Molecular mechanisms of T cell co-stimulation and co-inhibition

PD-1 and PD-L1 Immune Checkpoint Blockade to Treat Breast Cancer

Hartkopf, A. D., Taran, F., Wallwiener, M., Walter, C. B., Krämer, B., Grischke, E., & Brucker, S. Y. (2016) · Breast Care · doi:10.1159/000453569 · Cited by 30,989 · see citing works

The blockade of immune checkpoints in cancer immunotherapy

Pardoll, D. M. (2012) · Nature Reviews Cancer · doi:10.1038/nrc3239 · Cited by 13,838 · see citing works

Safety, activity, and immune correlates of anti–PD-1 antibody in cancer

Topalian, S. L., Hodi, F. S., Brahmer, J. R., Gettinger, S. N., Smith, D. C., McDermott, D. F., Powderly, J. D., Carvajal, R. D., Sosman, J. A., Atkins, M. B., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1200690 · Cited by 12,628 · see citing works

PD-1 and Its Ligands in Tolerance and Immunity

Keir, M. E., Butte, M. J., Freeman, G. J., & Sharpe, A. H. (2008) · Annual Review of Immunology · doi:10.1146/annurev.immunol.26.021607.090331 · Cited by 5,378 · see citing works

T cell exhaustion

Wherry, E. J. (2011) · Nature Immunology · doi:10.1038/ni.2035 · Cited by 4,062 · see citing works

Cancer immunotherapy comes of age

Mellman, I., Coukos, G., & Dranoff, G. (2011) · Nature · doi:10.1038/nature10673 · Cited by 3,893 · see citing works

The B7 family revisited

Greenwald, R. J., Freeman, G. J., & Sharpe, A. H. (2005) · Annual Review of Immunology · doi:10.1146/annurev.immunol.23.021704.115611 · Cited by 2,318 · see citing works

Cytokine Storm in a Phase 1 Trial of the Anti-CD28 Monoclonal Antibody TGN1412

Suntharalingam, G., Perry, M. R., Ward, S., Brett, S. J., Castello-Cortes, A., Brunner, M. D., & Panoskaltsis, N. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa063842 · Cited by 2,164 · see citing works

PD-L1 regulates the development, maintenance, and function of induced regulatory T cells

Francisco, L. M., Salinas, V. H., Brown, K. E., Vanguri, V. K., Freeman, G. J., Kuchroo, V. K., & Sharpe, A. H. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20090847 · Cited by 2,072 · see citing works

Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4

Qureshi, O. S., Zheng, Y., Nakamura, K., Attridge, K., Manzotti, C., Schmidt, E. M., Baker, J., Jeffery, L. E., Kaur, S., Briggs, Z., et al. (2011) · Science · doi:10.1126/science.1202947 · Cited by 1,860 · see citing works

A Theory of Self-Nonself Discrimination

Bretscher, P., & Cohn, M. (1970) · Science · doi:10.1126/science.169.3950.1042 · Cited by 1,755 · see citing works

Programmed Death-1 Ligand 1 Interacts Specifically with the B7-1 Costimulatory Molecule to Inhibit T Cell Responses

Butte, M. J., Keir, M. E., Phamduy, T. B., Sharpe, A. H., & Freeman, G. J. (2007) · Immunity · doi:10.1016/j.immuni.2007.05.016 · Cited by 1,733 · see citing works

CTLA-4 is a second receptor for the B cell activation antigen B7.

Linsley, P. S., Brady, W., Urnes, M., Grosmaire, L. S., Damle, N. K., & Ledbetter, J. A. (1991) · The Journal of experimental medicine · doi:10.1084/jem.174.3.561 · Cited by 1,685 · see citing works

Combining immunotherapy and targeted therapies in cancer treatment

Vanneman, M. W., & Dranoff, G. (2012) · Nature reviews. Cancer · doi:10.1038/nrc3237 · Cited by 1,583 · see citing works

Clonal Expansion Versus Functional Clonal Inactivation: A Costimulatory Signalling Pathway Determines the Outcome of T Cell Antigen Receptor Occupancy

Mueller, D. L., Jenkins, M. K., & Schwartz, R. H. (1989) · Annual Review of Immunology · doi:10.1146/annurev.iy.07.040189.002305 · Cited by 1,501 · see citing works

T cell anergy

Schwartz, R. H. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141110 · Cited by 1,487 · see citing works

Monoclonal antibodies: versatile platforms for cancer immunotherapy

Weiner, L. M., Surana, R., & Wang, S. (2010) · Nature reviews. Immunology · doi:10.1038/nri2744 · Cited by 1,282 · see citing works

Differential T Cell Costimulatory Requirements in CD28-Deficient Mice

Shahinian, A., Pfeffer, K., Lee, K. P., Kündig, T. M., Kishihara, K., Wakeham, A. C., Kawai, K., Ohashi, P. S., Thompson, C. B., & Mak, T. W. (1993) · Science · doi:10.1126/science.7688139 · Cited by 1,258 · see citing works

Programmed cell death 1 forms negative costimulatory microclusters that directly inhibit T cell receptor signaling by recruiting phosphatase SHP2

Yokosuka, T., Takamatsu, M., Kobayashi-Imanishi, W., Hashimoto-Tane, A., Azuma, M., & Saito, T. (2012) · Journal of Experimental Medicine · doi:10.1084/jem.20112741 · Cited by 1,161 · see citing works

Control of peripheral T‐cell tolerance and autoimmunity via the CTLA‐4 and PD‐1 pathways

Fife, B. T., & Bluestone, J. A. (2008) · Immunological Reviews · doi:10.1111/j.1600-065x.2008.00662.x · Cited by 1,052 · see citing works

ICOS Receptor Instructs T Follicular Helper Cell versus Effector Cell Differentiation via Induction of the Transcriptional Repressor Bcl6

Choi, Y. S., Kageyama, R., Eto, D. S., Escobar, T. C., Johnston, R. J., Monticelli, L. A., Lao, C., & Crotty, S. (2011) · Immunity · doi:10.1016/j.immuni.2011.03.023 · Cited by 959 · see citing works

The role of TNF superfamily members in T-cell function and diseases

Croft, M. (2009) · Nature reviews. Immunology · doi:10.1038/nri2526 · Cited by 924 · see citing works

B70 antigen is a second ligand for CTLA-4 and CD28

Azuma, M., Ito, D., Yagita∥, H., Okumura, K., Phillips, J. H., Lanier, L. L., & Somoza, C. (1993) · Nature · doi:10.1038/366076a0 · Cited by 910 · see citing works

CD28 and CTLA-4 coreceptor expression and signal transduction

Rudd, C. E., Taylor, A., & Schneider, H. (2009) · Immunological Reviews · doi:10.1111/j.1600-065x.2009.00770.x · Cited by 898 · see citing works

Co-stimulatory members of the TNFR family: keys to effective T-cell immunity?

Croft, M. (2003) · Nature reviews. Immunology · doi:10.1038/nri1148 · Cited by 863 · see citing works

Plasmacytoid dendritic cells from mouse tumor-draining lymph nodes directly activate mature Tregs via indoleamine 2,3-dioxygenase

Sharma, M. D., Baban, B., Chandler, P., Hou, D., Singh, N., Yagita∥, H., Azuma, M., Blazar, B. R., Mellor, A. L., & Munn, D. H. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31911 · Cited by 791 · see citing works

PD‐1 inhibits T‐cell receptor induced phosphorylation of the ZAP70/CD3ζ signalosome and downstream signaling to PKCθ

Sheppard, K.-A., Fitz, L. J., Lee, J. M., Benander, C., George, J. A., Wooters, J., Qiu, Y., Jussif, J. M., Carter, L. L., Wood, C. R., et al. (2004) · FEBS Letters · doi:10.1016/j.febslet.2004.07.083 · Cited by 791 · see citing works

The emerging role of CTLA4 as a cell-extrinsic regulator of T cell responses

Walker, L. S. K., & Sansom, D. M. (2011) · Nature reviews. Immunology · doi:10.1038/nri3108 · Cited by 786 · see citing works

PD-1 signaling in primary T cells

Riley, J. L. (2009) · Immunological Reviews · doi:10.1111/j.1600-065x.2009.00767.x · Cited by 778 · see citing works

T-cell co-stimulation through B7RP-1 and ICOS

Yoshinaga, S. K., Whoriskey, J. S., Khare, S. D., Sarmiento, U. M., Guo, J., Horan, T., Shih, G. C., Zhang, M., Coccia, M. A., Kohno, T., et al. (1999) · Nature · doi:10.1038/45582 · Cited by 775 · see citing works

T-cell antigen CD28 mediates adhesion with B cells by interacting with activation antigen B7/BB-1.

