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Ischemia and reperfusion—from mechanism to translation

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Eltzschig, Holger K, Eckle, Tobias·2011·Nature Medicine
DOI 10.1038/nm.2507
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Abstract

Ischemia and reperfusion–elicited tissue injury contributes to morbidity and mortality in a wide range of pathologies, including myocardial infarction, ischemic stroke, acute kidney injury, trauma, circulatory arrest, sickle cell disease and sleep apnea. Ischemia-reperfusion injury is also a major challenge during organ transplantation and cardiothoracic, vascular and general surgery. An imbalance in metabolic supply and demand within the ischemic organ results in profound tissue hypoxia and microvascular dysfunction. Subsequent reperfusion further enhances the activation of innate and adaptive immune responses and cell death programs. Recent advances in understanding the molecular and immunological consequences of ischemia and reperfusion may lead to innovative therapeutic strategies for treating patients with ischemia and reperfusion–associated tissue inflammation and organ dysfunction.

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Metadata

Authors
Eltzschig, H. K., & Eckle, T.
Venue
Nature Medicine
Publisher
Springer Science and Business Media LLC
Published
2011-11
Volume
17
Issue
11
Pages
1391-1401
ISSN
  • 1078-8956 (ISSN-L)
  • 1546-170X
DOI
10.1038/nm.2507
OpenAlex
W2371948111
Cited by
3,382
References
14
FWCI
80.22
Type
journal article
Language
en
Open access
green
Licence
www.springer.com/tdm (tdm)

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