The DOI matches its Crossref record; 102 of the 102 references it cites were found in a registry or an index.
Ischaemia–reperfusion injury in liver transplantation—from bench to bedside
Open accessAbstract
Ischaemia–reperfusion injury (IRI) in the liver, a major complication of haemorrhagic shock, resection and transplantation, is a dynamic process that involves the two interrelated phases of local ischaemic insult and inflammation-mediated reperfusion injury. This Review highlights the latest mechanistic insights into innate–adaptive immune crosstalk and cell activation cascades that lead to inflammation-mediated injury in livers stressed by ischaemia–reperfusion, discusses progress in large animal experiments and examines efforts to minimize liver IRI in patients who have received a liver transplant. The interlinked signalling pathways in multiple hepatic cell types, the IRI kinetics and positive versus negative regulatory loops at the innate–adaptive immune interface are discussed. The current gaps in our knowledge and the pathophysiology aspects of IRI in which basic and translational research is still required are stressed. An improved appreciation of cellular immune events that trigger and sustain local inflammatory responses, which are ultimately responsible for organ injury, is fundamental to developing innovative strategies for treating patients who have received a liver transplant and developed ischaemia–reperfusion inflammation and organ dysfunction.
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Pattern Recognition Receptors and Inflammation
Takeuchi, O., & Akira, S. (2010) · Cell · doi:10.1016/j.cell.2010.01.022 · Cited by 8,895
Akira, S., & Takeda, K. (2004) · Nature reviews. Immunology · doi:10.1038/nri1391 · Cited by 8,312
Ischemia and reperfusion—from mechanism to translation
Eltzschig, H. K., & Eckle, T. (2011) · Nature Medicine · doi:10.1038/nm.2507 · Cited by 3,382
Cooperation of Toll-like receptor signals in innate immune defence
Trinchieri, G., & Sher, A. (2007) · Nature Reviews Immunology · doi:10.1038/nri2038 · Cited by 1,364
Endotoxin tolerance: new mechanisms, molecules and clinical significance
Biswas, S. K., & Lopez-Collazo, E. (2009) · Trends in Immunology · doi:10.1016/j.it.2009.07.009 · Cited by 1,318
Intravascular Danger Signals Guide Neutrophils to Sites of Sterile Inflammation
McDonald, B., Pittman, K., Menezes, G. B., Hirota, S. A., Slaba, I., Waterhouse, C. C. M., Beck, P. L., Muruve, D. A., & Kubes, P. (2010) · Science · doi:10.1126/science.1195491 · Cited by 1,210
The nuclear factor HMGB1 mediates hepatic injury after murine liver ischemia-reperfusion
Tsung, A., Sahai, R., Tanaka, H., Nakao, A., Fink, M. P., Lotze, M. T., Yang, H., Li, J., Tracey, K. J., Geller, D. A., et al. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20042614 · Cited by 1,113
Martin, M., Rehani, K., Jope, R. S., & Michalek, S. M. (2005) · Nature Immunology · doi:10.1038/ni1221 · Cited by 1,080
Toll‐like Receptor and RIG‐1‐like Receptor Signaling
Kawai, T., & Akira, S. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1443.020 · Cited by 986
NEUTROPHIL INFILTRATION AS AN IMPORTANT FACTOR IN LIVER ISCHEMIA AND REPERFUSION INJURY
TOLEDO-PEREYRA, L. H., RODRIGUEZ, F. J., & CEJALVO, D. (1993) · Transplantation · doi:10.1097/00007890-199306000-00011 · Cited by 894
Research works printed but not linked: 18
- Shen, X. D. et al. Inflammatory responses in a new mouse model of prolonged hepatic cold ischemia followed by arterialized orthotopic liver transplantation. Liver Transpl. 11, 1273–1281 (2005). · doi:10.1002/lt.20489
- Shen, X. D. et al. CD154-CD40 T-cell costimulation pathway is required in the mechanism of hepatic ischemia/reperfusion injury, and its blockade facilitates and depends on heme oxygenase-1 mediated cytoprotection. Transplantation 74, 315–319 (2002). · doi:10.1097/00007890-200208150-00005
- Magliocca, J. F. et al. Extracorporeal support for organ donation after cardiac death effectively expands the donor pool. J. Trauma 58, 1095–1101 (2005). · doi:10.1097/01.ta.0000169949.82778.df