Linsley, P. S., Clark, E. A., & Ledbetter, J. A. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.13.5031 · Cited by 755 · see citing works

Rational Development of LEA29Y (belatacept), a High-Affinity Variant of CTLA4-Ig with Potent Immunosuppressive Properties

Larsen, C. P., Pearson, T. C., Adams, A. B., Tso, P. L., Shirasugi, N., Strobertb, E., Anderson, D., Cowan, S. R., Price, K., Naemura, J. R., et al. (2005) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2005.00749.x · Cited by 721 · see citing works

VISTA, a novel mouse Ig superfamily ligand that negatively regulates T cell responses

Wang, L. L., Rubinstein, R., Lines, J. L., Wasiuk, A., Ahonen, C. L., Guo, Y., Lu, L., Gondek, D. C., Wang, Y., Fava, R. A., et al. (2011) · The Journal of Experimental Medicine · doi:10.1084/jem.20100619 · Cited by 713 · see citing works

The B7 family member B7-H6 is a tumor cell ligand for the activating natural killer cell receptor NKp30 in humans

Brandt, C. S., Baratin, M., Yi, E. C., Kennedy, J. J., Gao, Z., Fox, B. A., Haldeman, B. A., Ostrander, C. D., Kaifu, T., Chabannon, C., et al. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20090681 · Cited by 701 · see citing works

Comparative analysis of B7-1 and B7-2 costimulatory ligands: expression and function.

Hathcock, K. S., László, G., Pucillo, C. E. M., Linsley, P. S., & Hodes, R. J. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.180.2.631 · Cited by 670 · see citing works

B and T lymphocyte attenuator regulates T cell activation through interaction with herpesvirus entry mediator

Šedý, J. R., Gavrieli, M., Potter, K. G., Hurchla, M. A., Lindsley, R. C., Hildner, K. M., Scheu, S., Pfeffer, K., Ware, C. F., Murphy, T. L., et al. (2004) · Nature Immunology · doi:10.1038/ni1144 · Cited by 633 · see citing works

The tissue distribution of the B7-2 costimulator in mice: abundant expression on dendritic cells in situ and during maturation in vitro.

Inaba, K., Witmer-Pack, M. D., Inaba, M., Hathcock, K. S., Sakuta, H., Azuma, M., Yagita∥, H., Okumura, K., Linsley, P. S., Ikehara, S., et al. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.180.5.1849 · Cited by 593 · see citing works

T-Cell Proliferation Involving the CD28 Pathway Is Associated witH Cyclosporine-Resistant Interleukin 2 Gene Expression

June, C. H., Ledbetter, J. A., Gillespie, M., Lindsten, T., & Thompson, C. B. (1987) · Molecular and Cellular Biology · doi:10.1128/mcb.7.12.4472-4481.1987 · Cited by 565 · see citing works

Network Analysis Reveals Centrally Connected Genes and Pathways Involved in CD8+ T Cell Exhaustion versus Memory

Doering, T. A., Crawford, A., Angelosanto, J., Paley, M., Ziegler, C. G. K., & Wherry, E. J. (2012) · Immunity · doi:10.1016/j.immuni.2012.08.021 · Cited by 542 · see citing works

Selective effects of PD-1 on Akt and Ras pathways regulate molecular components of the cell cycle and inhibit T cell proliferation

Patsoukis, N., Brown, J., Petkova, V., Liu, F., Li, L., & Boussiotis, V. A. (2012) · Science Signaling · doi:10.1126/scisignal.2002796 · Cited by 529 · see citing works

B7-H1 is a ubiquitous antiapoptotic receptor on cancer cells

Azuma, T., Yao, S., Zhu, G., Flies, A. S., Flies, S. J., & Chen, L. (2008) · Blood · doi:10.1182/blood-2007-11-123141 · Cited by 528 · see citing works

Identification of an Alternative CTLA-4 Ligand Costimulatory for T Cell Activation

Hathcock, K. S., László, G., Dickler, H. B., Bradshaw, J., Linsley, P. S., & Hodes, R. J. (1993) · Science · doi:10.1126/science.7694361 · Cited by 517 · see citing works

SLAM Family Receptors and SAP Adaptors in Immunity

Cannons, J. L., Tangye, S. G., & Schwartzberg, P. L. (2011) · Annual Review of Immunology · doi:10.1146/annurev-immunol-030409-101302 · Cited by 495 · see citing works

The PD-1/PD-L1 complex resembles the antigen-binding Fv domains of antibodies and T cell receptors

Lin, D. Y.-W., Tanaka, Y., Iwasaki, M., Gittis, A. G., Su, H.-P., Mikami, B., Okazaki, T., Honjo, T., Minato, N., & Garboczi, D. N. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0712278105 · Cited by 465 · see citing works

Ligation of B7-1/B7-2 by Human CD4+ T Cells Triggers Indoleamine 2,3-Dioxygenase Activity in Dendritic Cells

Munn, D. H., Sharma, M. D., & Mellor, A. L. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.7.4100 · Cited by 453 · see citing works

The PDL1-PD1 Axis Converts Human T H 1 Cells into Regulatory T Cells

Amarnath, S., Mangus, C. W., Wang, J. C. M., Wei, F., He, A., Kapoor, V., Foley, J., Massey, P. R., Felizardo, T. C., Riley, J. L., et al. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3003130 · Cited by 449 · see citing works

Bat3 promotes T cell responses and autoimmunity by repressing Tim-3-mediated cell death and exhaustion

Rangachari, M., Zhu, C., Sakuishi, K., Xiao, S., Karman, J., Chen, A., Angin, M., Wakeham, A., Greenfield, E. A., Sobel, R. A., et al. (2012) · Nature Medicine · doi:10.1038/nm.2871 · Cited by 394 · see citing works

Unifying concepts in CD28, ICOS and CTLA4 co-receptor signalling.

Rudd, C. E., & Schneider, H. (2003) · Nature Reviews Immunology · doi:10.1038/nri1131 · Cited by 392 · see citing works

Coexpression of PD-1, 2B4, CD160 and KLRG1 on exhausted HCV-specific CD8+ T cells is linked to antigen recognition and T cell differentiation

Bengsch, B., Seigel, B., Ruhl, M., Timm, J., Kuntz, M., Blum, H. E., Pircher, H., & Thimme, R. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1000947 · Cited by 373 · see citing works

CD8(+) T cells specific for tumor antigens can be rendered dysfunctional by the tumor microenvironment through upregulation of the inhibitory receptors BTLA and PD-1

Fourcade, J., Sun, Z., Pagliano, O., Guillaume, P., Luescher, I. F., Sander, C., Kirkwood, J. M., Olive, D., Kuchroo, V., & Zarour, H. M. (2012) · Cancer Research · doi:10.1158/0008-5472.can-11-2637 · Cited by 372 · see citing works

Bcl6 and Maf Cooperate To Instruct Human Follicular Helper CD4 T Cell Differentiation

Kroenke, M. A., Eto, D. S., Locci, M., Cho, M., Davidson, T. M., Haddad, E. K., & Crotty, S. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1103246 · Cited by 355 · see citing works

LAG-3 in Cancer Immunotherapy

Goldberg, M. V., & Drake, C. G. (2010) · Current topics in microbiology and immunology · doi:10.1007/82_2010_114 · Cited by 337 · see citing works

B7-H1/CD80 interaction is required for the induction and maintenance of peripheral T-cell tolerance

Park, J., Omiya, R., Matsumura, Y., Sakoda, Y., Kuramasu, A., Augustine, M. M., Yao, S., Tsushima, F., Narazaki, H., Anand, S., et al. (2010) · Blood · doi:10.1182/blood-2010-01-265975 · Cited by 331 · see citing works

Engagement of B7 on effector T cells by regulatory T cells prevents autoimmune disease

Paust, S., Lu, L., McCarty, N., & Cantor, H. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0403342101 · Cited by 328 · see citing works

PD-L1 negatively regulates CD4+CD25+Foxp3+ Tregs by limiting STAT-5 phosphorylation in patients chronically infected with HCV

Franceschini, D., Paroli, M., Francavilla, V., Videtta, M., Morrone, S., Labbadia, G., Cerino, A., Mondelli, M. U., & Barnaba, V. (2009) · Journal of Clinical Investigation · doi:10.1172/jci36604 · Cited by 316 · see citing works

Timing and tuning of CD27–CD70 interactions: the impact of signal strength in setting the balance between adaptive responses and immunopathology

Nolte, M. A., van Olffen, R. W., van Gisbergen, K. P. J. M., & van Lier, R. A. W. (2009) · Immunological Reviews · doi:10.1111/j.1600-065x.2009.00774.x · Cited by 305 · see citing works

The CD160, BTLA, LIGHT/HVEM pathway: a bidirectional switch regulating T‐cell activation

Cai, G., & Freeman, G. J. (2009) · Immunological Reviews · doi:10.1111/j.1600-065x.2009.00783.x · Cited by 301 · see citing works

Ligands working as receptors: reverse signaling by members of the TNF superfamily enhance the plasticity of the immune system

Eißner, G., Kölch, W., & Scheurich, P. (2004) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2004.03.011 · Cited by 298 · see citing works

