The art and design of genetic screens: Drosophila melanogaster

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Items 201–300 of 547

1. Mitochondria Dysfunction in Frontotemporal Dementia/Amyotrophic Lateral Sclerosis: Lessons From Drosophila Models
   Sharifah Anoar, Nathaniel S. Woodling, Teresa Niccoli · 2021 · Frontiers in Neuroscience
2. Drosophila melanogaster As a Model Organism to Study RNA Toxicity of Repeat Expansion-Associated Neurodegenerative and Neuromuscular Diseases
   Alex Chun Koon, Ho Yin Edwin Chan · 2017 · Frontiers in Cellular Neuroscience
3. Old questions, new models: unraveling complex organ regeneration with new experimental approaches
   Marco Grillo, Nikolaos Konstantinides, Michalis Averof · 2016 · Current Opinion in Genetics & Development
4. Whole-Genome Sequencing and iPLEX MassARRAY Genotyping Map an EMS-Induced Mutation Affecting Cell Competition in Drosophila melanogaster
   Chang-Hyun Lee, Gerard Rimesso, D. Reynolds, Jin-Lu Cai, N. Baker · 2016 · G3: Genes, Genomes, Genetics
5. Drosophila as a lipotoxicity model organism — more than a promise?
   Ronald P. Kühnlein · 2009 · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
6. A Germline Clone Screen for Meiotic Mutants in Drosophila melanogaster
   S. Page, Rachel J. Nielsen, K. Teeter, C. Lake, Sengkai Ong, Kathleen R. Wright, K. L. Dean, Daniel Agne, William D. Gilliland, R. Hawley · 2007 · Fly
7. Genomic and functional conservation of lncRNAs: lessons from flies
   Carlos Camilleri‐Robles, Raziel Amador, Cecília C. Klein, Roderic Guigó, Montserrat Corominas, Marina Ruiz‐Romero · 2022 · Mammalian Genome
8. Alleviatory effects of Danshen, Salvianolic acid A and Salvianolic acid B on PC12 neuronal cells and Drosophila melanogaster model of Alzheimer’s disease
   F. H. Tan, A. Ting, Ban Guan Leow, N. Najimudin, N. Watanabe, Ghows Azzam · 2020 · bioRxiv
9. Arrayed mutant haploid embryonic stem cell libraries facilitate phenotype-driven genetic screens
   Guang Liu, Xue Lian Wang, Yufang Liu, Meili Zhang, Tao Cai, Zhirong Shen, Yuyan Jia, Yue Huang · 2017 · Nucleic Acids Research
10. Can IVF influence human evolution?: Table I
    Hans Ivar Hanevik, Dag O. Hessen, Arne Sunde, Jarle Breivik · 2016 · Human Reproduction
11. Modeling congenital disease and inborn errors of development inDrosophila melanogaster
    Matthew J. Moulton, Anthea Letsou · 2016 · Disease Models & Mechanisms
12. Genome-Wide Association Study of Down Syndrome-Associated Atrioventricular Septal Defects
    Dhanya Ramachandran, Zhen Zeng, Adam E. Locke, Jennifer G. Mullé, Lora Jh Bean, Tracie C. Rosser, Kenneth J. Dooley, Clifford L. Cua, George T. Capone, Roger H. Reeves et al. · 2015 · G3 Genes Genomes Genetics
13. Frequent Unanticipated Alleles of lethal giant larvae in Drosophila Second Chromosome Stocks
    F. Roegiers, J. Kavaler, N. Tolwinski, Yu-Ting Chou, Hong Duan, Fernando Bejarano, Diana Zitserman, E. Lai · 2009 · Genetics
14. LKB1 induces apical trafficking of Silnoon, a monocarboxylate transporter, in Drosophila melanogaster
    Cholsoon Jang, Gina Lee, Jongkyeong Chung · 2008 · Journal of Cell Biology
15. Mitotic Spindle Dynamics in Drosophila
    Ingrid Brust‐Mascher, Jonathan M. Scholey · 2007 · International review of cytology
16. Scaling up complexity in synthetic developmental biology
    G. Martínez-Ara, Kristina S. Stapornwongkul, Miki Ebisuya · 2022 · Science
17. The use of quantitative imaging to investigate regulators of membrane trafficking in Arabidopsis stomatal closure
