Kinase mutations in human disease: interpreting genotype–phenotype relationships

Cited by (429)

Items 301–400 of 429

1. Interaction Networks Explain Holoenzyme Allostery in Protein Kinase A
   Colin L. Welsh, Abigail E. Conklin, Lalima K. Madan · 2023 · Kinases and Phosphatases
2. Exploring drug repositioning possibilities of kinase inhibitors via molecular simulation**
   Qing-Xin Wang, Jiao Cai, Zi‐Jun Chen, Jia‐Chuan Liu, Jing‐Jing Wang, Hai Zhou, Qing‐Qing Li, Zixuan Wang, Yi‐Bo Wang, Zhen‐Jiang Tong et al. · 2024 · Molecular Informatics
3. Development of an enzyme-coupled activity assay for Janus kinase 2 inhibitor screening
   Angelika Pölläniemi, Anniina T. Virtanen, Olli Silvennoinen, T. Haikarainen · 2023 · SLAS DISCOVERY
4. A Critical Assessment of COVID-19 Genomic Vaccines
   Dima A. Sabbah, Rima Hajjo, Suhair Sunoqrot · 2023 · Current Topics in Medicinal Chemistry
5. Kinases and their derived inhibitors from natural products
   Takudzwa Chipeperengo Chiwoneso, Yajing Luo, Yifan Xu, Xinyu Chen, Li Chen, Jianbo Sun · 2025 · Bioorganic Chemistry
6. Targeted Therapies in Lung Cancers: Current Landscape and Future Prospects
   Xin Feng, Wenqing Ding, Junhong Ma, Baijun Liu, Hongmei Yuan · 2021 · Recent Patents on Anti-Cancer Drug Discovery
7. Screening Dyrk1A inhibitors by MALDI-QqQ mass spectrometry: systematic comparison to established radiometric, luminescence, and LC–UV–MS assays
   David Gode, Christian Schmitt, Matthias Engel, Dietrich A. Volmer · 2014 · Analytical and Bioanalytical Chemistry
8. Proximity‐Inducing Bifunctional Molecules Beyond PROTACs
   Sophia Lai, Ashley E. Modell, Amit Choudhary · 2022 · Wiley eBooks
9. Leucine rich repeat kinase 2 ( LRRK2 ) peptide modulators: Recent advances and future directions
   Leah G. Helton, Hardy J. Rideout, Friedrich W. Herberg, Eileen J. Kennedy · 2021 · Peptide Science
10. Effect of Kinases in Extracellular Vesicles from HIV-1-Infected Cells on Bystander Cells
    Gifty A. Mensah, Anastasia Williams, Pooja Khatkar, Yuriy Kim, James Erickson, A. Duverger, Heather Branscome, Kajal Patil, Hafsa M. Chaudhry, Yun-Tao Wu et al. · 2025 · Cells
11. A suite of in vitro and in vivo assays for monitoring the activity of the pseudokinase Bud32
    Jonah Beenstock, Samara Mishelle Ona, Frank Sicheri · 2022 · Methods in enzymology on CD-ROM/Methods in enzymology
12. Tyrosine kinase targeting uncovers oncogenic pathway plasticity in Tasmanian devil transmissible cancers
    Anna Schönbichler, Anna Orlova, Carmen Kreindl, Lukas Endler, Richard Wilson, Lindsay Kosack, Anna Hofmann, Csilla Viczenczová, Jocelyn M. Darby, Fettah Erdogan et al. · 2025 · The EMBO Journal
13. Regulations and Functions of ICK/MAK/MOK - A Novel MAPK-Related Kinase Family Linked to Human Diseases
    Zheng John · 2012 · InTech eBooks
14. Aiming for the Outliers: Cancer Precision Medicine through Targeting Kinases with Extreme Expression
    Srinivasan Yegnasubramanian, Anirban Maitra · 2013 · Cancer Discovery
15. Fundamental Bioinformatic and Chemoinformatic Data Processing
    J. B. Brown · 2018 · Methods in molecular biology
16. Structure-Activity Studies of Novel Di-substituted [1,2,5]oxadiazolo [3,4-b]pyrazine Analogs Targeting the A-loop Regulatory Site of p38 MAP Kinase
    Esther Carrasco, Patricia Gómez‐Gutierrez, Pedro M. Campos, Miguel Vega, Ángel Messeguer, Juan Jesús Pérez · 2021 · Current Medicinal Chemistry
