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Cited by 687

The DOI matches its Crossref record; 120 of the 120 references it cites were found in a registry or an index.

Engineering targeted viral vectors for gene therapy

Open access
Waehler, Reinhard, Russell, Stephen J., Curiel, David T.·2007·Nature Reviews Genetics
DOI 10.1038/nrg2141
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Abstract

To achieve therapeutic success, transfer vehicles for gene therapy must be capable of transducing target cells while avoiding impact on non-target cells. Despite the high transduction efficiency of viral vectors, their tropism frequently does not match the therapeutic need. In the past, this lack of appropriate targeting allowed only partial exploitation of the great potential of gene therapy. Substantial progress in modifying viral vectors using diverse techniques now allows targeting to many cell types in vitro. Although important challenges remain for in vivo applications, the first clinical trials with targeted vectors have already begun to take place.

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Crossref · 10.1038/nrg2141

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120 of 120 references verified0 citation errors · 0 not checkable

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Metadata

Authors
Waehler, R., Russell, S. J., & Curiel, D. T.
Venue
Nature Reviews Genetics
Publisher
Springer Science and Business Media LLC
Published
2007-07-03
Volume
8
Issue
8
Pages
573-587
ISSN
  • 1471-0056 (ISSN-L)
  • 1471-0064
DOI
10.1038/nrg2141
OpenAlex
W1988177186
Cited by
687
References
120
FWCI
3.38
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Engineering targeted viral vectors for gene therapy. https://app.cochat.ai/papers/10.1038/nrg2141
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Waehler, R., Russell, S. J., & Curiel, D. T. (2007). Engineering targeted viral vectors for gene therapy. Nature Reviews Genetics. https://doi.org/10.1038/nrg2141

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.