Understanding type 1 diabetes through genetics: advances and prospects

Polychronakos, Constantin, Li, Quan·2011·Nature Reviews Genetics

DOI 10.1038/nrg3069

Cited by (226)

Items 101–200 of 226

Monogenic Causes in the Type 1 Diabetes Genetics Consortium Cohort: Low Genetic Risk for Autoimmunity in Case Selection
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Resting-state functional MR imaging shed insights into the brain of diabetes
Yun Fei Wang, Xue Man Ji, Guangming Lu, Long Jiang Zhang · 2016 · Metabolic Brain Disease
The common, autoimmunity-predisposing 620Arg > Trp variant of PTPN22 modulates macrophage function and morphology
Meihang Li, Hugues Beauchemin, Natalija Popović, Alan C. Peterson, Eva B. d'Hennezel, Ciriaco A. Piccirillo, Chao Sun, Constantin Polychronakos · 2017 · Journal of Autoimmunity
Understanding childhood diabetes mellitus: new pathophysiological aspects
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Resolving the Variable Genome and Epigenome in Human Disease
Julian Charles Knight · 2012 · Journal of Internal Medicine
GWAS to Identify SNPs Associated with Common Diseases and Individual Risk: Genome Wide Association Studies (GWAS) to Identify SNPs Associated with Common Diseases and Individual Risk
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Measuring anti-islet autoimmunity in mouse and human by profiling peripheral blood antigen-specific CD4 T cells
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Lessons from Type 1 Diabetes for Understanding Natural History and Prevention of Autoimmune Disease
Kimber M. Simmons, Aaron W. Michels · 2014 · Rheumatic Disease Clinics of North America
Identification of a Multi–Long Noncoding RNA Signature for the Diagnosis of Type 1 Diabetes Mellitus
Guannan Geng, Zicheng Zhang, Liang Cheng · 2020 · Frontiers in Bioengineering and Biotechnology
Relationships between emissions of toxic airborne molecules and type 1 diabetes incidence in children: An ecologic study
Agostino Di Ciaula, Piero Portincasa · 2021 · World Journal of Diabetes
Statistical models and computational tools for predicting complex traits and diseases
Wonil Chung · 2021 · Genomics & Informatics
Co-Morbidity between Early-Onset Leukemia and Type 1 Diabetes – Suggestive of a Shared Viral Etiology?
Kari Hemminki, Richard S. Houlston, Jan Sundquist, Kristina Sundquist, Xiaochen Shu · 2012 · PLoS ONE
Diubiquitin (Ubd) is a susceptibility gene for virus-triggered autoimmune diabetes in rats
Laura Cort, M Habib, Ryan A. Eberwine, Martin J. Hessner, John P. Mordes, Elizabeth P. Blankenhorn · 2014 · Genes and Immunity
Toward Precision Medicine with Human Pluripotent Stem Cells for Diabetes
Bushra Memon, Essam Mohamed Abdelalim · 2022 · Stem Cells Translational Medicine
Advanced Delivery Strategies for Immunotherapy in Type I Diabetes Mellitus
Mingshu Huang, Weixing Chen, Min Wang, Yisheng Huang, Hongyu Liu, Yue Ming, Yuanxin Chen, Zhengming Tang, Bo Jia · 2023 · BioDrugs
New Insights and Biomarkers for Type 1 Diabetes: Review for Scandinavian Journal of Immunology
Mirkka T Heinonen, Robert Moulder, Riitta Lahesmaa · 2015 · Scandinavian Journal of Immunology
Insights into non-autoimmune type 1 diabetes with 13 novel loci in low polygenic risk score patients
Jingchun Qu, Hui‐Qi Qu, Jonathan P. Bradfield, Joseph Glessner, Xiao Chang, Lifeng Tian, Michael March, John J. Connolly, Jeffrey D. Roizen, Patrick M. Abou‐Sleiman et al. · 2021 · Scientific Reports
