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The role of TNF superfamily members in T-cell function and diseases
Open accessAbstract
Interactions that occur between several tumour necrosis factor (TNF)–TNF receptors that are expressed by T cells and various other immune and non-immune cell types are central to T-cell function. In this Review, I discuss the biology of four different ligand–receptor interactions — OX40 ligand and OX40, 4-1BB ligand and 4-1BB, CD70 and CD27, and TL1A and death receptor 3 — and their potential to be exploited for therapeutic benefit. Manipulating these interactions can be effective for treating diseases in which T cells have an important role, including inflammatory conditions, autoimmunity and cancer. Here, I explore how blocking or inducing the signalling pathways that are triggered by these different interactions can be an effective way to modulate immune responses.
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Cited by
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Chen, L., & Flies, D. B. (2013) · Nature Reviews Immunology · doi:10.1038/nri3405 · Cited by 3,114
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Luckheeram, R. V., Zhou, R., Verma, A. D., & Xia, B. (2012) · Clinical and Developmental Immunology · doi:10.1155/2012/925135 · Cited by 1,381
Lemos, D. R., Babaeijandaghi, F., Low, M., Chang, C.-K., Lee, S. T., Fiore, D., Zhang, R.-H., Natarajan, A., Nedospasov, S. A., & Rossi, F. M. V. (2015) · Nature Medicine · doi:10.1038/nm.3869 · Cited by 740
Zhang, C., Liu, J., Zhong, J. F., & Zhang, X. (2017) · Biomarker Research · doi:10.1186/s40364-017-0102-y · Cited by 578
Metadata
- Authors
- Croft, M.
- Venue
- Nature Reviews Immunology
- Published
- 2009-04
- Volume
- 9
- Issue
- 4
- Pages
- 271-285
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- OpenAlex
- W2047526240
- Cited by
- 920
- References
- 0
- FWCI
- 3.48
- Type
- journal article
- Language
- en
- Open access
- green
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