Immune regulation by 4‐1BB and 4‐1BBL: complexities and challenges

Wang, C., Lin, G. H. Y., McPherson, A. J., & Watts, T. H. (2009) · Immunological Reviews · doi:10.1111/j.1600-065x.2009.00765.x · Cited by 298 · see citing works

Progressive Loss of Memory T Cell Potential and Commitment to Exhaustion during Chronic Viral Infection

Angelosanto, J., Blackburn, S. D., Crawford, A., & Wherry, E. J. (2012) · Journal of Virology · doi:10.1128/jvi.00889-12 · Cited by 285 · see citing works

An Enigmatic Tail of CD28 Signaling

Boomer, J. S., & Green, J. M. (2010) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a002436 · Cited by 283 · see citing works

Clinical Experiences With Anti-CD137 and Anti-PD1 Therapeutic Antibodies

Ascierto, P. A., Simeone, E., Sznol, M., Fu, Y., & Melero, I. (2010) · Seminars in Oncology · doi:10.1053/j.seminoncol.2010.09.008 · Cited by 276 · see citing works

Emerging Tim-3 functions in antimicrobial and tumor immunity

Sakuishi, K., Jayaraman, P., Behar, S. M., Anderson, A. C., & Kuchroo, V. K. (2011) · Trends in Immunology · doi:10.1016/j.it.2011.05.003 · Cited by 258 · see citing works

Costimulation of T cells by B7-H2, a B7-like molecule that binds ICOS

Wang, S., Zhu, G., Chapoval, A. I., Dong, H., Tamada, K., Ni, J., & Chen, L. (2000) · Blood · doi:10.1182/blood.v96.8.2808 · Cited by 256 · see citing works

A coreceptor interaction between the CD28 and TNF receptor family members B and T lymphocyte attenuator and herpesvirus entry mediator

Gonzalez, L. C., Loyet, K. M., Calemine-Fenaux, J., Chauhan, V., Wranik, B. J., Ouyang, W., & Eaton, D. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409071102 · Cited by 252 · see citing works

Chimeric antigen receptors for T cell immunotherapy: current understanding and future directions

Curran, K. J., Pegram, H. J., & Brentjens, R. J. (2012) · The Journal of Gene Medicine · doi:10.1002/jgm.2604 · Cited by 250 · see citing works

Cutting Edge: A Monoclonal Antibody Specific for the Programmed Death-1 Homolog Prevents Graft-versus-Host Disease in Mouse Models

Flies, D. B., Wang, S., Xu, H., & Chen, L. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1100660 · Cited by 249 · see citing works

The signaling networks of the herpesvirus entry mediator (TNFRSF14) in immune regulation

Steinberg, M. W., Cheung, T. C., & Ware, C. F. (2011) · Immunological Reviews · doi:10.1111/j.1600-065x.2011.01064.x · Cited by 245 · see citing works

Regulation of CD4 T cell activation and effector function by inducible costimulator (ICOS)

Simpson, T. R., Quezada, S. A., & Allison, J. P. (2010) · Current Opinion in Immunology · doi:10.1016/j.coi.2010.01.001 · Cited by 233 · see citing works

OX40 signaling favors the induction of TH9 cells and airway inflammation

Xiao, X., Balasubramanian, S., Liu, W., Chu, X., Wang, H., Taparowsky, E. J., Fu, Y., Choi, Y., Walsh, M. C., & Li, X. C. (2012) · Nature Immunology · doi:10.1038/ni.2390 · Cited by 233 · see citing works

TNF superfamily in inflammatory disease: translating basic insights

Croft, M., Duan, W., Choi, H., Eun, S.-Y., Madireddi, S., & Mehta, A. K. (2011) · Trends in Immunology · doi:10.1016/j.it.2011.10.004 · Cited by 232 · see citing works

Regulating the regulators: costimulatory signals control the homeostasis and function of regulatory T cells

Bour‐Jordan, H., & Bluestone, J. A. (2009) · Immunological Reviews · doi:10.1111/j.1600-065x.2009.00775.x · Cited by 223 · see citing works

SLAM receptors and SAP influence lymphocyte interactions, development and function

Schwartzberg, P. L., Mueller, K. L., Qi, H., & Cannons, J. L. (2008) · Nature reviews. Immunology · doi:10.1038/nri2456 · Cited by 220 · see citing works

Spatiotemporal Basis of CTLA-4 Costimulatory Molecule-Mediated Negative Regulation of T Cell Activation

Yokosuka, T., Kobayashi, W., Takamatsu, M., Sakata-Sogawa, K., Zeng, H., Hashimoto, A. S., Yagita∥, H., Tokunaga, M., & Saito, T. (2010) · Immunity · doi:10.1016/j.immuni.2010.09.006 · Cited by 213 · see citing works

During Viral Infection of the Respiratory Tract, CD27, 4-1BB, and OX40 Collectively Determine Formation of CD8+ Memory T Cells and Their Capacity for Secondary Expansion

Hendriks, J., Xiao, Y., Rossen, J. W. A., van der Sluijs, K. F., Sugamura, K., Ishii, N., & Borst, J. G. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.3.1665 · Cited by 212 · see citing works

Crystal structure of the complex between programmed death-1 (PD-1) and its ligand PD-L2

Lázár‐Molnár, E., Yan, Q., Cao, E., Ramagopal, U. A., Nathenson, S. G., & Almo, S. C. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804453105 · Cited by 208 · see citing works

The Role of OX40-Mediated Co-stimulation in T-Cell Activation and Survival

Redmond, W. L., Ruby, C. E., & Weinberg, A. D. (2009) · Critical Reviews in Immunology · doi:10.1615/critrevimmunol.v29.i3.10 · Cited by 205 · see citing works

The Programmed Death-1 Ligand 1:B7-1 Pathway Restrains Diabetogenic Effector T Cells In Vivo

Paterson, A. M., Brown, K. E., Keir, M. E., Vanguri, V. K., Riella, L. V., Chandraker, A. K., Sayegh, M. H., Blazar, B. R., Freeman, G. J., & Sharpe, A. H. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1003496 · Cited by 202 · see citing works

Role of CD27/CD70 pathway of activation in immunity and tolerance

Denoeud, J., & Moser, M. (2010) · Journal of Leukocyte Biology · doi:10.1189/jlb.0610351 · Cited by 197 · see citing works

Cell Surface Signaling Molecules in the Control of Immune Responses: A Tide Model

Zhu, Y., Yao, S., & Chen, L. (2011) · Immunity · doi:10.1016/j.immuni.2011.04.008 · Cited by 196 · see citing works

Characterization of phosphotyrosine binding motifs in the cytoplasmic domain of B and T lymphocyte attenuator required for association with protein tyrosine phosphatases SHP-1 and SHP-2

Gavrieli, M., Watanabe, N., Loftin, S. K., Murphy, T. L., & MURPHY, K. M. M. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2003.11.070 · Cited by 190 · see citing works

Extended Co-Expression of Inhibitory Receptors by Human CD8 T-Cells Depending on Differentiation, Antigen-Specificity and Anatomical Localization

Baitsch, L., Legat, A., Barba, L., Marraco, S. A. F., Rivals, J., Baumgaertner, P., Christiansen-Jucht, C., Bouzourène, H., Rimoldi, D., Pircher, H., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030852 · Cited by 184 · see citing works

Synergistic T cell activation via the physiological ligands for CD2 and the T cell receptor.

Bierer, B. E., Peterson, A. S., Gorga, J. C., Herrmann, S. H., & Burakoff, S. J. (1988) · The Journal of Experimental Medicine · doi:10.1084/jem.168.3.1145 · Cited by 169 · see citing works

The Receptor Ly108 Functions as a SAP Adaptor-Dependent On-Off Switch for T Cell Help to B Cells and NKT Cell Development

Kageyama, R., Cannons, J. L., Zhao, F. R., Yusuf, I., Lao, C., Locci, M., Schwartzberg, P. L., & Crotty, S. (2012) · Immunity · doi:10.1016/j.immuni.2012.05.016 · Cited by 162 · see citing works

The clinical utility of inhibiting CD28‐mediated costimulation

Linsley, P. S., & Nadler, S. G. (2009) · Immunological Reviews · doi:10.1111/j.1600-065x.2009.00780.x · Cited by 160 · see citing works

T-cell Clonal AnergyPreprint

Schwartz, R. H., Mueller, D. L., Jenkins, M. K., & Quill, H. (1989) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.1989.054.01.072 · Cited by 159 · see citing works

GITR: A Modulator of Immune Response and Inflammation

Nocentini, G., & Riccardi, C. (2009) · Advances in experimental medicine and biology · doi:10.1007/978-0-387-89520-8_11 · Cited by 158 · see citing works

HVEM/LIGHT/BTLA/CD160 cosignaling pathways as targets for immune regulation

del Rio, M., Lucas, C. L., Bühler, L. H., Rayat, G. R., & Rodríguez-Barbosa, J.-I. (2009) · Journal of Leukocyte Biology · doi:10.1189/jlb.0809590 · Cited by 157 · see citing works

