Ido expression by dendritic cells: tolerance and tryptophan catabolism
Abstract
Indoleamine 2,3-dioxygenase (IDO) is an enzyme that degrades the essential amino acid tryptophan. The concept that cells expressing IDO can suppress T-cell responses and promote tolerance is a relatively new paradigm in immunology. Considerable evidence now supports this hypothesis, including studies of mammalian pregnancy, tumour resistance, chronic infections and autoimmune diseases. In this review, we summarize key recent developments and propose a unifying model for the role of IDO in tolerance induction.
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Metabolic interference mechanisms, such as IDO-1-dependent degradation of tryptophan by antigen presenting cells, may represent key regulatory mechanisms at sites of infection or inflammation.
“Metabolic interference mechanisms, such as indoleamine 2,3-dioxygenase (IDO)–1–dependent degradation of tryptophan by antigen presenting cells (APCs), may represent key regulatory mechanisms at sites of infection or inflammation (120).”
From Fueling Immunity: Insights into Metabolism and Lymphocyte Function (2013) · cites this paper as [120]
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References 153 · Cited by 2,341
- Authors
- Mellor, A. L., & Munn, D. H.
- Affiliations
- Augusta University (US)
- Corresponding author
- Mellor, Andrew L.
- Venue
- Nature Reviews Immunology
- Published
- 2004-10
- Volume
- 4
- Issue
- 10
- Pages
- 762-774
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- OpenAlex
- W1975929837
- Cited by
- 2,341
- References
- 153
- Citations by year
- 2026: 43 · 2025: 62 · 2024: 88 · 2023: 74 · 2022: 80 · 2021: 104 · 2020: 100 · 2019: 94 · 2018: 102 · 2017: 103 · 2016: 95 · 2015: 103 · 2014: 104 · 2013: 142 · 2012: 148
- FWCI
- 9.10
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Immunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Keywords
- indoleamine 2,3-dioxygenase, tryptophan catabolism, dendritic cells, immune tolerance, T cell suppression, pregnancy, tumor resistance, chronic infection, autoimmune disease
- MeSH terms
- Animals, Dendritic Cells, Humans, Immune Tolerance, Immunosuppression Therapy, Tryptophan, Tryptophan Oxygenase, Models, Immunological, Indoleamine-Pyrrole 2,3,-Dioxygenase
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