Understanding type 1 diabetes through genetics: advances and prospects

Finding the missing heritability of complex diseases

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Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses

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Projection of an Immunological Self Shadow Within the Thymus by the Aire Protein

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Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease

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HLA-DQβ gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus

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Incidence trends for childhood type 1 diabetes in Europe during 1989-2003 and predicted new cases 2005-20: a multicentre prospective registration study

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Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes

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Genome structural variation discovery and genotyping

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Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes

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A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes

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A genome-wide search for human type 1 diabetes susceptibility genes

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An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains

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Rare Variants of <i>IFIH1</i> , a Gene Implicated in Antiviral Responses, Protect Against Type 1 Diabetes

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A genome-wide association study of global gene expression

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The insulin gene is transcribed in the human thymus and transcription levels correlate with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes

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Mapping the Genetic Architecture of Gene Expression in Human Liver

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Worldwide increase in incidence of Type I diabetes - the analysis of the data on published incidence trends

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Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice

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Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus

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Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls

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HLA DR-DQ Haplotypes and Genotypes and Type 1 Diabetes Risk

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Common Regulatory Variation Impacts Gene Expression in a Cell Type–Dependent Manner

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A Polymorphic Locus Near the Human Insulin Gene Is Associated with Insulin-dependent Diabetes Melliitus

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A CENTRAL ROLE FOR CENTRAL TOLERANCE

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Autoimmune-associated lymphoid tyrosine phosphatase is a gain-of-function variant

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A genome-wide association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the interferon-induced helicase (IFIH1) region

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Analysis of Families in the Multiple Autoimmune Disease Genetics Consortium (MADGC) Collection: the PTPN22 620W Allele Associates with Multiple Autoimmune Phenotypes

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Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A

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Detecting shared pathogenesis from the shared genetics of immune-related diseases

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Assessing the role of HLA-linked and unlinked determinants of disease.

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A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene

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Promise and pitfalls of the Immunochip

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Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes

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Variant of TYR and Autoimmunity Susceptibility Loci in Generalized Vitiligo

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Expanded T cells from pancreatic lymph nodes of type 1 diabetic subjects recognize an insulin epitope

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What can exome sequencing do for you?

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Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity

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CTLs are targeted to kill β cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope

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Meta-Analysis of Genome-Wide Association Studies in Celiac Disease and Rheumatoid Arthritis Identifies Fourteen Non-HLA Shared Loci

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Concordance for islet autoimmunity among monozygotic twins

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Localization of a Type 1 Diabetes Locus in the IL2RA/CD25 Region by Use of Tag Single-Nucleotide Polymorphisms

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A Genome-Wide Meta-Analysis of Six Type 1 Diabetes Cohorts Identifies Multiple Associated Loci

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A Common Autoimmunity Predisposing Signal Peptide Variant of the Cytotoxic T-lymphocyte Antigen 4 Results in Inefficient Glycosylation of the Susceptibility Allele

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A trans-acting locus regulates an anti-viral expression network and type 1 diabetes risk

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Cell-specific protein phenotypes for the autoimmune locus IL2RA using a genotype-selectable human bioresource

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The geoepidemiology of type 1 diabetes

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Susceptibility to insulin dependent diabetes mellitus maps to a 4.1 kb segment of DNA spanning the insulin gene and associated VNTR

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Insulin Expression Levels in the Thymus Modulate Insulin-Specific Autoreactive T-Cell Tolerance

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A Structural Framework for Deciphering the Link Between I-A g7 and Autoimmune Diabetes

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Prediction and Interaction in Complex Disease Genetics: Experience in Type 1 Diabetes

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Geographic Patterns of Childhood Insulin-Dependent Diabetes Mellitus

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Regulatory T Cells: History and Perspective

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Acceleration of type 1 diabetes mellitus in proinsulin 2–deficient NOD mice

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Remapping the Insulin Gene/IDDM2 Locus in Type 1 Diabetes

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Lymphopenia in the BB Rat Model of Type 1 Diabetes is Due to a Mutation in a Novel Immune-Associated Nucleotide (Ian)-Related GenePreprint

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Simultaneous Detection of Circulating Autoreactive CD8+ T-Cells Specific for Different Islet Cell–Associated Epitopes Using Combinatorial MHC Multimers

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Lymphotoxin pathway directs thymic Aire expression

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Thymus‐specific deletion of insulin induces autoimmune diabetes

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Mouse models for the study of autoimmune type 1 diabetes: a NOD to similarities and differences to human disease

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Aire employs a histone-binding module to mediate immunological tolerance, linking chromatin regulation with organ-specific autoimmunity

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Regulation of ZAP-70 Activation and TCR Signaling by Two Related Proteins, Sts-1 and Sts-2

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Follow-Up Analysis of Genome-Wide Association Data Identifies Novel Loci for Type 1 Diabetes

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IFIH1 polymorphisms are significantly associated with type 1 diabetes and IFIH1 gene expression in peripheral blood mononuclear cells

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A Novel Susceptibility Locus for Type 1 Diabetes on Chr12q13 Identified by a Genome-Wide Association Study

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Structure, inhibitor, and regulatory mechanism of Lyp, a lymphoid-specific tyrosine phosphatase implicated in autoimmune diseases

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Confirmation of HLA class II independent type 1 diabetes associations in the major histocompatibility complex including HLA‐B and HLA‐A

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A Human Type 1 Diabetes Susceptibility Locus Maps to Chromosome 21q22.3

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A loss-of-function variant of PTPN22 is associated with reduced risk of systemic lupus erythematosus

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Imprinted and Genotype-specific Expression of Genes at the Locus in Pancreas and Leucocytes

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Statistical independence of the colocalized association signals for type 1 diabetes and RPS26 gene expression on chromosome 12q13

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Genome-Wide Scan for Linkage to Type 1 Diabetes in 2,496 Multiplex Families From the Type 1 Diabetes Genetics Consortium

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Lessons on autoimmune diabetes from animal models

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Autoimmune-associated PTPN22 R620W Variation Reduces Phosphorylation of Lymphoid Phosphatase on an Inhibitory Tyrosine Residue

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Toward Further Mapping of the Association Between the IL2RA Locus and Type 1 Diabetes

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PTPN22 Trp620 Explains the Association of Chromosome 1p13 With Type 1 Diabetes and Shows a Statistical Interaction With HLA Class II Genotypes

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Class III Alleles of the Variable Number of Tandem Repeat Insulin Polymorphism Associated with Silencing of Thymic Insulin Predispose to Type 1 Diabetes

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Use of Nonobese Diabetic Mice to Understand Human Type 1 Diabetes

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Increased incidence and prevalence of diabetes mellitus in Down's syndrome

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Sequence Requirements for Association of Protein-tyrosine Phosphatase PEP with the Src Homology 3 Domain of Inhibitory Tyrosine Protein Kinase p50

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