Synergy between sequence and size in Large-scale genomics
Abstract
Until recently the study of individual DNA sequences and of total DNA content (the C-value) sat at opposite ends of the spectrum in genome biology. For gene sequencers, the vast stretches of non-coding DNA found in eukaryotic genomes were largely considered to be an annoyance, whereas genome-size researchers attributed little relevance to specific nucleotide sequences. However, the dawn of comprehensive genome sequencing has allowed a new synergy between these fields, with sequence data providing novel insights into genome-size evolution, and with genome-size data being of both practical and theoretical significance for large-scale sequence analysis. In combination, these formerly disconnected disciplines are poised to deliver a greatly improved understanding of genome structure and evolution.
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Repeat element accumulation is a primary driver of genome size variation across Cypriniformes.
“indicating that repeat element accumulation is a primary driver of genome size variation across the order (26–28)”
From Convergent genome streamlining accompanies independent miniaturization in the world’s smallest fishes (2026) · cites this paper as [26]
Cites
Initial sequencing and comparative analysis of the mouse genome
Mouse Genome Sequencing Consortium (2002) · Nature · doi:10.1038/nature01262 · Cited by 7,187 · see citing works
The origins of genome complexity
Lynch, M., & Conery, J. S. (2003) · Science · doi:10.1126/science.1089370 · Cited by 1,698 · see citing works
Dujon, B., Sherman, D., Fischer, G., Durrens, P., Casaregola, S., Lafontaine, I., de Montigny, J., Marck, C., Neuvéglise, C., Talla, E., et al. (2004) · Nature · doi:10.1038/nature02579 · Cited by 1,623 · see citing works
Molecular paleontology of transposable elements in the <i>Drosophila melanogaster</i> genome
Kapitonov, V. V., & Jurka, J. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0732024100 · Cited by 288 · see citing works
Transposition of hAT elements links transposable elements and V(D)J recombination
Zhou, L., Mitra, R., Atkinson, P. W., Burgess Hickman, A., Dyda, F., & Craig, N. L. (2004) · Nature · doi:10.1038/nature03157 · Cited by 224 · see citing works
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Annotating non-coding regions of the genome.
Alexander, R. P., Fang, G., Rozowsky, J., Snyder, M., & Gerstein, M. B. (2010) · Nature Reviews Genetics · doi:10.1038/nrg2814 · Cited by 464 · see citing works
Delmont, T. O., Gaia, M., Hinsinger, D. D., Frémont, P., Vanni, C., Fernandez-Guerra, A., Eren, A. M., Kourlaiev, A., d'Agata, L., Clayssen, Q., et al. (2022) · Cell Genomics · doi:10.1016/j.xgen.2022.100123 · Cited by 173 · see citing works
Sudasinghe, H., Matschiner, M., Britz, R., Conway, K. W., Tan, H. H., Salzburger, W., Peichel, C. L., & Rüber, L. (2026) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2614605123
- Authors
- Gregory, T. R.
- Affiliations
- University of Guelph (CA)
- Corresponding author
- Gregory, T. Ryan
- ORCID
- Gregory, T. Ryan
- Venue
- Nature Reviews Genetics
- Published
- 2005-09
- Volume
- 6
- Issue
- 9
- Pages
- 699-708
- ISSN
- 1471-0056 (ISSN-L)
- 1471-0064
- OpenAlex
- W2125365332
- Cited by
- 348
- References
- 5
- Citations by year
- 2026: 14 · 2025: 14 · 2024: 12 · 2023: 12 · 2022: 19 · 2021: 19 · 2020: 18 · 2019: 18 · 2018: 13 · 2017: 15 · 2016: 20 · 2015: 14 · 2014: 20 · 2013: 20 · 2012: 16
- FWCI
- 2.03
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Genetics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Chromosomal and Genetic Variations
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genome Rearrangement Algorithms
- Keywords
- genome size, C-value, genome size evolution, non-coding DNA, eukaryotic genomes, genome structure, large-scale genomics, sequence analysis
- MeSH terms
- Base Sequence, Genome, Sequence Analysis, Evolution, Molecular, Genomics, Genome Components
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