The DOI matches its Crossref record; 107 of the 107 references it cites were found in a registry or an index.
Signalling through C-type lectin receptors: shaping immune responses
Open accessAbstract
C-type lectin receptors (CLRs) expressed by dendritic cells are crucial for tailoring immune responses to pathogens. Following pathogen binding, CLRs trigger distinct signalling pathways that induce the expression of specific cytokines which determine T cell polarization fates. Some CLRs can induce signalling pathways that directly activate nuclear factor-κB, whereas other CLRs affect signalling by Toll-like receptors. Dissecting these signalling pathways and their effects on host immune cells is essential to understand the molecular mechanisms involved in the induction of adaptive immune responses. In this Review we describe the role of CLR signalling in regulating adaptive immunity and immunopathogenesis and discuss how this knowledge can be harnessed for the development of innovative vaccination approaches.
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Cites
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Cited by
Pattern Recognition Receptors and Inflammation
Takeuchi, O., & Akira, S. (2010) · Cell · doi:10.1016/j.cell.2010.01.022 · Cited by 8,895
Toll-like receptors and their crosstalk with other innate receptors in infection and immunity
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Sterile inflammation: sensing and reacting to damage
Chen, G. Y., & Nuñez, G. (2010) · Nature Reviews Immunology · doi:10.1038/nri2873 · Cited by 3,051
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Innate Immune Pattern Recognition: A Cell Biological Perspective
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Metadata
- Authors
- Geijtenbeek, T. B. H., & Gringhuis, S. I.
- Venue
- Nature Reviews Immunology
- Published
- 2009-07
- Volume
- 9
- Issue
- 7
- Pages
- 465-479
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- OpenAlex
- W2129374849
- Cited by
- 1,379
- References
- 107
- FWCI
- 4.43
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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