Cited by 481Chemokine receptors and signalingImmune Response and InflammationInflammation biomarkers and pathways

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Tuning inflammation and immunity by chemokine sequestration: decoys and more

Mantovani, Alberto, Bonecchi, Raffaella, Locati, Massimo·2006·Nature Reviews Immunology

DOI 10.1038/nri1964

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Abstract

A set of chemokine receptors are structurally unable to elicit migration or conventional signalling responses after ligand engagement. These 'silent' (non-signalling) chemokine receptors regulate inflammatory and immune reactions in different ways, including by acting as decoys and scavengers. Chemokine decoy receptors recognize distinct and complementary sets of ligands and are strategically expressed in different cellular contexts. Importantly, viruses and parasites have evolved multiple strategies to elude chemokines, including the expression of decoy receptors. So, decoy receptors for chemokines represent a general strategy to tune, shape and temper innate and adaptive immunity.

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Chemokines
Zlotnik, A., & Yoshie, O. (2000) · Immunity · doi:10.1016/s1074-7613(00)80165-x · Cited by 3,923
Chemokines — Chemotactic Cytokines That Mediate Inflammation
Luster, A. D. (1998) · New England Journal of Medicine · doi:10.1056/nejm199802123380706 · Cited by 3,633
The many roles of chemokines and chemokine receptors in inflammation
Charo, I. F., & Ransohoff, R. M. (2006) · New England Journal of Medicine · doi:10.1056/nejmra052723 · Cited by 2,523
Chemokines
Rollins, B. J. (1997) · Blood · doi:10.1182/blood.v90.3.909.909_909_928 · Cited by 2,126
The Resistance Factor toPlasmodium vivaxin Blacks
Miller, L. H., Mason, S. J., CLYDE, D. F., & McGinniss, M. H. (1976) · New England Journal of Medicine · doi:10.1056/nejm197608052950602 · Cited by 1,259
The Molecular Biology of Leukocyte Chemoattractant Receptors
Murphy, P. M. (1994) · Annual Review of Immunology · doi:10.1146/annurev.iy.12.040194.003113 · Cited by 1,197
Interleukin-1 Type II Receptor: A Decoy Target for IL-1 That Is Regulated by IL-4
Colotta, F., Re, F., Muzio, M., Bertini, R., Polentarutti, N., Sironi, M., Giri, J. G., Dower, S., Sims, J. E., & Mantovani, A. (1993) · Science · doi:10.1126/science.8332913 · Cited by 979
Self-citation
Anti-Immunology: Evasion of the Host Immune System by Bacterial and Viral Pathogens
Finlay, B. B., & McFadden, G. (2006) · Cell · doi:10.1016/j.cell.2006.01.034 · Cited by 917
Chemokine receptors: multifaceted therapeutic targets
Proudfoot, A. E. I. (2002) · Nature reviews. Immunology · doi:10.1038/nri722 · Cited by 755
Transcytosis and Surface Presentation of IL-8 by Venular Endothelial Cells
Middleton, J., Neil, S. J. D., Wintle, J., Clark‐Lewis, I., Moore, H. D., Lam, C., Auer, M., Hub, E., & Rot, A. (1997) · Cell · doi:10.1016/s0092-8674(00)80422-5 · Cited by 729
The chemokine system: redundancy for robust outputs
Mantovani, A. (1999) · Immunology Today · doi:10.1016/s0167-5699(99)01469-3 · Cited by 708
Self-citation
A Receptor for the Malarial Parasite Plasmodium vivax : the Erythrocyte Chemokine Receptor
Horuk, R., Chitnis, C. E., Darbonne, W. C., Colby, T. J., Rybicki, A. C., Hadley, T. J., & Miller, L. H. (1993) · Science · doi:10.1126/science.7689250 · Cited by 579
Viral mimicry of cytokines, chemokines and their receptors
Alcamı́, A. (2003) · Nature reviews. Immunology · doi:10.1038/nri980 · Cited by 560
A soluble receptor for interleukin-1β encoded by vaccinia virus: A novel mechanism of virus modulation of the host response to infection
Alcamı́, A., & Smith, G. L. (1992) · Cell · doi:10.1016/0092-8674(92)90274-g · Cited by 478
Red blood cells are a sink for interleukin 8, a leukocyte chemotaxin.
