulin independence for over 5 years, but there is substantial surgical risk, and the requirement of immunosuppression.159”
From Type 1 diabetes (2018) · cites this paper as [159]
In the citing paper
“Both therapeutic options can effectively prevent hypoglycemia, restore normoglycemia, and possibly stabilize the progression of complications of type 1 diabetes (223-227).”
Citations
Cites
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International trial of the Edmonton protocol for islet transplantation
Shapiro, A. M. J., Ricordi, C., Hering, B. J., Auchincloss, H., Lindblad, R., Robertson, R. P., Secchi, A., Brendel, M. D., Berney, T., Brennan, D. C., et al. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa061267 · Cited by 1,942
(2000) · New England Journal of Medicine · doi:10.1056/nejm200002103420603 · Cited by 1,534
Reversal of Lesions of Diabetic Nephropathy after Pancreas Transplantation
Fioretto, P., Steffes, M. W., Sutherland, D. E. R., Goetz, F. C., & Mauer, M. S. (1998) · New England Journal of Medicine · doi:10.1056/nejm199807093390202 · Cited by 1,125
Improvement in outcomes of clinical islet transplantation: 1999–2010
Barton, F. B., Rickels, M. R., Alejandro, R., Hering, B. J., Wease, S., Naziruddin, B., Oberholzer, J., Odorico, J. S., Garfinkel, M. R., Levy, M., et al. (2012) · Diabetes Care · doi:10.2337/dc12-0063 · Cited by 725
Allotransplantation of the pancreas and duodenum along with the kidney in diabetic nephropathy
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Self-citationLong-term effect of diabetes and its treatment on cognitive function
(2007) · New England Journal of Medicine · doi:10.1056/nejmoa066397 · Cited by 646
Effects of Pancreatic Transplantation on Diabetic Neuropathy
Kennedy, W. R., Navarro, X., Goetz, F. C., Sutherland, D. E. R., & Najarian, J. S. (1990) · New England Journal of Medicine · doi:10.1056/nejm199004123221503 · Cited by 449
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DiMeglio, L. A., Evans-Molina, C., & Oram, R. A. (2018) · The Lancet · doi:10.1016/s0140-6736(18)31320-5 · Cited by 1,561
Holt, R. I. G., DeVries, J. H., Hess-Fischl, A., Hirsch, I. B., Kirkman, M. S., Klupa, T., Ludwig, B., Nørgaard, K., Pettus, J., Renard, E., et al. (2021) · Diabetes Care · doi:10.2337/dci21-0043 · Cited by 699
Hering, B. J., Clarke, W. R., Bridges, N. D., Eggerman, T. L., Alejandro, R., Bellin, M. D., Chaloner, K., Czarniecki, C. W., Goldstein, J. S., Hunsicker, L. G., et al. (2016) · Diabetes Care · doi:10.2337/dc15-1988 · Cited by 645
Sun, Y., Shi, H., Yin, S., Ji, C., Zhang, X., Zhang, B., Wu, P., Shi, Y., Mao, F., Yan, Y., et al. (2018) · ACS Nano · doi:10.1021/acsnano.7b07643 · Cited by 468
Holt, R. I. G., DeVries, J. H., Fischl, A. H., Hirsch, I. B., Kirkman, M. S., Klupa, T., Ludwig, B., Nørgaard, K., Pettus, J., Renard, É., et al. (2021) · Diabetologia · doi:10.1007/s00125-021-05568-3 · Cited by 470
Metadata
- Authors
- Gruessner, R. W. G., & Gruessner, A. C.
- Affiliations
- University of Arizona (US)
- Corresponding author
- Gruessner, Rainer W. G.
- Venue
- Nature Reviews Endocrinology
- Published
- 2013-07-30
- Volume
- 9
- Issue
- 9
- Pages
- 555-562
- ISSN
- 1759-5029 (ISSN-L)
- 1759-5037
- OpenAlex
- W1997688914
- Cited by
- 256
- References
- 76
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 13 · 2023: 26 · 2022: 15 · 2021: 19 · 2020: 20 · 2019: 25 · 2018: 21 · 2017: 13 · 2016: 37 · 2015: 39 · 2014: 14 · 2013: 1
- Type
- book review
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of Minnesota
- University of Arizona
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
- Health Sciences › Medicine › Surgery › Transplantation: Methods and Outcomes
- Health Sciences › Medicine › Surgery › Organ Transplantation Techniques and Outcomes
- Keywords
- pancreas transplantation, type 1 diabetes, type 2 diabetes, islet transplantation, graft survival, immunosuppression, diabetes complications, brittle diabetes, kidney transplantation, insulin independence
- MeSH terms
- Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Female, Humans, Male, Pancreas Transplantation, Islets of Langerhans Transplantation, Treatment Outcome
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