B7-H2 Is a Costimulatory Ligand for CD28 in Human

Yao, S., Zhu, Y., Zhu, G., Augustine, M. M., Zheng, L., Goode, D. J., Broadwater, M., Ruff, W. E., Flies, S. J., Xu, H., et al. (2011) · Immunity · doi:10.1016/j.immuni.2011.03.014 · Cited by 153 · see citing works

Roquin Differentiates the Specialized Functions of Duplicated T Cell Costimulatory Receptor Genes Cd28 and Icos

Linterman, M. A., Rigby, R. J., Wong, R. K., Silva, D., Withers, D. R., Anderson, G., Verma, N. K., Brink, R. A., Hutloff, A., Goodnow, C. C., et al. (2009) · Immunity · doi:10.1016/j.immuni.2008.12.015 · Cited by 152 · see citing works

The Adaptor SAP Controls NK Cell Activation by Regulating the Enzymes Vav-1 and SHIP-1 and by Enhancing Conjugates with Target Cells

Dong, Z., Davidson, D., Pérez‐Quintero, L., Kurosaki, T., Swat, W., & Veillette, A. (2012) · Immunity · doi:10.1016/j.immuni.2012.03.023 · Cited by 145 · see citing works

Opportunities and Challenges in the Development of Experimental Drug Combinations for Cancer

Humphrey, R. W., Brockway-Lunardi, L., Bonk, D., Dohoney, K. M., Doroshow, J. H., Meech, S. J., Ratain, M. J., Topalian, S. L., & Pardoll, D. M. (2011) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djr246 · Cited by 135 · see citing works

HVEM signalling at mucosal barriers provides host defence against pathogenic bacteria

Shui, J., Larangé, A., Kim, G., Vela, J. L., Zahner, S. P., Cheroutre, H., & Kronenberg, M. (2012) · Nature · doi:10.1038/nature11242 · Cited by 132 · see citing works

TL1A and DR3, a TNF family ligand‐receptor pair that promotes lymphocyte costimulation, mucosal hyperplasia, and autoimmune inflammation

Meylan, F., Richard, A. C., & Siegel, R. M. (2011) · Immunological Reviews · doi:10.1111/j.1600-065x.2011.01068.x · Cited by 132 · see citing works

B7 Expression on T Cells Down-Regulates Immune Responses through CTLA-4 Ligation via R-T Interactions

Taylor, P. A., Lees, C. J., Fournier, S., Allison, J. P., Sharpe, A. H., & Blazar, B. R. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.1.34 · Cited by 130 · see citing works

ICOS Ligation Recruits the p50α PI3K Regulatory Subunit to the Immunological Synapse

Fos, C., Salles, A., Lang, V., Carrette, F., Audebert, S., Pastor, S., Ghiotto, M., Olive, D., Bismuth, G., & Nunès, J. A. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.3.1969 · Cited by 127 · see citing works

Memory T cells need CD28 costimulation to remember

Boesteanu, A. C., & Katsikis, P. D. (2009) · Seminars in Immunology · doi:10.1016/j.smim.2009.02.005 · Cited by 124 · see citing works

Regulation of natural cytotoxicity by the adaptor SAP and the Src-related kinase Fyn

Bloch‐Queyrat, C., Fondanèche, M., Chen, R., Yin, L., Relouzat, F., Veillette, A., Fischer, A., & Latour, S. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20050449 · Cited by 124 · see citing works

Receptors that interact with nectin and nectin-like proteins in the immunosurveillance and immunotherapy of cancer

Chan, C. J., Andrews, D. M., & Smyth, M. J. (2012) · Current Opinion in Immunology · doi:10.1016/j.coi.2012.01.009 · Cited by 117 · see citing works

The CD4-like molecule LAG-3, biology and therapeutic applications

Sierro, S. R., Romero, P. J., & Speiser, D. E. (2010) · Expert Opinion on Therapeutic Targets · doi:10.1517/14712598.2011.540563 · Cited by 115 · see citing works

Positive and Negative Signaling through SLAM Receptors Regulate Synapse Organization and Thresholds of Cytolysis

Zhao, F. R., Cannons, J. L., Dutta, M., Griffiths, G. M., & Schwartzberg, P. L. (2012) · Immunity · doi:10.1016/j.immuni.2012.05.017 · Cited by 115 · see citing works

Premature Terminal Exhaustion of Friend Virus-Specific Effector CD8+ T Cells by Rapid Induction of Multiple Inhibitory Receptors

Takamura, S., Tsuji-Kawahara, S., Yagita∥, H., Akiba, H., Sakamoto, M., Chikaishi, T., Kato, M., & Miyazawa, M. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0903478 · Cited by 104 · see citing works

New Insights on OX40 in the Control of T Cell Immunity and Immune Tolerance In Vivo

Xiao, X., Gong, W., Demirci, G., Liu, W., Spoerl, S., Chu, X., Bishop, D. K., Turka, L. A., & Li, X. C. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1101373 · Cited by 102 · see citing works

Dynamic regulation of T cell activation and co‐stimulation through TCR‐microclusters

Saito, T., Yokosuka, T., & Hashimoto, A. S. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.11.036 · Cited by 98 · see citing works

Regulatory T Cells and Human Myeloid Dendritic Cells Promote Tolerance via Programmed Death Ligand-1

Amarnath, S., Costanzo, C. M., Mariotti, J., Ullman, J. L., Telford, W. G., Kapoor, V., Riley, J. L., Levine, B. L., June, C. H., Fong, T. C., et al. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000302 · Cited by 92 · see citing works

Sequence, structure, function, immunity: structural genomics of costimulation

Chattopadhyay, K., Lázár‐Molnár, E., Yan, Q., Rubinstein, R., Zhan, C., Vigdorovich, V. I., Ramagopal, U. A., Bonanno, J. B., Nathenson, S. G., & Almo, S. C. (2009) · Immunological Reviews · doi:10.1111/j.1600-065x.2009.00778.x · Cited by 92 · see citing works

Regulatory T Cell Expression of Herpesvirus Entry Mediator Suppresses the Function of B and T Lymphocyte Attenuator-Positive Effector T Cells

Tao, R., Wang, L., MURPHY, K. M. M., Fraser, C. C., & Hancock, W. W. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.10.6649 · Cited by 92 · see citing works

CD137 stimulation delivers an antigen-independent growth signal for T lymphocytes with memory phenotype

Zhu, Y., Zhu, G., Luo, L., Flies, A. S., & Chen, L. (2007) · Blood · doi:10.1182/blood-2006-10-043463 · Cited by 89 · see citing works

Association of Grb-2 and PI3K p85 with phosphotyrosile peptides derived from BTLA

Gavrieli, M., & Murphy, K. M. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.05.036 · Cited by 85 · see citing works

Coordinate Regulation of T Cell Activation by CD2 and CD28

Green, J. M., Karpitskiy, V. V., Kimzey, S. L., & Shaw, A. S. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.7.3591 · Cited by 84 · see citing works

Early CD30 signaling is critical for adoptively transferred CD4+CD25+ regulatory T cells in prevention of acute graft-versus-host disease

Zeiser, R., Nguyen, V. H., Hou, J., Beilhack, A., Zambricki, E. A., Buess, M., Contag, C. H., & Negrin, R. S. (2006) · Blood · doi:10.1182/blood-2006-07-038455 · Cited by 78 · see citing works

T Cell Ig and Mucin Domain Proteins and Immunity

Kane, L. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0902937 · Cited by 75 · see citing works

Functional Exhaustion of CD4+ T Lymphocytes during Primary Cytomegalovirus Infection

Antoine, P., Olislagers, V., Huygens, A., Lecomte, S., Liesnard, C., Donner, C., & Marchant, A. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1101165 · Cited by 75 · see citing works

Loss of the signaling adaptor TRAF1 causes CD8+ T cell dysregulation during human and murine chronic infection

Wang, C., McPherson, A. J., Jones, R. B., Kawamura, K. S., Lin, G. H. Y., Lang, P. A., Ambagala, T., Pellegrini, M., Calzascia, T., Aidarus, N., et al. (2011) · The Journal of Experimental Medicine · doi:10.1084/jem.20110675 · Cited by 72 · see citing works

Negative feedback of T cell activation through inhibitory adapters and costimulatory receptors

Saito, T., & Yamasaki, S. (2003) · Immunological Reviews · doi:10.1034/j.1600-065x.2003.00022.x · Cited by 72 · see citing works

Regulation of costimulation in the era of butyrophilins

Arnett, H. A., Escobar, S. M., & Viney, J. L. (2009) · Cytokine · doi:10.1016/j.cyto.2009.03.009 · Cited by 71 · see citing works

RELT, a new member of the tumor necrosis factor receptor superfamily, is selectively expressed in hematopoietic tissues and activates transcription factor NF-κB

Sica, G., Zhu, G., Tamada, K., Liu, D., Ni, J., & Chen, L. (2001) · Blood · doi:10.1182/blood.v97.9.2702 · Cited by 71 · see citing works

