The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
Regulation of hepatic glucose metabolism in health and disease
Open accessAbstract
The liver is crucial for the maintenance of normal glucose homeostasis — it produces glucose during fasting and stores glucose postprandially. However, these hepatic processes are dysregulated in type 1 and type 2 diabetes mellitus, and this imbalance contributes to hyperglycaemia in the fasted and postprandial states. Net hepatic glucose production is the summation of glucose fluxes from gluconeogenesis, glycogenolysis, glycogen synthesis, glycolysis and other pathways. In this Review, we discuss the in vivo regulation of these hepatic glucose fluxes. In particular, we highlight the importance of indirect (extrahepatic) control of hepatic gluconeogenesis and direct (hepatic) control of hepatic glycogen metabolism. We also propose a mechanism for the progression of subclinical hepatic insulin resistance to overt fasting hyperglycaemia in type 2 diabetes mellitus. Insights into the control of hepatic gluconeogenesis by metformin and insulin and into the role of lipid-induced hepatic insulin resistance in modifying gluconeogenic and net hepatic glycogen synthetic flux are also discussed. Finally, we consider the therapeutic potential of strategies that target hepatosteatosis, hyperglucagonaemia and adipose lipolysis.
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Cites
Role of AMP-Activated Protein Kinase in Mechanism of Metformin Action
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AMPK: a nutrient and energy sensor that maintains energy homeostasis
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Mechanisms for Insulin Resistance: Common Threads and Missing Links
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Self-citationThe Kinase LKB1 Mediates Glucose Homeostasis in Liver and Therapeutic Effects of Metformin
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A placebo-controlled trial of pioglitazone in subjects with nonalcoholic steatohepatitis
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Insulin-regulated hepatic gluconeogenesis through FOXO1–PGC-1α interaction
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Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease
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Self-citationMetformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase
Madiraju, A. K., Erion, D. M., Rahimi, Y., Zhang, X.-M., Braddock, D. T., Albright, R. A., Prigaro, B. J., Wood, J. L., Bhanot, S., MacDonald, M. J., et al. (2014) · Nature · doi:10.1038/nature13270 · Cited by 1,284
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Cited by
Mechanisms of Insulin Action and Insulin Resistance
Petersen, M. C., & Shulman, G. I. (2018) · Physiological Reviews · doi:10.1152/physrev.00063.2017 · Cited by 3,028
Self-citationRinella, M. E., Neuschwander-Tetri, B. A., Siddiqui, M. S., Abdelmalek, M. F., Caldwell, S., Barb, D., Kleiner, D. E., & Loomba, R. (2023) · Hepatology · doi:10.1097/hep.0000000000000323 · Cited by 2,667
Trends in insulin resistance: insights into mechanisms and therapeutic strategy
Li, M., Chi, X., Wang, Y., Setrerrahmane, S., Xie, W., & Xu, H. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01073-0 · Cited by 939
Cellular and Molecular Mechanisms of Metformin Action
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Self-citationMolecular phenomics and metagenomics of hepatic steatosis in non-diabetic obese women
Hoyles, L., Fernández-Real, J.-M., Federici, M., Serino, M., Abbott, J., Charpentier, J., Heymes, C., Luque, J. L., Anthony, E., Barton, R. H., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0061-3 · Cited by 720
Metadata
- Authors
- Petersen, M. C., Vatner, D. F., & Shulman, G. I.
- Venue
- Nature Reviews Endocrinology
- Published
- 2017-07-21
- Volume
- 13
- Issue
- 10
- Pages
- 572-587
- ISSN
- 1759-5029 (ISSN-L)
- 1759-5037
- OpenAlex
- W2736390409
- Cited by
- 1,133
- References
- 47
- FWCI
- 5.81
- Type
- journal article
- Language
- en
- Open access
- green
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