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Epigenetic regulation of centromeric chromatin: old dogs, new tricks?
Open accessAbstract
The assembly of just a single kinetochore at the centromere of each sister chromatid is essential for accurate chromosome segregation during cell division. Surprisingly, despite their vital function, centromeres show considerable plasticity with respect to their chromosomal locations and activity. The establishment and maintenance of centromeric chromatin, and therefore the location of kinetochores, is epigenetically regulated. The histone H3 variant CENP-A is the key determinant of centromere identity and kinetochore assembly. Recent studies have identified many factors that affect CENP-A localization, but their precise roles in this process are unknown. We build on these advances and on new information about the timing of CENP-A assembly during the cell cycle to propose new models for how centromeric chromatin is established and propagated.
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Citations
Cites
Chromatin modifications and their function
Kouzarides, T. (2007) · Cell · doi:10.1016/j.cell.2007.02.005 · Cited by 10,883
Cited by
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Talbert, P. B., & Henikoff, S. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2861 · Cited by 844
The Spindle Assembly Checkpoint
Lara-Gonzalez, P., Westhorpe, F. G., & Taylor, S. S. (2012) · Current Biology · doi:10.1016/j.cub.2012.10.006 · Cited by 773
Major Evolutionary Transitions in Centromere Complexity
Malik, H. S., & Henikoff, S. (2009) · Cell · doi:10.1016/j.cell.2009.08.036 · Cited by 375
HJURP is a CENP-A chromatin assembly factor sufficient to form a functional de novo kinetochore
Barnhart, M. C., Kuich, P. H. J. L., Stellfox, M. E., Ward, J. A., Bassett, E. A., Black, B. E., & Foltz, D. R. (2011) · Journal of Cell Biology · doi:10.1083/jcb.201012017 · Cited by 329
A Conserved Mechanism for Centromeric Nucleosome Recognition by Centromere Protein CENP-C
Kato, H., Jiang, J., Zhou, B.-R., Rozendaal, M., Feng, H., Ghirlando, R., Xiao, T. S., Straight, A. F., & Bai, Y. (2013) · Science · doi:10.1126/science.1235532 · Cited by 323
Metadata
- Authors
- Allshire, R. C., & Karpen, G. H.
- Venue
- Nature Reviews Genetics
- Published
- 2008-12
- Volume
- 9
- Issue
- 12
- Pages
- 923-937
- ISSN
- 1471-0056 (ISSN-L)
- 1471-0064
- OpenAlex
- W2106413052
- Cited by
- 568
- References
- 1
- FWCI
- 2.29
- Type
- journal article
- Language
- en
- Open access
- green
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- Allshire, R. C., & Karpen, G. H. (2008). Epigenetic regulation of centromeric chromatin: old dogs, new tricks? Nature Reviews Genetics. https://doi.org/10.1038/nrg2466
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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