The DOI matches its Crossref record; 91 of the 91 references it cites were found in a registry or an index.
The heritability of human disease: estimation, uses and abuses.
Abstract
Relatives provide the basic material for the study of inheritance of human disease. However, the methodologies for the estimation of heritability and the interpretation of the results have been controversial. The debate arises from the plethora of methods used, the validity of the methodological assumptions and the inconsistent and sometimes erroneous genetic interpretations made. We will discuss how to estimate disease heritability, how to interpret it, how biases in heritability estimates arise and how heritability relates to other measures of familial disease aggregation.
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“In addition to providing exceptional statistical power, the study directly addresses the concern of lack of replication in research findings 31,32 replicating results across 5 countries and health systems.”
From Association of Genetic and Environmental Factors With Autism in a 5-Country Cohort (2019) · cites this paper as [32]
Citations
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Research works printed but not linked: 1
- Trimble, B. K. An Empirical Simulation of Quasi-Continuous Inheritance Using Human Birthweight Data. Thesis, McGill Univ. (1971).
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Association of Genetic and Environmental Factors With Autism in a 5-Country Cohort
Bai, D., Yip, B. H. K., Windham, G. C., Sourander, A., Francis, R., Yoffe, R., Glasson, E., Mahjani, B., Suominen, A., Leonard, H., et al. (2019) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2019.1411 · Cited by 683
Pitfalls of predicting complex traits from SNPs
Wray, N. R., Yang, J., Hayes, B. J., Price, A. L., Goddard, M. E., & Visscher, P. M. (2013) · Nature Reviews Genetics · doi:10.1038/nrg3457 · Cited by 690
Research Review: Polygenic methods and their application to psychiatric traits
Wray, N. R., Lee, S., Mehta, D., Vinkhuyzen, A. A. E., Dudbridge, F., & Middeldorp, C. M. (2014) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.12295 · Cited by 683
Hilker, R., Helenius, D., Fagerlund, B., Skytthe, A., Christensen, K., Werge, T. M., Nordentoft, M., & Glenthøj, B. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.08.017 · Cited by 615
Genetic architecture: the shape of the genetic contribution to human traits and disease
Timpson, N. J., Greenwood, C. M. T., Soranzo, N., Lawson, D. J., & Richards, J. B. (2018) · Nature Reviews Genetics · doi:10.1038/nrg.2017.101 · Cited by 434
Metadata
- Authors
- Tenesa, A., & Haley, C. S.
- Affiliations
- Roslin Institute (GB)
- Corresponding author
- Tenesa, Albert
- Venue
- Nature Reviews Genetics
- Published
- 2013-01-18
- Volume
- 14
- Issue
- 2
- Pages
- 139-149
- ISSN
- 1471-0056 (ISSN-L)
- 1471-0064
- OpenAlex
- W2040924786
- Cited by
- 283
- References
- 90
- Citations by year
- 2026: 10 · 2025: 13 · 2024: 13 · 2023: 15 · 2022: 20 · 2021: 24 · 2020: 22 · 2019: 30 · 2018: 35 · 2017: 20 · 2016: 23 · 2015: 27 · 2014: 22 · 2013: 9
- FWCI
- 3.27
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Genetics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Cancer Research UK (C12229/A13154, 13154)
- Medical Research Council
- Biotechnology and Biological Sciences Research Council (BBS/E/D/20211553, BB/K000195/1)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and phenotypic traits in livestock
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genomics and Rare Diseases
- Keywords
- heritability, human disease, heritability estimation, genetic and environmental contributions, phenotypic variance, familial aggregation, relatives
- MeSH terms
- Disease, Environment, Female, Humans, Male, Models, Genetic, Pedigree, Models, Statistical, Bias, Linear Models, Twin Studies as Topic, Genetic Predisposition to Disease, Genetic Association Studies
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