    G. Bourdais, D. McLachlan, L. Rickett, Ji Zhou, Agnieszka Siwoszek, Heidrun Häweker, Matthew Hartley, H. Kuhn, R. J. Morris, D. MacLean et al. · 2019 · Traffic : the International Journal of Intracellular Transport
18. Genetic Complexity in aDrosophilaModel of Diabetes-Associated Misfolded Human Proinsulin
    Soo-Young Park, Michael Z. Ludwig, Natalia A. Tamarina, Bin He, Sarah H. Carl, Desiree A. Dickerson, Levi W. Barse, Bharath Arun, Calvin Williams, Cecelia M. Miles et al. · 2013 · Genetics
19. Live Cell Imaging inDrosophila melanogaster
    Richard M. Parton, Ana María Vallés, Ian M. Dobbie, Ilan Davis · 2010 · Cold Spring Harbor Protocols
20. An Optimized Method for Histological Detection of Dopaminergic Neurons in Drosophila melanogaster
    Daria Drobysheva, Kristen Ameel, B. Welch, E. Ellison, K. Chaichana, Bryan Hoang, Shilpy Sharma, W. Neckameyer, Irina Srinakevitch, Kelley J. Murphy et al. · 2008 · Journal of Histochemistry and Cytochemistry
21. Genes involved in Drosophilaglutamate receptor expression and localization
    Faith L. W. Liebl, David E. Featherstone · 2005 · BMC Neuroscience
22. Lactic acid bacteria feeding reversed the malformed eye structures and ameliorated gut microbiota profiles of Drosophila melanogaster Alzheimer’s disease model
    Guoxia Liu, Florence Hui Ping Tan, S.-Y.A. Lau, Mohd Hafiidz Jaafar, Fiona Yi-Li Chung, Ghows Azzam, Min‐Tze Liong, Yin Li · 2020 · Journal of Applied Microbiology
23. An assessment of the translational relevance of Drosophila in drug discovery
    K. Papanikolopoulou, A. Mudher, E. Skoulakis · 2019 · Expert Opinion on Drug Discovery
24. The ROP vesicle release factor is required in adult Drosophila glia for normal circadian behavior
    Fanny Ng, F. Rob Jackson · 2015 · Frontiers in Cellular Neuroscience
25. ASGARD: an open-access database of annotated transcriptomes for emerging model arthropod species
    Victor Zeng, Cassandra G. M. Extavour · 2012 · Database
26. Identification and Characterization of Genes Required for Compensatory Growth in Drosophila
    Abigail R. Gerhold, Daniel J. Richter, Albert S. Yu, Iswar K. Hariharan · 2011 · Genetics
27. A System for Performing High Throughput Assays of Synaptic Function
    C. Hempel, M. Sivula, J. Levenson, D. M. Rose, Bing Li, A. Sirianni, Eva Xia, T. A. Ryan, D. Gerber, Jeffrey R. Cottrell · 2011 · PLoS ONE
28. The role of mutagenesis in defining genes in behaviour
    Sofia I. H. Godinho, P. Nolan · 2006 · European Journal of Human Genetics
29. A universal method for automated gene mapping
    Peder Zipperlen, K. Nairz, Ivo Rimann, K. Basler, E. Hafen, M. Hengartner, Alex Hajnal · 2005 · Genome Biology
30. High-resolution SNP mapping by denaturing HPLC
    K. Nairz, Hugo Stocker, Benno Schindelholz, E. Hafen · 2002 · Proceedings of the National Academy of Sciences of the United States of America
31. artMAP: A user‐friendly tool for mapping ethyl methanesulfonate‐induced mutations in Arabidopsis
    P. Javorka, V. Raxwal, Jan Najvarek, K. Riha · 2019 · Plant Direct
32. Investigating long noncoding RNAs using animal models
    Michael J. Feyder, Loyal A. Goff · 2016 · Journal of Clinical Investigation
33. A modifier locus on chromosome 5 contributes to L1 cell adhesion molecule X-linked hydrocephalus in mice
    Alexis Tapanes-Castillo, Eli J. Weaver, Robin P. Smith, Yoshimasa Kamei, Tamara Caspary, Kara L. Hamilton‐Nelson, Susan H. Slifer, Eden R. Martin, John L. Bixby, Vance Lemmon · 2009 · Neurogenetics