Darbonne, W. C., Rice, G. C., Möhler, M., Apple, T., Hébert, C. A., Valente, A. J., & Baker, J. B. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115442 · Cited by 452
Decoy receptors: a strategy to regulate inflammatory cytokines and chemokines
Mantovani, A., Locati, M., Vecchi, A., Sozzani, S., & Allavena, P. (2001) · Trends in Immunology · doi:10.1016/s1471-4906(01)01941-x · Cited by 383
Self-citation
Chemokine receptor CXCR4–dependent internalization and resecretion of functional chemokine SDF-1 by bone marrow endothelial and stromal cells
Dar, A., Goichberg, P., Shinder, V., Kalinkovich, A., Kollet, Ó., Netzer, N., Margalit, R., Zsak, M., Nagler, A., Hardan, I., et al. (2005) · Nature Immunology · doi:10.1038/ni1251 · Cited by 364
Apoptotic neutrophils and T cells sequester chemokines during immune response resolution through modulation of CCR5 expression
Ariel, A., Fredman, G., Sun, Y., Kantarcı, A., Dyke, T. E. V., Luster, A. D., & Serhan, C. N. (2006) · Nature Immunology · doi:10.1038/ni1392 · Cited by 363
Human cytomegalovirus open reading frame US28 encodes a functional beta chemokine receptor.
Gao, J., & Murphy, P. M. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)61936-8 · Cited by 342
Viral exploitation and subversion of the immune system through chemokine mimicry
Murphy, P. M. (2001) · Nature Immunology · doi:10.1038/84214 · Cited by 336
Vaccinia and cowpox viruses encode a novel secreted interleukin-1-binding protein
Spriggs, M. K., Hruby, D. E., Maliszewski, C. R., Pickup, D. J., Sims, J. E., Buller, R. M. L., & VanSlyke, J. K. (1992) · Cell · doi:10.1016/0092-8674(92)90273-f · Cited by 320
Encoding of a Homolog of the IFN-γ Receptor by Myxoma Virus
Upton, C., Mossman, K. L., & McFadden, G. (1992) · Science · doi:10.1126/science.1455233 · Cited by 305
The Duffy antigen/receptor for chemokines (DARC) is expressed in endothelial cells of Duffy negative individuals who lack the erythrocyte receptor.
Peiper, S. C., Wang, Z., Neote, K. S., Martin, A. W., Showell, H. J., Conklyn, M. J., Ogborne, K. T., Hadley, T. J., Lu, Z. H., Hesselgesser, J., et al. (1995) · The Journal of Experimental Medicine · doi:10.1084/jem.181.4.1311 · Cited by 304
Chemokine Sequestration by Viral Chemoreceptors as a Novel Viral Escape Strategy: Withdrawal of Chemokines from the Environment of Cytomegalovirus-infected Cells
Bodaghi, B., Jones, T. R., Zipeto, D., Vita, C., Sun, L., Laurent, L., Arenzana‐Seisdedos, F., Virelizier, J., & Michelson, S. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.188.5.855 · Cited by 302
The chemokine receptor D6 limits the inflammatory response in vivo
Jamieson, T. J., Cook, D. N., Nibbs, R. J. B., Rot, A., Nixon, C., McLean, P., Alcamı́, A., Lira, S. A., Wiekowski, M., & Graham, G. J. (2005) · Nature Immunology · doi:10.1038/ni1182 · Cited by 302
From Malaria to Chemokine Receptor: The Emerging Physiologic Role of the Duffy Blood Group Antigen
Hadley, T. J., & Peiper, S. C. (1997) · Blood · doi:10.1182/blood.v89.9.3077 · Cited by 291
Functional and biochemical analysis of the cloned Duffy antigen: identity with the red blood cell chemokine receptor
Neote, K. S., Mak, J., Kolakowski, L. J., & Schall, T. J. (1994) · Blood · doi:10.1182/blood.v84.1.44.44 · Cited by 277
The β-Chemokine Receptor D6 Is Expressed by Lymphatic Endothelium and a Subset of Vascular Tumors
Nibbs, R. J. B., Kriehuber, E., Ponath, P. D., Parent, D., Qin, S., Campbell, J. D., Henderson, A., Kerjaschki, D., Maurer, D., Graham, G. J., et al. (2001) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64035-7 · Cited by 268
Interaction of chemokines and glycosaminoglycans: A new twist in the regulation of chemokine function with opportunities for therapeutic intervention
Johnson, Z., Proudfoot, A. E. I., & Handel, T. M. (2005) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2005.04.006 · Cited by 266
Cloning of glycoprotein D cDNA, which encodes the major subunit of the Duffy blood group system and the receptor for the Plasmodium vivax malaria parasite.
