Genetic contributions to behavioural diversity at the gene-environment interface
Abstract
Recent work on behavioural variation within and between species has furthered our understanding of the genetic architecture of behavioural traits, the identities of relevant genes and the ways in which genetic variants affect neuronal circuits to modify behaviour. Here we review our understanding of the genetics of natural behavioural variation in non-human animals and highlight the implications of these findings for human genetics. We suggest that gene-environment interactions are central to natural genetic variation in behaviour and that genes affecting neuromodulatory pathways and sensory processing are preferred sites of naturally occurring mutations.
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Variation in gene expression mediated by cis-regulatory elements plays an important role in evolutionary phenotypic change.
“Variation in gene expression mediated by cis-REs plays an important role in evolutionary phenotypic change (32, 42–46).”
From Variation in the Oxytocin Receptor Gene Predicts Brain Region–Specific Expression and Social Attachment (2016) · cites this paper as [42]
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References 153 · Cited by 103
- Authors
- Bendesky, A., & Bargmann, C. I.
- Affiliations
- Howard Hughes Medical Institute (US)
- Corresponding author
- Bargmann, Cornelia I.
- Venue
- Nature Reviews Genetics
- Published
- 2011-11-08
- Volume
- 12
- Issue
- 12
- Pages
- 809-820
- ISSN
- 1471-0056 (ISSN-L)
- 1471-0064
- OpenAlex
- W2015944340
- Cited by
- 103
- References
- 153
- Citations by year
- 2026: 4 · 2025: 9 · 2024: 6 · 2023: 2 · 2022: 7 · 2021: 4 · 2020: 11 · 2019: 6 · 2018: 6 · 2017: 12 · 2016: 5 · 2015: 8 · 2014: 5 · 2013: 10 · 2012: 8
- FWCI
- 0.70
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Genetics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Animal Behavior and Reproduction
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- behavioral diversity, gene-environment interaction, common genetic variants, natural genetic variation, sensory processing, neural circuits, non-human animals, human genetics, genetic mutations
- MeSH terms
- Animals, Disease Models, Animal, Biological Evolution, Gene Expression Regulation, Genetics, Behavioral, Humans, Genetic Linkage, Phenotype, Behavioral Research, Quantitative Trait Loci, Gene-Environment Interaction
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