HLA-DRB1 and –DQB1 Alleles, Haplotypes and Genotypes in Emirati Patients with Type 1 Diabetes Underscores the Benefits of Evaluating Understudied Populations
Zain Al Yafei, Steven J. Mack, Marion S. Alvares, Bassam R. Ali, Bachar O. Afandi, Salem Beshyah, Charu Sharma, Wael Mohammed Osman, Rajaa A. Mirghani, Amre Nasr et al. · 2022 · Frontiers in Genetics
Novel Biomarkers in Type 1 Diabetes
Yulan Jin, Jin‐Xiong She · 2012 · The Review of Diabetic Studies
The Missing Heritability in T1D and Potential New Targets for Prevention
Brian G. Pierce, Ryan A. Eberwine, Janelle Annette Noble, Michael Habib, Hennady P. Shulha, Zhiping Weng, Elizabeth P. Blankenhorn, John P. Mordes · 2013 · Journal of Diabetes Research
Orally efficacious novel small molecule 6-chloro-6-deoxy-1,2,3,4-tetra-O-galloyl-α-d-glucopyranose selectively and potently stimulates insulin receptor and alleviates diabetes
Yanyan Cao, Yunsheng Li, Jae Kyung Kim, Yulin Ren, Klaus B. Himmeldirk, Yi Liu, Yanrong Qian, Fengming Liu, Xiaozhuo Chen · 2013 · Journal of Molecular Endocrinology
Childhood and Adolescent Onset Type 1 Diabetes in India
Anandakumar Amutha, Kalpana Thai, Viswanathan Mohan · 2013 · MGM Journal of Medical Sciences
The progress and potential of proteomic biomarkers for type 1 diabetes in children
Robert Moulder, Santosh Dilip Bhosale, Riitta Lahesmaa, David R. Goodlett · 2016 · Expert Review of Proteomics
The surprising implications of familial association in disease risk
Morten Valberg, Mats Julius Stensrud, Odd O. Aalen · 2018 · BMC Public Health
Genetic Architecture of Type 2 Diabetes
Rashmi B. Prasad, Leif Groop · 2016 · Wiley eBooks
CD5 levels reveal distinct basal T‐cell receptor signals in T cells from non‐obese diabetic mice
Mengqi Dong, Cindy Audiger, Adeolu Adegoke, Marie‐Ève Lebel, Stefanie F. Valbon, Colin C. Anderson, Heather J. Melichar, Sylvie Lesage · 2021 · Immunology and Cell Biology
Association between Air Pollutant Emissions and Type 1 Diabetes Incidence in European Countries
Agostino Di Ciaula · 2014 · Advances in Research
Somatic Mutations and Autoimmunity
Maha Alriyami, Constantin Polychronakos · 2021 · Cells
Cytotoxic T-lymphocyte-associated protein 4 +49A/G polymorphisms contribute to the risk of type 1 diabetes in children: An updated systematic review and meta-analysis with trial sequential analysis
Bo Wang, Wei Dong Du, Yutao Jia, Xiaobai Zhang, Guorui Ma · 2017 · Oncotarget
Wellness and Health Omics Linked to the Environment: The WHOLE Approach to Personalized Medicine
Greg C. Gibson · 2013 · Advances in experimental medicine and biology
C1858T Polymorphism of Protein Tyrosine Phosphatase Non-receptor Type 22 (PTPN22): an eligible target for prevention of type 1 diabetes?
Giovanni Prezioso, Laura Comegna, Concetta Di Giulio, Simone Franchini, Francesco Chiarelli, Annalisa Blasetti · 2016 · Expert Review of Clinical Immunology
Immunotherapies and immune biomarkers in Type 1 diabetes: A partnership for success
Niels V. Rekers, Matthias G. von Herrath, Johnna D. Wesley · 2015 · Clinical Immunology
Translational implications of the β-cell epigenome in diabetes mellitus
Justin S. Johnson, Carmella Evans‐Molina · 2014 · Translational research
Pedigree-Defined Haplotypes and Their Applications to Genetic Studies
Chester A. Alper, Charles E. Larsen · 2017 · Methods in molecular biology
Population-based prevalence of self-reported pediatric diabetes and screening for undiagnosed type 2 diabetes in Chinese children in years 2017–2019, a cross-sectional study