Chaudhuri, A., Polyakova, J., Zbrzezna, V., Williams, K., Gulati, S., & Pogo, A. O. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.22.10793 · Cited by 255
Uncoupling of inflammatory chemokine receptors by IL-10: generation of functional decoys
D’Amico, G., Frascaroli, G., Bianchi, G., Transidico, P., Doni, A., Vecchi, A., Sozzani, S., Allavena, P., & Mantovani, A. (2000) · Nature Immunology · doi:10.1038/80819 · Cited by 252
Self-citation
The impact of CCR7 and CXCR5 on lymphoid organ development and systemic immunity
Müller, G., Höpken, U. E., & Lipp, M. (2003) · Immunological Reviews · doi:10.1034/j.1600-065x.2003.00073.x · Cited by 251
Interaction of KAI1 on tumor cells with DARC on vascular endothelium leads to metastasis suppression
Bandyopadhyay, S., Zhan, R., Chaudhuri, A., Watabe, M., Pai, S. K., Hirota, S., Hosobe, S., Tsukada, T., Miura, K., Takano, Y., et al. (2006) · Nature Medicine · doi:10.1038/nm1444 · Cited by 245
Constitutive Signaling of the Human Cytomegalovirus-encoded Chemokine Receptor US28
Casarosa, P., Bakker, R. A., Verzijl, D., Navis, M., Timmerman, H., Leurs, R., & Smit, M. J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008965200 · Cited by 240
Modulating CCR2 and CCL2 at the blood–brain barrier: relevance for multiple sclerosis pathogenesis
Mahad, D., Callahan, M. K., Williams, K. A., Ubogu, E. E., Kivisäkk, P., Tucky, B. H., Kidd, G. J., Kingsbury, G. A., Chang, A., Fox, R. J., et al. (2005) · Brain · doi:10.1093/brain/awh655 · Cited by 227
Cloning and Characterization of a Novel Promiscuous Human β-Chemokine Receptor D6
Nibbs, R. J. B., Wylie, S. M., Yang, J., Landau, N. R., & Graham, G. J. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.51.32078 · Cited by 221
T2 open reading frame from the shope fibroma virus encodes a soluble form of the TNF receptor
Smith, C. A., Davis, T., Wignall, J. M., Din, W. S., Farrah, T., Upton, C., McFadden, G., & Goodwin, R. G. (1991) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(91)90929-2 · Cited by 219
Exaggerated response to endotoxin in mice lacking the Duffy antigen/receptor for chemokines (DARC)
Dawson, T. C., Lentsch, A. B., Wang, Z., Cowhig, J. E., Rot, A., Maeda, N., & Peiper, S. C. (2000) · Blood · doi:10.1182/blood.v96.5.1681 · Cited by 217
The T1/35kDa Family of Poxvirus-Secreted Proteins Bind Chemokines and Modulate Leukocyte Influx into Virus-Infected Tissues
Graham, K., Lalani, A. S., Macen, J., Ness, T. L., Barry, M., Liu, L.-Y., Lucas, A. R., Clark‐Lewis, I., Moyer, R. W., & McFadden, G. (1997) · Virology · doi:10.1006/viro.1996.8423 · Cited by 215
Cutting Edge: Identification of a Novel Chemokine Receptor That Binds Dendritic Cell- and T Cell-Active Chemokines Including ELC, SLC, and TECK
Gosling, J., Dairaghi, D. J., Wang, Y., Hanley, M. R., Talbot, D., Miao, Z., & Schall, T. J. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.6.2851 · Cited by 214
A Broad Spectrum Secreted Chemokine Binding Protein Encoded by a Herpesvirus
Parry, C. M., Simas, J. P., Smith, V. P., Stewart, C. A., Minson, A. C., Efstathiou, S., & Alcamı́, A. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.191.3.573 · Cited by 210
Poxvirus Genomes Encode a Secreted, Soluble Protein That Preferentially Inhibits β Chemokine Activity yet Lacks Sequence Homology to Known Chemokine Receptors
Smith, C. A., Smith, T. D., Smolak, P. J., Friend, D. J., Hagen, H., GERHART, M. J., Park, L., Pickup, D. J., Torrance, D., Mohler, K. M., et al. (1997) · Virology · doi:10.1006/viro.1997.8730 · Cited by 189
The Chemokine Receptor D6 Constitutively Traffics to and from the Cell Surface to Internalize and Degrade Chemokines
Weber, M., Blair, E., Simpson, C. V., O'Hara, M., Blackburn, P. E., Rot, A., Graham, G. J., & Nibbs, R. J. B. (2004) · Molecular Biology of the Cell · doi:10.1091/mbc.e03-09-0634 · Cited by 188
Cutting Edge: Scavenging of Inflammatory CC Chemokines by the Promiscuous Putatively Silent Chemokine Receptor D6
Fra, A., Locati, M., Otero, K., Sironi, M., Signorelli, P., Massardi, M. L., Gobbi, M., Vecchi, A., Sozzani, S., & Mantovani, A. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.5.2279 · Cited by 185
Self-citation
The domain on the Duffy blood group antigen for binding Plasmodium vivax and P. knowlesi malarial parasites to erythrocytes.