17. Real‐Time and Continuous Sensors of Protein Kinase Activity Utilizing Chelation‐Enhanced Fluorescence
    Laura B. Peterson, Barbara Imperiali · 2014
18. Global impact of phosphorylation on protein endurance
    Chong-De Wu, Qian Ba, Wen-Xue Li, Barbora Šalovská, P. Hou, Torsten Mueller, George A. Rosenberger, Erli Gao, Yi Di, Yan-Sheng Liu · 2020 · bioRxiv
19. EnsDTI-kinase: Web-server for Predicting Kinase-Inhibitor Interactions with Ensemble Computational Methods and Its Applications
    Yijingxiu Lu, Sangsoo Lim, Sungjoon Park, MinGyu Choi, Changyun Cho, Soosung Kang, Sun Kim · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
20. Quantitative proteomic mass spectrometry of protein kinases to determine dynamic heterogeneity of the human kinome
    Michael P. East, Robert W. Sprung, Denis O. Okumu, José F. Olivares-Quintero, Chinmaya U. Joisa, Xin Chen, Qiang Zhang, Petra Erdmann-Gilmore, Yiling Mi, Noah Sciaky et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
21. Modulation of host functions by bacterial serine/threonine protein kinase effector proteins
    Jinli Ge, Jiazhang Qiu · 2025 · Journal of Biological Chemistry
22. Cyclopropyl as a versatile tool in the development of kinase-targeted therapeutics
    Wenwu Liu, Yaoguang Huang, Wenyan Hao, Zhuona Rong, Xinhua Liu, Ying Zhou, Song Song, Xiaocong Pang · 2026 · European Journal of Medicinal Chemistry
23. Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Cancer: Mechanisms, Clinical Applications and Emerging Strategies
    Henry Dickerson, Ahmad Diab, Othman Almusaimi · 2026 · IntechOpen eBooks
24. MELK inhibition disrupts actin cytoskeleton and broadly restricts human coronavirus infections
    Kuai Yu, Qiaorui Yao, Dong Wang, Qingtao Hu, Dan-Dan Li, Fang Li, Feng Chen, Jingyi Su, Ting-Hsiang Huang, Qing Zhang et al. · 2026 · Nature Communications
25. Signalisation cellulaire et cancer : caractérisation de cibles thérapeutiques
    Patricia de Crémoux, Jacques Robert · 2012 · Pathologie Biologie
26. Something from Nothing: The First Phosphorylation
    Kimberly A. Malecka · 2013 · Postdoc Journal
27. Exploring protein domain organization by recognition of secondary structure packing interfaces
    Lizong Deng, Aiping Wu, Wentao Dai, Tingrui Song, Ya Cui, Taijiao Jiang · 2014 · Bioinformatics
28. A Novel Kinase-substrate Relation Prediction Method Based on Substrate Sequence Similarity and Phosphorylation Network
    Haichun Li, Xiaoyi Xu, Huanqing Feng, Minghui Wang · 2015 · IFAC-PapersOnLine
29. A promiscuous kinase inhibitor reveals secrets to cancer cell survival
    Paul S. Shapiro · 2019 · Journal of Biological Chemistry
30. HPLC-UV method for simultaneous determination of MK-1775 and AZD-7762 in both acetonitrile-aqueous solution and mouse plasma
    Kareem Ebeid, Giang N. Ho, Aliasger K. Salem · 2016 · Journal of Chromatography B
31. Kinase Inhibitors
    Giuseppe Tridente · 2017 · Elsevier eBooks
32. Kinases
    Giuseppe Tridente · 2017 · Elsevier eBooks
33. Using the Structural Kinome to Systematize Kinase Drug Discovery
    Zheng Zhao, Philip E. Bourne · 2021 · Biochemistry
34. Mass spectrometry for human kinome analysis
    Weili Miao, Yinsheng Wang · 2021 · Elsevier eBooks
35. Identification of New Inhibitors of the Kinase Activity of CDK2 and CDK9 by Molecular Modeling and High-Efficiency Screening
