The DOI matches its Crossref record; 163 of the 163 references it cites were found in a registry or an index.
Necrotizing enterocolitis: new insights into pathogenesis and mechanisms
Open accessAbstract
Necrotizing enterocolitis (NEC) is the most frequent and lethal disease of the gastrointestinal tract of preterm infants. At present, NEC is thought to develop in the premature host in the setting of bacterial colonization, often after administration of non-breast milk feeds, and disease onset is thought to be due in part to a baseline increased reactivity of the premature intestinal mucosa to microbial ligands as compared with the full-term intestinal mucosa. The increased reactivity leads to mucosal destruction and impaired mesenteric perfusion and partly reflects an increased expression of the bacterial receptor Toll-like receptor 4 (TLR4) in the premature gut, as well as other factors that predispose the intestine to a hyper-reactive state in response to colonizing microorganisms. The increased expression of TLR4 in the premature gut reflects a surprising role for this molecule in the regulation of normal intestinal development through its effects on the Notch signalling pathway. This Review will examine the current approach to the diagnosis and treatment of NEC, provide an overview of our current knowledge regarding its molecular underpinnings and highlight advances made within the past decade towards the development of specific preventive and treatment strategies for this devastating disease.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Dermyshi, E., Wang, Y., Yan, C., Hong, W., Qiu, G., Gong, X., & Zhang, T. (2017) · Neonatology · doi:10.1159/000454668 · Cited by 24,451
Changes of Intestinal Functions in Liver Cirrhosis
Fukui, H., & Wiest, R. (2016) · Inflammatory Intestinal Diseases · doi:10.1159/000444436 · Cited by 6,808
Breastfeeding and the Use of Human Milk
Breastfeeding, S. O. (2005) · Pediatrics · doi:10.1542/peds.2004-2491 · Cited by 5,323
Blencowe, H., Cousens, S., Oestergaard, M. Z., Chou, D., Moller, A.-B., Narwal, R., Adler, A., Vera Garcia, C., Rohde, S., Say, L., et al. (2012) · The Lancet · doi:10.1016/s0140-6736(12)60820-4 · Cited by 4,568
Breastfeeding and the use of human milk
BREASTFEEDING, S. O., Eidelman, A. I., Schanler, R. J., Johnston, M., Landers, S., Noble, L., Szucs, K., & Viehmann, L. (2012) · Pediatrics · doi:10.1542/peds.2011-3552 · Cited by 4,357
Recognition of Commensal Microflora by Toll-Like Receptors Is Required for Intestinal Homeostasis
Rakoff-Nahoum, S., Paglino, J., Eslami-Varzaneh, F., Edberg, S., & Medzhitov, R. (2004) · Cell · doi:10.1016/j.cell.2004.07.002 · Cited by 4,251
Neonatal Necrotizing Enterocolitis: Therapeutic Decisions Based upon Clinical Staging
BELL, M. J., TERNBERG, J. L., FEIGIN, R. D., KEATING, J. P., MARSHALL, R., BARTON, L., & BROTHERTON, T. (1978) · Annals of Surgery · doi:10.1097/00000658-197801000-00001 · Cited by 3,514
Intestinal epithelial cells: regulators of barrier function and immune homeostasis
Peterson, L. W., & Artis, D. (2014) · Nature Reviews Immunology · doi:10.1038/nri3608 · Cited by 3,173
An Immunomodulatory Molecule of Symbiotic Bacteria Directs Maturation of the Host Immune System
Mazmanian, S. K., Liu, C. H., Tzianabos, A. O., & Kasper, D. L. (2005) · Cell · doi:10.1016/j.cell.2005.05.007 · Cited by 2,910
Trends in Care Practices, Morbidity, and Mortality of Extremely Preterm Neonates, 1993-2012
Stoll, B. J., Hansen, N. I., Bell, E. F., Walsh, M. C., Carlo, W. A., Shankaran, S., Laptook, A. R., Sánchez, P. J., Van Meurs, K. P., Wyckoff, M., et al. (2015) · JAMA · doi:10.1001/jama.2015.10244 · Cited by 2,791
Cited by
Probiotics for Preterm Infants: A Strain‐Specific Systematic Review and Network Meta‐analysis
van den Akker, C. H. P., van Goudoever, J. B., Szajewska, H., Embleton, N. D., Hojsak, I., Reid, D., Shamir, R., & ESPGHAN Working Group for Probiotics, P. &. C. O. N. (2018) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000001897 · Cited by 167
Para-probiotics for Preterm Neonates—The Next Frontier
Deshpande, G., Athalye-Jape, G., & Patole, S. (2018) · Nutrients · doi:10.3390/nu10070871 · Cited by 164
Pärnänen, K. M., Hultman, J., Markkanen, M., Satokari, R., Rautava, S., Lamendella, R., Wright, J., McLimans, C. J., Kelleher, S. L., & Virta, M. P. (2022) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqab353 · Cited by 99
Gross Margolis, K., Vittorio, J., Talavera, M., Gluck, K., Li, Z., Iuga, A., Stevanovic, K., Saurman, V., Israelyan, N., Welch, M. G., et al. (2017) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00215.2017 · Cited by 28
Zhang, X., Tian, B., Deng, Q., Cao, J., Ding, X., Liu, Q., Zhang, Y., Ye, C., Deng, C., Qiu, L., et al. (2022) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2022.04.008 · Cited by 21
Metadata
- Authors
- Niño, D. F., Sodhi, C. P., & Hackam, D. J.
- Venue
- Nature Reviews Gastroenterology & Hepatology
- Published
- 2016-08-18
- Volume
- 13
- Issue
- 10
- Pages
- 590-600
- ISSN
- 1759-5045 (ISSN-L)
- 1759-5053
- OpenAlex
- W2512327724
- Cited by
- 616
- References
- 163
- FWCI
- 9.20
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Necrotizing enterocolitis: new insights into pathogenesis and mechanisms. https://app.cochat.ai/papers/10.1038/nrgastro.2016.119
- The paper
- Niño, D. F., Sodhi, C. P., & Hackam, D. J. (2016). Necrotizing enterocolitis: new insights into pathogenesis and mechanisms. Nature Reviews Gastroenterology & Hepatology. https://doi.org/10.1038/nrgastro.2016.119
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
