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Cited by 1,685

The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.

Synonymous but not the same: the causes and consequences of codon bias

Open access
Plotkin, Joshua B., Kudla, Grzegorz·2011·Nature Reviews Genetics

Abstract

Despite their name, synonymous mutations have significant consequences for cellular processes in all taxa. As a result, an understanding of codon bias is central to fields as diverse as molecular evolution and biotechnology. Although recent advances in sequencing and synthetic biology have helped to resolve longstanding questions about codon bias, they have also uncovered striking patterns that suggest new hypotheses about protein synthesis. Ongoing work to quantify the dynamics of initiation and elongation is as important for understanding natural synonymous variation as it is for designing transgenes in applied contexts.

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Metadata

Authors
Plotkin, J. B., & Kudla, G.
Venue
Nature Reviews Genetics
Published
2010-11-23
Volume
12
Issue
1
Pages
32-42
ISSN
  • 1471-0056 (ISSN-L)
  • 1471-0064
OpenAlex
W2066829062
Cited by
1,685
References
21
FWCI
4.06
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Synonymous but not the same: the causes and consequences of codon bias. https://app.cochat.ai/papers/10.1038/nrg2899
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Plotkin, J. B., & Kudla, G. (2011). Synonymous but not the same: the causes and consequences of codon bias. Nature Reviews Genetics. https://doi.org/10.1038/nrg2899

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