Wei Wu, Jianwei Zhang, Yangxi Li, Ke Huang, Ruimin Chen, Mireguli Maimaiti, Jingsi Luo, Shao-Ke Chen, Di Wu, Min Zhu et al. · 2024 · The Lancet Regional Health - Western Pacific
Pluripotent Stem Cell-Derived Pancreatic β-Cells: Potential for Regenerative Medicine in Diabetes
Der-I Kao, Shuibing Chen · 2012 · Regenerative Medicine
Metabolic adaptation orchestrates tissue context‐dependent behavior in regulatory T cells
Haiping Wang, Chun‐Hao Lu, Ping‐Chih Ho · 2020 · Immunological Reviews
HLA class II susceptibility pattern for type 1 diabetes (T1D) in an Iranian population
Javad Kiani, Mehrdad Hajilooi, Daniel E Furst, Hamzeh Rezaei, S. Shahryari‐Hesami, S. Kowsarifard, Alireza Zamani, Ghasem Solgi · 2015 · International Journal of Immunogenetics
Reactivated CD4+Tm Cells of T1D Patients and Siblings Display an Exaggerated Effector Phenotype With Heightened Sensitivity to Activation-Induced Cell Death
Michael Lei Bian, Oscar L. Haigh, David J. Munster, Mark Anglin Harris, Andrew M. Cotterill, John J. Miles, Slavica Vučković · 2014 · Diabetes
Unveiling nanoscale optical signatures of cytokine-induced β-cell dysfunction
Licia Anna Pugliese, Valentina De Lorenzi, Mario Bernardi, Samuele Ghignoli, Marta Tesi, Piero Marchetti, Luca Pesce, Francesco Cardarelli · 2023 · Scientific Reports
Estimating heritability of drug-induced liver injury from common variants and implications for future study designs
Casey Lynnette Overby, George M. Hripcsak, Yufeng Shen · 2014 · Scientific Reports
Sleeping BeautyTransposon Mutagenesis as a Tool for Gene Discovery in the NOD Mouse Model of Type 1 Diabetes
Colleen M. Elso, Edward Po-Fan Chu, May A. Alsayb, Leanne Mackin, Sean T. Ivory, Michelle P. Ashton, Stefan Bröer, Pablo A. Silveira, Thomas C. Brodnicki · 2015 · G3 Genes Genomes Genetics
Collective Genetic Interaction Effects and the Role of Antigen-Presenting Cells in Autoimmune Diseases
Hyung Jun Woo, Chenggang Yu, Jaques Reifman A · 2017 · PLoS ONE
CD11a/ICAM‐1 blockade combined with IL‐2 targeting therapy causes a paradoxical acceleration of type 1 diabetes
Ekua Brenu, T Bartley, Casey Maree Wright, Emma E. Hamilton‐Williams · 2017 · Immunology and Cell Biology
Rethinking Ovarian Cancer Genomics: where Genome-Wide Association Studies Stand?
Ricardo Pinto, Joana Assis, Augusto Nogueira, Carina Pereira, Deolinda Pereira, Rui Medeiros · 2017 · Pharmacogenomics
Genetics of canine diabetes mellitus part 2: Current understanding and future directions
Alice L. Denyer, Briän Catchpole, Lucy J. Davison · 2021 · The Veterinary Journal
Maintenance of peripheral tolerance to islet antigens.
E. Hamilton-Williams, A. Bergot, Peta L. S. Reeves, R. Steptoe · 2016 · Journal of Autoimmunity
Classic Type 1 Diabetes Mellitus and Fulminant Type 1 Diabetes Mellitus: Similarity and Discrepancy of Immunological Characteristics and Cytokine Profile
Lingwen Ying, Yong Zhang, Jun Yin, Yufei Wang, Wei Lu, Wei Zhu, Yuqian Bao, Jian Zhou · 2021 · Diabetes Metabolic Syndrome and Obesity
Genome-wide association study of the age of onset of type 1 diabetes reveals HTATIP2 as a novel T cell regulator
Christopher J. Cardinale, Xiao Chang, Zhi Wei, Hui‐Qi Qu, Jonathan P. Bradfield, Constantin Polychronakos, Hakon H. Hakonarson · 2023 · Frontiers in Immunology
Circulating hsa-miR-320a and its regulatory network in type 1 diabetes mellitus
Rasheeba Nizam, Md. Zubbair Malik, Sindhu P. Jacob, Osama A Alsmadi, Heikki A. Koistinen, Jaakko O. Tuomilehto, Hessa Alkandari, Fahd Al‐Mulla, Thangavel Alphonse Thanaraj · 2024 · Frontiers in Immunology