Chitnis, C. E., Chaudhuri, A., Horuk, R., Pogo, A. O., & Miller, L. H. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.184.4.1531 · Cited by 182
The Human Cytomegalovirus US28 Protein Is Located in Endocytic Vesicles and Undergoes Constitutive Endocytosis and Recycling
Fraile‐Ramos, A., Kledal, T. N., Pelchen–Matthews, A., Bowers, K., Schwartz, T. W., & Marsh, M. (2001) · Molecular Biology of the Cell · doi:10.1091/mbc.12.6.1737 · Cited by 181
The purified myxoma virus gamma interferon receptor homolog M-T7 interacts with the heparin-binding domains of chemokines
Lalani, A. S., Graham, K., Mossman, K. L., Rajarathnam, K., Clark‐Lewis, I., Kelvin, D. J., & McFadden, G. (1997) · Journal of Virology · doi:10.1128/jvi.71.6.4356-4363.1997 · Cited by 179
The Viral Chemokine Macrophage Inflammatory Protein-II Is a Selective Th2 Chemoattractant
Sozzani, S., Luini, W., Bianchi, G., Allavena, P., Wells, T. N. C., Napolitano, M., Bernardini, G., Vecchi, A., D’Ambrosio, D., Mazzeo, D., et al. (1998) · Blood · doi:10.1182/blood.v92.11.4036 · Cited by 167
Self-citation
Schistosoma mansoni secretes a chemokine binding protein with antiinflammatory activity
Smith, P., Fallon, R. E., Mangan, N. E., Walsh, C. M., Saraiva, M., Sayers, J. R., McKenzie, A. N. J., Alcami, A., & Fallon, P. G. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20050955 · Cited by 160
β-Arrestin-dependent Constitutive Internalization of the Human Chemokine Decoy Receptor D6
Galliera, E., Jala, V. R., Trent, J. O., Bonecchi, R., Signorelli, P., Lefkowitz, R. J., Mantovani, A., Locati, M., & Haribabu, B. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m400363200 · Cited by 160
Self-citation
The chemokine receptor CCX‐CKR mediates effective scavenging of CCL19 in vitro
Comerford, I., Milasta, S., Morrow, V. A., Milligan, G., & Nibbs, R. J. B. (2006) · European Journal of Immunology · doi:10.1002/eji.200535716 · Cited by 155
Duffy Antigen Facilitates Movement of Chemokine Across the Endothelium In Vitro and Promotes Neutrophil Transmigration In Vitro and In Vivo
Lee, J. S., Frevert, C. W., Wurfel, M. M., Peiper, S. C., Wong, V. A., Ballman, K. K., RUZINSKI, J. T., Rhim, J. S., Martin, T. R., & Goodman, R. B. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.10.5244 · Cited by 153
Sulphated tyrosines mediate association of chemokines and Plasmodium vivax Duffy binding protein with the Duffy antigen/receptor for chemokines (DARC)
Choe, H., Moore, M. J., Owens, C. M., Wright, P. L., Vasilieva, N., Li, W., Singh, A. P., Shakri, R., Chitnis, C. E., & Farzan, M. (2005) · Molecular Microbiology · doi:10.1111/j.1365-2958.2004.04478.x · Cited by 148
Enhanced expression of Duffy antigen receptor for chemokines by breast cancer cells attenuates growth and metastasis potential
Wang, J., Ou, Z.-L., Hou, Y.-F., Luo, J.-M., Shen, Z.-Z., Ding, J., & Shao, Z.-M. (2006) · Oncogene · doi:10.1038/sj.onc.1209703 · Cited by 145
The Cytomegalovirus US28 Protein Binds Multiple CC Chemokines with High Affinity
Kuhn, D. E., Beall, C. J., & Kolattukudy, P. E. (1995) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1995.1814 · Cited by 145
Increased inflammation in mice deficient for the chemokine decoy receptor D6
de la Torre, Y. M., Locati, M., Buracchi, C., Dupor, J. I., Cook, D. N., Bonecchi, R., Nebuloni, M., Rukavina, D., Vago, L., Vecchi, A., et al. (2005) · European Journal of Immunology · doi:10.1002/eji.200526114 · Cited by 141
Self-citation
Glycoprotein G isoforms from some alphaherpesviruses function as broad-spectrum chemokine binding proteins.