34. Genetic, molecular and parent-of-origin regulation of early embryogenesis in flowering plants.
    A. Armenta-Medina, C. Gillmor · 2019 · Current Topics in Developmental Biology
35. Drosophila Model in Cancer: An Introduction
    Deeptiman Chatterjee, Wu‐Min Deng · 2019 · Advances in experimental medicine and biology
36. Studying Circadian Rhythm and Sleep Using Genetic Screens in Drosophila
    Sofia Axelrod, Lino Sáez, Michael W. Young · 2014 · Methods in enzymology on CD-ROM/Methods in enzymology
37. Methods and applications of in vivo CRISPR screening
    António J. Santinha, Alessio Strano, Randall J. Platt · 2025 · Nature Reviews Genetics
38. The use ofDrosophila melanogasteras a model organism to study immune-nanotoxicity
    Cheng Teng Ng, Liya E. Yu, Choon Nam Ong, Boon‐Huat Bay, Gyeong Hun Baeg · 2018 · Nanotoxicology
39. New insights into behaviour using mouse ENU mutagenesis
    Peter L. Oliver, Kay Elizabeth Davies · 2012 · Human Molecular Genetics
40. Isolation of homozygous mutant mouse embryonic stem cells using a dual selection system
    Yue Huang, Stephen J. Pettitt, Ge Guo, Guang Liu, Meng Amy Li, Fengtang Yang, Allan Bradley · 2011 · Nucleic Acids Research
41. Suppression of the Lethality of High Light to a Quadruple HLI Mutant by the Inactivation of the Regulatory Protein PfsR in Synechocystis PCC 6803
    Saowarath Jantaro, Quaisar Ali, Samea Lone, Qingfang He · 2006 · Journal of Biological Chemistry
42. In Vivo Modeling of Malignant Glioma
    Timothy P. Kegelman, Bin Hu, Luni Emdad, Swadesh Kumar Das, Devanand Sarkar, Paul B. Fisher · 2014 · Advances in cancer research
43. Using mutants, knockdowns, and transgenesis to investigate gene function in Drosophila
    D. St Johnston · 2013 · Wiley Interdisciplinary Reviews: Developmental Biology
44. Genome-wide chemical mutagenesis screens allow unbiased saturation of the cancer genome and identification of drug resistance mutations
    Jonathan S. Brammeld, Mia Petljak, Iñigo Martincorena, Steven P. Williams, Luz García‐Alonso, Alba Dalmases, Beatríz Bellosillo, Carla Daniela Robles‐Espinoza, Stacey Price, Syd Barthorpe et al. · 2017 · Genome Research
45. CRISPR/Cas9 genome editing in human pluripotent stem cells: Harnessing human genetics in a dish
    Federico Gonzãlez · 2016 · Developmental Dynamics
46. Functional genomics in Drosophila models of human disease
    K.-F. Chen, Damian C. Crowther · 2012 · Briefings in Functional Genomics
47. Saturation of the Human Phenome
    Mark E. Samuels · 2010 · Current Genomics
48. Alphabet, a Ser/Thr phosphatase of the protein phosphatase 2C family, negatively regulates RAS/MAPK signaling in Drosophila.
    C. Baril, M. Therrien · 2006 · Developmental Biology
49. Identification of co-regulated transcripts affecting male body size in Drosophila
    Cynthia J. Coffman, Marta L. Wayne, S. Nuzhdin, L. A. Higgins, L. McIntyre · 2005 · Genome Biology
50. Molecular Genetics of Axial Patterning, Growth and Disease in the Drosophila Eye
    A. Singh, Madhuri Kango-Singh · 2020 · Springer: New York
51. In vivo bioassay to test the pathogenicity of missense human AIP variants
    E. Aflorei, Benjamin Klapholz, Chenghao Chen, S. Radian, Anca Neluta Dragu, Nina Moderau, C. Prodromou, P. Ribeiro, R. Stanewsky, M. Korbonits · 2018 · Journal of Medical Genetics
52. Metabolic profiling of Drosophila melanogaster metamorphosis: a new insight into the central metabolic pathways
    An Nguyen Thuy Phan, M. Yamaguchi, Eiichiro Fukusaki · 2017 · Metabolomics
53. Insects as a model system for aging studies
    Hye‐Yeon Lee, Shin‐Hae Lee, Kyung‐Jin Min · 2014 · Entomological Research
54. Non-Canonical Roles for Yorkie and Drosophila Inhibitor of Apoptosis 1 in Epithelial Tube Size Control
    Renée M. Robbins, Samantha C. Gbur, Greg J. Beitel · 2014 · PLoS ONE
55. Drosophilaas a genetic and cellular model for studies on axonal growth
    Natalia Sánchez‐Soriano, Guy Tear, Paul M. Whitington, Andreas Prokop · 2007 · Neural Development
