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RNA interference in the nucleus: roles for small RNAs in transcription, epigenetics and beyond

Open access
Castel, Stephane E., Martienssen, Robert A.·2013·Nature Reviews Genetics

Abstract

A growing number of functions are emerging for RNA interference (RNAi) in the nucleus, in addition to well-characterized roles in post-transcriptional gene silencing in the cytoplasm. Epigenetic modifications directed by small RNAs have been shown to cause transcriptional repression in plants, fungi and animals. Additionally, increasing evidence indicates that RNAi regulates transcription through interaction with transcriptional machinery. Nuclear small RNAs include small interfering RNAs (siRNAs) and PIWI-interacting RNAs (piRNAs) and are implicated in nuclear processes such as transposon regulation, heterochromatin formation, developmental gene regulation and genome stability.

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Metadata

Authors
Castel, S. E., & Martienssen, R. A.
Venue
Nature Reviews Genetics
Published
2013-01-18
Volume
14
Issue
2
Pages
100-112
ISSN
  • 1471-0056 (ISSN-L)
  • 1471-0064
OpenAlex
W2038720758
Cited by
976
References
3
FWCI
9.10
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: RNA interference in the nucleus: roles for small RNAs in transcription, epigenetics and beyond. https://app.cochat.ai/papers/10.1038/nrg3355
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Castel, S. E., & Martienssen, R. A. (2013). RNA interference in the nucleus: roles for small RNAs in transcription, epigenetics and beyond. Nature Reviews Genetics. https://doi.org/10.1038/nrg3355

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.