Bryant, N. A., Davis‐Poynter, N., Vanderplasschen, A., & Alcami, A. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg092 · Cited by 141
Intracellular Signaling by the Chemokine Receptor US28 during Human Cytomegalovirus Infection
Billstrom, M. A., Johnson, G. L., Avdi, N. J., & Worthen, G. S. (1998) · Journal of Virology · doi:10.1128/jvi.72.7.5535-5544.1998 · Cited by 140
Cloning and Characterization of a Novel Murine β Chemokine Receptor, D6
Nibbs, R. J. B., Wylie, S. M., Pragnell, I. B., & Graham, G. J. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.19.12495 · Cited by 140
Differential Recognition and Scavenging of Native and Truncated Macrophage-Derived Chemokine (Macrophage-Derived Chemokine/CC Chemokine Ligand 22) by the D6 Decoy Receptor
Bonecchi, R., Locati, M., Galliera, E., Vulcano, M., Sironi, M., Fra, A., Gobbi, M., Vecchi, A., Sozzani, S., Haribabu, B., et al. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.8.4972 · Cited by 139
Self-citation
The Duffy antigen/receptor for chemokines (DARC) regulates prostate tumor growth
Shen, H., Schuster, R. M., Stringer, K. F., Waltz, S. E., & Lentsch, A. B. (2006) · The FASEB Journal · doi:10.1096/fj.05-4764com · Cited by 139
A chemokine-binding domain in the tumor necrosis factor receptor from variola (smallpox) virus
Alejo, A., Ruiz-Argüello, M. B., Ho, Y. Y., Smith, V. P., Saraiva, M., & Alcamı́, A. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510462103 · Cited by 137
RANTES Binding and Down-Regulation by a Novel Human Herpesvirus-6 β Chemokine Receptor
Milne, R. S. B., Mattick, C., Nicholson, L., Devaraj, P. E., Alcamı́, A., & Gompels, U. A. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.5.2396 · Cited by 135
Argos inhibits epidermal growth factor receptor signalling by ligand sequestration
Klein, D. E., Nappi, V. M., Reeves, G. T., Shvartsman, S. Y., & Lemmon, M. A. (2004) · Nature · doi:10.1038/nature02840 · Cited by 134
Distinct Transcriptional Programs Activated by Interleukin-10 with or without Lipopolysaccharide in Dendritic Cells: Induction of the B Cell-Activating Chemokine, CXC Chemokine Ligand 131
Perrier, P., Martínez, F., Locati, M., Bianchi, G., Nebuloni, M., Vago, G., Bazzoni, F., Sozzani, S., Allavena, P., & Mantovani, A. (2003) · Journal of Immunology · doi:10.4049/jimmunol.172.11.7031 · Cited by 130
Self-citation
Myxoma Virus M-T7, a Secreted Homolog of the Interferon-γ Receptor, Is a Critical Virulence Factor for the Development of Myxomatosis in European Rabbits
Mossman, K. L., Nation, P. N., Macen, J., Garbutt, M., Lucas, A. R., & McFadden, G. (1996) · Virology · doi:10.1006/viro.1996.0003 · Cited by 129
LD78β, A Non-allelic Variant of Human MIP-1α (LD78α), Has Enhanced Receptor Interactions and Potent HIV Suppressive Activity
Nibbs, R. J. B., Yang, J., Landau, N. R., Mao, J., & Graham, G. J. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.25.17478 · Cited by 128
Broad spectrum chemokine antagonistic activity of a human poxvirus chemokine homolog
Damon, I. K., Murphy, P. M., & Moss, B. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.11.6403 · Cited by 128
Contribution of Duffy antigen to chemokine function
Rot, A. (2005) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2005.05.011 · Cited by 126
Human cytomegalovirus encodes a highly specific RANTES decoy receptor
Wang, D., Bresnahan, W. A., & Shenk, T. E. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407233101 · Cited by 124
CTLA-4 regulates cell cycle progression during a primary immune response
Greenwald, R. J., Oosterwegel, M. A., van der Woude, D., Kubal, A., Mandelbrot, D. A., Boussiotis, V. A., & Sharpe, A. H. (2002) · European Journal of Immunology · doi:10.1002/1521-4141(200202)32:2 · Cited by 120
Endocytosis of the Viral Chemokine Receptor US28 Does Not Require Beta‐Arrestins But Is Dependent on the Clathrin‐Mediated Pathway
Fraile‐Ramos, A., Kohout, T. A., Waldhoer, M., & Marsh, M. (2003) · Traffic · doi:10.1034/j.1600-0854.2003.00079.x · Cited by 118
The human Duffy antigen binds selected inflammatory but not homeostatic chemokines
Gardner, L., Patterson, A. M., Ashton, B. A., Stone, M. A., & Middleton, J. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.06.146 · Cited by 115
Structural Basis of Chemokine Sequestration by a Herpesvirus Decoy Receptor