56. Phenotype-first screening for the identification of novel drug targets.
    M. Austen, C. Dohrmann · 2005 · Drug Discovery Today
57. Analysis of the Drosophila Compound Eye with Light and Electron Microscopy.
    M. Mishra, E. Knust · 2019 · Methods in molecular biology
58. Non-Rodent Genetic Animal Models for Studying Tauopathy: Review of Drosophila, Zebrafish, and C. elegans Models
    Hoi-Khoanh Giong, Manivannan Subramanian, Kweon Yu, Jeong-Soo Lee · 2021 · International Journal of Molecular Sciences
59. Rosy Beginnings: Studying Peroxisomes in Drosophila
    C. Pridie, Kazuki Ueda, Andrew James Simmonds · 2020 · Frontiers in Cell and Developmental Biology
60. A genetic interaction map of cell cycle regulators
    Maximilian Billmann, Thomas L. Horn, Bernd Fischer, Thomas Sandmann, Wolfgang K. Huber, Michael Boutros · 2016 · Molecular Biology of the Cell
61. A simple TALEN-based protocol for efficient genome-editing in Drosophila.
    Xu Zhang, Irene R. S. Ferreira, F. Schnorrer · 2014 · Methods
62. Neuropeptide biology in Drosophila.
    E. Clynen, Ank Reumer, G. Baggerman, I. Mertens, L. Schoofs · 2010 · Advances in Experimental Medicine and Biology
63. Investigating cytosolic 5′-nucleotidase II family genes as candidates for neuropsychiatric disorders in Drosophila (114/150 chr)
    E. Singgih, M. van der Voet, Marlies Schimmel-Naber, Emma L Brinkmann, A. Schenck, B. Franke · 2021 · Translational Psychiatry
64. Advances in functional genetic screening with transposons and CRISPR/Cas9 to illuminate cancer biology
    Kathryn A. O’Donnell · 2018 · Current Opinion in Genetics and Development
65. Unbiased compound-protein interface mapping and prediction of chemoresistance loci through forward genetics in haploid stem cells
    Moritz Horn, Virginia Kroef, Kira Allmeroth, Nicole Schuller, Stephan Miethe, Martin Peifer, Josef Martin Penninger, Ulrich Elling, Martin Sebastian Denzel · 2018 · Oncotarget
66. Screens, maps & networks: from genome sequences to personalized medicine
    Thomas Sandmann, Michael Boutros · 2012 · Current Opinion in Genetics & Development
67. Meeting the Challenges of Aquatic Vertebrate Ecotoxicology
    M. Carvan, J. Incardona, M. Rise · 2008
68. Screens in fly and beetle reveal vastly divergent gene sets required for developmental processes
    M. S. Hakeemi, Salim Ansari, Matthias Teuscher, Matthias Weisskopf, Daniela Grossmann, Tobias Kessel, Jürgen Dönitz, J. Siemanowski, Xuebin Wan, D. Schultheis et al. · 2022 · BMC Biology
69. Invadolysin, a conserved lipid droplet-associated metalloprotease, is required for mitochondrial function in Drosophila
    Francesca Di Cara, Edward Duca, Donald R. Dunbar, Gerard Cagney, Margarete M. S. Heck · 2013 · Journal of Cell Science
70. Drosophila as a model for antiviral immunity.
    Jing-Huan Wang, S. Valanne, M. Rämet · 2010 · World Journal of Biological Chemsitry
71. Drosophila spermatogenesis: insights into testicular cancer
    Gary R. Hime, Kate L. Loveland, Helen E. Abud · 2007 · International Journal of Andrology
72. Chromatin as a Tool for the Study of Genome Function in Cancer
    Fyodor D. Urnov · 2003 · Annals of the New York Academy of Sciences
73. Selective breeding modifies mef2ca mutant incomplete penetrance by tuning the opposing Notch pathway
    Juliana Sucharov, K. Ray, Elliott P. Brooks, J. Nichols · 2019 · PLoS Genetics
74. Population Genomics on the Fly: Recent Advances in Drosophila
    Annabelle Haudry, Stefan Laurent, Martin Kapun · 2020 · Methods in molecular biology
75. Identification of Methylosome Components as Negative Regulators of Plant Immunity Using Chemical Genetics
    Shuai Huang, Aruna D. Balgi, Yaping Pan, Meng Li, Xiaoran Zhang, Li‐Lin Du, Ming Zhou, Michel Roberge, Xin Li · 2016 · Molecular Plant
