Assessing pleiotropy and its evolutionary consequences: pleiotropy is not necessarily limited, nor need it hinder the evolution of complexity
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Prior work using model organism knockouts indicated that risk loci affecting multiple disorders might be subject to stronger selection than those affecting one disorder.
“Previous studies of model organisms using gene knock-out experiments suggested that pleiotropic risk loci may undergo stronger selection than non-pleiotropic loci (Hill and Zhang, 2012).”
From Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders (2019) · cites this paper as Hill and Zhang, 2012
Cited by
Sorted by citations
Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders
Lee, P. H., Anttila, V., Won, H., Feng, Y.-C. A., Rosenthal, J., Zhu, Z., Tucker-Drob, E. M., Nivard, M. G., Grotzinger, A. D., Posthuma, D., et al. (2019) · Cell · doi:10.1016/j.cell.2019.11.020 · Cited by 1,381 · see citing works
“…loci in neuronal cells was also associated with the degree of pleiotropy, as highlighted in Figure 5D. Previous studies of model organisms using gene knock-out experiments suggested that pleiotropic risk loci may undergo stronger selection than non-pleiotropic loci (Hill and Zhang, 2012).”
ResultHemani, G., Bowden, J., Haycock, P., Zheng, J., Davis, O., Flach, P., Gaunt, T., & Smith, G. D. (2017) · doi:10.1101/173682 · Cited by 85 · see citing works
- Authors
- Hill, W. G., & Zhang, X.-S.
- Affiliations
- University of Edinburgh (GB)
- Health Protection Agency (GB)
- Corresponding author
- Hill, William G.
- Venue
- Nature Reviews Genetics
- Published
- 2012-02-21
- Volume
- 13
- Issue
- 4
- Pages
- 296-296
- ISSN
- 1471-0056 (ISSN-L)
- 1471-0064
- OpenAlex
- W1977824824
- Cited by
- 46
- References
- 0
- Citations by year
- 2026: 1 · 2025: 2 · 2023: 5 · 2022: 2 · 2021: 4 · 2020: 2 · 2019: 7 · 2018: 3 · 2017: 6 · 2016: 1 · 2015: 2 · 2014: 5 · 2013: 3 · 2012: 3
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Nature Reviews Genetics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Physical Sciences › Mathematics › Geometry and Topology › Morphological variations and asymmetry
- Social Sciences › Arts and Humanities › History and Philosophy of Science › Philosophy and History of Science
- Keywords
- pleiotropy, genotype-phenotype mapping, evolvability, evolution of complexity, quantitative genetic variation, fitness landscape
- MeSH terms
- Animals, Female, Humans, Male, Evolution, Molecular, Genetic Association Studies, Genetic Pleiotropy
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