TCR-Independent CD30 Signaling Selectively Induces IL-13 Production Via a TNF Receptor-Associated Factor/p38 Mitogen-Activated Protein Kinase-Dependent Mechanism

Harlin, H., Podack, E. R., Boothby, M. R., & Alegre, M. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.5.2451 · Cited by 70 · see citing works

Bimodal regulation of T cell-mediated immune responses by TIM-4

Mizui, M., Shikina, T., Arase, H., Suzuki, K., Yasui, T., Rennert, P. D., Kumanogoh, A., & Kikutani, H. (2008) · International Immunology · doi:10.1093/intimm/dxn029 · Cited by 68 · see citing works

The Adaptor Protein TRADD Is Essential for TNF-Like Ligand 1A/Death Receptor 3 Signaling

Pobezinskaya, E. L., Choksi, S., Morgan, M. J., Cao, X., & Liu, Z.-G. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1002374 · Cited by 66 · see citing works

Dichotomous regulation of GVHD through bidirectional functions of the BTLA-HVEM pathway

Sakoda, Y., Park, J., Zhao, Y., Kuramasu, A., Geng, D., Liu, Y., Dávila, E., & Tamada, K. (2011) · Blood · doi:10.1182/blood-2010-08-301325 · Cited by 54 · see citing works

Transcription factor regulation of CD8+ T‐cell memory and exhaustion

Angelosanto, J., & Wherry, E. J. (2010) · Immunological Reviews · doi:10.1111/j.1600-065x.2010.00927.x · Cited by 54 · see citing works

Differential Requirement of ZAP-70 for CD2-Mediated Activation Pathways of Mature Human T Cells

Meinl, E., Lengenfelder, D., Blank, N., Pirzer, R., Taborda‐Barata, L., & Hivroz, C. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.7.3578 · Cited by 51 · see citing works

LAIR and collagens in immune regulation

Meyaard, L. (2009) · Immunology Letters · doi:10.1016/j.imlet.2009.09.014 · Cited by 48 · see citing works

Modulating Co-Stimulation During Antigen Presentation to Enhance Cancer Immunotherapy

Liechtenstein, T., Dufait, I., Lanna, A., Breckpot, K., & Escors, D. (2012) · Immunology Endocrine & Metabolic Agents - Medicinal Chemistry · doi:10.2174/187152212802001875 · Cited by 46 · see citing works

CD30—Governor of Memory T Cells?

Podack, E. R., Štrbo, N., SOTOSEC, V., & Muta, H. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb05945.x · Cited by 45 · see citing works

Biochemical and Genetic Evidence for a SAP-PKC-θ Interaction Contributing to IL-4 Regulation

Cannons, J. L., Wu, J. Z., Gómez‐Rodríguez, J., Zhang, J., Dong, B., Liu, Y., Shaw, S., Siminovitch, K. A., & Schwartzberg, P. L. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0902182 · Cited by 44 · see citing works

An improved understanding of TNFL/TNFR interactions using structure-based classifications

Magis, C., van der Sloot, A. M., Serrano, L., & Notredame, C. (2012) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2012.06.002 · Cited by 34 · see citing works

Migration of Th1 Lymphocytes Is Regulated by CD152 (CTLA-4)-Mediated Signaling via PI3 Kinase-Dependent Akt Activation

Knieke, K., Lingel, H., Chamaon, K., & Brunner-Weinzierl, M. C. (2012) · PLoS ONE · doi:10.1371/journal.pone.0031391 · Cited by 29 · see citing works

Evidence Implicating the Ras Pathway in Multiple CD28 Costimulatory Functions in CD4+ T Cells

Janardhan, S. V., Praveen, K., Marks, R., & Gajewski, T. F. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024931 · Cited by 28 · see citing works

Tim-4 inhibition of T-cell activation and T helper type 17 differentiation requires both the immunoglobulin V and mucin domains and occurs via the mitogen-activated protein kinase pathway

Cao, W., Ryan, M., Buckley, D. A., O’Connor, R., & Clarkson, M. (2011) · Immunology · doi:10.1111/j.1365-2567.2011.03424.x · Cited by 23 · see citing works

Suppression of Allograft Rejection by Tim-1-Fc through Cross-Linking with a Novel Tim-1 Binding Partner on T Cells

Xiao, L., Fu, Z., Liu, F., Zhang, L., Shi, X.-M., Shen, X., Ni, Z., Fu, H. Y., Li, R., Cao, X., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0021697 · Cited by 12 · see citing works

Combined targeted and immunotherapy: the future of personalized medicine

Marabelle, A., & Caux, C. (2012) · Blood · doi:10.1182/blood-2012-09-455105 · Cited by 7 · see citing works

Letter: Cellular proliferation can be an unreliable index of immune competence.

Cunningham, A. J., & Lafferty, K. J. (1974) · PubMed · Cited by 6 · see citing works

Combating Chronic T-cell Exhaustion

McAfee, M. S., & Blattman, J. N. (2012) · Immunotherapy · doi:10.2217/imt.12.46 · Cited by 3 · see citing works

Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq

Tirosh, I., Izar, B., Prakadan, S. M., Wadsworth, M. H., Treacy, D., Trombetta, J. J., Rotem, A., Rodman, C., Lian, C., Murphy, G., et al. (2016) · Science · doi:10.1126/science.aad0501 · Cited by 4,944 · see citing works

Molecular and genetic properties of tumors associated with local immune cytolytic activity

Rooney, M. S., Shukla, S. A., Wu, C. J., Getz, G., & Hacohen, N. (2015) · Cell · doi:10.1016/j.cell.2014.12.033 · Cited by 3,825 · see citing works

The history and advances in cancer immunotherapy: understanding the characteristics of tumor-infiltrating immune cells and their therapeutic implications

Zhang, Y., & Zhang, Z. (2020) · Cellular and Molecular Immunology · doi:10.1038/s41423-020-0488-6 · Cited by 2,815 · see citing works

Tumor Mutational Burden as an Independent Predictor of Response to Immunotherapy in Diverse Cancers

Goodman, A. M., Kato, S., Bazhenova, L., Patel, S. P., Frampton, G. M., Miller, V., Stephens, P. J., Daniels, G. A., & Kurzrock, R. (2017) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-17-0386 · Cited by 2,264 · see citing works

Landscape of Infiltrating T Cells in Liver Cancer Revealed by Single-Cell Sequencing

Zheng, C., Zheng, L., Yoo, J.-K., Guo, H., Zhang, Y., Guo, X., Kang, B., Hu, R., Huang, J. Y., Zhang, Q., et al. (2017) · Cell · doi:10.1016/j.cell.2017.05.035 · Cited by 2,152 · see citing works

The Microenvironmental Landscape of Brain Tumors

Quail, D. F., & Joyce, J. A. (2017) · Cancer Cell · doi:10.1016/j.ccell.2017.02.009 · Cited by 1,875 · see citing works

Landscape and Dynamics of Single Immune Cells in Hepatocellular Carcinoma

Zhang, Q., He, Y., Luo, N., Patel, S. J., Han, Y., Gao, R., Modak, M., Carotta, S., Haslinger, C., Kind, D., et al. (2019) · Cell · doi:10.1016/j.cell.2019.10.003 · Cited by 1,624 · see citing works

T cell costimulatory receptor CD28 is a primary target for PD-1–mediated inhibition

Hui, E., Cheung, J., Zhu, J., Su, X., Taylor, M. J., Wallweber, H. A., Sasmal, D. K., Huang, J., Kim, J. M., Mellman, I., et al. (2017) · Science · doi:10.1126/science.aaf1292 · Cited by 1,689 · see citing works

Regulatory T cells in cancer immunosuppression — implications for anticancer therapy

Togashi, Y., Shitara, K., & Nishikawa, H. (2019) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-019-0175-7 · Cited by 1,553 · see citing works

Pan-cancer single-cell landscape of tumor-infiltrating T cells

Zheng, L., Qin, S., Si, W., Wang, A., Xing, B., Gao, R., Ren, X., Wang, L., Wu, X., Zhang, J., et al. (2021) · Science · doi:10.1126/science.abe6474 · Cited by 1,402 · see citing works

Traumatic Spinal Cord Injury: An Overview of Pathophysiology, Models and Acute Injury Mechanisms

Alizadeh, A., Dyck, S. M., & Karimi‐Abdolrezaee, S. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.00282 · Cited by 1,447 · see citing works

A Paradigm Shift in Cancer Immunotherapy: From Enhancement to Normalization

Sanmamed, M. F., & Chen, L. (2018) · Cell · doi:10.1016/j.cell.2018.09.035 · Cited by 1,394 · see citing works

Advances in immunotherapy for hepatocellular carcinoma

Sangro, B., Sarobe, P., Hervás-Stubbs, S., & Melero, I. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-021-00438-0 · Cited by 1,306 · see citing works

Spinal Cord Injury: Pathophysiology, Multimolecular Interactions, and Underlying Recovery Mechanisms

