The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Mechanisms underlying mutational signatures in human cancers
Open accessAbstract
The collective somatic mutations observed in a cancer are the outcome of multiple mutagenic processes that have been operative over the lifetime of a patient. Each process leaves a characteristic imprint — a mutational signature — on the cancer genome, which is defined by the type of DNA damage and DNA repair processes that result in base substitutions, insertions and deletions or structural variations. With the advent of whole-genome sequencing, researchers are identifying an increasing array of these signatures. Mutational signatures can be used as a physiological readout of the biological history of a cancer and also have potential use for discerning ongoing mutational processes from historical ones, thus possibly revealing new targets for anticancer therapies.
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Cites
Signatures of mutational processes in human cancer
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Self-citationComprehensive molecular characterization of human colon and rectal cancer
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Self-citationOncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints
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Self-citationOncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication
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A comprehensive catalogue of somatic mutations from a human cancer genome
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The Life History of 21 Breast Cancers
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Self-citation
Cited by
Maftools: efficient and comprehensive analysis of somatic variants in cancer
Mayakonda, A., Lin, D.-C., Assenov, Y., Plass, C., & Koeffler, H. P. (2018) · Genome Research · doi:10.1101/gr.239244.118 · Cited by 4,935
Pan-cancer analysis of whole genomes
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Self-citationLandscape of somatic mutations in 560 breast cancer whole-genome sequences
Nik-Zainal, S., Davies, H., Staaf, J., Ramakrishna, M., Glodzik, D., Zou, X., Martincorena, I., Alexandrov, L. B., Martin, S., Wedge, D. C., et al. (2016) · Nature · doi:10.1038/nature17676 · Cited by 2,218
Self-citationSchulze, K., Imbeaud, S., Letouzé, E., Alexandrov, L. B., Calderaro, J., Rebouissou, S., Couchy, G., Meiller, C., Shinde, J., Soysouvanh, F., et al. (2015) · Nature Genetics · doi:10.1038/ng.3252 · Cited by 1,803
Repair Pathway Choices and Consequences at the Double-Strand Break
Ceccaldi, R., Rondinelli, B., & D’Andrea, A. D. (2016) · Trends in Cell Biology · doi:10.1016/j.tcb.2015.07.009 · Cited by 1,499
Metadata
- Authors
- Helleday, T., Eshtad, S., & Nik-Zainal, S.
- Venue
- Nature Reviews Genetics
- Published
- 2014-07-01
- Volume
- 15
- Issue
- 9
- Pages
- 585-598
- ISSN
- 1471-0056 (ISSN-L)
- 1471-0064
- OpenAlex
- W1965151932
- Cited by
- 838
- References
- 19
- FWCI
- 5.51
- Type
- journal article
- Language
- en
- Open access
- green
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