    G.V. Andrianov, Ilya G. Serebriiskii · 2021 · Učënye zapiski Kazanskogo universiteta. Seriâ Estestvennye nauki/Učënye zapiski Kazanskogo universiteta. Seriâ Estestvennye nauki/Učenye zapiski Kazanskogo gosudarstvennogo universiteta. Seriâ Estestvennye nauki
36. Identification of human immunodeficiency virus -1 E protein-targeting lead compounds by pharmacophore based screening
    Mazen Mohammed Almehmadi, Alaa Shafie, Mamdouh A. Allahyani, Tahir Muhammad, Soukayna Baammi, Abdulelah Aljuaid, Abdulraheem Ali Almalki, Ahad Amer Alsaiari, Amal Adnan Ashour · 2022 · Saudi Medical Journal
37. Endocytic downregulation of the oncoproteins ErbB2 and ErbB3
    Monika Szymańska · 2016 · NORA - Norwegian Open Research Archives
38. Cushing’s Syndrome mutant PKA L205R exhibits altered substrate specificity
    Joshua M. Lubner, Kimberly L. Dodge‐Kafka, Cathrine R. Carlson, George McDonald Church, Michael F. Chou, Daniel Schwartz · 2016 · bioRxiv (Cold Spring Harbor Laboratory)
39. Ancestral resurrection reveals mechanisms of kinase regulatory evolution
    Dajun Sang, Sudarshan Pinglay, Sezen Vatansever, Hua Jane Lou, Benjamin E. Turk, Zeynep Hulya Gumus, Liam J. Holt · 2018 · bioRxiv (Cold Spring Harbor Laboratory)
40. Developing a computational approach to investigate the impacts of disease-causing mutations on protein function
    Camilla Pang · 2018 · UCL Discovery (University College London)
41. Kinases in motion: impact of protein and small molecule interactions on kinase conformations
    Valentina Kugler, Selina Schwaighofer, Andreas Feichtner, Florian Enzler, Jakob Fleischmann, Sophie Luise Strich, Sarah Schwarz, Rebecca Wilson, Philipp Tschaikner, Jakob Troppmair et al. · 2024 · eLife
42. Prédiction des constantes cinétiques de complexes protéine-ligand
    Sonia Ziada · 2019
43. IDENTIFICATION AND CHARACTERIZATION OF CULLIN-3, -4, -5 AND DDB1 IN THE PLANARIAN SCHMIDTEA MEDITERRANEA AND FUNCTION OF ICK-FAMILY KINASES IN NEURAL STEM CELL SELF- RENEWAL, PROLIFERATION, AND MIGRATION
    Melissa Carrillo · 2011 · California State University ScholarWorks (system-wide DSpace)
44. Systematic Methods to Interrogate Genetic Perturbations and Map Phosphorylation-Dependent Signaling
    Richelle Sopko, Norbert Perrimon · 2015 · Elsevier eBooks
45. Development of new lead-like dual inhibitors of the cdc2-like kinase 1 (Clk1) and dual specificity Y-phosphorylation regulated kinases 1A and 1B (Dyrk1A and Dyrk1B)
    Schmitt, Christian · 2014 · Publications of the UdS (Saarland University)
46. Anàlisi in silico de malalties: des de les mutacions fins les xarxes biològiques
    Eduard Porta‐Pardo · 2013 · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)
47. Reprint of: Gene susceptibility to oxidative damage: From single nucleotide polymorphisms to function
    Valeria Simonelli, Filomena Mazzei, Mariarosaria D’Errico, Eugenia Dogliotti Y · 2012 · Mutation research. Fundamental and molecular mechanisms of mutagenesis
48. Development and Validation of a Single-Well Cell-Based Assay for the Detection of Endogenous Phosphoproteins
    Antony J. Sheehan, Wendy Goodrich, Peter Banks, Michael F. Crouch, Ronald I. W. Osmond · 2012 · Assay and Drug Development Technologies
49. IN THE SPOTLIGHT Aiming for the Outliers: Cancer Precision Medicine through Targeting Kinases with Extreme Expression