Anjum, A., Yazid, M. D., Daud, M., Idris, J., Ng, M. H., Naicker, A. S., Ismail, O. H. R., Kumar, R., & Lokanathan, Y. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21207533 · Cited by 1,327 · see citing works

Immune checkpoint blockade therapy for cancer: An overview of FDA-approved immune checkpoint inhibitors

Hargadon, K. M., Johnson, C. E., & Williams, C. J. (2018) · International Immunopharmacology · doi:10.1016/j.intimp.2018.06.001 · Cited by 1,211 · see citing works

Multimodal Analysis of Composition and Spatial Architecture in Human Squamous Cell Carcinoma

Ji, A. L., Rubin, A. J., Thrane, K., Jiang, S., Reynolds, D. L., Meyers, R. M., Guo, M. G., George, B. M., Mollbrink, A., Bergenstråhle, J., et al. (2020) · Cell · doi:10.1016/j.cell.2020.05.039 · Cited by 1,117 · see citing works

The Immunoreceptor TIGIT Regulates Antitumor and Antiviral CD8 + T Cell Effector Function

Johnston, R. J., Comps‐Agrar, L., Hackney, J. A., Yu, X., Huseni, M. A., Yang, Y., Park, S., Javinal, V., Chiu, H. H., Irving, B. A., et al. (2014) · Cancer Cell · doi:10.1016/j.ccell.2014.10.018 · Cited by 1,191 · see citing works

Review of Indications of FDA-Approved Immune Checkpoint Inhibitors per NCCN Guidelines with the Level of Evidence

Vaddepally, R. K., Kharel, P., Pandey, R. K., Garje, R., & Chandra, A. B. (2020) · Cancers · doi:10.3390/cancers12030738 · Cited by 1,189 · see citing works

Exploring treatment options in cancer: tumor treatment strategies

Liu, B., Zhou, H., Tan, L., Siu, K. T. H., & Guan, X.-Y. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01856-7 · Cited by 1,201 · see citing works

Combination cancer immunotherapy and new immunomodulatory targets

Mahoney, K. M., Rennert, P. D., & Freeman, G. J. (2015) · Nature Reviews Drug Discovery · doi:10.1038/nrd4591 · Cited by 1,294 · see citing works

Blockade of the checkpoint receptor TIGIT prevents NK cell exhaustion and elicits potent anti-tumor immunity

Zhang, Q., Bi, J., Zheng, X., Chen, Y., Wang, H., Wu, W., Wang, Z., Wu, Q., Peng, H. C., Wei, H., et al. (2018) · Nature Immunology · doi:10.1038/s41590-018-0132-0 · Cited by 1,122 · see citing works

T cells in health and disease

Sun, L., Su, Y., Jiao, A., Wang, X., & Zhang, B. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01471-y · Cited by 1,060 · see citing works

Precision Tumor Recognition by T Cells With Combinatorial Antigen-Sensing Circuits

Roybal, K. T., Rupp, L. J., Morsut, L., Walker, W. J., McNally, K. A., Park, J. S., & Lim, W. A. (2016) · Cell · doi:10.1016/j.cell.2016.01.011 · Cited by 1,010 · see citing works

CD28 Costimulation: From Mechanism to Therapy

Esensten, J. H., Helou, Y. A., Chopra, G., Weiss, A., & Bluestone, J. A. (2016) · Immunity · doi:10.1016/j.immuni.2016.04.020 · Cited by 937 · see citing works

Metastasis is regulated via microRNA-200/ZEB1 axis control of tumour cell PD-L1 expression and intratumoral immunosuppression

Chen, L., Gibbons, D. L., Goswami, S., Cortez, M. A., Ahn, Y., Byers, L. A., Zhang, X., Yi, X., Dwyer, D. W., Lin, W., et al. (2014) · Nature Communications · doi:10.1038/ncomms6241 · Cited by 972 · see citing works

Recent advances in the development of protein–protein interactions modulators: mechanisms and clinical trials

Lu, H., Zhou, Q., He, J., Jiang, Z., Peng, C., Tong, R., & Shi, J. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00315-3 · Cited by 891 · see citing works

The immune system’s role in sepsis progression, resolution, and long-term outcome

Delano, M. J., & Ward, P. A. (2016) · Immunological Reviews · doi:10.1111/imr.12499 · Cited by 880 · see citing works

M2b macrophage polarization and its roles in diseases

Wang, L., Zhang, S.-X., Wu, H., Rong, X., & Guo, J. (2018) · Journal of Leukocyte Biology · doi:10.1002/jlb.3ru1018-378rr · Cited by 889 · see citing works

Enhancing immunotherapy in cancer by targeting emerging immunomodulatory pathways

Kraehenbuehl, L., Weng, C.-H., Eghbali, S., Wolchok, J., & Merghoub, T. (2021) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-021-00552-7 · Cited by 731 · see citing works

Immune dysregulation in human subjects with heterozygous germline mutations in CTLA4

Kuehn, H. S., Ouyang, W., Lo, B., Deenick, E. K., Niemela, J. E., Avery, D. T., Schickel, J., Tran, D. Q., Stoddard, J. L., Zhang, Y., et al. (2014) · Science · doi:10.1126/science.1255904 · Cited by 854 · see citing works

Quantitative Assessment of the Heterogeneity of PD-L1 Expression in Non–Small-Cell Lung Cancer

McLaughlin, J. F., Han, G., Schalper, K. A., Carvajal‐Hausdorf, D., Pelekanou, V., Rehman, J., Velcheti, V., Herbst, R. S., LoRusso, P. M., & Rimm, D. L. (2015) · JAMA Oncology · doi:10.1001/jamaoncol.2015.3638 · Cited by 835 · see citing works

Integrated molecular analysis of adult T cell leukemia/lymphoma

Kataoka, K., Nagata, Y., Kitanaka, A., Shiraishi, Y., Shimamura, T., Yasunaga, J., Totoki, Y., Chiba, K., Sato‐Otsubo, A., Nagae, G., et al. (2015) · Nature Genetics · doi:10.1038/ng.3415 · Cited by 819 · see citing works

Structural Design of Engineered Costimulation Determines Tumor Rejection Kinetics and Persistence of CAR T Cells

Zhao, Z., Condomines, M., van der Stegen, S. J. C., Perna, F., Kloss, C. C., Gunset, G., Plotkin, J., & Sadelain, M. (2015) · Cancer Cell · doi:10.1016/j.ccell.2015.09.004 · Cited by 843 · see citing works

Next generation of immune checkpoint therapy in cancer: new developments and challenges

Marin-Acevedo, J. A., Dholaria, B., Soyano, A. E., Knutson, K. L., Chumsri, S., & Lou, Y. (2018) · Journal of Hematology & Oncology · doi:10.1186/s13045-018-0582-8 · Cited by 802 · see citing works

Regulatory mechanisms of PD-1/PD-L1 in cancers

Lin, X., Kang, K., Chen, P., Zeng, Z., Li, G., Xiong, W., Yi, M., & Xiang, B. (2024) · Molecular Cancer · doi:10.1186/s12943-024-02023-w · Cited by 850 · see citing works

The future of cancer immunotherapy: microenvironment-targeting combinations

Murciano‐Goroff, Y. R., Warner, A. B., & Wolchok, J. D. (2020) · Cell Research · doi:10.1038/s41422-020-0337-2 · Cited by 753 · see citing works

Robust prediction of response to immune checkpoint blockade therapy in metastatic melanoma

Auslander, N., Zhang, G., Lee, J. S., Frederick, D. T., Miao, B., Moll, T. O. C., Tian, T., Wei, Z., Madan, S., Sullivan, R. J., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0157-9 · Cited by 743 · see citing works

Immunosenescence and Its Hallmarks: How to Oppose Aging Strategically? A Review of Potential Options for Therapeutic Intervention

Aiello, A., Farzaneh, F., Candore, G., Caruso, C., Davinelli, S., Gambino, C. M., Ligotti, M. E., Zareian, N., & Accardi, G. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02247 · Cited by 693 · see citing works

The growing role of precision and personalized medicine for cancer treatment

Krzyszczyk, P., Acevedo, A., Davidoff, E. J., Timmins, L. M., Marrero-Berríos, I., Patel, M., White, C., Lowe, C., Sherba, J. J., Hartmanshenn, C., et al. (2018) · TECHNOLOGY · doi:10.1142/s2339547818300020 · Cited by 726 · see citing works

The Pathogenesis of Sepsis and Potential Therapeutic Targets

Huang, M., Cai, S., & Su, J. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20215376 · Cited by 776 · see citing works

Universal Chimeric Antigen Receptors for Multiplexed and Logical Control of T Cell Responses

Cho, J. H., Collins, J. J., & Wong, W. W. (2018) · Cell · doi:10.1016/j.cell.2018.03.038 · Cited by 685 · see citing works

Siglec-15 as an immune suppressor and potential target for normalization cancer immunotherapy

Wang, J., Sun, J., Liu, L. N., Flies, D. B., Nie, X., Toki, M. I., Zhang, J., Song, C. C., Zarr, M. A., Zhou, X., et al. (2019) · Nature Medicine · doi:10.1038/s41591-019-0374-x · Cited by 676 · see citing works

Eradication of metastatic mouse cancers resistant to immune checkpoint blockade by suppression of myeloid-derived cells

Kim, K., Skora, A. D., Li, Z., Liu, Q., Tam, A. J., Blosser, R. L., Diaz, L. A., Papadopoulos, N., Kinzler, K. W., Vogelstein, B., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1410626111 · Cited by 676 · see citing works

Sepsis-induced immune dysfunction: can immune therapies reduce mortality?