Alexander, J. M., Nelson, C. A., van Berkel, V. H., Lau, E. K., Studts, J., Brett, T. J., Speck, S. H., Handel, T. M., Virgin, H. W., & Fremont, D. H. (2002) · Cell · doi:10.1016/s0092-8674(02)01007-3 · Cited by 105
The Genes Encoding the Human CC-Chemokine Receptors CC-CKR1 to CC-CKR5 (CMKBR1–CMKBR5) Are Clustered in the p21.3–p24 Region of Chromosome 3
Samson, M., Soularue, P., Vassart, G., & Parmentier, M. (1996) · Genomics · doi:10.1006/geno.1996.0498 · Cited by 104
Overexpression of the duffy antigen receptor for chemokines (DARC) by NSCLC tumor cells results in increased tumor necrosis
Addison, C., Belperio, J. A., Burdick, M. D., & Strieter, R. M. (2004) · BMC Cancer · doi:10.1186/1471-2407-4-28 · Cited by 101
A Secreted Chemokine Binding Protein Encoded by Murine Gammaherpesvirus-68 Is Necessary for the Establishment of a Normal Latent Load
Bridgeman, A., Stevenson, P. G., Simas, J. P., & Efstathiou, S. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.194.3.301 · Cited by 99
Secreted Immunomodulatory Viral Proteins as Novel Biotherapeutics
Lucas, A. R., & McFadden, G. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.8.4765 · Cited by 98
Cloning, Expression, and Chromosomal Mapping of a Novel Human CC-Chemokine Receptor (CCR10) That Displays High-Affinity Binding for MCP-1 and MCP-3
Bonini, J. A., Martin, S. K., Dralyuk, F., Roe, M. W., Philipson, L. H., & Steiner, D. F. (1997) · DNA and Cell Biology · doi:10.1089/dna.1997.16.1249 · Cited by 94
A high endothelial venule-expressing promiscuous chemokine receptor DARC can bind inflammatory, but not lymphoid, chemokines and is dispensable for lymphocyte homing under physiological conditions
Kashiwazaki, M. (2003) · International Immunology · doi:10.1093/intimm/dxg121 · Cited by 90
THE EXPRESSION OF THE CYTOMEGALOVIRUS CHEMOKINE RECEPTOR HOMOLOG US28 SEQUESTERS BIOLOGICALLY ACTIVE CC CHEMOKINES AND ALTERS IL-8 PRODUCTION
Randolph‐Habecker, J., Rahill, B. M., Torok‐Storb, B., Vieira, J., Kolattukudy, P. E., Rovin, B. H., & Sedmak, D. D. (2002) · Cytokine · doi:10.1006/cyto.2002.0874 · Cited by 88
Critical role for a high-affinity chemokine-binding protein in γ-herpesvirus–induced lethal meningitis
van Berkel, V. H., Levine, B., Kapadia, S. B., Goldman, J. E., Speck, S. H., & Virgin, H. W. (2002) · Journal of Clinical Investigation · doi:10.1172/jci14358 · Cited by 84
CIIV, MIIC and other compartments for MHC class II loading
Neefjes, J. (1999) · European Journal of Immunology · doi:10.1002/(sici)1521-4141(199905)29:05 · Cited by 84
The Promiscuous CC Chemokine Receptor D6 Is a Functional Coreceptor for Primary Isolates of Human Immunodeficiency Virus Type 1 (HIV-1) and HIV-2 on Astrocytes
Neil, S. J. D., Aasa-Chapman, M. M. I., Clapham, P. R., Nibbs, R. J. B., McKnight, Á., & Weiss, R. A. (2005) · Journal of Virology · doi:10.1128/jvi.79.15.9618-9624.2005 · Cited by 74
Cutting Edge: The Silent Chemokine Receptor D6 Is Required for Generating T Cell Responses That Mediate Experimental Autoimmune Encephalomyelitis
Liu, L., Graham, G. J., Damodaran, A., Hu, T., Lira, S. A., Sasse, M. E., Canasto‐Chibuque, C., Cook, D. N., & Ransohoff, R. M. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.1.17 · Cited by 73
Purification and biochemical characterization of the D6 chemokine receptor
BLACKBURN, P. E., Simpson, C. V., Nibbs, R. J. B., O'HARA, M., BOOTH, R., POULOS, J., Isaacs, N. W., & Graham, G. J. (2004) · Biochemical Journal · doi:10.1042/bj20031266 · Cited by 71
Surface Expression and Endocytosis of the Human Cytomegalovirus-encoded Chemokine Receptor US28 Is Regulated by Agonist-independent Phosphorylation
Mokros, T., Rehm, A., Droese, J., Oppermann, M., Lipp, M., & Höpken, U. E. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m208214200 · Cited by 70
Modulation of chemokine receptor expression and chemotactic responsiveness during differentiation of human naive T cells into Th1 or Th2 cells
Colantonio, L., Recalde, H. R., Sinigaglia, F., & D’Ambrosio, D. (2002) · European Journal of Immunology · doi:10.1002/1521-4141(200205)32:5 · Cited by 69
Potential role for Duffy antigen chemokine-binding protein in angiogenesis and maintenance of homeostasis in response to stress
Du, J., Luan, J. Y., Liu, H., Daniel, T. O., Peiper, S. C., Chen, T. S., Yu, Y., Horton, L. W., Nanney, L. B., Strieter, R. M., et al. (2002) · Journal of Leukocyte Biology · doi:10.1189/jlb.71.1.141 · Cited by 67
The Duffy antigen/receptor for chemokines (DARC) and prostate cancer. A role as clear as black and white?