    Srinivasan Yegnasubramanian, Anirban Maitra · 2013
50. Applications of Optical Control of Oligonucleotide and Protein Function
    James Hemphill · 2015 · D-Scholarship@Pitt (University of Pittsburgh)
51. Functional Characterization of the Kinase and Pseudokinase Domains in the Janus Tyrosine Kinase (JAK) 2
    Yashavanthi Niranjan · 2014 · Tampere University Institutional Repository (Tampere University)
52. The expression of HLA-B27 modulates intracellular signaling in human monocytic macrophages
    Anna Sahlberg · 2014 · UTUPub (University of Turku)
53. Development of a Direct Activity Probe for Rho-Associated Protein Kinase
    Maia I. Kelly · 2016 · Lincoln (University of Nebraska)
54. Small Molecule Inhibitors of Stat3 Protein as Cancer Therapeutic Agents
    Brent D. G. Page · 2014 · TSpace (University of Toronto)
55. The influence of phase II conjugation on the biological activity of flavonoids
    Karsten Beekmann · 2016
56. Introduction
    Qing Yan · 2017 · Elsevier eBooks
57. Structural and Mechanistic Insights into RAF Kinase Regulation by the KSR/CNK/HYP Complex
    Thanashan Rajakulendran · 2012 · TSpace (University of Toronto)
58. Signal Transduction Networks Analysis: The Reverse Phase Protein Array
    Michele Signore, Valeria Manganelli, Ilio Vitale · 2017 · Elsevier eBooks
59. Análisis proteómico durante el desarrollo de la pancreatitis aguda experimental
    Violeta García Hernández · 2017 · Gredos (University of Salamanca)
60. Minimal models of invasion and clonal selection in cancer
    Chay Paterson · 2020 · arXiv (Cornell University)
61. Discerning Drivers of Cancer: Computational Approaches to Somatic Exome Sequencing Data
    Runjun D. Kumar · 2018 · Open Scholarship Institutional Repository (Washington University in St. Louis)
62. Introductory Chapter: Tyrosine Kinases as Drug Targets in Cancer Treatment
    Huan Ren · 2019 · IntechOpen eBooks
63. Análise estrutural de sítios de fosforilação em proteína
    Juan Enrique Faya Castillo · 2019
64. Characterization of NEK10 Tyrosine Kinase Activity in the Cellular Response to DNA Damage
    Nasir Haider · 2018 · TSpace (University of Toronto)
65. Biosynthesis of Curcumin and Molecular Targets and the Biological Mechanism of Curcumin
    Yücel Başpınar, Hasan Akbaba · 2020 · Royal Society of Chemistry eBooks
66. Decoding the functional Fes kinase signaling network topology in a lymphocyte model
    Andreas O. Helbig, Michael Kofler, Gerald D. Gish, Lourdes Sriraja, Kristina Lorenzen, Monika Tucholska, Cunjie Zhang, Frederick P. Roth, Tony J. Pawson, Karen Colwill et al. · 2017 · bioRxiv (Cold Spring Harbor Laboratory)
67. Allosteric regulation of BTK by the PHTH domain and small molecules
    Neha Amatya · 2021 · Iowa State University Digital Repository (Iowa State University)
68. Mitochondrial metabolism and carcinogenesis
    Siddhesh Aras, Neeraja Purandare, Lawrence I. Grossman · 2021 · Elsevier eBooks
69. Molecular Imaging of Cellular Signaling Pathways
    Kathryn E. Luker · 2021 · Elsevier eBooks
70. Predicting the structure and energetics of protein-ligand interaction
    Zhiwei Ma · 2019
71. Faculty Opinions recommendation of An alternatively spliced, non-signaling insulin receptor modulates insulin sensitivity via insulin peptide sequestration in C. elegans.