Delano, M. J., & Ward, P. A. (2016) · Journal of Clinical Investigation · doi:10.1172/jci82224 · Cited by 652 · see citing works

Antibody Structure and Function: The Basis for Engineering Therapeutics

Chiu, M. L., Goulet, D. R., Teplyakov, A., & Gilliland, G. L. (2019) · Antibodies · doi:10.3390/antib8040055 · Cited by 646 · see citing works

Immune escape to PD-L1/PD-1 blockade: seven steps to success (or failure)

Kim, J. M., & Chen, D. S. (2016) · Annals of Oncology · doi:10.1093/annonc/mdw217 · Cited by 648 · see citing works

Engineering CAR-T Cells for Next-Generation Cancer Therapy

Hong, M., Clubb, J. D., & Chen, Y. Y. (2020) · Cancer Cell · doi:10.1016/j.ccell.2020.07.005 · Cited by 644 · see citing works

Galectin-9 interacts with PD-1 and TIM-3 to regulate T cell death and is a target for cancer immunotherapy

Yang, R., Sun, L., Li, C.-F., Wang, Y.-H., Yao, J., Li, H., Yan, M., Chang, W., Hsu, J.-M., Cha, J., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-21099-2 · Cited by 637 · see citing works

Diverse macrophage populations mediate acute lung inflammation and resolution

Aggarwal, N. R., King, L. S., & D’Alessio, F. R. (2014) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00341.2013 · Cited by 583 · see citing works

The pharmacology of second-generation chimeric antigen receptors

van der Stegen, S. J. C., Hamieh, M., & Sadelain, M. (2015) · Nature Reviews Drug Discovery · doi:10.1038/nrd4597 · Cited by 561 · see citing works

Next generation of immune checkpoint inhibitors and beyond

Marin-Acevedo, J. A., Kimbrough, E. O., & Lou, Y. (2021) · Journal of Hematology & Oncology · doi:10.1186/s13045-021-01056-8 · Cited by 560 · see citing works

Tumor-repopulating cells induce PD-1 expression in CD8(+) T cells by transferring kynurenine and AhR activation

Liu, Y., Liang, X., Dong, W., Fang, Y., Lv, J., Zhang, T., Fiskesund, R., Xie, J., Liu, J., Yin, X., et al. (2018) · Cancer Cell · doi:10.1016/j.ccell.2018.02.005 · Cited by 535 · see citing works

Liposomes as vaccine delivery systems: a review of the recent advances

Schwendener, R. A. (2014) · Therapeutic Advances in Vaccines · doi:10.1177/2051013614541440 · Cited by 524 · see citing works

Emerging Concepts for Immune Checkpoint Blockade-Based Combination Therapies

Zappasodi, R., Merghoub, T., & Wolchok, J. D. (2018) · Cancer Cell · doi:10.1016/j.ccell.2018.03.005 · Cited by 519 · see citing works

Characterization of the immunophenotypes and antigenomes of colorectal cancers reveals distinct tumor escape mechanisms and novel targets for immunotherapy

Angelova, M., Charoentong, P., Hackl, H., Fischer, M. L., Snajder, R., Krogsdam, A., Waldner, M. J., Bindea, G., Mlecnik, B., Galon, J., et al. (2015) · Genome biology · doi:10.1186/s13059-015-0620-6 · Cited by 521 · see citing works

Updates on global epidemiology, risk and prognostic factors of gastric cancer

Yang, W., Zhao, H., Yu, Y. P., Wang, J.-H., Guo, L., Liu, J.-Y., Pu, J., & Lv, J. (2023) · World Journal of Gastroenterology · doi:10.3748/wjg.v29.i16.2452 · Cited by 537 · see citing works

Design and development of therapies using chimeric antigen receptor‐expressing T cells

Dotti, G., Gottschalk, S. M., Savoldo, B., & Brenner, M. K. (2013) · Immunological Reviews · doi:10.1111/imr.12131 · Cited by 510 · see citing works

Augmentation of Antitumor Immunity by Human and Mouse CAR T Cells Secreting IL-18

Hu, B., Ren, J., Luo, Y., Keith, B., Young, R. M., Scholler, J., Zhao, Y., & June, C. H. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.09.002 · Cited by 504 · see citing works

Therapeutic targets and biomarkers of tumor immunotherapy: response versus non-response

Wang, D., Wu, X., & Sun, Y. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01136-2 · Cited by 518 · see citing works

Biological Consequences of MHC-II Expression by Tumor Cells in Cancer

Axelrod, M. L., Cook, R. S., Johnson, D. B., & Balko, J. M. (2018) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-18-3200 · Cited by 496 · see citing works

Breast Cancer Treatments: Updates and New Challenges

Burguin, A., Diorio, C., & Durocher, F. (2021) · Journal of Personalized Medicine · doi:10.3390/jpm11080808 · Cited by 513 · see citing works

Induction and transcriptional regulation of the co-inhibitory gene module in T cells

Chihara, N., Madi, A., Kondo, T., Zhang, H., Acharya, N., Singer, M., Nyman, J., Marjanovic, N. D., Kowalczyk, M. S., Wang, C., et al. (2018) · Nature · doi:10.1038/s41586-018-0206-z · Cited by 438 · see citing works

CD8+ T cells in the cancer-immunity cycle

Giles, J. R., Globig, A.-M., Kaech, S. M., & Wherry, E. J. (2023) · Immunity · doi:10.1016/j.immuni.2023.09.005 · Cited by 467 · see citing works

The Evasion Mechanisms of Cancer Immunity and Drug Intervention in the Tumor Microenvironment

Kim, S. K., & Cho, S. W. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.868695 · Cited by 473 · see citing works

PD-1–PD-L1 immune-checkpoint blockade in B-cell lymphomas

Goodman, A. M., Patel, S. P., & Kurzrock, R. (2016) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2016.168 · Cited by 457 · see citing works

Dying cells actively regulate adaptive immune responses

Yatim, N., Cullen, S., & Albert, M. L. (2017) · Nature Reviews Immunology · doi:10.1038/nri.2017.9 · Cited by 442 · see citing works

Identifying and Targeting Human Tumor Antigens for T Cell-Based Immunotherapy of Solid Tumors

Leko, V., & Rosenberg, S. A. (2020) · Cancer Cell · doi:10.1016/j.ccell.2020.07.013 · Cited by 449 · see citing works

The emerging role of epigenetic therapeutics in immuno-oncology

Topper, M. J., Vaz, M., Marrone, K. A., Brahmer, J. R., & Baylin, S. B. (2020) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-019-0266-5 · Cited by 433 · see citing works

Targeting TGFβ signal transduction for cancer therapy

Liu, S., Ren, J., & ten Dijke, P. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00436-9 · Cited by 413 · see citing works

Management of Immunotherapy-Related Toxicities, Version 1.2022, NCCN Clinical Practice Guidelines in Oncology

Thompson, J. A., Schneider, B. J., Brahmer, J. R., Achufusi, A., Armand, P. A., Berkenstock, M., Bhatia, S., Budde, L. E., Chokshi, S., Davies, M. J., et al. (2022) · Journal of the National Comprehensive Cancer Network · doi:10.6004/jnccn.2022.0020 · Cited by 437 · see citing works

T‐cell exhaustion in HIV infection

Fenwick, C. W., Joo, V., Jacquier, P., Noto, A., Banga, R., Perreau, M., & Pantaleo, G. (2019) · Immunological Reviews · doi:10.1111/imr.12823 · Cited by 412 · see citing works

Reassessing B cell contributions in multiple sclerosis

Li, R., Patterson, K., & Bar-Or, A. (2018) · Nature Immunology · doi:10.1038/s41590-018-0135-x · Cited by 372 · see citing works

Th2 Cells in Health and Disease

Nakayama, T., Hirahara, K., Onodera, A., Endo, Y., Hosokawa, H., Shinoda, K., Tumes, D. J., & Okamoto, Y. (2016) · Annual Review of Immunology · doi:10.1146/annurev-immunol-051116-052350 · Cited by 398 · see citing works

Immunoregulation by Mesenchymal Stem Cells: Biological Aspects and Clinical Applications

Castro-Manrreza, M. E., & Montesinos, J. J. (2015) · Journal of Immunology Research · doi:10.1155/2015/394917 · Cited by 400 · see citing works

Blocking of the PD‐1/PD‐L1 Interaction by a D ‐Peptide Antagonist for Cancer Immunotherapy

Chang, H., Liu, B., Qi, Y., Zhou, Y., Chen, Y., Pan, K., Li, W., Zhou, X., Ma, W., Fu, C., et al. (2015) · Angewandte Chemie International Edition · doi:10.1002/anie.201506225 · Cited by 401 · see citing works

PD-1 expression on tumor-specific T cells: Friend or foe for immunotherapy?

