The DOI matches its Crossref record; 58 of the 58 references it cites were found in a registry or an index.
HJURP is a CENP-A chromatin assembly factor sufficient to form a functional de novo kinetochore
Open accessAbstract
Centromeres of higher eukaryotes are epigenetically marked by the centromere-specific CENP-A nucleosome. New CENP-A recruitment requires the CENP-A histone chaperone HJURP. In this paper, we show that a LacI (Lac repressor) fusion of HJURP drove the stable recruitment of CENP-A to a LacO (Lac operon) array at a noncentromeric locus. Ectopically targeted CENP-A chromatin at the LacO array was sufficient to direct the assembly of a functional centromere as indicated by the recruitment of the constitutive centromere-associated network proteins, the microtubule-binding protein NDC80, and the formation of stable kinetochore–microtubule attachments. An amino-terminal fragment of HJURP was able to assemble CENP-A nucleosomes in vitro, demonstrating that HJURP is a chromatin assembly factor. Furthermore, HJURP recruitment to endogenous centromeres required the Mis18 complex. Together, these data suggest that the role of the Mis18 complex in CENP-A deposition is to recruit HJURP and that the CENP-A nucleosome assembly activity of HJURP is responsible for centromeric chromatin assembly to maintain the epigenetic mark.
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Cites
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Metadata
- Authors
- Barnhart, M. C., Kuich, P. H. J. L., Stellfox, M. E., Ward, J. A., Bassett, E. A., Black, B. E., & Foltz, D. R.
- Venue
- Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2011-07-18
- Volume
- 194
- Issue
- 2
- Pages
- 229-243
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2102859326
- Cited by
- 329
- References
- 58
- FWCI
- 13.34
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Barnhart, M. C., Kuich, P. H. J. L., Stellfox, M. E., Ward, J. A., Bassett, E. A., Black, B. E., & Foltz, D. R. (2011). HJURP is a CENP-A chromatin assembly factor sufficient to form a functional de novo kinetochore. Journal of Cell Biology. https://doi.org/10.1083/jcb.201012017
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