    L. Ryan Baugh · 2020 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
72. Biochemical Characterization of the Release of FAK Autoinhibition
    Jessica E. Hall · 2017 · The Research Repository @ WVU (West Virginia University)
73. Βιοχημικές μελέτες στην GSK3β-like κινάση LjSK1 από το Lotus japonicus
    Θεοδώρα Σολοβού · 2022
74. Systematic Methods to Interrogate Genetic Perturbations and Map Phosphorylation-Dependent Signaling
    Richelle Sopko, Norbert Perrimon · 2016 · Elsevier eBooks
75. Application of hybrid biophysical-biochemical methods to unravel the molecular basis for auto-inhibition and activation of protein tyrosine phosphatase TCPTP/PTPN2
    Jai Prakash Singh, Yi-Yun Chen, Yuting Huang, Shang‐Te Danny Hsu, Tzu‐Ching Meng · 2023 · Methods in enzymology on CD-ROM/Methods in enzymology
76. Identification of Covalent Ligands – from Single Targets to Whole Proteome
    Chau Ngo, Arunika I. Ekanayake, Chao Zhang · 2023 · Israel Journal of Chemistry
77. Multi-omics analysis based on proteomics is fun! : development of proteogenomic software generating sample-specific proteome database and comprehensive kinase activity analysis
    Rei Noguchi · 2023 · SEIBUTSU BUTSURI KAGAKU
78. (Benz)imidazoles
    Junli Huang, Jianjun Chen · 2023 · Elsevier eBooks
79. Design and Molecular Dynamics Simulation of Thieno-pyrimidine derivative JAK3 Inhibitor
    Poowadon Fukasem, M. Paul Gleeson · 2023 · Biomedical Engineering International Conference
80. Identifying differences in molecular characteristics relevant for remodelling of periodontal ligament stem cells from upper and lower jaw
    Hanna Malyaran, Rogerio Bastos Craveiro, Sinan Mert, Christian Niederau, Sanne Lidewij Maas, Emiel P. C. van der Vorst, Frank Hölzle, Willi Jahnen‐Dechent, Michael F. Wolf, Sabine Neuß · 2023 · Research Square
81. Kinases in motion: impact of protein and small molecule interactions on kinase conformations
    Valentina Kugler, Selina Schwaighofer, Andreas Feichtner, Florian Enzler, Jakob Fleischmann, Sophie Luise Strich, Sarah Schwarz, Rebecca Wilson, Philipp Tschaikner, Jakob Troppmair et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
82. Lighting up kinase contacts in situ
    Guo‐Chao Chu, Yi‐Ming Li · 2024 · Nature Chemical Biology
83. Kinases in motion: impact of protein and small molecule interactions on kinase conformations
    Valentina Kugler, Selina Schwaighofer, Andreas Feichtner, Florian Enzler, Jakob Fleischmann, Sophie Luise Strich, Sarah Schwarz, Rebecca Wilson, Philipp Tschaikner, Jakob Troppmair et al. · 2024 · eLife
84. Reviewer #2 (Public Review): Kinases in motion: impact of protein and small molecule interactions on kinase conformations
    2024 · eLife
85. KIF18A is a novel target of JNK1/c-Jun signaling pathway involved in tumorigenesis
    Yajie Wang, Siqi Yu, Baihai Huang, Bowen Zhou, Xinyue Wu, Xiaoying Lian, Lianpu Wen, Changjun Zhu · 2024 · Research Square
86. Steady State and Time‐Dependent Fluorescent Peptide Assays for Protein Kinases
    Rachel M. Sammons, Ashwini K. Devkota, Tamer Saad Kaoud, Mangalika Warthaka, Eun Jeong Cho, Kevin N. Dalby · 2024 · Current Protocols
87. Proteinlerin Posttranslasyonel Modifikasyonları
    Nadir Gül · 2023 · Akademisyen Kitabevi eBooks
88. Additional file 3 of Multi-omics analysis identifies drivers of protein phosphorylation