Simon, S., & Labarrière, N. (2017) · OncoImmunology · doi:10.1080/2162402x.2017.1364828 · Cited by 399 · see citing works

A comparison of chimeric antigen receptors containing CD28 versus 4-1BB costimulatory domains

Cappell, K. M., & Kochenderfer, J. N. (2021) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-021-00530-z · Cited by 398 · see citing works

Progression of Lung Cancer Is Associated with Increased Dysfunction of T Cells Defined by Coexpression of Multiple Inhibitory Receptors

Thommen, D. S., Schreiner, J., Müller, P., Herzig, P., Roller, A., Belousov, A., Umaña, P., Pisa, P., Klein, C., Bacac, M., et al. (2015) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-15-0097 · Cited by 395 · see citing works

Restriction of PD-1 function by <i>cis</i> -PD-L1/CD80 interactions is required for optimal T cell responses

Sugiura, D., Maruhashi, T., Okazaki, I.-M., Shimizu, K., Maeda, T. K., Takemoto, T., & Okazaki, T. (2019) · Science · doi:10.1126/science.aav7062 · Cited by 386 · see citing works

T-cell exhaustion in chronic hepatitis B infection: current knowledge and clinical significance

Ye, B., Liu, X., Li, X., Kong, H.-J., Li, T., & Chen, Y. (2015) · Cell Death and Disease · doi:10.1038/cddis.2015.42 · Cited by 392 · see citing works

Structural Biology of the Immune Checkpoint Receptor PD-1 and Its Ligands PD-L1/PD-L2

Żak, K. M., Grudnik, P., Magiera‐Mularz, K., Dömling, A. S. S., Dubin, G., & Holak, T. A. (2017) · Structure · doi:10.1016/j.str.2017.06.011 · Cited by 386 · see citing works

A guide to manufacturing CAR T cell therapies

Vormittag, P., Gunn, R., Ghorashian, S., & Veraitch, F. S. (2018) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2018.01.025 · Cited by 389 · see citing works

Oncotarget

Ross-Adams, H., Ball, S., Lawrenson, K., Halim, S., Russell, R., Wells, C. A., Strand, S., Orntoft, T., Larson, M., Armasu, S., et al. (2016) · Oncotarget · doi:10.18632/oncotarget · Cited by 392 · see citing works

Lessons learned from the blockade of immune checkpoints in cancer immunotherapy

Li, X., Shao, C., Shi, Y., & Han, W. (2018) · Journal of Hematology & Oncology · doi:10.1186/s13045-018-0578-4 · Cited by 385 · see citing works

Integrating canonical and metabolic signalling programmes in the regulation of T cell responses

Pollizzi, K. N., & Powell, J. D. (2014) · Nature reviews. Immunology · doi:10.1038/nri3701 · Cited by 379 · see citing works

Type I interferon activates MHC class I-dressed CD11b+ conventional dendritic cells to promote protective anti-tumor CD8+ T cell immunity

Duong, E., Fessenden, T. B., Lutz, E., Dinter, T., Yim, L., Blatt, S., Bhutkar, A., Wittrup, K. D., & Spranger, S. (2022) · Immunity · doi:10.1016/j.immuni.2021.10.020 · Cited by 372 · see citing works

Immune-checkpoint proteins VISTA and PD-1 nonredundantly regulate murine T-cell responses

Liu, J., Yuan, Y., Chen, W., Putra, J., Suriawinata, A. A., Schenk, A. D., Miller, H. E., Guleria, I., Barth, R. J., Huang, Y. H., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1420370112 · Cited by 374 · see citing works

An osteopontin/CD44 immune checkpoint controls CD8+ T cell activation and tumor immune evasion

Klement, J. D., Paschall, A. V., Redd, P. S., Ibrahim, M. L., Lu, C., Yang, D., Celis, E., Abrams, S. I., Ozato, K., & Liu, K. (2018) · Journal of Clinical Investigation · doi:10.1172/jci123360 · Cited by 371 · see citing works

Mechanisms regulating T-cell infiltration and activity in solid tumors

Lanitis, E., Dangaj, D., Irving, M., & Coukos, G. (2017) · Annals of Oncology · doi:10.1093/annonc/mdx238 · Cited by 369 · see citing works

Targeting TREM2 on tumor-associated macrophages enhances immunotherapy

Binnewies, M., Pollack, J. L., Rudolph, J., Dash, S., Abushawish, M., Lee, T., Jahchan, N. S., Canaday, P., Lu, E., Norng, M., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109844 · Cited by 365 · see citing works

PD-1hi identifies a novel regulatory b-cell population in human hepatoma that promotes disease progression

Xiao, X., Lao, X.-M., Chen, M.-M., Liu, R.-X., Wei, Y., Ouyang, F.-Z., Chen, D.-P., Zhao, X.-Y., Zhao, Q., Li, X.-F., et al. (2016) · Cancer Discovery · doi:10.1158/2159-8290.cd-15-1408 · Cited by 352 · see citing works

Role of B cells as antigen presenting cells

Rastogi, I., Jeon, D., Moseman, J. E., Muralidhar, A., Potluri, H. K., & McNeel, D. G. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.954936 · Cited by 352 · see citing works

PD-L1 and Survival in Solid Tumors: A Meta-Analysis

Wu, P., Wu, D., Li, L., Chai, Y., & Huang, J. (2015) · PLoS ONE · doi:10.1371/journal.pone.0131403 · Cited by 351 · see citing works

Cd8 + T Cells Orchestrate pDC-XCR1 + Dendritic Cell Spatial and Functional Cooperativity to Optimize Priming

Brewitz, A., Eickhoff, S., Dähling, S., Quast, T., Bedoui, S., Kroczek, R. A., Kurts, C., Garbi, N., Barchet, W., Iannacone, M., et al. (2017) · Immunity · doi:10.1016/j.immuni.2017.01.003 · Cited by 339 · see citing works

A nanovaccine for antigen self-presentation and immunosuppression reversal as a personalized cancer immunotherapy strategy

Liu, C., Liu, X., Xiang, X., Pang, X., Chen, S., Zhang, Y., Ren, E., Zhang, L., Liu, X., Lv, P., et al. (2022) · Nature Nanotechnology · doi:10.1038/s41565-022-01098-0 · Cited by 351 · see citing works

Innate-adaptive immunity interplay and redox regulation in immune response

Sun, L., Wang, X., Saredy, J., Yuan, Z., Yang, X., & Wang, H. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101759 · Cited by 343 · see citing works

Exhausted CD8+T Cells in the Tumor Immune Microenvironment: New Pathways to Therapy

Jiang, W., He, Y., He, W., Wu, G. S., Zhou, X., Sheng, Q., Zhong, W., Lu, Y., Ding, Y., Qi, L., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.622509 · Cited by 339 · see citing works

Metabolic signaling in T cells

Shyer, J. A., Flavell, R. A., & Bailis, W. (2020) · Cell Research · doi:10.1038/s41422-020-0379-5 · Cited by 334 · see citing works

Targeting the CD40-CD40L pathway in autoimmune diseases: Humoral immunity and beyond

Karnell, J. L., Rieder, S. A., Ettinger, R., & Kolbeck, R. (2018) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2018.12.005 · Cited by 335 · see citing works

PD-1 blockade in subprimed CD8 cells induces dysfunctional PD-1+CD38hi cells and anti-PD-1 resistance

Verma, V., Shrimali, R. K., Ahmad, S., Dai, W., Wang, H., Lu, S., Nandre, R., Gaur, P., Lopez, J., Sade-Feldman, M., et al. (2019) · Nature Immunology · doi:10.1038/s41590-019-0441-y · Cited by 333 · see citing works

Signal Transduction Via Co-stimulatory and Co-inhibitory Receptors

Ogawa, S., & Abe, R. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-981-32-9717-3_4 · Cited by 22 · see citing works

T Cell Co-inhibitory Receptors-Functions and Signalling Mechanisms

Thaventhiran, T. (2013) · Journal of Clinical & Cellular Immunology · doi:10.4172/2155-9899.s12-004 · Cited by 20 · see citing works

Co-inhibitory molecules of the B7–CD28 family in the control of T-cell immunity

Chen, L. (2004) · Nature reviews. Immunology · doi:10.1038/nri1349 · Cited by 1,257 · see citing works

Commentary: Regulated equilibrium between opposite signals: a general paradigm for T cell function?

Moretta, A., & Bottino, C. (2004) · European Journal of Immunology · doi:10.1002/eji.200425388 · Cited by 9 · see citing works

Co-signal Molecules in T-Cell Activation

Azuma, M. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-981-32-9717-3_1 · Cited by 72 · see citing works