Islet cells in human type 1 diabetes: from recent advances to novel therapies – a symposium-based roadmap for future research
James Cantley, Decio Laks Eizirik, Esther Latres, Colin Mark Dayan, _ _ · 2023 · Journal of Endocrinology
Yeast one-hybrid screen of a thymus epithelial library identifies ZBTB7A as a regulator of thymic insulin expression
Julien R. St-Jean, Houria Ounissi‐Benkalha, Constantin Polychronakos · 2013 · Molecular Immunology
Association between the Rs3087243 polymorphism and risk for diabetes: a meta-analysis
Jun Liu, H.-X. Zhang · 2013 · Genetics and Molecular Research
Microbiota derived factors as drivers of type 1 diabetes
Bree J. Tillett, Emma E. Hamilton‐Williams · 2020 · Progress in molecular biology and translational science
Making the Most of Major Histocompatibility Complex Molecule Multimers: Applications in Type 1 Diabetes
Greg S. Gojanovich, Paul R. Hess · 2012 · Clinical and Developmental Immunology
Modulation of autoimmune diabetes by N-ethyl-N-nitrosourea- induced mutations in non-obese diabetic mice
Lucienne Chatenoud, Cindy Marquet, Fabrice Valette, Lindsay Scott, Jiexia Quan, Chun Hui Bu, Sara Hildebrand, Eva Marie Y. Moresco, Jean‐François Bach, Bruce Beutler · 2022 · Disease Models & Mechanisms
The MHC Class II Antigen-Processing and Presentation Pathway Is Dysregulated in Type 1 Diabetes
Ambroise Gilles, Lan Hu, Francesca Virdis, Derek B. Sant’Angelo, Nevenka Dimitrova, Joseph A. Hedrick, Lisa K. Denzin · 2023 · The Journal of Immunology
Bayesian Determination of Disease Associated Differences in Haplotype Blocks
Siti Siti · 2012 · Current Research in Bioinformatics
Hunting Autoimmune Disease Genes in NOD: Early Steps on a Long Road to Somewhere Important (Hopefully)
Edward K. Wakeland · 2014 · The Journal of Immunology
Critical Issues in Genetic Association Studies
Elizabeth C. Prom‐Wormley, Amy E. Adkins, Irwin D. Waldman, Danielle M. Dick · 2017 · Wiley eBooks
Rodent Models for Investigating the Dysregulation of Immune Responses in Type 1 Diabetes
Feng‐Cheng Chou, Heng-Yi Chen, Shyi‐Jou Chen, Mei-Cho Fang, Huey‐Kang Sytwu · 2013 · Journal of Diabetes Research
Definition, Diagnostic Criteria, Screening, Diagnosis, and Classification of Diabetes and Categories of Glucose Intolerance
Lakshmana Perumal Nandhini, Sadishkumar Kamalanathan, Jayaprakash Sahoo · 2019 · Springer eBooks
A Role for lncRNAs in Regulating Inflammatory and Autoimmune Responses Underlying Type 1 Diabetes
Thomas C. Brodnicki · 2022 · Advances in experimental medicine and biology
Identification of genetic variants that impact gene co-expression relationships using large-scale single-cell data
Shuang� Li, Katharina Schmid, Dylan H. de Vries, Maryna Korshevniuk, Roy Oelen, Irene V. van Blokland, Hilde E. Groot, Morris A. Swertz, Pim van der Harst, Harm-Jan Westra et al. · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
Significantly association of diabetes mellitus with CTLA-4 gene polymorphisms based on a meta-analysis of epidemiological evidence in Asians and non-Asians
Jun Liu, H.X. Zhang, Guo Feng, Lin He · 2013 · Genetics and Molecular Research
Evidence of genetic epistasis in autoimmune diabetes susceptibility revealed by mouse congenic sublines
Roxanne Collin, Véronique Dugas, Adam‐Nicolas Pelletier, Geneviève Chabot‐Roy, Sylvie Lesage · 2021 · Immunogenetics
Advanced glycation end products (AGEs) in diabetic patients with Systemic Lupus Erythematosus.