Lentsch, A. B. (2002) · The FASEB Journal · doi:10.1096/fj.02-0066hyp · Cited by 67
New genotypes in Fy(a− b−) individuals: nonsense mutations (Trp to stop) in the coding sequence of either FY A or FY B
Ríos, Chaudhuri, Mallinson, Sausais, Gomensoro‐Garcia, Hannon, Rosenberger, Poole, Burgess, Pogo, et al. (2000) · British Journal of Haematology · doi:10.1046/j.1365-2141.2000.01882.x · Cited by 65
CCR2 REGULATES THE LEVEL OF MCP-1/CCL2 IN VITRO AND AT INFLAMMATORY SITES AND CONTROLS T CELL ACTIVATION IN RESPONSE TO ALLOANTIGEN
Tylaska, L. A., Boring, L. F., Weng, W., Aiello, R. J., Charo, I. F., Rollins, B. J., & Gladue, R. P. (2002) · Cytokine · doi:10.1006/cyto.2002.1031 · Cited by 64
A Soluble Chemokine-Binding Protein from Vaccinia Virus Reduces Virus Virulence and the Inflammatory Response to Infection
Reading, P. C., Symons, J. A., & Smith, G. L. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.3.1435 · Cited by 58
Disruption of CCL21-Induced Chemotaxis In Vitro and In Vivo by M3, a Chemokine-Binding Protein Encoded by Murine Gammaherpesvirus 68
Jensen, K. K., Chen, S., Hipkin, R. W., Wiekowski, M., Schwarz, M. A., Chou, C., Simas, J. P., Alcamı́, A., & Lira, S. A. (2002) · Journal of Virology · doi:10.1128/jvi.77.1.624-630.2003 · Cited by 57
Structure-function analysis of the extracellular domains of the Duffy antigen/receptor for chemokines: characterization of antibody and chemokine binding sites
Tournamille, C., Filipe, A., Wasniowska, K., Gane, P., Lisowska, E., Cartron, J., Colin, Y., & Le Van Kim, C. (2003) · British Journal of Haematology · doi:10.1046/j.1365-2141.2003.04533.x · Cited by 56
Chemokine scavenging by D6: a movable feast?
Graham, G. J., & McKimmie, C. S. (2006) · Trends in Immunology · doi:10.1016/j.it.2006.06.006 · Cited by 56
The influence of Duffy blood group on renal allograft outcome in african americans
Akalin, E., & Neylan, J. F. (2003) · Transplantation · doi:10.1097/01.tp.0000061228.38243.26 · Cited by 50
Expression of L-CCR in HEK 293 cells reveals functional responses to CCL2, CCL5, CCL7, and CCL8
Biber, K. P. H., Zuurman, M. W., Homan, H., & Boddeke, H. W. G. M. (2003) · Journal of Leukocyte Biology · doi:10.1189/jlb.0802415 · Cited by 48
Cloning and Characterization of a Novel Human Chemokine Receptor
Fan, P., Kyaw, H., Su, K., Zeng, Z., Augustus, M., Carter, K. C., & Li, Y. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.7981 · Cited by 47
When renal allografts turn darc1
Segerer, S., Böhmig, G. A., Exner, M., Colin, Y., Cartron, J., Kerjaschki, D., Schlöndorff, D., & Regele, H. M. (2003) · Transplantation · doi:10.1097/01.tp.0000054679.91112.6f · Cited by 45
Viral chemokine-modulatory proteins: tools and targets
Boomker, J. M., de Leij, L. F. M. H., THE, T. H., & Harmsen, M. C. (2005) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2004.12.002 · Cited by 42
HCMV-encoded chemokine receptor US28 employs multiple routes for internalization
Droese, J., Mokros, T., Hermosilla, R., Schülein, R., Lipp, M., Höpken, U. E., & Rehm, A. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.07.076 · Cited by 38
The gammaherpesvirus chemokine binding protein can inhibit the interaction of chemokines with glycosaminoglycans
Webb, L. M. C., Smith, V. P., & Alcamı́, A. (2004) · The FASEB Journal · doi:10.1096/fj.03-0485fje · Cited by 38
Duffy antigen receptor and genetic susceptibility of African Americans to acute rejection and delayed function
Mange, K. C., Prak, E. T. L., Kamoun, M., Du, Y., Goodman, N. G., Danoff, T. M., Hoy, T., Newman, M., Joffe, M. M., & Feldman, H. I. (2004) · Kidney International · doi:10.1111/j.1523-1755.2004.00871.x · Cited by 22
Structural basis of the herpesvirus M3–chemokine interaction
Alcamı́, A. (2003) · Trends in Microbiology · doi:10.1016/s0966-842x(03)00077-5 · Cited by 17
RENAL ALLOGRAFT SURVIVAL IN AFRICAN-AMERICANS: INFLUENCE OF THE DUFFY BLOOD GROUP.
