The DOI matches its Crossref record; 106 of the 106 references it cites were found in a registry or an index.
Tuning inflammation and immunity by chemokine sequestration: decoys and more
Abstract
A set of chemokine receptors are structurally unable to elicit migration or conventional signalling responses after ligand engagement. These 'silent' (non-signalling) chemokine receptors regulate inflammatory and immune reactions in different ways, including by acting as decoys and scavengers. Chemokine decoy receptors recognize distinct and complementary sets of ligands and are strategically expressed in different cellular contexts. Importantly, viruses and parasites have evolved multiple strategies to elude chemokines, including the expression of decoy receptors. So, decoy receptors for chemokines represent a general strategy to tune, shape and temper innate and adaptive immunity.
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In the citing paper
“As they persist in tissues, senescent cells likely create a proinflammatory tissue environment, which is known to be protumorigenic [ 3 , 64 ].”
From Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor (2008) · cites this paper as [64]
In the citing paper
“Actually, MCP1 and MUC5AC are responsible for inflammatory cells infiltration[37] and hypersecretion of mucus [38].”
Citations
Cites
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Luster, A. D. (1998) · New England Journal of Medicine · doi:10.1056/nejm199802123380706 · Cited by 3,633
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The Molecular Biology of Leukocyte Chemoattractant Receptors
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Interleukin-1 Type II Receptor: A Decoy Target for IL-1 That Is Regulated by IL-4
Colotta, F., Re, F., Muzio, M., Bertini, R., Polentarutti, N., Sironi, M., Giri, J. G., Dower, S., Sims, J. E., & Mantovani, A. (1993) · Science · doi:10.1126/science.8332913 · Cited by 979
Self-citationAnti-Immunology: Evasion of the Host Immune System by Bacterial and Viral Pathogens
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Chemokine receptors: multifaceted therapeutic targets
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Transcytosis and Surface Presentation of IL-8 by Venular Endothelial Cells
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Research works printed but not linked: 1
- Rollins, B. J. Chemokines. Blood 90, 909–928 (1997). · DOI
Cited by
Sorted by citations
Coppé, J.-P., Patil, C. K., Rodier, F., Sun, Y., Muñoz, D. P., Goldstein, J., Nelson, P. S., Desprez, P.-Y., & Campisi, J. (2008) · PLoS Biology · doi:10.1371/journal.pbio.0060301 · Cited by 302
“As they persist in tissues, senescent cells likely create a proinflammatory tissue environment, which is known to be protumorigenic [3,64].”
BackgroundChemokine signaling via the CXCR2 receptor reinforces senescence
Acosta, J. C., O'Loghlen, A., Banito, A., Guijarro, M. V., Augert, A., Raguz, S., Fumagalli, M., Da Costa, M., Brown, C., Popov, N., et al. (2008) · Cell · doi:10.1016/j.cell.2008.03.038 · Cited by 1,801
The Chemokine Superfamily Revisited
Zlotnik, A., & Yoshie, O. (2012) · Immunity · doi:10.1016/j.immuni.2012.05.008 · Cited by 1,239
Regulation of the Inflammatory Response in Cardiac Repair
Frangogiannis, N. G. (2012) · Circulation Research · doi:10.1161/circresaha.111.243162 · Cited by 1,239
Leukocyte Migration into Inflamed Tissues
Nourshargh, S., & Alon, R. (2014) · Immunity · doi:10.1016/j.immuni.2014.10.008 · Cited by 1,236
Metadata
- Authors
- Mantovani, A., Bonecchi, R., & Locati, M.
- Affiliations
- University of Milan (IT)
- Corresponding author
- Mantovani, Alberto
- Venue
- Nature Reviews Immunology
- Published
- 2006-12-01
- Volume
- 6
- Issue
- 12
- Pages
- 907-918
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- OpenAlex
- W1970170374
- Cited by
- 481
- References
- 106
- Citations by year
- 2026: 5 · 2025: 11 · 2024: 8 · 2023: 14 · 2022: 16 · 2021: 21 · 2020: 22 · 2019: 17 · 2018: 21 · 2017: 27 · 2016: 22 · 2015: 29 · 2014: 24 · 2013: 39 · 2012: 39
- FWCI
- 3.10
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Nature reviews. Immunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministero della Salute
- Ministero dell'Università e della Ricerca
- Topics
- Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Immunology and Microbiology › Immunology › Inflammation biomarkers and pathways
- Keywords
- chemokine receptors, leukocyte recruitment, inflammation regulation, immunomodulation, parasite evasion, innate immunity, adaptive immunity
- MeSH terms
- Animals, Cell Movement, Immunity, Inflammation, Parasites, Protein Conformation, Viruses, Chemokines, Receptors, Chemokine, Mice
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