    Tian Zhang, Gregory R. Keele, Isabela Gerdes Gyuricza, Matthew J. Vincent, Catherine Brunton, Timothy A. Bell, Pablo Hock, Ginger D. Shaw, Steven C. Munger, Fernando Pardo‐Manuel de Villena et al. · 2023 · Figshare
89. Additional file 4 of Multi-omics analysis identifies drivers of protein phosphorylation
    Tian Zhang, Gregory R. Keele, Isabela Gerdes Gyuricza, Matthew J. Vincent, Catherine Brunton, Timothy A. Bell, Pablo Hock, Ginger D. Shaw, Steven C. Munger, Fernando Pardo‐Manuel de Villena et al. · 2023 · Figshare
90. Additional file 6 of Multi-omics analysis identifies drivers of protein phosphorylation
    Tian Zhang, Gregory R. Keele, Isabela Gerdes Gyuricza, Matthew J. Vincent, Catherine Brunton, Timothy A. Bell, Pablo Hock, Ginger D. Shaw, Steven C. Munger, Fernando Pardo‐Manuel de Villena et al. · 2023 · Figshare
91. Additional file 5 of Multi-omics analysis identifies drivers of protein phosphorylation
    Tian Zhang, Gregory R. Keele, Isabela Gerdes Gyuricza, Matthew J. Vincent, Catherine Brunton, Timothy A. Bell, Pablo Hock, Ginger D. Shaw, Steven C. Munger, Fernando Pardo‐Manuel de Villena et al. · 2023 · Figshare
92. Additional file 2 of Multi-omics analysis identifies drivers of protein phosphorylation
    Tian Zhang, Gregory R. Keele, Isabela Gerdes Gyuricza, Matthew J. Vincent, Catherine Brunton, Timothy A. Bell, Pablo Hock, Ginger D. Shaw, Steven C. Munger, Fernando Pardo‐Manuel de Villena et al. · 2023 · Figshare
93. Inhibitors of CK2 Kinase for the Treatment of Gliomas and Other Brain Tumors
    Emanuela B. Pucko, Robert P. Ostrowski · 2024 · Acta Poloniae Pharmaceutica - Drug Research
94. Chemical Coverage of the Human Reactome
    Haejin Angela Kwak, Lihua Liu, Claudia Tredup, Sandra Röhm, Panagiotis Prinos, Jark Böttcher, Matthieu Schapira · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
95. Leveraging Machine Learning and AlphaFold2 Steering to Discover State-Specific Inhibitors Across the Kinome
    Francesco Trozzi, Oanh Tran, Carmen Al Masri, Shu-Hang Lin, Balaguru Ravikumar, Rayees Rahman · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
96. Mechanistic studies and therapeutic potential of angiopoietin in head and neck tumor angiogenesis
    Xiaojuan Zhong, Yujie Fei, Haihui Zhao, Jiao Chen, Mingyu Gao, Yi Huang, Wei Fei · 2025 · Frontiers in Oncology
97. Ab Initio Exploration of the Phosphoryl Transfer Reaction Provides Insights into Interpreting Models of SN2 Mechanisms
    Robert F. Spaine, Fei Wang, Kenneth W. Foreman, Lee A. Solomon · 2025 · The Journal of Physical Chemistry C
98. Comprehensively Testing the Function of Missense Variation in the STK11 Tumour Suppressor
    Daniel Zimmerman, Atina G. Coté, Warren van Loggerenberg, Marinella Gebbia, Nishka Kishore, Jochen Weile, Roujia Li, Chloe Reno, Ashley P.L. Marsh, Felicia Hernandez et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
99. Integrating machine learning and single-cell sequencing to reveal the role of kinase-related genes in subtype classification and prognostic significance of lung squamous cell carcinoma
    Yan Lv, Zhihan Xiao, Xu Zhan, Xinji Liu, Wei Tang, Qihang Sun, Qi Wang, Ruijie Zhang, Wei Ping, Ni Zhang · 2026 · Discover Oncology
100. Master Orchestrators of Cellular Regulation: Advances in Protein Kinase Inhibitors for Therapeutic Intervention
     Hena Khanam, Ayaz Mahmood Dar, Bashir Ahmad Dar · 2025 · Arabian Journal for Science and Engineering