The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Evolution of the cancer genome
Open accessAbstract
The advent of massively parallel sequencing technologies has allowed the characterization of cancer genomes at an unprecedented resolution. Investigation of the mutational landscape of tumours is providing new insights into cancer genome evolution, laying bare the interplay of somatic mutation, adaptation of clones to their environment and natural selection. These studies have demonstrated the extent of the heterogeneity of cancer genomes, have allowed inferences to be made about the forces that act on nascent cancer clones as they evolve and have shown insight into the mutational processes that generate genetic variation. Here we review our emerging understanding of the dynamic evolution of the cancer genome and of the implications for basic cancer biology and the development of antitumour therapy.
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Cites
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Self-citation
Cited by
Detection of Circulating Tumor DNA in Early- and Late-Stage Human Malignancies
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The causes and consequences of genetic heterogeneity in cancer evolution
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Intratumor heterogeneity in human glioblastoma reflects cancer evolutionary dynamics
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Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia
Shlush, L. I., Zandi, S., Mitchell, A., Chen, W. C., Brandwein, J. M., Gupta, V., Kennedy, J. A., Schimmer, A. D., Schuh, A. C., Yee, K. W., et al. (2014) · Nature · doi:10.1038/nature13038 · Cited by 1,443
Metadata
- Authors
- Yates, L. R., & Campbell, P. J.
- Venue
- Nature Reviews Genetics
- Published
- 2012-10-09
- Volume
- 13
- Issue
- 11
- Pages
- 795-806
- ISSN
- 1471-0056 (ISSN-L)
- 1471-0064
- OpenAlex
- W2033666853
- Cited by
- 640
- References
- 30
- FWCI
- 3.05
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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