- Hong, J. C. et al. Regulated hepatic reperfusion mitigates ischemia and reperfusion injury and improves survival after prolonged liver warm ischemia: a pilot study on a novel concept of organ resuscitation in a large animal model. J. Am. Coll. Surg. 214, 505–515 (2012). · doi:10.1016/j.jamcollsurg.2011.12.010
- Garcia-Valdecasas, J. C. et al. Liver conditioning after cardiac arrest: the use of normothermic recirculation in an experimental animal model. Transpl. Int. 11, 424–432 (1998). · doi:10.1111/j.1432-2277.1998.tb00831.x
- Fondevila, C. et al. Superior preservation of DCD livers with continuous normothermic perfusion. Ann. Surg. 254, 1000–1007 (2011). · doi:10.1097/sla.0b013e31822b8b2f
- Minor, T., Manekeller, S., Sioutis, M. & Dombrowski, F. Endoplasmic and vascular surface activation during organ preservation: refining upon the benefits of machine perfusion. Am. J. Transplant. 6, 1355–1366 (2006). · doi:10.1111/j.1600-6143.2006.01338.x
- Goto, M. et al. Hepatic tissue oxygenation as a predictive indicator of ischemia-reperfusion liver injury. Hepatology 15, 432–437 (1992). · doi:10.1002/hep.1840150313
- Monden, M. & Fortner, J. G. Twenty-four- and 48-hour canine liver preservation by simple hypothermia with prostacyclin. Ann. Surg. 196, 38–42 (1982). · doi:10.1097/00000658-198207000-00009
- Ghonem, N. et al. Treprostinil, a prostacyclin analog, ameliorates ischemia-reperfusion injury in rat orthotopic liver transplantation. Am. J. Transplant. 11, 2508–2516 (2011). · doi:10.1111/j.1600-6143.2011.03568.x
- Klein, M. et al. Preconditioning of donor livers with prostaglandin I2 before retrieval decreases hepatocellular ischemia-reperfusion injury. Transplantation 67, 1128–1132 (1999). · doi:10.1097/00007890-199904270-00007
- Mehrabi, A. et al. Thymoglobulin and ischemia reperfusion injury in kidney and liver transplantation. Nephrol. Dial. Transplant. 22 (Suppl. 8), viii54–viii60 (2007).
- Goggins, W. C. et al. A prospective randomized clinical trial of intraoperative versus postoperative thymoglobulin in adult cadaveric renal transplant recipients. Transplantation 76, 798–802 (2003). · doi:10.1097/01.tp.0000081042.67285.91
- Bogetti, D. et al. Thymoglobulin induction protects liver allografts from ischemia/reperfusion injury. Clin. Transplant. 19, 507–511 (2005). · doi:10.1111/j.1399-0012.2005.00375.x
- Tsuchihashi, S. et al. Molecular characterization of rat leukocyte P-selectin glycoprotein ligand-1 and effect of its blockade: protection from ischemia-reperfusion injury in liver transplantation. J. Immunol. 176, 616–624 (2006). · doi:10.4049/jimmunol.176.1.616
- Kristo, I. et al. Effect of intraportal infusion of tacrolimus on ischaemic reperfusion injury in orthotopic liver transplantation: a randomized controlled trial. Transpl. Int. 24, 912–919 (2011). · doi:10.1111/j.1432-2277.2011.01284.x
- Khan, A. W. et al. A prospective randomized trial of N-acetyl cysteine administration during cold preservation of the donor liver for transplantation. Ann. Hepatol. 4, 121–126 (2005). · doi:10.1016/s1665-2681(19)32075-7
- Hilmi, I. A. et al. N-acetylcysteine does not prevent hepatorenal ischaemia-reperfusion injury in patients undergoing orthotopic liver transplantation. Nephrol. Dial Transplant. 25, 2328–2333 (2010). · doi:10.1093/ndt/gfq077
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Liu, H., Dong, J., Song, S., Zhao, Y., Wang, J., Fu, Z., & Yang, J. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.08.162 · Cited by 38
Emerging Roles of High-mobility Group Box-1 in Liver Disease
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Metadata
- Authors
- Zhai, Y., Petrowsky, H., Hong, J. C., Busuttil, R. W., & Kupiec-Weglinski, J. W.
- Venue
- Nature Reviews Gastroenterology & Hepatology
- Published
- 2012-12-11
- Volume
- 10
- Issue
- 2
- Pages
- 79-89
- ISSN
- 1759-5045 (ISSN-L)
- 1759-5053
- OpenAlex
- W2000394721
- Cited by
- 843
- References
- 102
- FWCI
- 4.65
- Type
- journal article
- Language
- en
- Open access
- green
- Licence
- www.springer.com/tdm (tdm)
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