Danoff, T. M., Hallows, K. R., Burns, J. E., Brayman, K. L., & Feldman, H. I. (1999) · Transplantation · doi:10.1097/00007890-199904150-00036 · Cited by 10

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Rollins, B. J. Chemokines. Blood 90, 909–928 (1997). · DOI

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Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor
Coppé, J.-P., Patil, C. K., Rodier, F., Sun, Y., Muñoz, D. P., Goldstein, J., Nelson, P. S., Desprez, P.-Y., & Campisi, J. (2008) · PLoS Biology · doi:10.1371/journal.pbio.0060301 · Cited by 302
“As they persist in tissues, senescent cells likely create a proinflammatory tissue environment, which is known to be protumorigenic [3,64].”
Background
Chemokine signaling via the CXCR2 receptor reinforces senescence
Acosta, J. C., O'Loghlen, A., Banito, A., Guijarro, M. V., Augert, A., Raguz, S., Fumagalli, M., Da Costa, M., Brown, C., Popov, N., et al. (2008) · Cell · doi:10.1016/j.cell.2008.03.038 · Cited by 1,801
The Chemokine Superfamily Revisited
Zlotnik, A., & Yoshie, O. (2012) · Immunity · doi:10.1016/j.immuni.2012.05.008 · Cited by 1,239
Regulation of the Inflammatory Response in Cardiac Repair
Frangogiannis, N. G. (2012) · Circulation Research · doi:10.1161/circresaha.111.243162 · Cited by 1,239
Leukocyte Migration into Inflamed Tissues
Nourshargh, S., & Alon, R. (2014) · Immunity · doi:10.1016/j.immuni.2014.10.008 · Cited by 1,236

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Authors: Mantovani, A., Bonecchi, R., & Locati, M.
Affiliations: University of Milan (IT)
Corresponding author: Mantovani, Alberto
ORCID: Mantovani, Alberto
Bonecchi, Raffaella
Locati, Massimo
Venue: Nature Reviews Immunology
Publisher: Springer Science and Business Media LLC
Published: 2006-12-01
Volume: 6
Issue: 12
Pages: 907-918
ISSN: 1474-1733 (ISSN-L)
1474-1741
DOI: 10.1038/nri1964
OpenAlex: W1970170374
Cited by: 481
References: 106
Citations by year: 2026: 5 · 2025: 11 · 2024: 8 · 2023: 14 · 2022: 16 · 2021: 21 · 2020: 22 · 2019: 17 · 2018: 21 · 2017: 27 · 2016: 22 · 2015: 29 · 2014: 24 · 2013: 39 · 2012: 39
FWCI: 3.10
Type: journal article
Language: en
Open access: closed
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature reviews. Immunology (publishedVersion)
PubMed (publishedVersion)
Funders: Ministero della Salute
Ministero dell'Università e della Ricerca
Topics: Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Immunology and Microbiology › Immunology › Inflammation biomarkers and pathways
Keywords: chemokine receptors, leukocyte recruitment, inflammation regulation, immunomodulation, parasite evasion, innate immunity, adaptive immunity
MeSH terms: Animals, Cell Movement, Immunity, Inflammation, Parasites, Protein Conformation, Viruses, Chemokines, Receptors, Chemokine, Mice

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Tuning inflammation and immunity by chemokine sequestration: decoys and more

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