Fatma Hussain, M. A. Sheikh, Muhammad Arif Maan, Amer Jamil · 2012 · International Journal of Agriculture and Biology
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Pieter-Jan Martens, Conny A. Gysemans, Chantal Mathieu · 2023 · Elsevier eBooks
Familial risks in understanding type 1 diabetes genetics
Kari Hemminki · 2012 · Nature Reviews Genetics
Clonal copy-number mosaicism in autoreactive T lymphocytes in diabetic NOD mice
Maha Alriyami, Luc Marchand, Li Quan, Xiaoyu Du, Martin Olivier, Constantin Polychronakos · 2019 · Genome Research
The Regulation of Mammalian Target of Rapamycin
Jianling Xie · 2012 · Figshare
Study of the association between alleles of the growth hormone receptor and prolactin receptor genes of bulls and the milk productivity of their daughters
Michael Grigorievich Smaragdov · 2012 · Russian Journal of Genetics
Update on Genetic Determinants of Type1 Diabetes
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VDR Gene Haplotypes Associate with Type 1 Diabetes and Suggest Interaction with HLA, IL2RA and CTLA4 loci in Colombian Families
Nicolás Pineda-Trujillo · 2018 · Current Research in Diabetes & Obesity Journal
Immunotherapy for Diabetogenic Pancreatitis and Pancreatic Cancer: An Update
Sathish Kumar Mungamuri, Anil Kumar Pasupulati, Vijay Aditya Mavuduru · 2019 · Springer eBooks
Microbiome and Cellular Players in Type 1 Diabetes: From Pathogenesis to Protection
Darshan Badal, Mahinder Paul, Neenu Jacob, Naresh Kumar Sachdeva · 2020 · Springer eBooks
Establishment of three human induced pluripotent stem cell lines from a type 1 diabetic family harboring sequence variants associated with autoimmunity
Edward Po-Fan Chu, Chia-Hung Lin, Candy Hsin-Hua Cho, I‐Fen Cheng, Tzu-Chien Kuo, Ruei-Ying Chen, Chia-Nan Liao, Jen-Chien Cheng, Jason Tsai, Po‐Chuan Wang et al. · 2020 · Stem Cell Research
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A. Aubin, Daria Vdovenko, Roxanne Collin, Lois A. Balmer, Lise Coderre, Grant Morahan, Félix Lombard‐Vadnais, Sylvie Lesage · 2024 · Immunology and Cell Biology
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Licia Anna Pugliese, Valentina De Lorenzi, Mario Bernardi, Samuele Ghignoli, Marta Tesi, Piero Marchetti, Francesco Cardarelli, Luca Pesce · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
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Özkan Aydemir, Jeffrey A. Bailey, Daniel Agardh, Åke Lernmark, Janelle Annette Noble, Agnes Andersson Svärd, Elizabeth P. Blankenhorn, Hemang M. Parikh, Anette‐Gabriele Ziegler, Jorma Toppari et al. · 2023 · eLife
Polymorphisms in Intron 1 of HLA-DRA Differentially Associate with Type 1 Diabetes and Celiac Disease and Implicate Involvement of Complement System Genes C4A and C4B
Özkan Aydemir, Jeffrey A. Bailey, Daniel Agardh, Åke Lernmark, Janelle Annette Noble, Agnes Andersson Svärd, Elizabeth P. Blankenhorn, Hemang M. Parikh, Anette‐Gabriele Ziegler, Jorma Toppari et al. · 2023 · eLife
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Felipe Leal Valentim, Océane Konza, A. Ortiz Velasquez, Ahmed Saadawi, Nidhiben Patel, Roberta Lorenzon, Nicolas Tchitchek, Encarnita Mariotti‐Ferrandiz, David Klatzmann, Adrien Six · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
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Identificação de cascatas gênicas com base na modulação transcricional de células sanguíneas mononucleares periféricas de pacientes com diabetes mellitus do tipo 1
Thaís Arns · 2013 · Digital Library of Theses and Dissertations (Universidade de São Paulo)
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Natacha Bouhours‐Nouet, R. Coutant · 2011 · EMC - Pediatría
Response to 'Familial risks in understanding type 1 diabetes genetics'
Constantin Polychronakos, Quan Li · 2012 · Nature Reviews Genetics
Similaridades entre o Transcriptoma Humano e Murino Focando Genes Situados em Regiões de Susceptibilidade ao Diabetes mellitus do Tipo 1
Renata dos Santos Almeida · 2012 · Digital Library of Theses and Dissertations (Universidade de São Paulo)
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SERUM IMMUNOGLOBULIN LEVELS IN TYPE 2 DIABETIC PATIENTS IN KORLE-BU TEACHING HOSPITAL, GHANA
Collins Paa Kwesi Botchey · 2014
Stress-inducible Mig6 promotes pancreatic beta cell destruction in the pathogenesis of diabetes
Yi‐Chun Chen · 2014
Magnetic resonance imaging of pancreatic islets transplantation
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The Roles of Iddm30 and Iddm24 in the Immunopathogenesis of Type 1 Diabetes in BioBreeding Rats
Ying-Chieh Gary Chao · 2015 · TSpace (University of Toronto)
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Justin S. A. Perry · 2016 · Open Scholarship Institutional Repository (Washington University in St. Louis)
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Linda Åkerman · 2016 · Linköping University medical dissertations
Differential Expression of MiR-18b in PBMC from T1D Patients in Isfahan population
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