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Sex and the singular DM domain: insights into sexual regulation, evolution and plasticity
Open accessAbstract
Most animals reproduce sexually, but the genetic and molecular mechanisms that determine the eventual sex of each embryo vary remarkably. DM domain genes, which are related to the insect gene doublesex, are integral to sexual development and its evolution in many metazoans. Recent studies of DM domain genes reveal mechanisms by which new sexual dimorphisms have evolved in invertebrates and show that one gene, Dmrt1, was central to multiple evolutionary transitions between sex-determining mechanisms in vertebrates. In addition, Dmrt1 coordinates a surprising array of distinct cell fate decisions in the mammalian gonad and even guards against transdifferentiation of male cells into female cells in the adult testis.
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Cited by
Sex-specific pruning of neuronal synapses in Caenorhabditis elegans
Oren-Suissa, M., Bayer, E. A., & Hobert, O. (2016) · Nature · doi:10.1038/nature17977 · Cited by 121
The conserved sex regulator DMRT1 recruits SOX9 in sexual cell fate reprogramming
Lindeman, R. E., Murphy, M. W., Agrimson, K. S., Gewiss, R. L., Bardwell, V. J., Gearhart, M. D., & Zarkower, D. (2021) · Nucleic Acids Research · doi:10.1093/nar/gkab448 · Cited by 66
Self-citationCo-opting evo-devo concepts for new insights into mechanisms of behavioural diversity
Hoke, K. L., Adkins-Regan, E., Bass, A. H., McCune, A. R., & Wolfner, M. F. (2019) · Journal of Experimental Biology · doi:10.1242/jeb.190058 · Cited by 42
Migliano, A. B., Romero, I. G., Metspalu, M., Leavesley, M., Pagani, L., Antao, T., Huang, D.-W., Sherman, B. T., Siddle, K., Scholes, C., et al. (2013) · Human Biology · doi:10.1353/hub.2013.a530634 · Cited by 23
Metadata
- Authors
- Matson, C. K., & Zarkower, D.
- Venue
- Nature Reviews Genetics
- Published
- 2012-02-07
- Volume
- 13
- Issue
- 3
- Pages
- 163-174
- ISSN
- 1471-0056 (ISSN-L)
- 1471-0064
- OpenAlex
- W1979997225
- Cited by
- 410
- References
- 0
- FWCI
- 4.14
- Type
- journal article
- Language
- en
- Open access
- green
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