76. RNA Interference Technology: High-throughput genome-wide RNAi analysis
    K. Appasani, A. Fire, M. Nirenberg · 2005
77. Drosophila as an emerging model to study metastasis.
    Madhuri Kango‐Singh, Georg A. Halder · 2004 · Genome biology
78. The genome-wide rate and spectrum of EMS-induced heritable mutations in the microcrustacean Daphnia: on the prospect of forward genetics
    Marelize Snyman, T. V. Huỳnh, Matthew T. Smith, Sen Xu · 2021 · Heredity
79. Using Drosophila melanogaster To Discover Human Disease Genes: An Educational Primer for Use with “Amyotrophic Lateral Sclerosis Modifiers in Drosophila Reveal the Phospholipase D Pathway as a Potential Therapeutic Target”
    S. Banerjee, Shimshon Benji, Sarah Liberow, Josefa Steinhauer · 2020 · Genetics
80. Drug-Inducible Control of Lethality Genes: A Low Background Destabilizing Domain Architecture Applied to the Gal4-UAS System in Drosophila
    Manjunatha Kogenaru, M. Isalan · 2018 · ACS Synthetic Biology
81. Genome editing in Drosophila melanogaster: from basic genome engineering to the multipurpose CRISPR-Cas9 system
    Xingjie Ren, Kristof Holsteens, Haiyi Li, Jin Sun, Yifan Zhang, Luping Liu, Qingfei Liu, Jian‐Quan Ni · 2017 · Science China Life Sciences
82. The Role of Gene Editing in Neurodegenerative Diseases
    Hueng-Chuen Fan, Ching-Shiang Chi, Yih-Jing Lee, Jeng‐Dau Tsai, Shinn‐Zong Lin, Horng-Jyh Harn · 2018 · Cell Transplantation
83. Drosophila Oocytes as a Model for Understanding Meiosis: An Educational Primer to Accompany “Corolla Is a Novel Protein That Contributes to the Architecture of the Synaptonemal Complex of Drosophila”
    Elizabeth T. Ables · 2015 · Genetics
84. Chromatin regulators in neurodevelopment and disease: Analysis of fly neural circuits provides insights
    Hiroaki Taniguchi, Adrian Walton Moore · 2014 · BioEssays
85. The past, present and future of gene targeting in Drosophila
    Natalia Wesolowska, Yi-Kang S. Rong · 2010 · Fly
86. High-throughput screening using siRNA (RNAi) libraries
    Mei-Hong Chen, Quan Du, Hong-Yan Zhang, Xiaoxia Wang, Zi-Cai Liang · 2007 · Expert Review of Molecular Diagnostics
87. Enhanced antibacterial efficacy of biocompatible Ag-doped ZnO/AgO/TiO2 nanocomposites against multiresistant bacteria
    Rafael O. Trevisan, J. Oliveira, Hugo F. Perini, Ulisses Travaglini, Thaís K. de L. Rezende, F. D. Dos Santos, Luciana R. de S. Floresta, Ana L. S. Borges, Letícia C. Ruiz, Leonardo E. de A. e Silva et al. · 2025 · Next Materials
88. Energy homeostasis regulation in Drosophila: a lipocentric perspective.
    R. Kühnlein · 2010 · Results and problems in cell differentiation
89. Promoting validation and cross-phylogenetic integration in model organism research
    Keith C. Cheng, Rebecca D. Burdine, Mary E. Dickinson, Stephen Carl Ekker, Alex Y. Lin, K. C. Kent Lloyd, Cathleen M. Lutz, Calum A. MacRae, John H. Morrison, David H. O’Connor et al. · 2022 · Disease Models & Mechanisms
90. A timer gene network is spatially regulated by the terminal system in the Drosophila embryo
    Erik Clark, Margherita Battistara, M. A. Benton · 2022 · bioRxiv
91. Genome-wide phenotypic RNAi screen in the Drosophila wing: phenotypic description of functional classes
    Ana López-Varea, Patricia Vega-Cuesta, A. Ruiz-Gómez, Cristina M. Ostalé, Cristina Molnar, C. Hevia, Mercedes Martín, María F. Organista, Jésus de Celis, Joaquín Culí et al. · 2021 · G3
92. Brain wiring with composite instructions
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93. Acquisition, Processing and Analysis of Electrocardiogram in Awake Zebrafish
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94. Drosophila and experimental neurology in the post-genomic era
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95. Cognition and behavior in neurofibromatosis type 1: report and perspective from the Cognition and Behavior in NF1 (CABIN) Task Force
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96. Exploiting the Potential of Drosophila Models in Lysosomal Storage Disorders: Pathological Mechanisms and Drug Discovery
    Laura Rigon, Concetta De Filippis, Barbara Napoli, Rosella Tomanin, Genny Orso · 2021 · Biomedicines
97. Drosophila RNAi screening in a postgenomic world
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98. The buzz on fly neuronal remodeling
    Randall S. Hewes · 2008 · Trends in Endocrinology and Metabolism
99. Target Identification and Validation in Drug Discovery
    J. Moll, Sebastian Carotta · 2019 · Methods in Molecular Biology
100. Functional genomic analysis of the Drosophila immune response.
     S. Valanne · 2014 · Developmental and Comparative Immunology